Loading...
  • ALCOHOLIC LIVER D
  • EASL Scientific Committee Member Prof. Frank Lammert commented: "Among heavy drinkers, the severity of alcoholic liver disease does not strictly correlate with the amount of alcohol intake, meaning that other factors must be influencing its development. (eurekalert.org)
  • These findings provide first evidence for a causal role of gut microbiota in alcohol-induced inflammation, and open up new avenues for the treatment of alcoholic liver disease with potentially better patient outcomes. (eurekalert.org)
  • Exciting new data presented today at the International Liver Congress 2014 shows that the gut microbiota has a potential role in the development of alcoholic liver disease (ALD). (medicalxpress.com)
  • autoimmune diseases
  • Immunology is the study of how the body defends itself against pathogenic microorganisms and cancer but is also fundamental to debilitating autoimmune diseases, asthma and allergies. (abdn.ac.uk)
  • Th1 cells produce cytokines (interferon (IFN)-gamma, interleukin (IL)-2, tumour-necrosis factor (TNF)-alpha and lymphotoxin) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. (jove.com)
  • toxicology
  • Pharmacology is concerned with the discovery, characterisation and toxicology of drugs that are used either as medicines or as experimental tools for advancing our understanding of the body in health and disease. (abdn.ac.uk)
  • SNPs
  • With the advent of next-generation sequencing, several common single nucleotide polymorphisms (SNPs) have been discovered in association with disease susceptibility. (diabetesjournals.org)
  • SNPs that correlate with specific diseases could serve as predictive biomarkers to aid the development of new drugs. (news-medical.net)
  • Through the statistical analysis of GWAS summary data, it is possible to identify the disease-associated SNPs. (news-medical.net)
  • Therefore, among tens of thousands of genomics data and hundreds of thousands of SNPs analyzed, the number of markers described within a candidate disease gene often reaches severl tens. (news-medical.net)
  • severity
  • 1. A method for reduction of incidence and/or severity, prophylaxis and/or treatment of an inflammatory disease comprising administering a pharmaceutical effective amount of a BSSL antagonist to a subject in need of such treatment. (patents.com)
  • 7. A pharmaceutical composition comprising a BSSL antagonist and a pharmaceutically acceptable carrier or excipient for use in reduction of incidence and/or severity, prophylaxis and/or treatment of an inflammatory disease. (patents.com)
  • Pharmacological blockade or lack of S1PR2 signaling decreased EAE disease severity as the result of enhanced endothelial barrier function. (jci.org)
  • Th1-specific Cell Surface Protein Tim-3 Regulates Macrophage Activation and Severity of an Autoimmune Disease Nature. (jove.com)
  • heterogeneous
  • Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of slowly progressive diseases characterized by airflow obstruction that interferes with normal breathing ( 1 ). (cdc.gov)
  • gene expression
  • Comparative gene expression profiling of multiple tissues from rat strains with genetic predisposition to diverse cardiovascular diseases (CVD) can help decode the transcriptional program that governs organ-specific functions. (epa.gov)
  • When rats were treated with a synthetic glucocorticoid, sex-specific differences in gene expression in the rat liver, as measured by microarray analysis, were elevated. (sciencemag.org)
  • researchers
  • Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. (barnesandnoble.com)
  • diabetes
  • Exciting new data presented today at the International Liver Congress 2012 shows the gut microbiota's causal role in the development of diabetes and non-alcoholic fatty liver disease (NAFLD), independent of obesity. (medicalxpress.com)
  • psychiatric
  • This quality is particularly noticeable for psychiatric diseases, such as schizophrenia and bipolar disorder ( 2 ). (pnas.org)
  • Furthermore, stem cell-based cell replacement therapy offers enormous potential for the treatment of a variety of developmental, psychiatric, neurodegenerative and aging related diseases for which there are currently no cures. (washington.edu)
  • Classification
  • PLOS 18/10/13 New Avian Paramyxoviruses Type I Strains Identified in Africa Provide New Outcomes for Phylogeny Reconstruction and Genotype Classification Newcastle disease (ND) is one of the most lethal diseases of poultry worldwide. (pearltrees.com)
  • International Classification of Diseases, Tenth Revision (ICD-10) codes were used to identify cases of COPD. (cdc.gov)
  • development
  • This requires the continued development of strategies to study brain function in health and disease as the 'system', greater than the sum of its parts. (ox.ac.uk)
  • reveal
  • A major new effort to uncover the medium- and large-scale genetic differences within the human species may soon reveal DNA sequences that contribute to a wide range of diseases, according to a paper by Evan Eichler, UW associate professor of genome sciences, and 17 colleagues published in the May 10 issue of Nature . (washington.edu)
  • cancers
  • HBOC syndrome is an autosomal dominantly inherited disease characterized by a young age of onset, more than one synchronous or metachronous tumor, and a family history of first and second degree relatives with similar cancers ( 8 ). (spandidos-publications.com)
  • prevention
  • It provides methods and pharmaceutical compositions comprising antagonists to the protein Bile Salt-Stimulated Lipase (BSSL) for the prevention, prophylaxis and treatment of inflammatory diseases, such as rheumatoid arthritis. (patents.com)
  • regulates
  • We identified sphingosine-1-phosphate receptor 2 (S1PR2) as a sex- and strain-specific, disease-modifying molecule that regulates BBB permeability by destabilizing adherens junctions. (jci.org)
  • scientists
  • The congress annually attracts in excess of 9000 clinicians and scientists from around the world and provides an opportunity to hear the latest research, perspectives and treatments of liver disease from principal experts in the field. (eurekalert.org)
  • large
  • This is a part of large susceptibility project in the lab. (epa.gov)
  • To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. (pnas.org)
  • patterns
  • These results identify a link between S1PR2 signaling and BBB polarity and implicate S1PR2 in sex-specific patterns of disease during CNS autoimmunity. (jci.org)
  • identify
  • With this algorithm, we can easily identify new drug targets, thereby deepening our understanding of diseases and unlock new therapies to treat it. (news-medical.net)