Symptomatic extracranial. Medical search. Frequent questions

Generally, symptomatic patients with greater than 50% stenosis and healthy, asymptomatic patients with greater than 60% stenosis warrant consideration for CEA. (medscape.com)
Methods We screened 1239 patients with extracranial VA stenosis, of whom 321 patients with severe VA V1 segment stenosis (≥70%) were enrolled in our study. (bmj.com)
4 5 However, both the Vertebral Artery Stenting Trial (VAST) 6 7 and the Vertebral Artery Ischemia Stenting Trial (VIST) 8 9 have failed to demonstrate the superiority of stenting in preventing recurrent strokes in patients with symptomatic VA stenosis compared with optimal medical management. (bmj.com)
[ 2 ] Several reports favor earlier carotid revascularization (≤ 7 d or even ≤ 48 h) for recently symptomatic stenosis, in view of their finding that there is no change in the safety profile of CEA done in the hyperacute period (≤ 48 h) as compared with CEA done at a later time (day 3-14). (medscape.com)
As mentioned above, CEA is indicated for symptomatic 70-99% carotid stenosis and is three times as effective as medical therapy alone in reducing the incidence of stroke. (medscape.com)
Scholars@Duke publication: Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis. (duke.edu)
BACKGROUND: Symptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. (duke.edu)
We aimed to compare vertebral stenting with medical treatment for symptomatic vertebral stenosis. (duke.edu)
METHODS: We did a preplanned pooled individual patient data analysis of three completed randomised controlled trials comparing stenting with medical treatment in patients with symptomatic vertebral stenosis. (duke.edu)
Analyses were performed for vertebral stenosis at any location and separately for extracranial and intracranial stenoses. (duke.edu)
FINDINGS: Data were from 354 individuals from three trials, including 179 patients from VIST (148 with extracranial stenosis and 31 with intracranial stenosis), 115 patients from VAST (96 with extracranial stenosis and 19 with intracranial stenosis), and 60 patients with intracranial stenosis from SAMMPRIS (no patients had extracranial stenosis). (duke.edu)
Across all trials, 168 participants (46 with intracranial stenosis and 122 with extracranial stenosis) were randomly assigned to medical treatment and 186 to stenting (64 with intracranial stenosis and 122 with extracranial stenosis). (duke.edu)
INTERPRETATION: Stenting for vertebral stenosis has a much higher risk for intracranial, compared with extracranial, stenosis. (duke.edu)
Stenting for extracranial stenosis might be beneficial, but further larger trials are required to determine the treatment effect in this subgroup. (duke.edu)
Total serum homocysteine--a predictor of extracranial carotid artery stenosis in male patients with symptomatic peripheral arterial disease. (cdc.gov)
Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial. (ox.ac.uk)
OBJECTIVE: To compare in the Vertebral Artery Ischaemia Stenting Trial (VIST) the risks and benefits of vertebral angioplasty and stenting with best medical treatment (BMT) alone for symptomatic vertebral artery stenosis. (ox.ac.uk)
Participants with symptomatic vertebral stenosis ≥50% were randomly assigned (1:1) to vertebral angioplasty/stenting plus BMT or to BMT alone with randomization stratified by site of stenosis (extracranial vs intracranial). (ox.ac.uk)
CONCLUSIONS: Stenting in extracranial stenosis appears safe with low complication rates. (ox.ac.uk)
CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for patients with symptomatic vertebral stenosis, angioplasty with stenting does not reduce the risk of stroke. (ox.ac.uk)
Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis: North American Symptomatic Carotid Endarterectomy Trial Collaborators. (ima-press.net)
Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. (ima-press.net)
The results were published in an article titled "Safety and Efficacy of Rapamycin-Eluting Vertebral Stents in Patients with Symptomatic Extracranial Vertebral Artery Stenosis" in Frontiers in Neurology , an authoritative journal in the field of neurology. (microport.com)
The Bridge ® Rapamycin Target Eluting Vertrbral Stent System is the first drug-eluting stent designed for symptomatic vertebral artery stenosis in China. (microport.com)
The PESS study published the angiographic follow-up at 6 months and the final clinical follow-up at 12 months: there were 101 subjects with symptomatic vertebral artery stenosis enrolled for interventional therapy, and a total of 104 target lesions were successfully stented at the vertebral artery stenosis. (microport.com)
70% symptomatic carotid stenosis (TIA within last 2 weeks) were taken for simultaneous CEA along with CABG. (ejcvsmed.org)
Regarding to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) [2] and Asymptomatic Carotid Atherosclerosis Study (ACAS) [3] carotid endarterectomy (CEA) reduced the risk of stroke in patients with ICA stenosis. (ejcvsmed.org)

Management of acute symptomatic internal carotid artery (ICA) occlusion remains controversial. (ajnr.org)
We evaluated outcome predictors of a good recovery in patients with acute symptomatic ICA occlusion. (ajnr.org)
mean age, 66 years) with: 1) acute symptomatic ICA occlusion within 6 hours of symptom onset or with mismatch of symptoms and an early infarct area, 2) National Institutes of Health Stroke Scale (NIHSS) score of 6 or more, and 3) attempted endovascular revascularization of the occluded ICA. (ajnr.org)
Active revascularization of acute symptomatic ICA occlusion resulted in good recovery in one third of patients after 1 year. (ajnr.org)
Compared with studies regarding the effect of middle cerebral artery (MCA) occlusion, 1 there have only been a few studies regarding the efficacy of revascularization in patients with symptomatic acute internal carotid artery (ICA) occlusion. (ajnr.org)
16 In addition, the management of patients with acute symptomatic carotid artery occlusion remains controversial, though the angiographic finding of ICA occlusion reveals a spectrum of ICA occlusions, as well as a tandem lesion in the intracranial artery in addition to the level (below or above the ophthalmic artery) and type (atherosclerotic or embolic) of lesion. (ajnr.org)
2 , 17 We evaluated outcome of the acute symptomatic ICA occlusion and estimated how the clinical outcome differs according to the 14 prognostic factors associated with the clinical outcomes. (ajnr.org)
mean age, 66 years) who experienced the following: 1) acute symptomatic ICA occlusion within 6 hours of symptom onset or with mismatch of symptoms and early infarct area, 2) initial National Institutes of Health Stroke Scale (NIHSS) ≥6, and 3) attempted intraarterial revascularization, were enrolled in this study. (ajnr.org)
Management of acute ischemic stroke due to tandem occlusion: extracranial or intracranial revascularization first? (cns.org)
No Benefit of EC/IC Bypass vs Meds in Large-Artery Stroke Despite surgical advances, adding extracranial-intracranial bypass to medical therapy does not reduce stroke or death in symptomatic occlusion of the internal carotid or middle cerebral artery. (medscape.com)
Objective To test the safety and efficacy of emergent microsurgical intervention in patients with acute ischemic stroke and symptomatic middle cerebral artery occlusion after failure of mechanical thrombectomy. (osu.cz)

and 4 patients (6.1%) had symptomatic intracranial hemorrhage within 24 hours postprocedure. (cns.org)
In the setting of clinical practice, intravenous TPA within 4.5 hours improved the functional outcome despite an increased risk of symptomatic intracranial hemorrhage in very elderly Korean patients. (j-stroke.org)
In Japanese and Taiwanese studies, symptomatic intracranial hemorrhage (SICH) was not substantially and significantly increased with TPA, but most patients were treated with a lower dose [ 17 , 18 ]. (j-stroke.org)
Early initiation of anticoagulation with a DOAC following acute ischemic stroke in patients with atrial fibrillation does not lead to an increased risk of symptomatic intracranial hemorrhage and may be more effective in preventing recurrent stroke. (joulecma.ca)
Symptomatic intracranial hemorrhage occurred in 0.2% (n = 2) patients in both groups. (empendium.com)
The authors concluded that the incidence of recurrent ischemic stroke, systemic embolism, major extracranial bleeding, symptomatic intracranial hemorrhage, or vascular death at 30 days was estimated at 2.8 percentage points lower to 0.5 percentage points higher with early initiation of DOAC therapy as compared with the later start. (empendium.com)

It was shown that cerebral revascularization using extracranial to intracranial bypass may result in neurological symptoms improvement and an objective increase in regional cerebral blood flow in a selective cohort of patients with symptomatic chronic cerebrovascular ischemia [ 1 ]. (hindawi.com)
7 - 9 ] In these patients, according to the 2021 Japan Stroke Guidelines, extracranial-intracranial bypass is recommended. (surgicalneurologyint.com)
Acute extracranial-intracranial bypass using a radial artery graft along with trapping of a ruptured blood blister-like aneurysm of the internal carotid artery. (unboundmedicine.com)
The authors describe the clinical course of patients with subarachnoid hemorrhage (SAH) caused by BBA rupture and emphasize the value of internal carotid artery trapping combined with high-flow extracranial-intracranial (trapping/EC-IC) bypass during the acute period following SAH. (unboundmedicine.com)
Kamijo K, Matsui T. Acute extracranial-intracranial bypass using a radial artery graft along with trapping of a ruptured blood blister-like aneurysm of the internal carotid artery. (unboundmedicine.com)
Randomised trial fails to show benefit with bypass surgery in symptomatic. (neuronewsinternational.com)
The initial findings from a recent randomised controlled trial (RCT) do not support the addition of extracranial to intracranial (EC-IC) bypass surgery to the. (neuronewsinternational.com)
Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke: results of an international randomized trial: the EC/IC Bypass Study Group. (ima-press.net)
Microsurgical embolectomy and/or extracranial-intracranial bypass was performed in all MSIG patients at center 1. (osu.cz)

The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging. (nih.gov)
Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. (j-stroke.org)

Affects medium and small arteries over a diffuse CNS area, without symptomatic extracranial vessel involvement. (wikipedia.org)
As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. (nih.gov)
All patients underwent cardiovascular magnetic resonance (CMR) for brain and intracranial and extracranial arteries. (nih.gov)
No current evidence-based guidelines address anticoagulation in patients with symptomatic stenoses of extracranial and intracranial arteries. (medscape.com)
Atherosclerosis has a predilection for certain arteries, including the extracranial carotid artery. (medscape.com)
CX 2021: Stenting should be reserved for the extracranial vertebral arteries. (neuronewsinternational.com)
Nevertheless, the histopathology of ICAS has not been well studied as extracranial atherosclerosis (ECAS), probably due to the infrequency of ICAS in Caucasians and the relative inaccessibility of intracranial arteries. (j-stroke.org)
They assessed the extent and severity of atherosclerosis in the aorta, coronary, carotid, and cerebral arteries, demonstrating that the cerebral arteries were free from atherosclerosis up to the fourth decade, almost 20 to 30 years later than extracranial arteries like coronary and carotid artery [ 5 - 7 ]. (j-stroke.org)

Hyperhomocysteinaemia: a risk factor for extracranial carotid artery atherosclerosis. (ox.ac.uk)
The prevalence of asymptomatic extracranial carotid artery atherosclerosis was determined by duplex ultrasound examination in 25 obligate heterozygotes with respect for cystathionine beta-synthase deficiency (whose children were known to be homozygous for this genetic defect) and in 21 controls. (ox.ac.uk)
Twelve of 25 obligate heterozygotes and 8 of 21 normal controls had evidence of extracranial carotid artery atherosclerosis. (ox.ac.uk)
Hyperhomocysteinemia is a weak risk factor for asymptomatic extracranial carotid atherosclerosis and the relative risk associated with this genetic trait is less than that observed in a study of patients presenting with clinical manifestations of vascular disease. (ox.ac.uk)
Atherosclerosis is strongly associated with symptomatic cardiovascular disease and ischemic stroke, which are the leading causes of death and disability in the Western world. (biomedcentral.com)

Seventeen patients (6%) had asymptomatic and 21 patients (7%) had symptomatic radiation effects. (thejns.org)
COMBI-MB clinical trial analyzed the role of dabrafenib + trametinib, with an intracranial response rate (icRR) of 58% for asymptomatic and 59% for symptomatic pts. (esmo.org)

Main outcome measures were favourable 3-month outcome (modified Rankin Scale 0-2) and 'major haemorrhage' [any intracranial haemorrhage (ICH) and major extracranial haemorrhage]. (hal.science)
The primary composite outcome was recurrent ischemic stroke, systemic embolism, major extracranial bleed, symptomatic intracranial bleed, or vascular death within 30 days after randomization. (joulecma.ca)

Moreover, the early group had fewer recurrent ischemic strokes (1.4% vs 2.5%), while symptomatic intracranial bleeds were uncommon in both groups (0.2%), suggesting that early initiation may be a safe and effective treatment approach for these patients. (joulecma.ca)
70% and symptomatic if there was any history of stroke or transient ischemic attack (TIA) within last 6 months involving same side. (ejcvsmed.org)

Relationship between Blood Pressure and Stroke Risk in Patients With Symptomatic Carotid Occlusive Disease. (ima-press.net)

Factors associated with longer survival included controlled extracranial disease, better Karnofsky Performance Scale score, fewer brain metastases, no prior WBRT, no prior chemotherapy, administration of immunotherapy, and no intratumoral hemorrhage before radiosurgery. (thejns.org)
For patients with symptomatic brain metastases, upfront local therapy (radiation and/or surgery) is strongly recommended. (medicalxpress.com)

Tandem occlusions in the anterior circulation had better outcomes with additional stenting of the extracranial lesion in a registry study of thrombectomy with the Solitaire device. (medpagetoday.com)

In patients with proximal artery stenoses, angioplasty can be used in addition to corticosteroid therapy for symptomatic relief. (medscape.com)

Patients with anterior occlusions had tandem extracranial/intracranial occlusive lesions in 18.7% Median time from symptom onset to groin puncture was 267 min, and from groin puncture to recanalization was 70 min. (bmj.com)
In cases of single metastatic lesions or large, symptomatic lesions in oligometastatic disease, resection is typically advised. (medscape.com)

The median survival for patients with a solitary brain metastasis, controlled extracranial disease, and administration of immunotherapy after radiosurgery was 22 months. (thejns.org)
The Warfarin-Aspirin Symptomatic Intracranial Disease study, which was performed at 59 medical centers in North America and included 569 patients with symptomatic ICAS, showed that women had a significantly higher risk for IS and for the combined endpoint of stroke and vascular death [ 6 ]. (karger.com)
Hyperhomocysteinemia arising from impaired methionine metabolism, and usually due to a deficiency of cystathionine beta-synthase is a significant and independent risk factor for symptomatic vascular disease. (ox.ac.uk)

Alcohol septal ablation for symptomatic hypertrophic obstructive cardiomyopathy had favorable long-term survival -- in the hands of a single operator at a single center. (medpagetoday.com)

The North American Symptomatic Carotid Endarterectomy Trial (NASCET) found that patients who underwent surgery within 2 weeks after the onset of neurologic deficits had better neurologic outcomes, with a 17% absolute reduction in the risk of ipsilateral stroke at 2 years. (medscape.com)
However, nationwide or multicenter large studies on gender differences in outcomes among symptomatic patients with ICAS have rarely been reported. (karger.com)
It is important to determine whether this pattern of outcomes of symptomatic ICAS is present in other Asian countries. (karger.com)

Furthermore, extracranial metastatic meningioma remains extremely rare (0.1%), with the most common location for metastasis being the lung. (amjcaserep.com)

2 ] may help to address the pathophysiology of symptomatic ICAS severity. (karger.com)

Of the 58 patients, co-existing intracranial and extracranial carotid artery plaques were found in 45 patients (77.6%), of which 7 (15.6%) had first time acute stroke and 26 (57.8%) had recurrent stroke. (nih.gov)
In addition to central injury in acute cerebrovascular diseases, which can lead to poor prognosis in patients, fluctuations in the properties and functions of local and circulating immune mediators can also trigger the body to enter an immune imbalance state, leading to poor prognosis in some patients after receiving systematic symptomatic support treatment. (ijpsonline.com)

Co-existing intracranial and extracranial carotid artery plaques are prevalent in symptomatic patients and the number of co-existing plaques is independently associated with the risk of recurrent stroke. (nih.gov)

Secondary endpoints are extracranial RR, intracranial progression free survival (icPFS), PFS, overall survival and safety. (esmo.org)

When performed, angiography is typically directed at the large branch vessels of the proximal aorta and extracranial carotid branch vessels. (medscape.com)

Secondary outcomes, measured during the treatment period (two weeks for IST and four weeks for CAST), were recurrent stroke, intracranial hemorrhage, major extracranial hemorrhage, and complete recovery from the stroke. (thennt.com)
and major extracranial hemorrhage occurred in 1% in both groups. (medscape.com)

No current evidence-based guidelines address anticoagulation in patients with symptomatic stenoses of extracranial arteries. (medscape.com)
This study investigated the correlation between intracranial and extracranial carotid artery atherosclerotic disease in symptomatic patients. (ismrm.org)
Patients do not usually have symptomatic or histologic respiratory involvement. (wikipedia.org)
The COSS results confirm both the importance of hemodynamic factors in the pathogenesis of recurrent stroke in patients with symptomatic AICAO and the accuracy of PET measures of oxygen extraction fraction in identifying those at high stroke risk because of poor collateral circulation, lead author William J. Powers, MD, from the University of North Carolina School of Medicine, Chapel Hill, and colleagues conclude. (medscape.com)
Based on limited data, clinical input, a chain of evidence and unmet medical need, CAS may be considered a reasonable treatment option in recently symptomatic patients when CEA cannot be performed due to anatomic reasons. (southcarolinablues.com)
Input strongly supported the use of carotid artery stenting (CAS) in recently symptomatic patients where surgical carotid endarterectomy cannot be performed due to anatomic reasons, although acknowledging the limited evidence about this subgroup. (southcarolinablues.com)
The lack of alternative treatments for recently symptomatic patients and the established increased risk of stroke were factors supporting this opinion. (southcarolinablues.com)
Stroke in the territory of the symptomatic vertebral artery occurred in 7 of 57 (12%) patients in a stenting group versus 4 of 58 (7%) patients in the medical group and the difference persisted at the final follow-up at 3 years. (surgicalneurologyint.com)
The North American Symptomatic Carotid Endarterectomy Trial (NASCET) found that patients who underwent surgery within 2 weeks after the onset of neurologic deficits had better neurologic outcomes, with a 17% absolute reduction in the risk of ipsilateral stroke at 2 years. (medscape.com)
Furthermore, re-auditing with an emphasis on patients turned down for intervention due to recurrent events while awaiting CEA may further highlight the need to prioritise symptomatic carotids. (jvsgbi.com)
This clinical trial compares the efficacy of extracranial-intracranial bypass surgery plus medical therapy vs medical therapy alone in symptomatic patients with internal carotid artery or middle cerebral artery occlusion and hemodynamic insufficiency on a composite of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years after randomization. (ama-assn.org)
Patients with biopsy confirmed advanced/ metastatic solid tumors of the following types: invasive ductal or lobular breast carcinoma (all histological and intrinsic subtypes), non-small cell lung cancer (NSCLC, all subtypes), gastrointestinal squamous cell or adenocarcinomas (including pancreatic cancer), bladder cancer , renal cell carcinoma, melanoma, and sarcoma, who require palliative radiation therapy to at least one site of extracranial metastastic disease. (survivornet.com)
Patients with at least one additional site of extracranial metastasis measuring at least 100 cc and suitable for elective palliative radiation therapy. (survivornet.com)
Patients should be asymptomatic or minimally symptomatic (e.g controlled by oral pain medications) and not in urgent need for palliation to this site of elective treatment. (survivornet.com)
Given these breakthroughs that have broadened the arsenal of treatment options for our patients, oncologists are now left with uncertainty about how to best sequence therapies for patients with HER2-positive BCBMs that will optimize both intracranial and extracranial progression-free survival (PFS), and OS, especially in the third-line setting and beyond. (onclive.com)
For example, patients receiving first-line TP would receive upfront local therapy and then continue on TP if extracranial disease is stable or absent. (onclive.com)
also demonstrate that although extracranial atherosclerosis may be a more common lesion in whites in Europe and America, ICAS is more common in Asian patients [ 6 ]. (biomedcentral.com)
The probability that a patient who has a positive test result for a particular disease or condition truly has that disease or condition is greatly affected by whether the test was used for screening asymptomatic patients or diagnosing symptomatic patients. (nih.gov)

E, F) Neck 3-dimentional angiogram showing complete recanalization of the right middle cerebral artery and 4 cm sized extracranial carotid artery aneurysm with contrast filling and thrombus. (the-jcen.org)
exhibited significantly greater plaque burden of middle cerebral artery (MCA) as compared to ipsilateral extracranial carotid artery and is more strongly associated with ischemia severity [ 4 ]. (biomedcentral.com)

6 ] The intracranial vertebrobasilar disease may represent a higher recurrent stroke risk than the extracranial vertebral disease. (surgicalneurologyint.com)

We found that extracranial artery disease showed larger plaque burden than intracranial artery disease. (ismrm.org)
This article describes the history and impact of this process as it occurs in the extracranial carotid artery. (medscape.com)
A giant thrombosed extracranial internal carotid artery aneurysm (ECCA) is extremely rare and its treatment is challenging. (the-jcen.org)
Extracranial internal carotid artery aneurysm (ECCA) is a rare disease. (the-jcen.org)

In the coronary, peripheral, and extracranial cerebral circulation, stenting has been shown to increase the safety and efficacy of balloon angioplasty for the treatment of arterial lesions (4-7) . (ajnr.org)

established ICAS as a major risk factor for stroke and suggested that its contribution to the proportion of all strokes may be greater than that of extracranial atherosclerosis [ 5 ]. (biomedcentral.com)

Extracranial complications mainly arise from access difficulties and can lead to iatrogenic dissection or vasospasm of the access vessel. (bmj.com)

Reduction of intracranial or extracranial vessels, renal arteriography with respect to localization of pheochromocytoma. (albionfoundation.org)

A head ultrasound (US), performed to rule out intracranial hemorrhage, showed diffuse echogenic modifications in the extracranial soft tissues, without a definitive diagnosis. (fortunejournals.com)

All symptomatic CEAs performed between January 2017 and December 2019 were retrospectively extracted from an electronic institutional database and analysed to determine the proportion of CEAs meeting benchmark targets and to assess factors contributing to delays. (jvsgbi.com)

These include symptomatic intracranial hemorrhage (sICH) and subarachnoid hemorrhage (SAH) or embolization within the same or a new vascular territory. (bmj.com)
GESTIÓN EN SALUD PÚBLICA: Updated Society for Vascular Surgery guidelines for management of e. (blogspot.com)
The syndrome of vascular neck pain is closely related to the various forms of extracranial vascular headache. (joialife.com)

Asymptomatic cases are only observed but if symptomatic then fibromuscular dysplasia responds well to angioplasty, with high long-term patency rates. (radiopaedia.org)

The treatment of these aneurysm is mandatory for symptomatic cases and some authors recommended to treat an aneurysm of more than 2-cm in size in asymptomatic case [ 2 ]. (the-jcen.org)

However, there were some encouraging findings including a trend towards a reduction in symptomatic ICH, researchers report, and the combination approach did not show any depletion of fibrinogen levels, which suggests a potential lower bleeding risk. (medscape.com)

Because this en- zyme converts polycyclic aromatic hydrocarbons to more active carcinogens and be- Cause enzyme concentrations are under genetic control, this observation suggested a possible genetic determinant of lung cancer risk. (nih.gov)

The primary outcome was the rate of all intracranial hemorrhage (symptomatic and asymptomatic) detected by neuroimaging. (medscape.com)

eight studies) for symptomatic intracranial haemorrhage. (nih.gov)

We can divide the types of complications into two groups: extracranial and intracranial. (bmj.com)

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