Survival tumor cell. Medical search. Frequent questions

Advances in immunotherapy have shed greater focus on the role of tumor-infiltrating immune cells, which are vital components of the tumor immune microenvironment (TIME). (aging-us.com)
TP53 mutations are also associated with the infiltration of immune cells into the tumor microenvironment [ 10 - 12 ]. (aging-us.com)
This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. (elifesciences.org)
Our results corroborate the previous findings suggesting an association between an immunologically active tumor microenvironment and response to ipilimumab treatment, and propose new potential biomarkers for predicting treatment efficacy and disease outcome. (mtak.hu)
Conclusions: Anti-CXCR4 and anti-PD-1 combination immunotherapy modulates tumor-infiltrating populations of the glioma microenvironment. (elsevierpure.com)
Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
Such tumors tend to be more homogeneous than human cancers, she notes, and do "not always completely simulate the tumor microenvironment of human cancers. (the-scientist.com)

While CAR-T cell therapies have shown remarkable success in hematologic malignancies, application to solid tumors has been broadly unsuccessful. (bmj.com)
A suitable clinical-grade platform is required for detection of somatic mutations with high sensitivity in cell-free DNA (cfDNA) of patients with solid tumors. (oncotarget.com)
We assessed plasma samples from 46 patients with various advanced metastatic solid tumors and known mutations by deep sequencing using an Ampliseq cancer hotspot panel V2 on Ion Proton. (oncotarget.com)
By contrast, analysis of solid tumors necessitates invasive procedures that might limit patient compliance. (wikipedia.org)
Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)

Background Human kallikrein-related peptidase 2 (KLK2) is an antigen with prostate-restricted expression which is maintained during prostate cancer progression - making it an attractive therapeutic target for chimeric antigen receptor (CAR) T cells. (bmj.com)
Panels A and B show Kaplan-Meier curves for the duration of progression-free survival and overall survival, respectively, according to the presence or absence of intratumoral T cells in 174 patients with stage III or IV epithelial ovarian cancer and complete, partial, or no response to therapy. (shu.edu)
Functional enrichment analysis of the DEGs in the high OSM-expressing CCA tissues showed that pathways related to tumor progression and immune response were significantly upregulated. (aging-us.com)
LOH was found in approximately 30% of cases and was strongly correlated with cancer progression, tumor recurrence and decreased patient survival. (mssm.edu)
Taken together, these findings suggest that KLF6 LOH represents a clinically-relevant biomarker predicting patient survival and tumor recurrence and that dysregulation of KLF6 function plays an important role in HNSCC progression. (mssm.edu)
The pathway is involved in both tumor development and progression. (harvard.edu)
Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
Increased expression of EGFR-positive myeloid cells associated with tumor progression and reduced survival in bowel cancer. (pharmacytimes.com)

The most important prognostic factors are tumor size, local spread and distant metastases, tumor node metastasis (TNM) staging. (diva-portal.org)
CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis. (ox.ac.uk)
Growth factors and cytokines involved in liver regeneration have also been shown to influence tumour growth and metastasis. (nih.gov)
Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
In this study, we collected single-cell sequencing datasets of LUAD and applied an integrated bioinformatic method to depict the transcriptome characteristic of LUAD in normal, tumoral, and metastasis condition. (aging-us.com)
Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
As early as the 1800's when Recaimer first coined the term "metastasis", circulating tumor cells (CTCs) have been postulated to be critical to the process [ 5 , 6 ]. (biomedcentral.com)
In fact, the initiation of metastasis may be a relatively early event in tumor biology, underscoring the need to understand the significance of CTCs. (biomedcentral.com)
Therefore, it is of importance to identify the molecular mechansims that drive metastasis of melanoma cells. (lu.se)

Tumor TNM staging is the main basis for prognosis and treatment decision for head and neck squamous cell carcinoma (HNSCC) despite significant heterogeneity in terms of outcome among patients with the same clinical stage. (diva-portal.org)
While uncertainty persists regarding the explanation of the high recurrence-rate in node negative colon cancer, there is emerging evidence that the appearance of isolated tumor cells (ITC) and micro-metastases in LN could be associated with worse prognosis [ 8 - 14 ]. (biomedcentral.com)
CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
These results are exciting because of the possible implications for a patient population that currently has the poorest possible prognosis going into treatment, those with malignant brain tumors that have recurred after initial treatment," said James Vredenburgh, M.D., a brain cancer specialist at Duke's Preston Robert Tisch Brain Tumor Center and lead researcher on the study. (sciencedaily.com)
When the tumor returns after initial treatment -- which usually includes surgery, chemotherapy and radiation -- the prognosis is even more grim, with an average life expectancy of three to nine months. (sciencedaily.com)
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. (elifesciences.org)
Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. (elifesciences.org)
The present study aimed to determine the diagnostic applicability of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) to evaluating the response and prognosis after trimodality therapy for esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
Associations between SUVmax and pathological response of primary tumor and prognosis were analyzed. (biomedcentral.com)
Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
The presence of EGFR-positive myeloid cells in these tumors produced a poorer prognosis for survival. (pharmacytimes.com)
Nevertheless, Ahmed, a neurosurgery research fellow, told Reuters Health by email, "The findings of this study may be utilized by physicians and surgeons in a more personalized effort to assess patient-specific prognosis for patients with metastatic spinal tumors, and may therefore assist clinicians in pursuing the most appropriate treatment for a given spinal oncology patient. (medscape.com)

Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
HNSCC is the sixth oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
the goal is to cause as little functional squamous cell carcinoma type (HNSCC) and includes and cosmetic damage as possible ( 6 , 9 ). (cdc.gov)

To overcome these challenges, we are developing a KLK2 targeted off-the-shelf CAR-T cell product using our induced pluripotent stem cell (iPSC)-derived immunotherapy platform. (bmj.com)
Therefore the application of immunotherapy has driven the treatment of brain tumors to the study of the response of intratumoral and systemic immune cells and cytokines to these malignancies 10 - 12 . (researchsquare.com)
It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)
Many targeted therapies in development act on the PI3K/AKT pathway, one of the most frequently aberrantly activated signaling pathways in human cancer cells. (harvard.edu)
Moreover, because glutathione is only one of several antioxidants within cells, the researchers wonder whether there are other antioxidant pathways in tumor cells that are hijacked by the PI3K/AKT pathway to drive cancer. (harvard.edu)
Further analyses revealed that simultaneously targeting HuR, with MS-444, and WNT5A signaling, with Box5, reduces melanoma cell migration and invasion via two different and partially overlapping signaling pathways, which are PKC and PI3K-AKT. (lu.se)

Similarly, ITC were associated with significantly worse overall survival (hazard ratio = 3.50, p = 0.043). (biomedcentral.com)
This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. (biomedcentral.com)
The strongest link between the number of TILs and overall survival was for patients with high-grade serous ovarian cancer, which is the most common and most lethal histological type, or histotype, of the disease. (shu.edu)
The five-year overall survival rate was 38.0 percent among patients whose tumors contained T cells and 4.5 percent among patients whose tumors contained no T cells in islets. (shu.edu)
In this study, we evaluated in parallel ultra-deep NGS with MassARRAY and allele-specific droplet digital PCR (ddPCR) for cfDNA genotyping and correlated cfDNA yield and mutation status with overall survival (OS) of patients. (oncotarget.com)
The primary treatment option for early-stage CCA patients is surgical resection, but the 5-year overall survival (OS) rate is below 10% because majority of the CCA patients are diagnosed in the advanced stages and are not amenable for surgery [ 2 , 3 ]. (aging-us.com)
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer. (bvsalud.org)
Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to determine its influence on overall survival . (bvsalud.org)
The development of modern agents specifically targeting these processes may improve disease-free and overall survival rates after oncological hepatectomy. (nih.gov)
Overall survival and median survival were assessed. (elsevierpure.com)
We will first review the clinical trial data that validated CTCs ability to predict disease free and overall survival. (biomedcentral.com)
and overall survival will not be measured. (medscape.com)
Overall survival is a secondary outcome. (medscape.com)
Overall survival and QoL will not be tracked. (medscape.com)
The mean overall survival after surgery was 282 days, ranging from 55 days for patients with bladder cancer to more than 4.5 years for those with multiple myeloma. (medscape.com)
Development and External Validation of a Novel 12-Gene Signature for Prediction of Overall Survival in Muscle-Invasive Bladder Cancer. (cdc.gov)
Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival. (cdc.gov)

The Krüppel-like transcription factor (KLF6) gene is a tumor suppressor gene (TSG) reported to be dysregulated and inactivated through loss of heterozygosity (LOH) and/or somatic mutation in a number of major human cancers. (mssm.edu)
and the tumor suppressor genes WT1 and MASH2 are imprinted, depending on their maternal or paternal origin. (medscape.com)
Mice that received combination therapy demonstrated immune memory and decreased populations of immunosuppressive tumor-infiltrating leukocytes, such as monocytic myeloid-derived suppressor cells and microglia within the brain. (elsevierpure.com)
The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzyme in PGE 2 catabolism, converting it into its inactive metabolite 15-keto- PGE 2 , and is often down-regulated in cancer. (lu.se)
therefore, we investigated a potential link between CysLT2 signaling and the tumor suppressor 15-PGDH in colon cancer cells. (lu.se)

The aim for this thesis was to investigate rapid and low cost blood based biomarkers which could indicate the risk of HNC, recurrence of the disease or the survival of HNC patients. (diva-portal.org)
The presence of intratumoral T cells independently correlated with delayed recurrence or delayed death in multivariate analysis and was associated with increased expression of interferon-γ, interleukin-2, and lymphocyte-attracting chemokines within the tumor. (shu.edu)
The likelihood of recurrence depends on the site of the tumor as well as the completeness of resection. (medscape.com)
However, long-term survival in these patients is limited by the high incidence of tumor recurrence. (nih.gov)
GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)
The primary outcomes in the phase 2 part of the study include circulating-tumor DNA (ctDNA) clearance or ctDNA recurrence-free survival 6 months after randomization among patients with detectable ctDNA status at randomization. (medscape.com)

Patients and methods This phase-II trial investigated a peptide vaccination against survivin, an oncogenic inhibitor-of-apoptosis protein crucial for the survival of tumor cells, in HLA-A1/-A2/-B35-positive patients with treatment-refractory stage-IV metastatic melanoma. (uni-wuerzburg.de)
Associations of labeled cell densities with survival were also found for most cell types studied in nodal metastases, and for CD16+ and CD68+ cells in skin/s.c. metastatic cases. (mtak.hu)
Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. (biomedcentral.com)
NEW YORK (Reuters Health) - The predictive accuracy of scoring systems for survival after surgery for metastatic spine disease may vary, according to a study of nine such prognostic calculators. (medscape.com)

This seems counter-intuitive - serous tumors would be considered "cold" tumors, yet, immune checkpoint blockade induces responses in these patients. (shu.edu)
Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors. (cienciavida.org)
In normal cells, mdm2 availability is controlled by ARF, the product of the p14ARF gene located on INK4a/ARF locus, which binds with mdm2 and induces its degradation. (medscape.com)
PGE 2 induces angiogenesis and tumor cell survival, proliferation and migration. (lu.se)
PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. (lu.se)

We also tested the effect of KLF6 inhibition in HNSCC cell lines on proliferation and p21 expression. (mssm.edu)
Targeted stable reduction of KLF6 in HNSCC cell lines increased cellular proliferation while decreasing p21 expression. (mssm.edu)
Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
However, the underlying mechanisms explaining the interactions between regenerating liver tissue and tumour cell proliferation remain unclear. (nih.gov)
MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/ml of NGF or the NGF inhibitor Tanezumab for 24 h, CCK-8 and Transwell assays were employed to test cell proliferation, invasion, and migration, respectively. (hindawi.com)
This radiolabeled monoclonal antibody from Telix Pharmaceuticals targets carbonic anhydrase IX (CAIX), an enzyme that regulates cell proliferation and is highly expressed in many tumor types. (medscape.com)

According to the TNM classification system micro-metastases are defined as tumor deposits of 0.2 mm to ≤ 2 mm in diameter, labeled as pN1(mi), and ITC as either single tumor cells or clusters of tumor cells of 0.2 mm or less, labeled as pN0(i+) [ 15 ]. (biomedcentral.com)
CTCs can extravasate and become seeds for the subsequent growth of additional tumors (metastases) in distant organs, a mechanism that is responsible for the vast majority of cancer-related deaths. (wikipedia.org)
therefore, the prognostic and predictive associations of immune cell infiltration were evaluated separately in the two groups of metastases as well as in all samples as a whole. (mtak.hu)
Higher prevalence of several immune cell types was seen in lymph node metastases of the responders compared to non-responders, particularly FOXP3+ cells and CD8+ T lymphocytes. (mtak.hu)
Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)

The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)

abstract = "Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. (johnshopkins.edu)
ABSTRACT The 5-year survival rate of female breast cancer cases in Jordan and some of the factors that affected survival were measured. (who.int)

The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, defined as cell deposits ≤ 0.2 mm) in loco-regional LN of stage I & II colon cancer patients. (biomedcentral.com)
The prognostic value of FoxP3(+) regulatory T cells (Tregs) in cancer remains controversial. (nih.gov)
0.001), but the prognostic effect varied greatly according to tumor site. (nih.gov)
The stratified analysis suggested the molecular subtype and tumor stage significantly influenced the prognostic value of FoxP3(+) Tregs in certain types of cancer. (nih.gov)
In conclusion, our meta-analysis suggests that the prognostic role of FoxP3(+) Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage. (nih.gov)
However, it is ambiguous for simple tumor makers to evaluate patients' changing conditions and to predict outcomes, not to mention the evaluation and prognostic significance of patients with negative tumor indicators. (researchsquare.com)
The two signatures allowed patients with specimens in the test set to be divided into four quartiles with widely disparate median lengths of survival (13.6, 11.1, 10.8, and 3.9 years), independently of clinical prognostic variables. (elsevierpure.com)
Previous researchers had conducted a comprehensive analysis of single-cell RNA-sequencing data of LUAD and identified prognostic signatures based on B cells [ 12 ] and natural killer cells [ 13 ]. (aging-us.com)
Then, multivariate analysis was performed to demonstrate that the signature was an independent prognostic factor and highly correlated with immune-cell infiltrations and immune-suppressive states. (aging-us.com)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. (lu.se)
might be related to the moderately high risk of bias due to shortcomings in the design, conduct, analysis and reporting associated to determining key predictive factors for survival and validation of prognostic studies. (medscape.com)
In addition, to our knowledge, this is indeed the first study to compare the predicting performance of existing prognostic calculators for different types of primary tumor. (medscape.com)

They found that the two drugs together halted tumor growth up to twice as long as comparative therapies. (sciencedaily.com)

More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)

Teratomas (from Greek teras, "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors (GCTs) are relatively common solid neoplasms in children. (medscape.com)
Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)
The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)

Background Therapeutic vaccination directed to induce an anti-tumoral T-cell response is a field of extensive investigation in the treatment of melanoma. (uni-wuerzburg.de)
Patients and methods This phase-II trial investigated a peptide vaccination against survivin, an oncogenic Background Therapeutic vaccination directed to induce an anti-tumoral T-cell response is a field of extensive investigation in the treatment of melanoma. (uni-wuerzburg.de)
Conclusion Survivin-specific T-cell reactivities strongly correlate with tumor response and patient survival, indicating that vaccination with survivin-derived peptides is a promising treatment strategy in melanoma. (uni-wuerzburg.de)
Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. (lu.se)
Malignant melanoma is the most aggressive type of skin cancer, which initiates in the pigment-producing cells called melanocytes. (lu.se)
High expression of wingless-type MMTV integration site family 5A (WNT5A) has been reported in melanoma and correlates with increased migration and invasion of melanoma cells. (lu.se)
In this thesis, we investigate that WNT5A and interleukin-6 (IL-6) form a positive feedback loop, which accelerates the invasive property of melanoma cells. (lu.se)
In addition, we demonstrate that combined targeting of IL-6 signaling and WNT5A expression, using an anti-IL-6 antibody and a WNT5A antagonist peptide (Box5), respectively, more effectively reduces melanoma cell dissemination, as compared to each factor alone. (lu.se)
Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)
Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)
Taken together, our results extend our knowledge about WNT5A regulation in melanoma and highlight the importance of HuR and WNT5A in melanoma cell migration and invasion. (lu.se)

In a cell line that did not induce CAIX under hypoxia, RT112, we found no effect on the ability of cells transfected with CAIX to invade or migrate. (ox.ac.uk)
For recent decades, it has been recognized that malignant tumor cells potentially induce local and systemic immunosuppression 9 . (researchsquare.com)
Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)

Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)

Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)

In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. (diva-portal.org)
In paper I, a possible role of plasma cytokines or proteins associated with immune response or inflammation, as biomarkers for the survival of HNC patients was investigated. (diva-portal.org)

Clear cell and mucinous cancers were more likely to have no CD8+ positive cells. (shu.edu)
Recent studies demonstrate that somatic mutations in the tumor tissues influence immunotherapeutic response in several cancers [ 6 , 7 ]. (aging-us.com)
whereas, FoxP3(+) Tregs were associated with improved survival in colorectal, head and neck, and oesophageal cancers. (nih.gov)
As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers. (medlineplus.gov)
Growing tumor models like those used in the study "can be great for asking proof-of-concept questions," Anderson says, but they sometimes make a poor proxy for human cancers, in which immune cells may lose functionality over time. (the-scientist.com)
Treatment Gastrointestinal stromal tumors are rare cancers that start in specific cells in the wall of the digestive tract. (msdmanuals.com)
During the past decade, federal health agencies have focused on reducing the incidence of oral and pharyngeal cancer and increasing the 5-year survival rate from these cancers in the United States. (cdc.gov)

Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)
Our study demonstrates that OSM expression and TP53 mutation status regulate the tumor infiltration by immune cells and survival outcomes in CCA. (aging-us.com)
However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)

Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice. (cdc.gov)

Researches with the Ovarian Tumor Tissue Analyses Consortium analyzed the CD8+ (cytotoxic T-cell) content of tumors from 5,500 patients and compared them with clinical outcome. (shu.edu)
The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)
Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
Recently, next-generation sequencing, especially single-cell RNA sequencing is a possible option for the analysis of detailed cell population subtypes of LUAD from bulk tissue samples at single cell level [ 10 , 11 ]. (aging-us.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

Approximately 18,000 people are diagnosed with gliomas in the United States each year, making them the most common and most deadly malignant tumors of the central nervous system. (sciencedaily.com)
Most of the malignant tumors produce markers that can be serologically assessed. (medscape.com)

Avastin, a relatively new type of drug that shrinks cancerous tumors by cutting off their blood supply, can slow the growth of the most common and deadly form of brain cancer, a pilot study conducted at Duke University Medical Center has found. (sciencedaily.com)
Gastrointestinal stromal tumors (GISTs) are sarcomas (cancerous tumors of connective. (msdmanuals.com)

76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)

The authors conclude that EGEE and EGME exert their anti tumor effect through increased immunological competence or immunomodulation. (cdc.gov)
In conclusion, the restoration of 15-PGDH expression through CysLT 2 signaling promotes the differentiation of colon cancer cells, indicating an anti-tumor effect of CysLT 2 signaling. (lu.se)

Oncostatin M (OSM) is a cytokine secreted by differentiated histiocytic lymphoma cells [ 14 ]. (aging-us.com)
CONCLUSIONS: The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis. (elsevierpure.com)
Purpose:Targeted inhibition of anaplastic lymphoma kinase (ALK) has been widely used for the treatment of advanced non-small cell lung cancer (NSCLC) with ALK rearrangements. (elsevierpure.com)
Other types include islet cell tumors, pancreatic lymphoma, and cystic tumors, such as intraductal papillary mucinous neoplasms (IPMN or IPMT). (bidmc.org)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
were evaluated using Dalton Lymphoma ascites (DLA) tumor model in Swiss Albino mice. (bvsalud.org)

However, the identification of factors predicting a worse survival in stage II colon cancer led the American Society of Clinical Oncology (ASCO) [ 3 - 5 ], the Nationonal Comprehensive Cancer Network (NCCN) and the European Society for Medical Oncology (ESMO) to define a collective of high-risk patients who may benefit from adjuvant chemotherapy. (biomedcentral.com)
The researchers tested the effectiveness of Avastin in conjunction with a standard chemotherapy agent in patients with recurrent cancerous brain tumors called gliomas. (sciencedaily.com)
In the pilot study, the researchers found that dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumors or restricted their growth in nearly all cases for up to three months longer than comparative therapies. (sciencedaily.com)
Chemotherapy may be used to treat this tumor. (medlineplus.gov)
Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. (harvard.edu)
This adaptation can allow cancer cells to survive even in the face of toxic chemotherapy. (harvard.edu)
Our work has uncovered a vulnerability in human breast cancer that is used by tumor cells to escape the lethal effects of conventional chemotherapy and that leads to resistance to such therapies," explained Toker, chief of the Division of Signal Transduction at Beth Israel Deaconess. (harvard.edu)
If cancer has already spread (metastasized) to other parts of the body at the time a leiomyosarcoma is found, then chemotherapy may lead to slightly longer survival. (msdmanuals.com)

The results suggest that the engineered Salmonella helped ensure that antigen-detecting dendritic cells , which immunosuppressive tumors can disable or keep at bay, came into contact with the tumor antigens and activated an immune response. (the-scientist.com)
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)
In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
Reprogramming cancer cells to antigen-presenting cells. (lu.se)

The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
The bacteria captured the negatively charged antigens and ferried them to dendritic cells in the tumors' periphery, where a tumor-targeting immune response was initiated, improving the animals' odds of survival. (the-scientist.com)

Higher levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) were detected in plasma of the patients compared with the levels in the controls. (diva-portal.org)

Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)

Teratomas (from Greek teras, meaning "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors are relatively common solid neoplasms in children. (medscape.com)

These tumors are grouped together because they all appear to arise from postmeiotic germ cells. (medscape.com)
The best evidence suggests that most are due to abnormal differentiation of fetal germ cells that arise from the fetal yolk sac. (medscape.com)
Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)
Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)

Overall, median survival of patients with LOH was less than half (19 vs. 41 months, p = 0.036, stratified on stage) than those without loss. (mssm.edu)
Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)
The median survival time for the controls was 8 days. (cdc.gov)
EGME and EGEE treatment did not affect median survival time in syngeneic mice, indicating that these compounds did not inhibit tumor growth. (cdc.gov)

Combination of upregulated CRP and TNF-α in the patient plasma was significantly related to shorter patient survival, independent of clinical stage. (diva-portal.org)

Those high-risk stage II colon cancer patients feature at least one of the follwing characteristics: pT4 tumor, poorly differentiated histology, presence of lymphovascular invasion, localized perforation, bowel obstruction or less than 12 lymph nodes (LN) analyzed [ 4 , 6 ]. (biomedcentral.com)
Classification of childhood cancer based on tumor histology. (cdc.gov)
A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)

The presence of ITC was associated with a significantly worse disease-free survival (hazard ratio = 4.73, p = 0.005). (biomedcentral.com)
We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
However, Cox proportional regression showed that tumour stage was the only factor that significantly influenced survival analysis after controlling for other factors. (who.int)

Using a panel of 11 antibodies against different immune cell types, intratumoral immune cell densities were determined and evaluated in relation to response to ipilimumab treatment and disease outcome. (mtak.hu)

The impact of ITC on survival was assessed using Cox regression analyses. (biomedcentral.com)
Nomogram and multivariate Cox Regression analysis indicated increased Tc cells was related to reduced risk death(p = 0.001,HR = 0.217 95%CI = 0.085-0.551). (researchsquare.com)

100 mm3) VCap and PC3-KLK2 subcutaneous xenograft models with greater than 90% tumor growth inhibition and associated increased survival. (bmj.com)
Follow-up dose titration studies demonstrated that a single dose of CAR-KLK2 iT cells was sufficient to mediate approximately 70% tumor growth inhibition. (bmj.com)
The absence of intratumoral T cells was associated with increased levels of vascular endothelial growth factor. (shu.edu)
Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. (ox.ac.uk)
RNAi-treated cells showed growth delay in dense monolayer culture and a 50% reduction in clonogenic survival under hypoxia. (ox.ac.uk)
Thus, CAIX plays an important role in the growth and survival of tumor cells under normoxia and hypoxia, making it a potential target for cancer therapy, but is not involved in invasion. (ox.ac.uk)
common current treatment normally offers only six to 12 weeks of halted growth before the tumor grows and spreads, ultimately destroying cognitive and physical function and leading to death. (sciencedaily.com)
Avastin may be effective in treating gliomas because these tumors have a high concentration of vascular endothelial growth factor, a protein that stimulates development of new blood vessels in a process known as angiogenesis. (sciencedaily.com)
New blood vessels spur a tumor's growth and ability to spread, so researchers are interested in cutting off angiogenesis to slow tumors down. (sciencedaily.com)
In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
In a mouse model, we were able to show that EGFR-positive myeloid cells stimulate tumor growth," said lead investigator Maria Sibilia. (pharmacytimes.com)
By switching of the EGFR in these immune cells, growth was as good as stopped. (pharmacytimes.com)
The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)

Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and cytokine receptors. (qub.ac.uk)
Dive into the research topics of 'Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and cytokine receptors. (qub.ac.uk)
Background: Emerging evidence suggests that myeloid cells play a critical role in glioblastoma (GBM) immunosuppression. (elsevierpure.com)

Colorectal cancer with at least one measurable tumor. (medscape.com)

We used RNA interference (RNAi) to examine the function of CAIX in MDA468 and MDA231 breast carcinoma cells, which express high levels of CAIX under hypoxia. (ox.ac.uk)

The study endpoints were survivin-specific T-cell reactivity (SSTR), safety, response, and survival (OS). (uni-wuerzburg.de)
55 patients (PP) were evaluable for response and survival, and 41/55 for SSTR. (uni-wuerzburg.de)
Post-SUVmax and ΔSUVmax were valuable preoperative factors for predicting tumor response and survival in patients with ESCC after trimodality therapy. (biomedcentral.com)

Preclinical in vitro analyses of these CAR-KLK2 iT cells demonstrated potent and specific cytotoxicity against multiple prostate cancer cell lines, including VCap cells which naturally express KLK2, PC3 cells engineered to express KLK2, and DU-145 cells engineered to express KLK2. (bmj.com)
Survival Analyses of Patients with Ovarian Carcinoma, According to the Presence or Absence of Intratumoral T Cells. (shu.edu)
Subsequent analyses revealed KLF6 mutations in only 2 of 20 samples, but altered subcellular protein localization in 64% of tumors. (mssm.edu)
In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

Head and neck cancer (HNC) is a collective name for heterogeneous tumors located in the head and neck regions for which smoking, alcohol and human papillomavirus (HPV) are documented risk factors. (diva-portal.org)
The aim of the present study was to examine KLF6 gene status and expression in head and neck squamous cell carcinomas (HNSCC). (mssm.edu)
Patients usually do not increased incidence of oropharyngeal squamous cell carci- seek counseling until the tumors are large because small noma (OSCC), the head and neck cancer in which HPV is tumors cause little distress and may not be noticed by the most commonly found ( 4 ). (cdc.gov)

Methods: C57BL/6 mice were implanted with GL261-Luc+ glioma cells and randomized into 4 arms: (1) control (2) anti-PD-1 (3) anti-CXCR4, and (4) anti-PD-1 and anti-CXCR4 therapy. (elsevierpure.com)
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice. (the-scientist.com)
Measuring dendritic cell activation as a proxy for the anti-tumor immune response, they observed an 83 percent survival rate compared with just 25 percent in mice treated with radiotherapy and injected with saline. (the-scientist.com)
IMMUNE ASSISTANTS: Following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano-particles near tumors in mice. (the-scientist.com)
Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
B6C3F1-mice received oral doses of 600, 1,200 or 2,400 milligrams per kilogram (mg/kg) EGEE, or 300, 600, or 1,200mg/kg EGME 12 to 8 days prior to tumor transplantation, or cyclophosphamide (50180) (CP) at 180mg/kg intraperitoneally 1 day prior to tumor transplant. (cdc.gov)
Syngeneic mice were challenged with 100,000 L1210 cells on day 0 and were treated on days 1 to 5 and 8 to 12 at the same EGEE and EGME doses as the allogeneic mice. (cdc.gov)
Blood smears of allogeneic mice were made for differential counts on the last day of treatment, day of death, and 43 days post tumor transplantation. (cdc.gov)
All allogeneic mice challenged with 3,000,000 L1210 cells and receiving water or CP treatment died. (cdc.gov)
But mice receiving EGME or EGEE and challenged with the same tumor cell concentration showed over 83 percent survival rates. (cdc.gov)
Differential counts showed presence of monocytosis in mice dying before day 43 post tumor transplantation. (cdc.gov)

A proliferative exhausted CD8 + T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. (elifesciences.org)
This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)

The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to the cytotoxic effect of dFdC. (biomedcentral.com)

Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)

The discovery appears online in the journal Nature Cell Biology . (harvard.edu)
REC-4881, developed by Recursion, inhibits the MEK pathway, a prime mover in cancer cell biology. (medscape.com)

In 2005, another group of researchers also saw a correlation between the presence of tumor-infiltrating CD8+ T-cells and clinical outcome in a series of 117 patients . (shu.edu)
Recent clinical and experimental studies have indicated that cellular and molecular mechanisms associated with liver regeneration after partial hepatectomy may have a proliferative effect on occult micrometastases and circulating tumor cells and are thus responsible for recurrent disease. (nih.gov)

Small CTCs have been implicated in progressive disease and differentiation into small cell carcinomas, which often require a different therapeutic course. (wikipedia.org)

The secondary objective was to assess the effect of anti-OX40 on lymphocyte subsets in the tumor and blood. (bepress.com)

In the MDA468 cells, there was no effect of RNAi treatment on invasion. (ox.ac.uk)
When the tumor recurs after treatment, there are no standard therapies," Vredenburgh said. (sciencedaily.com)
Here, we describe the development of ABBV-011, a novel SEZ6-targeted, calicheamicin-based ADC for the treatment of small cell lung cancer (SCLC). (aacrjournals.org)
Risk of death for patients with LOH was 8 times greater independent of tumor size, nodal status, tobacco smoking or treatment modality (HR 7.89, 95% CI: 1.9-32.4). (mssm.edu)
Treatment of a Leydig cell tumor depends on its stage. (medlineplus.gov)
Finding testicular cancer early is important for successful treatment and survival. (medlineplus.gov)
Treatment-resistant breast cancer cells. (harvard.edu)
Dynamic changes of activated Tc cells were associated with treatment patterns and evaluation of the disease(p = 0.038 and p = 0.043). (researchsquare.com)
Measuring the ratio of traditional CTC to apoptotic CTCs-from baseline to therapy-provides clues to treatment efficacy in targeting and killing cancer cells. (wikipedia.org)
A significant increase in survival was found after cetuximab-IONP convection-enhanced delivery treatment of 3 intracranial rodent GBM models employing human EGFR-expressing GBM xenografts. (oncotarget.com)
Weitzenfeld and Fred Hutchinson Cancer Research Center's Kristin Anderson, who also didn't participate in the work, say they expect the treatment to work better in tumors with a high mutation rate. (the-scientist.com)
NGF promoted MiaPaCa-2 and CFPAC-1 cell invasion and migration, while Tanezumab treatment showed the opposite results. (hindawi.com)
Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)
Any pancreatic tumor, as well as benign conditions such as pancreatitis, require diagnosis and treatment by expert specialists. (bidmc.org)
Modern approaches to diagnosis and treatment can result in high rates of long-term survival and even cure. (medscape.com)
We observed a significant up-regulation of 15-PGDH after treatment with LTC 4 , a CysLT 2 ligand, in colon cancer cells at both the mRNA and protein levels, which could be reduced by a CysLT 2 antagonist or a JNK inhibitor. (lu.se)
These findings are important for cancer treatment planning and help professionals to seek greater survival. (bvsalud.org)

We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length of survival. (elsevierpure.com)
A molecular predictor of survival was constructed from these genes and validated in an independent test set of 96 specimens. (elsevierpure.com)

A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics from a primary tumor and is carried around the body in the blood circulation. (wikipedia.org)
The responses of 111 patients with ESCC who underwent neoadjuvant chemoradiotherapy (nCRT) followed by surgery were monitored by measuring the maximal standardized uptake value (SUVmax) of the primary tumor on FDG-PET before and after nCRT. (biomedcentral.com)
Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
Disease-free survival, assessed up to 6 years after randomization, is the primary outcome in phase 3. (medscape.com)
[ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)

In 1965, Teilum first suggested the germ cell origin of gonadal tumors. (medscape.com)
According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)

The dCK activity of our cell lines varied considerably and differed up to three fold from 5 to 15 pmol/h/mg protein between the tested cell lines. (biomedcentral.com)

Anatomy23

Organisms10

Diseases74

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes47

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care14

Microenvironment9

Solid tumors5

Progression9

Metastasis12

Prognosis12

Squamous cell carc5

Immunotherapy3

Pathways5

Overall survival17

Suppressor5

Recurrence6

Metastatic4

Induces6

Proliferation7

Metastases5

Nonseminomatous Germ Cell T2

Abstract2

Prognostic12

Halted tumor growth1

Inhibition of tumor growth1

GCTs3

Melanoma11

Induce4

Lymphocytes3

Biomarker1

Biomarkers3

Cancers7

Infiltration4

Circulating tumor DNA1

Tissue5

Malignant tumors2

Cancerous tumors2

Endodermal sinus1

Anti tumor effect2

Lymphoma6

Chemotherapy8

Antigen6

Dendritic cells2

Necrosis factor1

Oncology1

Neoplasms1

Germ cells5

Median4

Patient survival1

Histology3

Significantly4

Immune cell1

Regression2

Growth15

Glioblastoma3

Measurable tumor1

Hypoxia1

Response and survival3

Analyses4

Head and neck3

Mice11

Outcomes2

Correlate1

Heterogeneous1

Biology2

Clinical2

Carcinomas1

Lymphocyte subsets1

Treatment17

Molecular2

Primary5

Gonadal2

Protein1