A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles. (musc.edu)
Lupus2
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (musc.edu)
In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)
Encodes2
HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. (wikipedia.org)
The DR3-DQ2 haplotype is notable because of the very strong linkage between genes that extends into the HLA-A, -B and -C regions of the HLA gene complex in northern and northwestern Europe. (wikipedia.org)
Haplotype4
HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. (wikipedia.org)
HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). (wikipedia.org)
HLA DR3-DQ2 is the serotypic representation of a HLA-DRB1:DQA1:DQB1 cis-chromosomal haplotype on human 6p21.3 in a region known as the HLA complex. (wikipedia.org)
The linked haplotype is HLA A1-B8-DR3-DQ2 (AH8.1 in the most recent literature) Because of its strong linkage disequilibrium, each of the genes in the haplotype are markers for probable presence of adjacent genes. (wikipedia.org)
Genes1
This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)
Recognize2
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
CHAINS1
HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Linkage1
D′ can therefore take on values between 0 and 1, and it is a measure of linkage disequilibrium that is normalized for variations in allele frequencies at the two loci. (musculoskeletalkey.com)
Human1
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
Specific1
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
Major3
This graph shows the total number of publications written about "HLA-DR2 Antigen" by people in this website by year, and whether "HLA-DR2 Antigen" was a major or minor topic of these publications. (musc.edu)
The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Disease1
An example of phenotypes that can mediate CD and T1D, the DR3-DQ2/X serotypes and the DR5-DQ7/DR7-DQ2 serotypes can mediate celiac disease with equal efficiency but the DR5-DQ7/DR7-DQ2 cannot mediate T1D as successfully as DR4-DQ8 or DR3-DQ2 (X is not DR3-DQ2 or DR7-DQ2). (wikipedia.org)
Individuals1
The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
Recent1
Below are the most recent publications written about "HLA-DR2 Antigen" by people in Profiles. (musc.edu)
Alleles6
We determined HLA alleles B , DRB1 , DQA1, and DQB1 , by sequence-based typing. (nih.gov)
p -Values were corrected for comparisons of multiple HLA alleles. (nih.gov)
In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. (nih.gov)
p values were corrected for comparisons of multiple HLA alleles (p(c)) by multiplication of the raw p value by the estimated number of HLA alleles present within the loci examined. (nih.gov)
Molecular genetic testing of first-degree relatives of a proband (including young children) to monitor those with known celiac disease-susceptibility alleles for early evidence of celiac disease in order to institute gluten-free diet early in the disease course. (nih.gov)
Genomewide single-nucleotide polymorphism (SNP) analysis has identified over 30 additional susceptibility alleles. (clinicalgate.com)
Celiac disease12
An example of phenotypes that can mediate CD and T1D, the DR3-DQ2/X serotypes and the DR5-DQ7/DR7-DQ2 serotypes can mediate celiac disease with equal efficiency but the DR5-DQ7/DR7-DQ2 cannot mediate T1D as successfully as DR4-DQ8 or DR3-DQ2 (X is not DR3-DQ2 or DR7-DQ2). (wikipedia.org)
Influence of HLA-DQ2 and DQ8 on severity in celiac Disease. (cdc.gov)
A new PCR-SSP method for HLA DR-DQ risk assessment for celiac disease. (cdc.gov)
Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci. (cdc.gov)
HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects. (cdc.gov)
HLA class II high-resolution genotyping in Greek children with celiac disease and impact on disease susceptibility. (cdc.gov)
Human leukocyte antigen DQ2.2 and celiac disease. (cdc.gov)
HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. (cdc.gov)
HLA genotyping in pediatric celiac disease patients. (cdc.gov)
HLA-DQ2/DQ8 and HLA-DQB1*02 homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population. (cdc.gov)
HLA Genotyping: Methods for the Identification of the HLA-DQ2,-DQ8 Heterodimers Implicated in Celiac Disease (CD) Susceptibility. (cdc.gov)
Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
Allele1
Twenty-two human major histocompatibility complex (MHC) region microsatellite (Msat) markers were studied for diversity and linkage disequilibrium (LD) with HLA loci in hematopoietic cell transplant recipients and their HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele-matched unrelated donors. (nih.gov)
DRB11
In addition, the ability of Msats to predict HLA-A-B-DRB1 haplotypes was studied. (nih.gov)
Confer1
Genetic factors influencing the immune response to abacavir might confer susceptibility. (nih.gov)
Genetic1
Susceptibility to AS is determined largely by genetic factors, with B27 comprising less than one-half of the genetic component. (clinicalgate.com)
Identification1
For serotypic identification of the DQ2.5cis isoform requires the DR3 (or HLA-DR17 or HLA-DR18) and DQ2 serotypes. (wikipedia.org)
Found1
In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. (nih.gov)
Factors1
This has studies of potential etiologic determinants, focusing been due, in part, to a failure to account for host on host and environmental risk factors and their inter- susceptibility in most studies. (nih.gov)
Provide1
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
Cells1
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)