Susceptible mice. Medical search. Frequent questions

Daneshvar, H. , Burchmore, R. , Hagan, P. and Phillips, R. S. (2009) Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major . (gla.ac.uk)
These cells are special, and somehow very susceptible to the infection. (cosmosmagazine.com)
It's not clear why grain-fed mice are better able to recover after infection, but a study's findings suggest food type may skew the results of animal studies. (the-scientist.com)
Oral administration of PTC-672 reduces Ng infection in a mouse model and may have therapeutic potential for treatment of Ng that is resistant to current drugs. (elifesciences.org)
Charles Brown At the time of the conference, Victoria Blaho was a graduate student studying a mouse model of Lyme infection in Charles Brown's newly opened lab at the University of Missouri. (asbmb.org)
Taconic has added SARS-CoV-2 testing for models which are susceptible to SARS-CoV-2 infection. (taconic.com)
Although most animals are highly resistant to M. leprae and will rapidly dispose the organisms, laboratory mice will develop a very limited infection when they are inoculated into the cool temperatures of their hind foot pads. (cdc.gov)
However, armadillos are also unique and appear to be markedly susceptible to the infection. (cdc.gov)
This paper describes a novel mouse model that recreates the transition of pneumococci from asymptomatic carriage to disease upon viral infection. (lu.se)
In this model, mice are first intranasally inoculated with biofilm-grown pneumococci to establish asymptomatic carriage, followed by IAV infection of both the nasopharynx and lungs. (lu.se)

Loss of GM-CSF signalling or genetic susceptibility to TB (C3HeB/FeJ mice ) result in type I IFN-induced neutrophil extracellular trap (NET) formation that promotes bacterial growth and promotes disease severity . (bvsalud.org)
We found several biological responses, including some related to the hormonal and immune systems, that were associated with stress susceptibility or resilience in mice. (usda.gov)
Accordingly, we used the chronic social defeat stress paradigm and investigated specific CNS, endocrine and immune responses to identify signatures of stress-resilience and stress susceptibility in mice. (usda.gov)
The scientists later found that mouse susceptibility to social stress could be turned on and off by manipulating the firing rates of these neurons. (nih.gov)
Mice, like humans, show differences in susceptibility to chronic stress. (jneurosci.org)
Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise -induced hearing loss in mice. (cdc.gov)
Only weeks after the IOM came out with their report in early 2004, stating that thimerosal is not connected in any way with autism, Columbia University researchers reported, "The mercury preservative used in some vaccines can cause behavioral abnormalities in newborn mice characteristic of autism, but only in mice with a specific genetic susceptibility. (educate-yourself.org)
Importantly, this model reproduces the susceptibility of aging, because compared to young mice, old mice display more severe clinical illness and succumb to disease more frequently. (lu.se)

Alterations of their tumorigenic phenotypes including survival rate, tumor formation and tumor spectrum, were assessed in FVB/N-Trp53 em2Hwl /Korl and C57BL/6-Trp53 em1Hwl /Korl knockout (KO) mice over 16 weeks. (biomedcentral.com)
Furthermore, numerous solid tumors were also observed in various regions of the surface skin of FVB/N-Trp53 em2Hwl /Korl KO mice, but were not detected in C57BL/6-Trp53 em1Hwl /Korl KO mice. (biomedcentral.com)
Our results indicate that the spectrum and incidence of tumors induced by the TALEN-mediated Trp53 mutant gene is greater in FVB/N-Trp53 em2Hwl /Korl KO mice than C57BL/6-Trp53 em1Hwl /Korl KO mice over 16 weeks. (biomedcentral.com)
The first Trp53 KO mice were generated by the recombination of intron 4 and exon 5 in C57BL/6 mice using embryonic stem cell (ESC) targeting techniques. (biomedcentral.com)
Similar tumors were also observed in KO mice having the exon 2 or exon 2-6 deletion in C57BL/6 mice. (biomedcentral.com)
This study was therefore undertaken to compared the tumorigenic phenotypes of FVB/N-Trp53 em2Hwl /Korl and C57BL/6-Trp53 em1Hwl /Korl KO mice encompassing the TALEN-mediated Trp53 mutant gene (Fig. 1 ). (biomedcentral.com)
14- or 28-day chronic stress model induced a depressive syndrome defined by lowered reward sensitivity in C57BL/6J mice and changed gene expression of peroxidation enzymes as shown in microarray assays. (ox.ac.uk)
A chronic stress paradigm comprising exposure to predation, tail suspension and restraint induces a depressive syndrome in C57BL/6J mice that occurs in some, but not all, animals. (ox.ac.uk)
Six week old C57BL/6 female mice were injected with either, Gardasil, Gardasil+pertussis toxin (Pt), Al hydroxide, or, vehicle control in amounts equivalent to human exposure. (sanevax.org)

Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia. (ox.ac.uk)
Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia. (ox.ac.uk)
Furthermore, prefrontal cortex mRNA expression of corticotrophin-releasing factor (Crf) was increased in susceptible mice relative to resilient mice. (usda.gov)

This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. (biomedcentral.com)
The most frequently observed tumor in both the Trp53 KO mice was malignant lymphoma, while soft tissue teratomas and hemangiosarcomas were only detected in the FVB/N-Trp53 em2Hwl /Korl KO mice. (biomedcentral.com)
Numerous Trp53 KO mice containing large deletions of the Trp53 gene have been produced to investigate the role of Trp53 during the developmental process or tumor formation in mammals. (biomedcentral.com)
At 15 to 25 weeks of age, the homozygote variants of these mice were found to be dramatically susceptible to the development of multiple tumor types, and malignant lymphoma and sarcomas were frequently observed in the thymus and major visceral organs of these animals [ 9 ]. (biomedcentral.com)
Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. (cdc.gov)
We hypothesized that p53+/- mice would be susceptible to lung tumor development after exposure to either tangled (t-) or rod-like (r-) MWCNTs. (cdc.gov)

With 14-day stress, a comparison of the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) and accumulation of malondialdehyde (MDA) revealed a decrease of the first two measures in susceptible, but not in resilient animals or in stressed mice chronically dosed with imipramine (7mg/kg/day). (ox.ac.uk)
Compared to resilient animals, susceptible mice showed elevated expression of tumour necrosis factor alpha (TNF) and the 5-HT transporter (SERT) in the pre-frontal area. (ox.ac.uk)
At the cellular level, increased numbers of Iba-1-positive microglial cells were also present in the prefrontal area of susceptible animals compared to resilient animals. (ox.ac.uk)

Virtually 100% of T-LGL leukemias in IL-15 transgenic mice expressed NKp46, as did a majority of human T-LGL leukemias. (jci.org)
Furthermore, interruption of IL-15 signaling using a neutralizing antibody could prevent LGL leukemia in IL-15 transgenic mice. (jci.org)

Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. (jci.org)
Collectively, our data demonstrate that NKp46 identifies a functionally distinct NKT subset in mice and humans that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. (jci.org)
This gene is clearly regulating processes that are central to aging in mice and humans," said Clarke, "and stem cells are severely compromised. (sciencedaily.com)
We want to emphasize that for severe (lethal) inflammatory conditions such as systemic inflammatory response syndrome (SIRS) including acute lung injury and fulminant hepatitis in humans, in which proper therapeutic strategy has not been established yet, our findings using MT knockout mice may open doors to the alternative therapeutic target. (hindawi.com)
Guinea pigs differ from mice and rats, and that just might make them more suitable due to the fact that these results are more easily translated to humans. (noldus.com)
The long-term effects of Zika on adult brains are still unknown, and the team says more research is needed to ascertain whether the mouse model echoes the virus' effect on humans. (cosmosmagazine.com)
The maximum amount of cadmium that the mice ingested was the equivalent to the amount that humans in the United States have in their blood, including people who have never smoked. (medicalnewstoday.com)
Monocytes derived from either of these lineages consist of two main types: (1) classical "inflammatory" monocytes that are CCR2 + Ly6C hi in mice and CD14 + CD16 − in humans, and (2) non-classical "patrolling" monocytes that are CCR2 lo Ly6C lo in mice and CD14 lo CD16 + in humans. (frontiersin.org)

Thus, in the present chronic stress depression paradigm, lasting alterations in brain peroxidation occur not only during anhedonia but also in the recovery period and are accompanied by behavioural abnormalities in mice. (ox.ac.uk)

Using a mouse model of chronic stress, we sought to determine which mice were susceptible to chronic stress and which mice were resilient to chronic stress, and identify physiological responses that were unique to either the stress-susceptible or stress-resilient groups. (usda.gov)
The researchers found that while stress-resilient mice had VTA dopamine neurons with stable firing rates and normal dopamine activity, these neurons had higher levels of an excitatory electrical current than those of stressed mice. (nih.gov)

Homozygotes for a second null allele exhibit enhanced responses to various T cell stimuli and are more susceptible to developing autoimmune diseases. (jax.org)
They found, "Profound behavioral and neuropathologic disturbances were observed after postnatal thimerosal in SJL/J mice, but not in strains without autoimmune sensitivity. (educate-yourself.org)
Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. (sanevax.org)

We investigated the influence of 2% carboxymethylcellulose (CMC) on the biostructure of the intestinal microbiota in IL-10 gene-deficient mice. (nih.gov)
Twenty to 27-week-old IL-10 gene-deficient mice received either 2% CMC solution (n = 7) or water (n = 6) orally for 3 weeks. (nih.gov)
CMC-treated IL-10 gene-deficient mice demonstrated a massive bacterial overgrowth, distention of spaces between villi, with bacteria filling these spaces, adherence of bacteria to the mucosa, and migration of bacteria to the bottom of the crypts of Lieberkuehn. (nih.gov)

Researchers led by John Schimenti, Ph.D., at Cornell University studied mice to help determine how problems with DNA replication and repair affect embryonic development. (nih.gov)
In past work, a group of researchers led by Dr. Ming-Hu Han of the Icahn School of Medicine at Mount Sinai found that neurons in the ventral tegmental area (VTA)-one of the "reward" areas deep in the brain-fire at higher rates in mice that are more susceptible to social stress. (nih.gov)
The researchers conducted their studies in both mouse and human cells. (sciencedaily.com)
The researchers didn't confine their studies to laboratory mice. (sciencedaily.com)
Here, we're looking at the effects of different housing strategies for mice, and how PhenoTyper provides researchers with insight. (noldus.com)
A published in Cell Stem Cell by US researchers found the virus targets stem cells in parts of a fully grown mouse brain responsible for learning and memory and stops them proliferating. (cosmosmagazine.com)
Then, the researchers added low doses of cadmium to the drinking water, which the mice drank for 14 weeks. (medicalnewstoday.com)
University of Montreal researchers have found that diets high in fat increase depressive behavior and anxiety in mice. (beliefnet.com)
In the study, researchers studied a particular strain of mice that are susceptible to obesity. (beliefnet.com)
Researchers have discovered several compounds that can cure mice of malaria in a single dose. (popsci.com)

Detergents and emulsifiers added to food may destroy the mucus barrier, which normally isolates bacteria from the intestinal wall, and lead to chronic bowel inflammation in susceptible persons. (nih.gov)
CMC induces bacterial overgrowth and small bowel inflammation in susceptible animals. (nih.gov)
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. (bvsalud.org)
Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. (bvsalud.org)
The anti-inflammatory properties of testosterone appear to protect male mouse embryos from certain types of DNA damage and inflammation that are fatal to female mouse embryos, according to a recent NIH-supported study. (nih.gov)
Our work shows how DNA damage and inflammation compromise the health of female mouse embryos," said Cornell's Dr. Schimenti. (nih.gov)
While receptor antagonists were unable to inhibit NF-κB activation, blocking of the fusion between EVs and their target cells with heparin mitigated inflammation in mice challenged with EVs. (lu.se)

Mice that have been genetically altered to not produce glutathione in the liver will die after one month. (uclahealth.org)

Mice unable to form glutathione will die before birth. (uclahealth.org)
People with mutations in the enzymes that form glutathione are more susceptible to oxidative stress. (uclahealth.org)
The trypanothione pathway combines 2 larizes the immune response towards a Th1 metabolic pathways: the polyamine biosyn- type in susceptible BALB/c mice infected thetic pathway and the glutathione pathway. (who.int)
Since glutathione (GSH) is involved in a with interleukin-12 and indomethacin pro- number of vital functions within cells, motes increased resistance in BALB/c mice chiefly defence against oxidative damage, with established L. major infections [ 7 ]. (who.int)

No lesions developed in BALB/c mice infected with L. major H-line, whereas L. major wild-type (WT) induced a Th2 like response with progressive lesions. (gla.ac.uk)
Analysis of splenocyte IFN-γ and IL-4 production following stimulation with promastigotes shows that the L. major H-line preferentially induces Th1-like responses and possibly down-regulates Th2 responses in BALB/c mice. (gla.ac.uk)
L. major H-line parasites remained localized in the skin and draining lymph node, whereas L. major WT parasites disseminated into the visceral organs of BALB/c mice. (gla.ac.uk)
and is absent in the in susceptible BALB/c mice infected with host systems. (who.int)
type in susceptible BALB/c mice infected with Leishmania mexicana. (who.int)
increased resistance in BALB/c mice with established Leishmania major in- 5. (who.int)

MT (−/−) mice are reportedly susceptible to metal- and chemical-induced carcinogenesis [ 7 , 8 ]. (hindawi.com)
M. P. Waalkes, J. Liu, R. A. Goyer, and B. A. Diwan, "Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation," Cancer Research , vol. 64, no. 21, pp. 7766-7772, 2004. (hindawi.com)

A new mouse strain susceptible to mammary cancer. (jax.org)

Enhancing brain mechanisms triggered by stress raised the resilience of mice to stress and relieved depression-like behaviors. (nih.gov)
Some mice exposed to repeated encounters with a dominant animal develop depression-like behaviors, while others don't. (nih.gov)
After twelve weeks on the diet, the mice went through a series of tests to measure their behaviors, including an anxiety test that measures how rodents respond to a new environment. (beliefnet.com)
After repeated exposure to social defeat stress, for example, some mice show long-term reductions in social interaction and increased avoidance of open areas, whereas others do not exhibit such depression- and anxiety-like behaviors. (jneurosci.org)
Moreover, Sirt1 overexpression or Sirt1 activation in the NAc increased anxiety- and depression-like behaviors in open-field, elevated-plus-maze, sucrose-preference, and/or forced swim tests even in unstressed mice. (jneurosci.org)

All chronically stressed animals, displayed increased level of anxiety, but susceptible mice exhibited an increased propensity to float in the forced swim test and demonstrate hyperactivity under stressful lighting conditions. (ox.ac.uk)
The mice who consumed the high fat diet were less active, avoided open areas and explored less - all key traits of higher anxiety levels in animals. (beliefnet.com)
Mice who consumed the same amount of fat - but healthy fats such as olive oil - experienced less depression and anxiety. (beliefnet.com)
Chronic stress can lead to depression and anxiety in susceptible individuals. (jneurosci.org)

If you adopt rats or mice, you'll need to provide them with a comfortable habitat that meets all their needs. (peta.org)
Traditional standard tests with rats or mice are carried out immediately after human interference. (noldus.com)

Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. (sanevax.org)

Eventually, the study team determined that the female embryos were susceptible to problems because they lacked the anti-inflammatory effects of testosterone. (nih.gov)
We sought to evaluate the effects of Al adjuvant and the HPV vaccine Gardasil versus the true placebo on behavioral and inflammatory parameters in young female mice. (sanevax.org)
Our findings reveal that fusion renders non-responsive cells susceptible to inflammatory signaling, as evidenced by increased NF-κB activation and the release of inflammatory mediators. (lu.se)

In mice, they exist in two regions that are important for learning and memory: the subventricular zone of the anterior forebrain and the subgranular zone of the hippocampus. (cosmosmagazine.com)
The fluorescent biomarker (in green) revealed that the adult mouse brain could be infected by Zika in a region called the subgranular zone of the hippocampus. (cosmosmagazine.com)
The authors conclude that exposure to cadmium "impaired neuronal differentiation of adult-born neurons" in the hippocampus of male mice with the APOE4 gene. (medicalnewstoday.com)
Immunohistochemistry analysis revealed microglial activation in the CA1 area of the hippocampus of Gardasil-injected mice compared to the control. (sanevax.org)

Our findings further suggest that weaker purifying selection in highly susceptible crows is attributable to this higher viremia, polyinfections and complementation. (cdc.gov)

Mice with mutations in genes that regulate an important DNA replication complex, called the minichromosome maintenance complex or MCM, are susceptible to genomic instability and cancer. (nih.gov)
While these mice have been studied previously, the research team noticed that mice with certain MCM mutations had drastically more male pups than female pups. (nih.gov)
In fact, when pregnant mice with MCM mutations were given either testosterone injections or ibuprofen, the gender ratios became normal. (nih.gov)

In turn, indoleamine-2,3-dioxygenase (IDO) was significantly unregulated in the raphe of susceptible animals. (ox.ac.uk)
Consequently, the susceptible animals display a unique molecular profile when compared to resilient, but anxious, animals. (ox.ac.uk)
Rats and mice are family-oriented, sensitive, empathetic animals. (peta.org)
If you have children, they may become frustrated when the animals aren't awake to play, and-like all animals-mice and rats don't enjoy being disturbed when they're sleeping. (peta.org)
Wire enclosures are much healthier for mice and rats than aquariums, as they're ventilated to allow fresh air in instead of trapping odors, they stay cooler, and they provide the animals with more contact and interaction with their surroundings. (peta.org)
Sensitive mice avoid other animals and lose their preference for sugar. (nih.gov)
Waltzing mice prove of Benefit As life savers silly deaf Little animals most susceptible to Carbon monoxide Gas and May be Means of preventing disasters in mines Washington d. (newspaperarchive.com)
Methods: MFS was performed on the buccal aspect of the left side of the mandible (BL) in 20 male CF1 Musdomesticus mice divided into two groups with the same number of animals: the experimental group was treated once daily with raloxifene injections (3 mg/kg), and the placebo group was treated with daily injections of the vehicle. (bvsalud.org)

Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model. (acs.org)
However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53+/-) mice has not been investigated. (cdc.gov)

Thus, BPA exposure is associated with a higher number of yellow mice predisposed to obesity and diabetes. (cdc.gov)

Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice. (elsevierpure.com)
Dive into the research topics of 'Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice. (elsevierpure.com)

Mice infected with L. major H-line acquired some resistance against L. major WT. (gla.ac.uk)
A fourth group of compounds blocked an enzyme that previous treatments haven't targeted, which may make them less susceptible to resistance. (popsci.com)

No lung or pleural tumors were observed in p53+/+ or p53+/- mice exposed to either t- or rMWCNTs. (cdc.gov)

A new study in mice finds that cadmium exposure, combined with a genetic predisposition to Alzheimer's, can trigger symptoms of cognitive decline. (medicalnewstoday.com)
New research in mice suggests that people who already have a copy of the APOE4 gene and are thus at risk of Alzheimer's may experience cognitive decline as a result of exposure to cadmium - a neurotoxic heavy metal. (medicalnewstoday.com)
Wild-type (p53+/+) or p53+/- mice were exposed to MWCNTs (1 mg/kg) via oropharyngeal aspiration weekly over four consecutive weeks and evaluated for cellular and pathologic outcomes 11-months post-initial exposure. (cdc.gov)
Fifteen days following an 8 h, 113 dB noise exposure, the Pmca2+/- mice displayed significant (P (cdc.gov)

These symptoms occurred earlier in mice with the APOE4 gene than those with APOE3 . (medicalnewstoday.com)

This review will highlight the roles of monocytes in the immune response to some of the major fungi that cause invasive human disease, including Aspergillus, Cryptococcus, Candida, Histoplasma, Blastomyces , and Coccidioides , and discuss potential strategies to manipulate monocyte responses in order to enhance anti-fungal immunity in susceptible hosts. (frontiersin.org)
This model can also serve as an important tool for identifying potential therapeutic targets against secondary pneumococcal pneumonia in susceptible hosts. (lu.se)

As a result, their brains age faster and are susceptible to early onset neurodegenerative disorders. (sciencedaily.com)
Male mice experienced an earlier onset than females with the same genetic makeup. (medicalnewstoday.com)

Using long-term home cage behavioral research, scientists successfully created a behavioral characterization of Stargazer mutant mouse, a model often used in epilepsy research. (noldus.com)
A swim test commonly used by drug companies to test new antidepressants, measured something called "behavioral despair" by forcing the mice to swim for six minutes in a glass cylinder filled with water. (beliefnet.com)

Here, we used the σR1-knockout mouse ( Sigmar1 −/− ) to demonstrate unambiguously the role of the σR1 in protecting the retinal ganglion cells against degeneration after acute damage to the optic nerve. (molvis.org)

We also report differences in hippocampal synaptic plasticity between resilient and susceptible mice. (usda.gov)

Comparing susceptible and unsusceptible mice can therefore provide insights into the molecular mechanisms of stress resilience. (jneurosci.org)

The Zika virus might not just harm the brain of the developing foetus - it could also affect parts of the adult brain, a new study in mice suggests. (cosmosmagazine.com)

To test this theory, the team monitored the brains of mice infected with Zika, using glowing biomarkers to track the virus and measure affected areas of the brain. (cosmosmagazine.com)

At the cellular level, these mice showed a marked increase in both excitatory and inhibitory currents, resulting in normal neuron activity. (nih.gov)

While studying this model, Blaho had found that treating mice with Celebrex could prevent their arthritis from healing. (asbmb.org)
But unlike most mouse models, the Lyme disease model involved a whole pathogen, rather than a single molecular component, and a systemic immune response to it. (asbmb.org)
Objective: To evaluate the effect of raloxifene in preventing alveolar bone resorption after MFS using an experimental model of mouse mandibles. (bvsalud.org)

Treating pregnant mice with testosterone or ibuprofen improved the survival of female embryos with DNA damage and resulted in normal gender ratios among the mouse pups. (nih.gov)
For example, when pregnant mice are fed bisphenol A (BPA), a chemical present in many commonly used products , the number of offspring with the yellow obese coat color increases dramatically. (cdc.gov)
When pregnant mice are exposed to BPA along with a vitamin B cocktail (including B12 and folic acid) which increase methylation of the Agouti gene, the offspring are no longer predominantly yellow and obese. (cdc.gov)

However, you know, appendages don't just fall off, rather the lack of sensation makes them very susceptible to secondary injury and trauma. (cdc.gov)

Over 5 days, the scientists repeatedly infused the VTA of susceptible mice with a drug called lamotrigine, which is known to increase excitatory currents. (nih.gov)
In the new study, the scientists used mouse models of Alzheimer's disease with an activated version of the E4 or E3 variant of the APOE gene. (medicalnewstoday.com)

Clinicians have known for some time that people treated for HIV also become much more susceptible to diabetes and heart disease. (news-medical.net)

If zebrafish are the new mice, guinea pigs might be the new rats. (noldus.com)

The treated mice socialized more and their characteristic rodent sweet tooth came back. (nih.gov)

Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

have discovered that one difference between susceptible and resilient mice is activation of Sirt1, a histone deacetylase that produces epigenetic modifications. (jneurosci.org)

Our results showed that mice behaviourally susceptible to stress (indexed by a reduction in social interaction behaviour) had higher plasma corticosterone levels and adrenal hypertrophy. (usda.gov)
Sirt1 expression increased in the nucleus accumbens (NAc) only in stress-exposed mice that subsequently showed decreased social interaction. (jneurosci.org)

Mice and voles are small rodents that sometimes damage plants in gardens and greenhouses. (rhs.org.uk)
Young male mice seemed overall more susceptible to the effects of this interaction than young female rodents. (medicalnewstoday.com)

Mice inoculated with severe acute respiratory syndrome-associated coronavirus showed decreased weight gain and developed neutralizing antibodies. (cdc.gov)

Male mice woo their mates with high-pitched love songs , and infant rats giggle when they're tickled. (peta.org)
Conclusion: In this study, raloxifene did not inhibit alveolar bone resorption following MFS in male mice. (bvsalud.org)

Additionally, at three months of age, compared to control mice, Al-injected mice showed a significantly decreased preference for the new arm in the Y maze test (p=0.03), indicating short-term memory impairment. (sanevax.org)

Mice differ from voles in having tails that are longer than their bodies. (rhs.org.uk)

Mouse models are essential for neuroscience research. (noldus.com)
Biochemical, biophysical, and biological data support the efficacy of these molecules both in vitro and in mouse models. (elifesciences.org)
In other mouse models of arthritis, which are driven by an antibody response to the mouse's own tissue, inhibiting Cox-2 prevents joint pain. (asbmb.org)

Anatomy16

Organisms24

Diseases24

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes12

Information Science2

Health Care1

Infection10

Susceptibility8

C57BL9

Prefrontal cortex3

Tumor6

Resilient animals3

Transgenic2

Humans8

Anhedonia1

Stress-resilient2

Autoimmune3

Deficient3

Researchers10

Inflammation7

Genetically1

Glutathione4

BALB6

Carcinogenesis2

Strain1

Behaviors5

Anxiety4

Rats or mice2

Abnormalities1

Inflammatory3

Hippocampus4

Findings1

Mutations3

Animals8

Chronic2

Obesity1

Pulmonary2

Resistance2

Lung1

Exposure4

Symptoms1

Hosts2

Onset2

Behavioral2

Knockout1

Differences1

Resilience1

Study in mice1

Brains1

Cellular level1

Model3

Pregnant mice3

Secondary1

Scientists2

Diabetes1

Zebrafish1

Characteristic1

Genes1

Activation1

Social interaction2

Rodents2

Showed decreased1

Male2

Preference1

Differ1

Models3