Once born, neurons do not divide (see mitosis), and many will live the lifespan of the animal, except under extraordinary and usually pathogenic circumstances. (wikipedia.org)
First, this may generate a subclass of neuronal progenitors called intermediate neuronal precursors (INP)s, which will divide one or more times to produce neurons. (wikipedia.org)
Thus, the generation of neurons occurs in a specific tissue compartment or 'neurogenic niche' occupied by their parent stem cells. (wikipedia.org)
In this study, the IgSF Sidekick-2 (Sdk2) in VG3-ACs and W3B RGCs drives these neurons to connect with each other far more than they connect with the Sdk2-negative neurons they contact. (elifesciences.org)
Radial glial cells4
Types of NSCs include neuroepithelial cells (NECs), radial glial cells (RGCs), basal progenitors (BPs), intermediate neuronal precursors (INPs), subventricular zone astrocytes, and subgranular zone radial astrocytes, among others. (wikipedia.org)
These early stem cells are called neuroepithelial cells (NEC)s, but soon take on a highly elongated radial morphology and are then known as radial glial cells (RGC)s. (wikipedia.org)
Out of all the three cell types, neuroepithelial cells that pass through neurogenic divisions have a much more extended cell cycle than those that go through proliferative divisions, such as the radial glial cells and basal progenitors. (wikipedia.org)
In vivo time course studies revealed the presence of ZIKV in apical radial glial cells (aRGCs) at early time points following virus exposure, while basal intermediate progenitor cells (bIPCs) became maximally (ZIKV + ) after 3 d of virus exposure. (eneuro.org)
Basal1
Additionally, elucidation of cell morphologic features using in utero electroporation (IUE) revealed substantial but incomplete interruption of basal fibers, a finding that implies interference with neuronal migration. (eneuro.org)
Neural4
RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone, which lies adjacent to the central fluid-filled cavity (ventricular system) of the neural tube. (wikipedia.org)
Epigenetic modifications play a key role in regulating gene expression in the cellular differentiation of neural stem cells. (wikipedia.org)
The transcriptional signatures of neural precursor cells (NPCs) were used for the first time to test Zika virus (ZIKV) susceptibility in a direct fetal brain infection model. (eneuro.org)
Fate2
These modifications are critical for cell fate determination in the developing and adult mammalian brain. (wikipedia.org)
To investigate this heterogeneous vulnerability, we performed genetic fate mapping using cell type-specific probes derived from a mouse embryonic day (E)15.5 neocortical wall single-cell RNA sequencing (scRNAseq) dataset. (eneuro.org)
Neurogenesis2
Following RGC proliferation, neurogenesis involves a final cell division of the parent RGC, which produces one of two possible outcomes. (wikipedia.org)
Here, a novel murine model of fetal ZIKV infection incorporating intraventricular infection and cell type-specific in utero electroporation (IUE) was used to identify the time course of ZIKV infection and to determine the identity of cells that are initially infected or spared during neocortical neurogenesis. (eneuro.org)
Types3
Nearly 50 different mouse retinal ganglion cell (RGC) types sample the visual scene for distinct features. (elifesciences.org)
RGC feature selectivity arises from their synapses with a specific subset of amacrine (AC) and bipolar cell (BC) types, but how RGC dendrites arborize and collect input from these specific subsets remains poorly understood. (elifesciences.org)
The improved specificity of apical radial glial cell (aRGC) labeling afforded by the cell-specific labeling tools uncover functional differences between aRGC types that will have important implications for children exposed to ZIKV as well as for understanding corticogenesis. (eneuro.org)
Growth1
We conclude that Sdk1 shapes dendrite growth and wiring to help S1-RGCs become feature selective. (elifesciences.org)
Brain1
Prenatal exposure to Zika virus (ZIKV) can result in microencephaly and congenital Zika syndrome, although some brain cells and structures are spared by the virus for unknown reasons. (eneuro.org)
Neuronal3
Types of NSCs include neuroepithelial cells (NECs), radial glial cells (RGCs), basal progenitors (BPs), intermediate neuronal precursors (INPs), subventricular zone astrocytes, and subgranular zone radial astrocytes, among others. (wikipedia.org)
First, this may generate a subclass of neuronal progenitors called intermediate neuronal precursors (INP)s, which will divide one or more times to produce neurons. (wikipedia.org)
Restricted to a layer adjacent to the inner basement membrane, RGCs show 'typical' neuronal polarity, with basally oriented axons and apically oriented dendritic trees. (biomedcentral.com)
Embryonic2
RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone, which lies adjacent to the central fluid-filled cavity (ventricular system) of the neural tube. (wikipedia.org)
We review the evidence supporting a unified model in which centrosome defects reduce cell proliferation in the developing cortex by prolonging mitosis and activating a mitotic surveillance pathway. (nih.gov)
Proliferation1
Following RGC proliferation, neurogenesis involves a final cell division of the parent RGC, which produces one of two possible outcomes. (wikipedia.org)
If hippocampal cells are cultured soon after their final mitotic divisions, multiple neurites emerge simultaneously at seemingly random orientations. (biomedcentral.com)
Model1
Retinal ganglion cells (RGCs) are an excellent model system with which to study the above questions. (biomedcentral.com)
Critical1
These modifications are critical for cell fate determination in the developing and adult mammalian brain. (wikipedia.org)
Study1
Against this backdrop, this study performed a clinical experiment and a phantom experiment. (nih.gov)