• The results in mice and humans suggest that exposure to adversity during childhood triggers activation of the immune system, leading to permanent changes that sensitize the immune system and increase susceptibility to the effects of cocaine in adulthood. (elsevier.com)
  • DAVIS, Calif. - Diets deficient in amino acids -- chemicals that make up proteins -- can significantly increase susceptibility to epileptic seizures in rats, according to a study by researchers at the University of California, Davis. (eurekalert.org)
  • NEW YORK (GenomeWeb) - A rare genetic mutation can increase susceptibility to the common cold, according to a US National Institute of Allergy and Infectious Diseases-led team of researchers. (genomeweb.com)
  • Apart from being necessary for our subsequent animal experiments exploring in vivo antifungal susceptibility, these findings also helped us understand at least part of the reason for the differences in the epidemiology and the pitfalls associated with the establishment of genus rather than species specific breakpoints. (nih.gov)
  • Eighty-two samples of this yeast isolated from dogs with the symptoms of external otitis from the Porto Alegre region were tested for their susceptibility to antifungal agents using the Broth Microdilution Method. (mendeley.com)
  • The isolates of M. pachydermatis showed an excellent level of susceptibility to antifungal azole agents, with all strains being susceptible to Itraconazole, and with only 2.4% and 3.7% being resistant to Fluconazole and Ketoconazole, respectively. (mendeley.com)
  • The use of the broth microdilution method allows the assessment of the susceptibility of large numbers of samples from M. pachydermatis isolates to the most common antifungal agents. (mendeley.com)
  • Consistent results among laboratories could greatly benefit the establishment of proper comparisons between studies on antifungal susceptibility and therapeutic trials. (mendeley.com)
  • 14 organisms identified at CDC were isolated from blood Antifungal Susceptibility of taken from men 39-78 years of age with symptoms includ- ing swelling of the lower extremities (2 patients), septice- Candida viswanathii , India mia (3 patients), and bacteremia (1 patient). (cdc.gov)
  • Susceptibility testing of fungi against antifungal drugs commonly used for therapy is a key component of the care of patients with invasive fungal infections. (mdpi.com)
  • The next step," Owens concludes, "is to discover more about the precise physiological mechanisms that lead to the unusually high susceptibility of large mammals to parasitic diseases. (scientificamerican.com)
  • Compared with nonsusceptible respondents, those with low and high susceptibility hod higher odds of initiating intercourse two years later (odds ratios, 2.5 and 8.1, respectively). (rti.org)
  • However, during the second half of the 20th century, after radiography became available, it became clear that the extent of disease, radiographic pattern, and individual susceptibility were more important than pregnancy itself in determining the course and prognosis of the disease. (hindawi.com)
  • As neither the Danish epidemiology nor the susceptibility of fungal pathogens was well described when we initiated our studies we initially wanted to be able to include animal models in our work. (nih.gov)
  • To promote colonisation, pathogens and pests produce virulence factors, called effectors, which interact with specific plant targets to re-programme plant pathways, a process referred to as effector-triggered susceptibility (ETS). (jic.ac.uk)
  • The safety and efficacy of these drugs in treating clinical infections due to such bacteria may or may not have been established in adequate and well-controlled clinical trials and the clinical significance of such susceptibility information in those instances is unknown. (fda.gov)
  • Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria i. 3rd ed. (fda.gov)
  • A 30-minute test could help doctors assess the antibiotic susceptibility of bacteria in urine samples. (acs.org)
  • Therefore, the susceptibility of waterborne bacteria to antibacterial agents including iodine and nalidixic acid is highly variable and dependant upon the organism, antecedent growth conditions and biofilm formation. (sae.org)
  • Claims of current and future benefits from genetic susceptibility screening are misleading because genetic variants are poor predictors of most diseases in most people and biology is complex. (els.net)
  • Although our findings strongly suggest that MMP12 has a role in determining lung function and susceptibility to COPD in high-risk groups, knowledge of the genotype for an MMP12 variant does not add to clinical variables in predicting the onset of COPD. (medpagetoday.com)
  • Regulation of the clinical validity and utility of genetic susceptibility tests is also needed. (els.net)
  • The lack of a premarket assessment of clinical validity and utility means that most genetic susceptibility tests currently on sale are misleading to consumers. (els.net)
  • 6 Although these serologic studies suggest that infants whose mothers were born in the vaccine era would be more susceptible to measles disease than would infants of older mothers, no study actually has documented increased susceptibility to clinical measles disease. (aappublications.org)
  • This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. (clinicaltrials.gov)
  • To summarize the literature regarding susceptibility of pregnant women to infectious diseases and severity of resulting disease, we conducted a review using a PubMed search and other strategies. (hindawi.com)
  • Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. (nih.gov)
  • This is the first successful analysis of whole genome sequence from a family that revealed a new gene implicated in KD susceptibility," said senior author Jane C. Burns, MD, professor and director of the Kawasaki Disease Research Center at UC San Diego School of Medicine and Rady Children's Hospital-San Diego. (ucsd.edu)
  • Reported situations in which previous influenza virus exposures have enhanced susceptibility are rare and poorly understood," said Matthew Miller, senior author of the paper, an assistant professor of biochemistry and biomedical sciences at McMaster University, and senior researcher with its Michael G. DeGroote Institute of Infectious Disease Research. (newswise.com)
  • Rare Disease to Inform Ebola Susceptibility? (the-scientist.com)
  • The susceptibility of the five cell lines IB-RS-2, RK-13, Vero, BHK-21, CER - to reovirus S1133 and infectious bursal disease virus (IBDV vaccine GBV-8 strain) was studied to better define satisfactory and sensitive cell culture systems. (scielo.br)
  • Now, the research group of Prof. Alfons Meindl (Klinikum rechts der Isar of the Technische Universität München), in collaboration with other groups from Germany, the U.K., and the U.S., can identify another gene that increases susceptibility to breast and ovarian cancer. (mytum.de)
  • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. (mytum.de)
  • What Are Factors Affecting Children's Susceptibility to Exposures? (cdc.gov)
  • In addition to investigating environmental activating factors (e.g., sunlight) that may play a role in outbreaks, researchers for some time have been looking at the possible role of genetic factors in virus susceptibility and activation. (scienceblog.com)
  • Researchers at Columbia University and the University of Pennsylvania describe an apparent role for the chromosome 15 gene C2CD4A in insulin secretion from pancreatic beta-cells and related susceptibility to type 2 diabetes (T2D). (genomeweb.com)
  • Mar 27, 2013 (CIDRAP News) - Experiments by Hong Kong researchers to gauge the susceptibility of several human and animal cell lines to novel coronavirus (NCoV) found signs that it can infect a broad range of tissues, which might shed light on the disease's seemingly high mortality rate. (umn.edu)
  • Here, in what we believe is the first study of its kind in humans, we have revisited microsatellite genome scan linkage data for three infectious diseases in contrasting populations, to determine the extent to which genomewide heterozygosity is an important predictor of susceptibility to some diseases, particularly in populations where inbreeding is common. (royalsocietypublishing.org)
  • Remarkably, pharmacologically blocking this immune activation during early life stress prevents the development of the susceptibility to cocaine in adulthood," said senior author Valeria Carola, PhD. Mice who received an antibiotic to prevent activation of immune cells during social stress did not have cellular changes or drug-seeking behavior. (elsevier.com)
  • When the scientists treated the mice with drugs that blocked well-known inflammatory factors, inhibitors of COX-2 dramatically reduced susceptibility both in mice with previous infections and in mice that had not been infected earlier. (eurekalert.org)
  • Here we have shown that increased myofilament Ca2+ sensitivity, also a common feature in both inherited and acquired human cardiomyopathies, created arrhythmia susceptibility in mice, even in the absence of anatomical abnormalities. (jci.org)
  • Even though there is an increasing incidence with increased exposure, this is not absolute and our findings suggest that there is also a personal susceptibility to pitch. (bmj.com)
  • The Rush Inherited Susceptibility to Cancer Clinic provides counseling and testing (usually blood tests) for genetic mutations that can increase risk for cancer, such as BRCA1 and BRCA2 mutations. (rush.edu)
  • If preliminary evidence of efficacy is demonstrated, the concept may be amenable to development of a broad program that provides preventive information delivered to adolescents and young adults patients during dental appointments to decrease their susceptibility to opioid use disorders. (merlot.org)
  • In that report, MS was present in ≈21% of enrolled patients (a number similar to that quoted above for the US population 6 but much higher than previous Japan estimates 2 ), and AF was twice as common in MS patients than in individuals without MS. Similarly, Echahidi et al 10 assessed the relation of MS to AF susceptibility in patients undergoing coronary artery surgery. (ahajournals.org)
  • Conclusions- PCSWI appears to be superior to susceptibility-weighted imaging, time-of-flight MR angiography, and contrast-enhanced MR angiography in detecting arteriovenous shunting in BVMs and may be useful in the initial diagnosis and follow-up of patients with BVMs. (ahajournals.org)
  • In a paper published online this week in the journal EBioMedicine, the scientists reported the development of a rapid susceptibility test for Staphylococcus aureus, a bacterium that causes some 60 percent of hospital-acquired infections and which has spread in communities, causing pneumonia and a variety of skin and tissue infections in both healthy and immune-compromised individuals. (ucsd.edu)
  • Thirty-eight percent of respondents were classified as being nonsusceptible to initiating intercourse, 34% as having low susceptibility and 28% as being highly susceptible. (rti.org)
  • A study of smoking susceptibility among adolescents who had never smoked has found that Hispanics are more susceptible to smoking during their adolescent years than their non-Hispanic White counterparts are. (nih.gov)
  • Overall, susceptibility peaks at age 14, when 27 percent of youth are susceptible. (nih.gov)
  • CONCLUSIONS: The cognitive susceptibility index provides a valid method for assessing sexual risk before the onset of intercourse. (rti.org)
  • The Gill Center Cancer Susceptibility Program provides families of children with genetic predispositions to cancer with access to the most advanced genetic counseling, ongoing screening and oncology specialists. (childrens.com)
  • These susceptibility rates can be used as a screening tool during annual pediatric wellness visits to reduce smoking initiation among at-risk youth. (nih.gov)
  • The presence of arteriovenous shunting in PCSWI or susceptibility-weighted imaging sequences was defined by the presence of abnormal signal hyperintensity in the venous structures adjacent to the BVM. (ahajournals.org)
  • The susceptibility of Hispanic adolescents peaks at age 12 and again at age 16, according to the study. (nih.gov)