IsolatesAmpicillinCeftazidimeColistinCarbapenemsSusceptibilityPenicillinsImipenemCefoxitinCephalosporins and aztreonamCiprofloxacinOrganismsIntravenous aztreonamMonobactamResistantResistanceTigecyclineBacterialStaphylococcusActivity against susceptibleProteusGram-negativeCell wall synthesisAzactamConcomitantMBLsBeta-lactamaseBreakpointsPatientsLevofloxacinAntagonismInfectionAntibioticsVersusInjectionClinicalTreatment
Isolates11
- The combination of aztreonam and avibactam has demonstrated to be active against 80% of MBL isolates reaching a clinical infection resolution in 80% of MBL-infected patients. (wikipedia.org)
- the subset of isolates that underwent antimicrobial susceptibility testing for cefiderocol were susceptible to this agent. (cdc.gov)
- The need for ESBL detection is under challenge on the supposition that it is possible to set breakpoints for injectable cephalosporins and aztreonam that accurately discriminate which ESBL-producing isolates can and cannot be reliably treated with these drugs. (asm.org)
- However, isolates of Enterobacteriaceae with MBLs (eg, NDM, VIM, and IMP) have been shown to be susceptible to a combination of ceftazidime + avibactam + aztreonam. (clsi.org)
- Several of the isolates found in the study were susceptible only to colistin, a drug that dates back to the 1960s and is considered toxic to the kidneys, and tigecycline, which was only licensed in the US in 2005. (superbugtheblog.com)
- Isolates with inducible AmpC expression may initially test as susceptible to 3rd-generation cephalosporins, which can complicate treatment decisions, especially for Enterobacterales. (merckmanuals.com)
- All isolates tested were susceptible to at-least ten (10) of the fourteen antibiotics evaluated. (e-fas.org)
- Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus inosus , Streptococcus intermedius , and Streptococcus constellatus ), and Enterococcus faecalis . (centerwatch.com)
- Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and ‑resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (druglib.com)
- Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (druglib.com)
- The majority of the isolates were resistant to amoxacillin and ampicillin but susceptible to ceftriaxone. (bvsalud.org)
Ampicillin4
- Ampicillin and amoxicillin are the agents of choice for susceptible strains. (medscape.com)
- Ampicillin is the drug of choice for monotherapy of susceptible E faecalis infection . (medscape.com)
- Very major error rates higher than the totals were noted with Enterobacter cloacae versus ampicillin-sulbactam, aztreonam, ticarcillin, and ticarcillin-clavulanate and with P. aeruginosa versus mezlocillin, ticarcillin, and ticarcillin-clavulanate. (ox.ac.uk)
- ESBL-producing Enterobacterales from the GCC region show high levels of resistance to ampicillin, aztreonam, third-/fourth-generation cephalosporins, fluoroquinolones, and trimethoprim-sulfamethoxazole. (frontiersin.org)
Ceftazidime4
- Aztreonam can be safely used in patients with a penicillin or cephalosporin allergy (except for patients with a ceftazidime allergy as ceftazidime and aztreonam share a similar side chain). (wikipedia.org)
- In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). (wikipedia.org)
- 1 Providing antimicrobial susceptibility testing of an isolate to aztreonam, ceftazidime-avibactam, 2 and aztreonam-avibactam 3 can provide useful information to guide patient treatment. (clsi.org)
- Aztreonam shares structural similarities with few other beta-lactams, making cross-hypersensitivity unlikely, except with ceftazidime and cefiderocol , which have similar R1 side chains. (msdmanuals.com)
Colistin2
- The bacterium was susceptible only to one antibiotic, colistin. (europa.eu)
- 12 The REVISIT trial is a phase 3, randomized, multicenter, open label, comparative study assessing the efficacy and safety of aztreonam-avibactam +/- metro versus meropenem +/- colistin for the treatment of serious infections due to gram negative bacteria (including urinary tract infections). (contagionlive.com)
Carbapenems2
- It showed resistance to all the following antibiotics: all beta-lactams (penicillins and cephalosporins, the carbapenems and aztreonam), the aminoglycosides, the fluoroquinolones (e.g. ciprofloxacin), trimethoprim/sulfamethoxazole and tigecycline. (europa.eu)
- She had just received her culture results showing ESBL that is susceptible only to carbapenems. (sinaiem.org)
Susceptibility3
- ESBL producers are usually multiply drug resistant ( 5 , 30 ), but their cephalosporin and aztreonam resistance is not reliably detected by susceptibility tests ( 33 ). (asm.org)
- Multidrug resistance (MDR) bacteria is defined as non-susceptibility to one or more antimicrobials on three or more antimicrobial classes, while strains that are non-susceptible to all antimicrobials, are classified as extreme drug-resistant strains [ 2 ]. (biomedcentral.com)
- For purposes of comparison, susceptibility categories (susceptible, intermediate, or resistant) were assigned on the basis of the results of both methods. (ox.ac.uk)
Penicillins2
- Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
- ESBLs are typically inhibitor-susceptible β-lactamases that hydrolyze penicillins, cephalosporins, and aztreonam and are encoded by mobile genes. (asm.org)
Imipenem1
- Certain antibiotics (eg, cefoxitin, imipenem) may induce high levels of beta-lactamase in vitro in some Gram-negative aerobes such as Enterobacter and Pseudomonas species, resulting in antagonism to many beta-lactam antibiotics including aztreonam. (pfizermedicalinformation.com)
Cefoxitin1
- Increase in production of beta-lactamases by cefoxitin can inactivate aztreonam. (medscape.com)
Cephalosporins and aztreonam1
- ESBL (extended-spectrum beta-lactamases) producing organisms are resistant to most beta-lactams including cephalosporins and aztreonam. (sinaiem.org)
Ciprofloxacin1
- Yet in the phase 3 SURE1 trial, a multi-center, double-blind study, comparing sulopenem to ciprofloxacin, sulopenem was not non-inferior to ciprofloxacin in patients with quinolone susceptible organisms. (contagionlive.com)
Organisms2
- Aztreonam for Injection is indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms, including abscesses, infections complicating hollow viscus perforations, cutaneous infections, and infections of serous surfaces. (pfizermedicalinformation.com)
- Necrotizing pneumonia was diagnosed, and the patient was started on broad-spectrum antibiotics (aztreonam and clindamycin) to cover all Gram-positive and Gram-negative organisms, pending the outcome of the sputum and blood cultures. (rcjournal.com)
Intravenous aztreonam2
- 390 patients were randomized to ceftobiprole or daptomycin, with or without intravenous aztreonam for coverage of Gram-negative pathogens, for up to 42 days of treatment. (basilea.com)
- The diagnosis was revised to necrotizing pneumonia due to GCBHS, and treatment with intravenous aztreonam and clindamycin were continued. (rcjournal.com)
Monobactam1
- Aztreonam is currently the only available monobactam. (msdmanuals.com)
Resistant5
- Acinetobacter anitratus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci, Staphylococcus aureus, Staphylococcus haemolyticus and Xanthomonas maltophilia are resistant to it. (wikipedia.org)
- Some resistant pathogens may not be recognized because they are falsely susceptible in routine tests. (asm.org)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (pfizermedicalinformation.com)
- In September 1999, the U.S. Food and Drug Administration labeled quinupristin-dalfopristin (Synercid) for use in the treatment of serious or life-threatening infections associated with vancomycin-resistant Enterococcus faecium bacteremia and complicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus and Streptococcus pyogenes (group A streptococcus). (aafp.org)
- Susceptible vancomycin-resistant E. faecium (VREF) infections, nosocomial and community-acquired pneumonia, complicated skin and skin structure infections (including diabetic foot infections) without osteomyelitis, uncomplicated skin and skin structure infections. (renalandurologynews.com)
Resistance4
- MIC values were categorized as susceptible, intermediate, or resistance following Clinical and Laboratory Standards Institute ( https://clsi.org ) M100-S30 breakpoints ( http://em100.edaptivedocs.net/dashboard.aspx ). (cdc.gov)
- and Streptococcus pyogenes have developed resistance to aztreonam to varying degrees. (wikipedia.org)
- Aztreonam is also not labile to metallo-beta-lactamases and can therefore be useful for some infections in which resistance to other beta-lactam antibiotics is mediated by that enzyme. (msdmanuals.com)
- E. coli WZ33 and WZ51 exhibited discrepant-level resistance to most clinically frequent used antimicrobials, but still susceptible to trimethoprim/sulfamethoxazole, amikacin, fosfomycin, tigecycline and polymyxin B. E. coli WZ33 and WZ51 were positive for bla NDM-1 determined by PCR and DNA sequencing. (biomedcentral.com)
Tigecycline2
- Efficacy and safety of tigecycline monotherapy compared with vancomycin-aztreonam in the treatment of complicated skin and skin structure infections in patients from India and Taiwan. (druglib.com)
- BACKGROUND: To compare the monotherapy of tigecycline with vancomycin-aztreonam in hospitalized patients from India and Taiwan with complicated skin and skin structure infections (cSSSIs). (druglib.com)
Bacterial2
- Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. (wikipedia.org)
- Subjects with wound infections could have received aztreonam and/or metronidazole as adjunctive therapy for gram-negative bacterial coverage, if needed. (centerwatch.com)
Staphylococcus1
- Staphylococcus aureus 8 - >128 μg/ml Staphylococcus epidermidis 8 - 32 μg/ml Streptococcus pyogenes 8 - ≥128 μg/ml Synergism between aztreonam and arbekacin or tobramycin against P. aeruginosa has been suggested. (wikipedia.org)
Activity against susceptible2
- Aztreonam has strong activity against susceptible gram-negative bacteria, including Pseudomonas aeruginosa. (wikipedia.org)
- This combination results in synergistic bactericidal activity against susceptible enterococcal strains. (medscape.com)
Proteus1
- There is a risk for false-susceptible results for the Proteae tribe (including Proteus spp. (acpinternist.org)
Gram-negative4
- Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. (wikipedia.org)
- Aztreonam use has been recently reconsidered for human infections sustained by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. (wikipedia.org)
- Aztreonam for Injection is effective against most of the commonly encountered Gram-negative aerobic pathogens seen in general surgery. (pfizermedicalinformation.com)
- In either treatment groups, patients who had Gram-negative bacilli isolated from the infection site could also receive aztreonam 1 to 2g every 8-12 hours IV. (renalandurologynews.com)
Cell wall synthesis1
- They inhibit enzymes in the cell wall of susceptible bacteria, disrupting cell wall synthesis. (msdmanuals.com)
Azactam1
- Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam), or inhaled (trade name Cayston) using an ultrasonic nebulizer. (wikipedia.org)
Concomitant2
- Both groups received concomitant aztreonam (1 to 2g every 8 hours IV). (renalandurologynews.com)
- Concomitant aztreonam was administered if clinically indicated. (renalandurologynews.com)
MBLs1
- Aztreonam is known to be stable against hydrolysis by MBLs but is susceptible to hydrolysis by serine beta-lactamases. (contagionlive.com)
Beta-lactamase1
- These in vitro findings suggest that such beta-lactamase inducing antibiotics not be used concurrently with aztreonam. (pfizermedicalinformation.com)
Breakpoints2
- Aztreonam-avibactam - MIC will be reported with no interpretation (agent not FDA-approved and no CLSI or FDA breakpoints are available). (clsi.org)
- For aztreonam-avibactam, a minimum inhibitory concentration (MIC) is reported without an interpretation because clinical breakpoints for this drug combination have not been established. (clsi.org)
Patients1
- Concurrent initial therapy with other antimicrobial agents and aztreonam for injection is recommended before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. (pfizermedicalinformation.com)
Levofloxacin1
- It was susceptible only to levofloxacin and TMP/SMX, as noted in Table 1 . (hindawi.com)
Antagonism3
- aztreonam decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
- aztreonam decreases effects of microbiota oral by pharmacodynamic antagonism. (medscape.com)
- aztreonam decreases effects of typhoid vaccine live by pharmacodynamic antagonism. (medscape.com)
Infection1
- Aztreonam, while your infection is healing, read more. (njacs.org)
Antibiotics1
- There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)
Versus1
- As presented at IDWeek, ceftobiprole met the primary endpoint by demonstrating non-inferiority versus daptomycin, with or without aztreonam. (basilea.com)
Injection1
- Aztreonam for Injection may be administered intravenously or by intramuscular injection. (pfizermedicalinformation.com)
Clinical2
- The combination of aztreonam and avibactam are in phase 3 clinical trails. (wikipedia.org)
- Of note, the betalactam combination of aztreonam-avibactam is in Phase III clinical trials. (clsi.org)
Treatment1
- This is particularly problematic in the urinary tract and vagina, where a seemingly successful treatment leaves you susceptible to infections in future. (enjoypregnancyclub.com)