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  • type 1 diabet
  • HLA genes, islet autoantibodies and residual C-peptide were studied to determine the independent association of each exposure with diabetic retinopathy (DR), 15 years after the clinical onset of type 1 diabetes in 15-34 year old individuals. (pubmedcentralcanada.ca)
  • While other diseases, like type 1 diabetes may have several, highly different, genes that attribute risk. (wikipedia.org)
  • To aid in the search for additional type 1 diabetes genes within and outside the HLA region, an international collaboration (the Type 1 Diabetes Genetics Consortium) has collected and is continuing to collect a large number of type 1 diabetic families (multiplex and simplex) from various populations ( 20 ). (diabetesjournals.org)
  • genotypes
  • HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. (springer.com)
  • HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Sk√•ne (DiPiS) study. (springer.com)
  • 1998
  • The 1998 Nomenclature Committee recognized more HLA genes all of which are in the class I and Ib regions: HLA-E, -F, -G, -H, -J, -K and -L 59 . (dorak.info)
  • causative genes
  • However, identification of the causative genes has been difficult. (beds.ac.uk)
  • Though the development of GWA studies has led to considerable progress in the area of complex disease genomics and this would be generally considered the more appropriate approach to use currently to identify genes involved in adverse drug reactions, there are a several examples where candidate gene studies have been valuable in identifying causative genes. (biomedcentral.com)
  • DR53
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • hypothesis
  • As a test of our original hypothesis that the HLA-associated susceptibility to childhood leukaemia is a recessive trait and not a simple allelic association 5;6 , we examined the homozygosity rates. (dorak.info)
  • DLQI items Factor 1 Share full text access The epidermal barrier dysfunction hypothesis suggests that AD patients develop AD as a result of skin barrier defects that allow for the entry of antigens, resulting in the production of inflammatory cytokines. (bestskincare101.com)
  • environmental triggers
  • It has been suggested that these associations among CD and other AD may be explained by the sharing of a common pathogenic basis involving genetic susceptibility, similar environmental triggers, and the loss of intestinal barrier secondary to dysfunction of intercellular tight junctions with increased intestinal permeability, and possibly by other undiscovered mechanisms [ 7 , 11 - 16 ]. (hindawi.com)
  • molecular
  • The HSP70 genes encode cytosolic molecular chaperons and might have donated to the PBR region to the ancestor MHC gene 62 . (dorak.info)
  • homozygosity
  • We believe that the reasons are the general negligence of HLA supertypes, homozygosity and the gender effect. (dorak.info)
  • allelic
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • For the alignment of DRB4 allelic sequences, see the IMGT/HLA Sequence Database alignment page . (dorak.info)
  • resistance
  • In addition, HLA-A*68 (dialysis patients) and HLA-A*03 and HLA-B*15 (transplant patients) appear to be associated with increased resistance to S. aureus nasal carriage. (biomedcentral.com)
  • inflammation
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • mutations
  • To evaluate for mutations in the gene for TACI, we PCR amplified and sequenced TACI exons 3 and 4 from these patients. (beds.ac.uk)
  • found
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • HLA *B44 was also found to be over-represented among patients who presented to our clinic with adult-onset recurrent sinopulmonary infections (RESPI) and normal serum immunoglobulin levels, a cohort that included first and second degree relatives of patients with CVID. (beds.ac.uk)
  • fetal
  • It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
  • common
  • An exchange of reagents was necessary to compare antisera to standardize the definition of antigens and to establish a common nomenclature. (ihiws.org)
  • proteins
  • Specifically, MHC contains a group of genes that code for several proteins expressed on the surface of a variety of cell types. (biomedcentral.com)