Survival than patients. Medical search. Frequent questions

95% confidence interval) Progression-free survival was also longer in the EV group than in the chemotherapy group. (news-medical.net)
The primary endpoint of the study was OS, and secondary endpoints focused on progression-free survival (PFS) and objective response rate (ORR). (curetoday.com)
Erdafitinib was also associated with a significantly longer median progression-free survival (PFS) and a greater likelihood of objective response than chemotherapy. (esmo.org)
The primary endpoint for the trial is OS, and secondary endpoints include objective response rate and progression-free survival. (businesswire.com)
LYNPARZA plus bevacizumab also improved median progression-free survival (PFS) to nearly four years (46.8 months) versus 17.6 months with bevacizumab plus placebo, and 46.1% of patients who received LYNPARZA in combination with bevacizumab remain progression free versus 19.2% of patients who received bevacizumab alone. (merck.com)
More recently, bevacizumab in combination with RT-temozolomide in first-line treatment showed a significant prolonged progression-free survival but failed to demonstrate a significant overall survival (OS) benefit [ 15 , 16 ]. (springer.com)
The Danish study, led by Dr. Anders Jakobsen at Vejle Hospital, aimed to identify the potential additive effects of bevacizumab and delta-tocotrienol by observing the stabilization and control of disease, progression-free survival (PFS), and overall survival (OS). (nutraceuticalsworld.com)
Initial results from the TITAN study presented at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) and simultaneously published in The New England Journal of Medicine showed the addition of ERLEADA ® (apalutamide) to ADT compared to placebo plus ADT significantly improved the dual primary endpoints of OS and radiographic progression-free survival (rPFS) in patients with mCSPC. (jnj.com)
After a median follow-up duration of 12 months, the estimated 3-year progression-free survival (PFS) and overall survival (OS) rates were 61.3 and 61.7% respectively. (bvsalud.org)

Currently, most treatment guidelines do not recommend immunotherapy treatment due to lack of randomized results to indicate that it is safe, well tolerated and increases overall survival for this poor prognosis population. (news-medical.net)
IPSOS is the first randomised trial to show that immunotherapy treatment with first-line atezolizumab treatment significantly improves overall survival compared to single-agent chemotherapy for these poor prognosis patients, with twice as many remaining alive at two years. (news-medical.net)
The authors assessed whether model accuracy could be improved by including symptoms of depression or history of recent fall, serum albumin, physician's subjective estimate of prognosis, and physician and patient preferences for general approach to care. (rand.org)
The physician's perception of the patient's preferences and the physician's subjective estimate of the patient's prognosis improved the estimate of survival time significantly. (rand.org)
The aim of this study was to evaluate whether radioactive iodine therapy after total thyroidectomy improves prognosis and survival in patients with HCC. (thyroid.org)
These functions are used to understand the effect of calcium channel blockers on PAH patients and to determine prognosis. (wolfram.com)
Anxiety makes it difficult to remember details - and the worse the prognosis, the less the patient tends to remember. (hawaiipublicradio.org)
During a two-day session at Memorial Sloan Kettering on communicating with cancer patients, three doctors were brought to a small room, where they practiced giving a prognosis to an actor. (hawaiipublicradio.org)
The doctors were encouraged to set an agenda for the discussion, ask the patient what he or she wanted from the session, and to present the prognosis as a best-case, worst-case and most likely scenario. (hawaiipublicradio.org)
They were encouraged to tell patients to prepare for all three scenarios, and to write down the prognosis so the patient would remember the specifics. (hawaiipublicradio.org)
She could see that the patient was becoming visibly distressed by the uncertainty of her prognosis. (hawaiipublicradio.org)
INTRODUCTION: The prognosis for patients with melanoma has improved due to better treatments in recent years and updated tools to accurately predict an individual's risk are warranted. (lu.se)

The study showed that atezolizumab significantly improved overall survival and resulted in a clinically meaningful long-term survival benefit, with twice as many patients (24%) who were treated with atezolizumab remaining alive at two years compared to those treated with chemotherapy (12%), despite over 50% of chemotherapy patients who were still alive at two years receiving subsequent immunotherapy. (news-medical.net)
OS was superior versus placebo, with long-term survival shown,' said Kang. (curetoday.com)
Long-term survival rates for patients with advanced prostate cancer suggest they can be good candidates for surgery, Mayo Clinic researchers have found. (healthnewstrack.com)
At least partial hematological response after first cycle of treatment predicts organ response and long-term survival for patients with AL amyloidosis receiving bortezomib-based treatment. (bvsalud.org)
We retrospectively evaluated the organ response (OR) and long-term survival of newly diagnosed AL amyloidosis patients who received first-line bortezomib -containing induction therapy , aiming to identify the clinical indication of a 50% reduction in the difference between involved and uninvolved free light chains (dFLC) after first cycle of treatment . (bvsalud.org)
These results demonstrated that early reduction of dFLC after the first cycle of treatment is predictive of achieving an OR and long-term survival in AL patients receiving bortezomib . (bvsalud.org)
prospects for AYA long-term survival have also increased. (cdc.gov)

In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers report in a new study. (sciencedaily.com)
The findings, based on data from a large observational study nested in a clinical trial, are in line with earlier studies showing a connection between regular coffee consumption and improved outcomes in patients with non-metastatic colorectal cancer. (sciencedaily.com)
The investigators found that in 1,171 patients treated for metastatic colorectal cancer, those who reported drinking two to three cups of coffee a day were likely to live longer overall, and had a longer time before their disease worsened, than those who didn't drink coffee. (sciencedaily.com)
The new study drew on data from the Alliance/SWOG 80405 study, a phase III clinical trial comparing the addition of the drugs cetuximab and/or bevacizumab to standard chemotherapy in patients with previously untreated, locally advanced or metastatic colorectal cancer. (sciencedaily.com)
This study adds to the large body of literature supporting the importance of diet and other modifiable factors in the treatment of patients with colorectal cancer," Ng adds. (sciencedaily.com)
Further research is needed to determine if there is indeed a causal connection between coffee consumption and improved outcomes in patients with colorectal cancer, and precisely which compounds within coffee are responsible for this benefit. (sciencedaily.com)
According to a new study led by researchers at Dana-Farber Cancer Institute, clinical trial patients with metastatic colorectal cancer who had high levels of vitamin D in their bloodstream prior to treatment with chemotherapy and targeted drugs, survived longer, on average, than patients with lower levels of the vitamin. (dana-farber.org)
The research, based on data from more than 1,000 patients with metastatic colorectal cancer who enrolled in a phase 3 clinical trial of chemotherapy plus biologic therapies, adds to vitamin D's already impressive luster as a potential cancer-inhibiting agent. (dana-farber.org)
This is the largest study that has been undertaken of metastatic colorectal cancer patients and vitamin D," said the study's lead author, Kimmie Ng, MD, MPH , a medical oncologist in the Gastrointestinal Cancer Treatment Center at Dana-Farber. (dana-farber.org)
In the study, researchers measured blood levels of 25-hydroxyvitamin D, a substance produced in the liver from vitamin D, in 1,043 patients when they enrolled in a phase 3 trial of three different drug combinations for newly diagnosed, advanced colorectal cancer. (dana-farber.org)
Genome wide DNA alterations were evaluated by array CGH in addition to RNA expression profiling in colorectal cancer from patients with excellent and poor survival following primary operations. (lu.se)

A Cohort of 251 patients with hemochromatosis was followed up for 14.1 +/- 6.8 years. (nih.gov)
In a Cohort 1 of the phase III THOR study, treatment with erdafitinib resulted in significantly longer median overall survival (OS) than chemotherapy among patients with locally advanced or metastatic urothelial carcinoma with FGFR alterations after previous treatment with anti-PD1 or anti-PD-L1 therapy. (esmo.org)
In Cohort 1, the study investigators assessed whether erdafitinib would improve survival over chemotherapy among patients with FGFR -altered metastatic urothelial carcinoma whose disease progressed after one or two previous treatments that included an anti-PD1 or anti-PD-L1 agent. (esmo.org)
In Cohort 2, they are examining erdafitinib as compared with pembrolizumab in patients who had not previously received an anti-PD1 or anti-PD-L1 agent. (esmo.org)
In Cohort 1, patients were randomly assigned in a 1:1 ratio to receive erdafitinib or the investigator's choice of chemotherapy (docetaxel or vinflunine). (esmo.org)
Nationwide population-based cohort study including all patients with newly-diagnosed and histologically confirmed glioblastoma in France in 2008 and followed until 2015. (springer.com)
The research, which was published in BMC Cancer , studied a European cohort of 159,045 patients tracked between 1992 and 2000. (wcrf-uk.org)
I was surprised that we were able to find a significant impact of neighborhood-level disadvantage on survival in our relatively small cohort of patients with IPF. (medicalxpress.com)
In a cohort study reported in JAMA Network Open , Wang et al found that overall survival in patients with non-small cell lung cancer (NSCLC) who stopped smoking prior to their cancer diagnosis was better than overall survival among those who were current smokers at the time of their diagnosis. (ascopost.com)
The study involved patients with NSCLC who were recruited to the Boston Lung Cancer Survival Cohort at Massachusetts General Hospital between 1992 and 2022. (ascopost.com)
The investigators concluded, "In this cohort study of patients with NSCLC, quitting smoking early was associated with lower mortality following a lung cancer diagnosis, and the association of smoking history with overall survival may have varied depending on clinical stage at diagnosis, potentially owing to the differing treatment regimens and efficacy associated with smoking exposure following diagnosis. (ascopost.com)

This controversy has become critical as multiple phase III trials of anti-VEGF agents combined with cytotoxics failed to show overall survival benefit in newly diagnosed glioblastoma (nGBM) patients and several other cancers. (mit.edu)

In a new study led by researchers at Yale Cancer Center (YCC), the drug enfortumab vedotin (EV) significantly prolonged survival as compared with standard chemotherapy in patients with locally advanced or metastatic urothelial carcinoma or bladder cancer, who had previously received platinum-based treatment and a PD-1-PD-L1 inhibitor. (news-medical.net)

Patients with multiple myeloma (MM) who are enrolled in a Medicare Part D plan or other creditable prescription drug coverage have better survival than patients without prescription drug coverage. (ajmc.com)
Structural racism - including racial and economic segregation - may drive persistent inequities in multiple myeloma (MM) treatment and survival. (ispor.org)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)

Demographics of pediatric patients awaiting kidney transplant: United States, 2020. (medscape.com)
Pediatric patients have been underrepresented in Ebola virus disease studies because total numbers of affected children in any given Ebola virus disease outbreak, whether associated with Ebola virus or Sudan virus or Bundibugyo virus are usually low because of outbreak dynamics and societal structure. (cdc.gov)
The case- fatality rate for pediatric patients in this outbreak was lower than for adults, but the reasons for this increased survival were unknown. (cdc.gov)
The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with Ebola virus disease. (cdc.gov)
In addition to the samples from the 55 pediatric patients, people less than 21 years of age, who had laboratory-confirmed Ebola virus disease, we selected samples from 50 adult patients, more than 21 years of age, who had laboratory-confirmed infection. (cdc.gov)
A total of 45 of the 55 pediatric patients and 49 of the 50 selected adult patients had sufficient serum available for the proposed studies. (cdc.gov)
No statistically significant differences were found between viral loads in adults and pediatric patients. (cdc.gov)
however, in the pediatric population, this difference did not reach statistical significance, likely because of the small sample size and the wide range of observed values in the pediatric patients with nonfatal cases. (cdc.gov)

Patients who receive chemotherapy and radiation after surgery for gastric cancer appear to have better survival rates than those who had surgery followed by only chemotherapy, according to results of a look-back study of more than 500 people by Johns Hopkins scientists. (hopkinsmedicine.org)
In a controlled study, Dr. Des Powe, a senior healthcare research scientist at Queen's Medical Centre, Nottingham University Hospital NHS Trust, Nottingham, UK, and his team found that the group of patients treated with beta-blockers showed a significant reduction in metastasis and better survival. (ecancer.org)

There was a 37 percent reduced risk of death in patients with advanced gastric or gastroesophageal junction (GEJ) cancer who were treated with Opdivo (nivolumab) compared to placebo, following second or later-line chemotherapy, according to the findings from the phase 3 ONO-4538-12 trial presented at the 2017 Gastrointestinal Cancers Symposium. (curetoday.com)
The addition of radiation especially improved survival rates among gastric cancer patients whose cancers had spread to lymph nodes in the immediate region of the stomach, says Timothy Pawlik, M.D., M.P.H., Ph.D., professor of surgery at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center. (hopkinsmedicine.org)
The incidence and 10-year survival of interval breast cancers in Wales. (medigraphic.com)
The patients who received radioactive iodine therapy were younger (average age: 54 versus 56 years), had larger cancers (average cancer: 3.8 versus 3.5 cm), showed more frequent cancer extension outside the thyroid gland (17% versus 13%), and had more advanced disease including spread outside the neck (16% versus 12%) as compared to those who did not receive radioactive iodine therapy. (thyroid.org)
Older patients with larger cancers or more advanced cancer stage had increased disease-specific mortality. (thyroid.org)
This finding may assist treatment in two ways, say the researchers: it appears to slow down tumour growth and could also be used to target those patients who have an increased risk of developing secondary cancers. (ecancer.org)
Commenting on the research, Dr. Barrie Tan, president of American River Nutrition said that "as one of the most deadly cancers in women, ovarian cancer needs further attention, and I applaud Dr. Jakobsen and his group for their novel approach in finding alternative treatment options for these patients. (nutraceuticalsworld.com)

In a new study, use of transcatheter rather than surgical aortic valve replacement (TAVR/SAVR) reduced the risk of early death in low-risk patients with severe aortic stenosis, calling into question whether TAVR should be the preferred option. (medscape.com)
Leesburg, Virginia (PRWEB) August 25, 2015 -- A study published today in the September issue of the American Journal of Roentgenology finds that a combination of CT texture analysis of metastases, initial tumor size changes and serum biomarker lactate dehydrogenase is highly accurate in predicting the overall survival of patients with metastatic melanoma whose tumors fail to shrink significantly in response to bevacizumab therapy. (prweb.com)
Former President Jimmy Carter announced last week that he has been diagnosed with metastatic melanoma and is receiving treatment similar to that of the patients in the study. (prweb.com)
The retrospective study included 42 patients who received bevacizumab therapy in the context of a randomized prospective phase II clinical trial. (prweb.com)
A global study, led by UCL and UCLH and sponsored by Roche, has shown that the cancer immunotherapy atezolizumab significantly improved the overall survival of advanced stage non-small cell lung cancer patients who were not able to be treated with platinum-containing chemotherapy, when compared to single-agent chemotherapy. (news-medical.net)
Professor Siow Ming Lee (UCL Cancer Institute and UCL Hospitals), who chaired the study Steering Committee and conceptualized the study design, said: 'For over two decades, clinical trials have failed to provide significant therapeutic benefits to older NSCLC patients with poor health who are unfit for standard platinum doublet chemotherapy. (news-medical.net)
In this phase 3 study, ipilimumab--which blocks cytotoxic T-lymphocyte-associated antigen 4 to potentiate an antitumor T-cell response--administered with or without a glycoprotein 100 (gp100) peptide vaccine was compared with gp100 alone in patients with previously treated metastatic melanoma. (nih.gov)
For this study, physicians conducted a global, open-label, phase 3 trial of EV for the treatment of patients with locally advanced or metastatic urothelial carcinoma who had previously received platinum-containing chemotherapy and had had disease progression during or after treatment with a PD-1-PD-L1 inhibitor. (news-medical.net)
The current study looked at the difference in disease progression in patients with differing mutations. (genengnews.com)
The study suggests that the survival improvement is due to the development of more effective chemotherapies. (scienceblog.com)
The decrease in the use of radiation started in 2005, concomitant to the publication of an important European randomized control study that demonstrated no significant survival benefit whether radiation was delivered at the time of diagnosis or later in the clinical course," said Xuezhi Dong, the study's first author. (scienceblog.com)
While many previous studies suggest that complete excision of low-grade gliomas is associated with longer patient survival, this latest study found that only about a third of U.S. patients underwent complete surgical resection. (scienceblog.com)
A recent study found that Opdivo improves survival in patients with gastric or gastroesophageal junction (GEJ) cancer. (curetoday.com)
In the double-blind study, which was conducted in Asia, the median overall survival (OS) was 5.32 months with Opdivo versus 4.14 months in the placebo arm. (curetoday.com)
This phase 3 study demonstrated the efficacy and safety of nivolumab as third or later line of treatment in patients with advanced gastric cancer,' said lead study investigator Yoon-Koo Kang, M.D., Ph.D., Department of Oncology at the University of Ulsan College of Medicine, Asan Medical Center in Seoul, Korea. (curetoday.com)
According to a study in Journal of Clinical Oncology, this improved survival seemed to be a result of patients having access to all treatment options. (ajmc.com)
The authors concluded that the study results showed that in a cancer that can be treated with effective oral agents, patients with prescription drug coverage are more likely to receive active care and have longer survival compared with patients who have no drug coverage. (ajmc.com)
The study, described in the October issue of the Annals of Surgical Oncology, is a so-called retrospective one, looking at the records of 505 gastric cancer patients treated between 2000 and 2012. (hopkinsmedicine.org)
In this retrospective study, patients living within the Auckland region, diagnosed with ABC between the 1st January 2013 to the 31st December 2015 were identified from the Breast Cancer Registry. (hindawi.com)
Of the 388 patients that met inclusion criteria for this study, median overall survival (medOS) was 18.9 months in the total population, with no difference between patients with de novo metastatic disease (dnMBC -18.9 m) and recurrent metastatic disease (rMBC -18.7 m). (hindawi.com)
Findings from a study suggest that anti-frameshift peptide antibodies may also predict incidence of immune-related adverse effects in patients with lung cancer following immune checkpoint inhibitor therapy. (cancernetwork.com)
THOR is a confirmatory, phase III, randomised study involving patients with previously treated metastatic urothelial carcinoma who were divided into two cohorts. (esmo.org)
17 NIDCM patients (6 patients suffered VA included) with complete survival time (time period of each patient from symptoms to heart transplantation) information were selected for the study. (hindawi.com)
The group of patients object of study showed an elevated global survival, which was mainly associated to older ages, the early diagnosis of the disease and the performance of radical surgery. (medigraphic.com)
This retrospective study used the nationwide (US-based) Flatiron Health electronic health record-derived de-identified database, focusing on patients diagnosed with MM from January 2011 to October 2022. (ispor.org)
CELESTIAL is a randomized, double-blind, placebo-controlled study of cabozantinib in patients with advanced HCC conducted at more than 100 sites globally in 19 countries. (businesswire.com)
In this study, the authors used the U.S. Surveillance, Epidemiology, and End Results (SEER) database to identified patients diagnosed with HCC who underwent total thyroidectomy between 2000 and 2018. (thyroid.org)
Among the 2279 patients included in the study, 1438 (63%) received radioactive iodine therapy treatment after their thyroid surgery. (thyroid.org)
To control for sex, age, race, year of diagnosis, cancer staging, spread outside the neck, and spread to the lymph nodes, a new patient sample was selected from the initial study group that included 733 patients. (thyroid.org)
The primary study outcome was cancer-specific survival (CSS), calculated as the time from the initial diagnosis to death from thyroid cancer, last follow-up or 12/31/2018, the first occurring event being chosen for each patient. (thyroid.org)
In this large SEER-based study, patients with HCC who underwent total thyroidectomy had overall an excellent cancer-specific survival. (thyroid.org)
In 2000, Prof. Brohi's team performed a study analysing blood samples from trauma patients brought in by the Air Ambulance Service at Barts Hospital. (qmul.ac.uk)
Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
A single-center eight-year study of 155 patients. (smw.ch)
In one study of terminally ill patients , just 20 percent of physician predictions were accurate. (hawaiipublicradio.org)
The study, published in the May 6 issue of the Journal of the American College of Cardiology, could provide new insight on how to treat and manage coronavirus patients once they are admitted to the hospital. (mountsinai.org)
The study found that hospitalized COVID-19 patients treated with anticoagulants had improved outcomes both in and out of the intensive care unit setting. (mountsinai.org)
The publication of this study follows recent research out of the Icahn School of Medicine at Mount Sinai that shows a large number of patients hospitalized with COVID-19 have developed high levels of life-threatening blood clots, leading to potentially deadly thromboembolic events. (mountsinai.org)
All patients in the study had blood work done when they arrived at the hospital, which included measuring various inflammatory markers. (mountsinai.org)
This multi-centre study was carried out to further explore the relationship between comorbidities and cancer survival. (wcrf-uk.org)
Their study found a 20-year survival rate for 80 percent of patients diagnosed with cancer that has potentially spread beyond the prostate, known as cT3 prostate cancer, and treated with radical prostatectomy, or surgery to remove the prostate gland. (healthnewstrack.com)
The study sample included patients diagnosed and operated on between 1987 and 1997. (healthnewstrack.com)
Our preliminary data from our single center study at the University of Pittsburgh indicates that neighborhood-level disadvantage may be associated with increased mortality and reduced odds of receiving a lung transplant in patients with IPF," stated Dr. Goobie, study author. (medicalxpress.com)
A recent study conducted at Denmark's Vejle Hospital, published in Pharmacological Research , provided evidence of delta-tocotrienol's benefits for cancer patients. (nutraceuticalsworld.com)
In the study of 23 advanced-stage ovarian cancer patients, tocotrienol was administered at a dosage of 300 mg three times a day, with bevacizumab given to patients at 10 mg/kg intravenously every three weeks. (nutraceuticalsworld.com)
The study treatment was shown to have low toxicity, with only three patients discontinuing their medications due to well-known side effects of bevacizumab therapy. (nutraceuticalsworld.com)
In the study, patients with the highest blood levels of vitamin D survived for a median period of 32.6 months, compared to 24.5 months for those with the lowest levels. (dana-farber.org)
The study didn't examine whether there is a biological cause-and-effect relationship between higher vitamin D levels and extended survival. (dana-farber.org)
RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
The TITAN final analysis further confirms that treatment with apalutamide can prolong overall survival and offer a clear long-term clinical benefit and established safety profile for patients with metastatic prostate cancer who are starting androgen deprivation therapy," said Dr. Kim Chi, Medical Oncologist at BC Cancer - Vancouver and principal investigator of the TITAN study. (jnj.com)
Patients with Merkel cell carcinoma (MCC) may have different sites of disease, stage at diagnosis, and survival outcomes according to their racial or ethnic group, a new study suggests. (oncologynurseadvisor.com)
The study showed that Hispanic patients had the best survival outcomes, and Black patients were more likely than White patients to present with advanced disease. (oncologynurseadvisor.com)
The study included 9557 patients with MCC from the Surveillance, Epidemiology, and End Results Program database who were followed from 2000 through 2018. (oncologynurseadvisor.com)
This study aims to describe a prognostic instrument for patients with cutaneous melanoma and its potential as a clinical device for treatment decisions. (lu.se)
The authors of a study published in Annals of Surgery [ 1 ] analyzed this problem using data from patients (N = 7086) obtained from 1998 to 2012 from the National Cancer Database. (medscape.com)
This study aimed to provide a realistic observation of survival by major site for 48,866 cancer patients treated at a tertiary cancer hospital in a rural area of China . (bvsalud.org)
In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (cdc.gov)

A number of 196 patients operated for breast cancer were analyzed by the Kaplan-Meier method over a period of ten years of survival after surgery. (medigraphic.com)
Kaplan-Meier survival curves showed that T/A PTLD was associated with decreased all-cause mortality compared with PTLD at other sites (log-rank 0.004), even after adjustment for histological subtype (P = .047). (bepress.com)

A total of 266 patients underwent randomisation: 136 to the erdafitinib group and 130 to the chemotherapy group. (esmo.org)
This long-term follow-up of patients who underwent surgery between 1987 and 1997 is an important advance in understanding the quality outcomes for cT3 patients. (healthnewstrack.com)

An understanding of how our treatments affect the survival of low-grade glioma patients will better enable us to help these patients," said senior author Clark C. Chen, MD, PhD , vice chairman of research and academic development, Division of Neurosurgery, UC San Diego School of Medicine. (scienceblog.com)
While the older drugs were less expensive, the median overall survival (OS) on those treatments was only 3 years. (ajmc.com)
Retrospective studies come with a certain amount of limitation and bias, Pawlik says, because researchers can only analyze how therapy was carried out and can't control which patients received which treatments. (hopkinsmedicine.org)
Coexisting conditions and residual side effects of previous therapy often prevent patients from receiving later-line treatments. (esmo.org)
In conclusion, tumor perfusion changes after antiangiogenic therapy may distinguish responders vs. nonresponders early in the course of this expensive and potentially toxic form of therapy, and these results may provide new insight into the selection of glioblastoma patients most likely to benefit from anti-VEGF treatments. (mit.edu)
A new method developed by UCLA scientists could eventually lead to a way to do just that, using data about patients' genetic sequences to produce more reliable projections for survival time and how they might respond to possible treatments. (uclahealth.org)
Marisol Miranda-Galvis, DDS, MS, PhD, highlights the importance of understanding which social determinants of health have the greatest influence on treatment-related outcomes in patients with hematologic malignancies, expands on key variables identified in a systematic review of these disparities, and emphasizes the importance of continuing to implement new strategies to increase access to quality treatments. (onclive.com)
In an interview with OncLive ® , Miranda-Galvis highlighted the importance of understanding which social determinants of health have the greatest influence on treatment-related outcomes in patients with hematologic malignancies, expanded on key variables identified in this systematic review, and emphasized the importance of continuing to implement new strategies to increase access to quality treatments, allowing for a more equitable distribution of benefit across all patient subgroups. (onclive.com)
Patients with advanced-stage ovarian cancer often have a recurrence of the disease after primary treatment, and despite second and third line treatments, these patients eventually become chemotherapy-resistant with few therapeutic options. (nutraceuticalsworld.com)

The Phase 3 PAOLA-1 trial evaluated LYNPARZA in combination with bevacizumab as first-line maintenance therapy in patients with advanced ovarian cancer, who were without evidence of disease after surgery or following response to platinum-based chemotherapy. (merck.com)
In an exploratory subgroup analysis of HRD-positive patients, LYNPARZA plus bevacizumab provided a clinically meaningful improvement in OS, reducing the risk of death by 38% (HR=0.62 [95% CI, 0.45-0.85]) versus bevacizumab alone. (merck.com)
65.5% of patients who received LYNPARZA plus bevacizumab were still alive at five years versus 48.4% who received bevacizumab alone. (merck.com)
Moreover, "standards of care" do not exist for progression/recurrent GBM patients (e.g., bevacizumab was approved for treatment of recurrent GBM in USA, but not in Europe). (springer.com)
Compared to a typically reported median PFS of 2-4 months and median OS of 5-7 months, combined treatment of bevacizumab and delta-tocotrienol nearly doubled survival, allowing patients to reach a median PFS of 6.9 months and a median OS of 10.9 months. (nutraceuticalsworld.com)

Conclusions: Accurate estimation of length of life for older hospitalized persons may be calculated using a limited amount of clinical information available from the medical chart plus a brief interview with the patient or surrogate. (rand.org)
Using clinical data collected over the past decade through a U.S. cancer registry, researchers at the University of California, San Diego School of Medicine demonstrated that significant strides have been made in improving the survival of adult patients with low-grade gliomas, a slow-growing yet deadly form of primary brain cancer. (scienceblog.com)
A lymphoma vaccine uniquely tailored for each patient extends disease-free survival by 14 months, with signs of an even better response for patients with a specific biological marker, a team led by scientists at The University of Texas MD Anderson Cancer Center reported today in the online version of Journal of Clinical Oncology. (medicaldaily.com)
the prediction model for survival time and incident ventricular arrhythmias is useful in clinical decision making for individual treatment. (hindawi.com)
ventricular arrhythmia (VA) is a major cause of clinical deterioration and demise in patients with NIDCM [ 3 - 6 ]. (hindawi.com)
Although NIDCM is characterized by genetic and clinical heterogeneity, few studies have explored the pathogenesis of VA in patients with NIDCM. (hindawi.com)
Furthermore, a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
The highest average survival was found in patients aged between 71-80 and over 80 years who had a lobular carcinoma, who had tumors in clinical stage IIa and who were subject to radical mastectomies. (medigraphic.com)
Here, we shed light on mechanisms of nGBM response to cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, using MRI techniques and blood biomarkers in prospective phase II clinical trials of cediranib with chemoradiation vs. chemoradiation alone in nGBM patients. (mit.edu)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Since 2005, one pivotal clinical trial defined the radiotherapy and temozolomide combination (RT-temozolomide) as the standard of care in patients with newly-diagnosed GBM, for patients 18-70 years old with a WHO performance status of ≤ 2 [ 6 ]. (springer.com)
Including the assessment of social determinants in clinical practice and implementing socially-targeted interventions could help improve the survival of those patients. (onclive.com)
We performed a systematic review of clinical studies conducted in the United States that evaluated any social determinants that could impact survival in patients with hematologic malignancies. (onclive.com)
This is the first-ever clinical trial using tocotrienols in ovarian cancer patients, according to American River. (nutraceuticalsworld.com)
Previous in vitro and in vivo studies, including a clinical trial in patients with pancreatic cancer, showed that delta-tocotrienol was especially active against malignancies, compared to other vitamin E isoforms. (nutraceuticalsworld.com)
To date, published results on ERLEADA ® include data from more than 2,000 patients across Phase 3 clinical studies. (jnj.com)

These findings are very encouraging as they continue to show EV is an effective tool in the fight to improve survival rates for patients with advanced bladder cancer. (news-medical.net)
Chemotherapy and radiation combination after surgery for gastric cancer appears to improve survival rates of patients. (hopkinsmedicine.org)
This new, critical resource is intended to help hospitals implement, monitor, and optimize sepsis programs and improve survival rates. (cdc.gov)

It is possible that patients who got radiation therapy were younger, healthier, and could more easily tolerate radiation therapy, which factored into longer survival. (hopkinsmedicine.org)
some predict longer survival times, others are linked to shorter times. (uclahealth.org)

Some reports have shown prolonged survival in patients who participated in these interventions, the researchers note. (medscape.com)
A group of researchers attribute longevity in amyotrophic lateral sclerosis (ALS) patients to a couple of properties of the SOD1 protein. (genengnews.com)
To examine the association between prescription drug coverage, care received, and subsequent survival, the researchers used SEER-Medicare data to identify enrollment in a Medicare PDP or OCC among 9755 Medicare beneficiaries with MM. Of the 9755 beneficiaries, 15% had no prescription drug coverage, 34% had a PDP, 37% had OCC, and 14% were Medicaid dual enrollees. (ajmc.com)
Using information on the patients' ages, tumor sizes and other factors collected from the multi-institutional U.S. Gastric Cancer Collaborative database, the researchers were able to build a score that measured how likely it would be for a patient to receive chemoradiation along with surgery. (hopkinsmedicine.org)
Treating hospitalized COVID-19 patients with anticoagulants-blood thinners that slow down clotting-may improve their chances of survival, researchers from the Mount Sinai COVID Informatics Center report. (mountsinai.org)
The Mount Sinai researchers say their work outlines an important therapeutic pathway for COVID-19 patients. (mountsinai.org)
The researchers evaluated the performance of survival predictors using a metric called C-index and found that across the six different types of cancer they analyzed, their isoform-based predictions performed consistently better than the conventional gene-based predictions. (uclahealth.org)
Researchers divided the patients into five groups based on vitamin D levels. (dana-farber.org)
Further investigations are warranted into the findings that, compared with White patients, Hispanic patients with MCC had improved outcomes, and Black patients did not have worse outcomes, despite presenting with more advanced disease," the researchers concluded. (oncologynurseadvisor.com)

To describe oncological patterns of care, prognostic factors, and survival for all patients in France with newly-diagnosed and histologically confirmed glioblastoma, and evaluate the impact of extended temozolomide use at the population level. (springer.com)
This work is requested by the French government and describes the oncological patterns of care, prognostic factors, and survival for all patients with newly-diagnosed and histologically confirmed GBM, for a country with more than 60 million inhabitants. (springer.com)

In 2019, the U.S. Food and Drug Administration (FDA) granted accelerated approval to EV to treat adult patients with advanced urothelial or bladder cancer. (news-medical.net)
Most adult patients with sepsis (87%) are brought to the hospital with an infection that is not getting better and almost any infection, including COVID-19, influenza, or RSV, can lead to sepsis. (cdc.gov)
We included all adult patients (≥ 18 yr) with out-of-hospital cardiac arrest of no obvious cause who were treated in private residences. (cmaj.ca)
We found that a higher percentage of pediatric than adult patients exhibited hemorrhage, but overall case-fatality rates remained lower for children than for adults. (cdc.gov)

A large percent of cancer patients use some form of complementary and alternative medicine (CAM), typically with the goal of relieving pain and controlling the adverse effects of disease or treatment. (medscape.com)
At times, these modalities can actually have a survival effect that could be similar to conventional care," said first author Moshe Frenkel, MD, chair of the Israeli Society of Complementary Medicine and founder of the Integrative Oncology Clinic at the University of Texas M.D. Anderson Cancer Center in Houston. (medscape.com)
He and his colleagues reviewed evidence from studies that assessed the use of mind-body interventions, nutrition, physical activity, and combined CAM approaches in cancer patients. (medscape.com)
Mind-body interventions include approaches such as guided imagery, mindfulness meditation, and yoga, which are commonly used by cancer patients to reduce stress. (medscape.com)
For example, the combined effect of stress reduction, improved nutrition, physical activity, and smoking-cessation instruction was shown to have a significant effect on survival in women with localized breast cancer ( Cancer . (medscape.com)
This list of notable breast cancer patients includes people who made significant contributions to their respective fields and who were diagnosed with breast cancer at some point in their lives, as confirmed by public information. (wikipedia.org)
Epidemiological studies have found that higher coffee intake was associated with improved survival in patients with stage 3 colon cancer, but the relationship between coffee consumption and survival in patients with metastatic forms of the disease hasn't been known. (sciencedaily.com)
The trial results, published today in The Lancet , are good news for non-small cell lung cancer patients who are not eligible for standard of care platinum-based chemotherapy, due to concerns about their ability to withstand the treatment. (news-medical.net)
Using the Surveillance, Epidemiology, and End Results (SEER) database, a national cancer registry sponsored by the National Cancer Institute, Chen's team demonstrated that the median survival of patients afflicted with low-grade gliomas increased from 44 months (in 1999) to 57 months (in 2010). (scienceblog.com)
These results indicate that nivolumab could be a new treatment option for patients with heavily pretreated advanced gastric cancer, and also provide a strong rationale to explore nivolumab in earlier lines of treatment for gastric cancer. (curetoday.com)
The trial randomized 493 patients with unresectable advanced or recurrent gastric or GEJ cancer in a 2-1 ratio to receive Opdivo (330 patients) or placebo (163 patients). (curetoday.com)
Since its initial approval in 2014 for metastatic melanoma, Opdivo has added numerous indications across a variety of settings for patients with lung cancer, renal cell carcinoma, Hodgkin lymphoma and continued indications in combination with Yervoy (ipilimumab) for melanoma. (curetoday.com)
ONO-4538-12 is the first randomized, phase 3 Immuno-Oncology trial to demonstrate improved survival for patients with previously treated advanced or recurrent gastric cancer,' Ian M. Waxman, M.D., development lead, Gastrointestinal Oncology, Bristol-Myers Squibb, said in a statement. (curetoday.com)
Previous research compared cancer survival by health insurance status. (ajmc.com)
Pawlik says the role of radiation therapy in treating gastric cancer has been understudied, "but these data would suggest that radiation therapy would benefit patients, in particular those patients who had disease that has spread to lymph nodes. (hopkinsmedicine.org)
The Auckland Advanced Breast Cancer Review (AABC) was a review of patients diagnosed with advanced inoperable/metastatic breast cancer (ABC) within the Auckland region of New Zealand, commissioned in response to a Breast Cancer Registry report (BCFNZR) that showed poor and inequitable survival outcomes. (hindawi.com)
Approximately 300 patients are diagnosed with advanced breast cancer (ABC) in New Zealand (NZ) annually. (hindawi.com)
Central to the report was a survival analysis of ABC cases registered in the Breast Cancer Foundation National Registry (BCR) between the year 2000-2015. (hindawi.com)
Interestingly, the metastasis free interval (mFI: 30 months) amongst patients who developed metastatic relapse after early breast cancer was similar to international standards. (hindawi.com)
The addition of cisplatin (Platinol) and oral etoposide (VePesid)to radiation therapy delays distant metastasis, thus increasingsurvival of patients with inoperable non-small-cell lung cancer,a comparison of RTOG 91-06 to RTOG 83-11 shows. (cancernetwork.com)
Patients treated with combined therapy had either stage IIIa orIIIb or medically inoperable stage II non-small-cell lung cancer.They were given 50 mg/m² of cisplatin on days one and eightof treatment. (cancernetwork.com)
However, only approximately 30% of patients with metastatic urothelial cancer have a response to PD1 or PD-L1 inhibitors. (esmo.org)
furthermore, the expanded γδ T cells were adoptively transferred into late-stage liver and lung cancer patients. (nature.com)
Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
To characterize the survival of patients with breast cancer at ten years of surgery. (medigraphic.com)
We are excited that these positive results from the phase 3 CELESTIAL trial bring us one step closer to the potential of offering previously treated patients with this aggressive form of advanced liver cancer a much-needed new treatment option," said Gisela Schwab, M.D., President, Product Development and Medical Affairs and Chief Medical Officer, Exelixis. (businesswire.com)
The trial was designed to enroll 760 patients with advanced HCC who received prior sorafenib and may have received up to two prior systemic cancer therapies for HCC and had adequate liver function. (businesswire.com)
More than two-thirds of patients with ovarian cancer are diagnosed with advanced disease, and approximately 50-70% of these patients die within five years. (merck.com)
Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
p=0.4118) in patients with newly diagnosed advanced ovarian cancer. (merck.com)
Wang X et al 2022 Radioactive iodine therapy does not improve cancer-specific survival in Hürthle cell carcinoma of the thyroid. (thyroid.org)
Radioactive iodine therapy treatment also did not improve the CSS rates in patients with more aggressive cancer features. (thyroid.org)
When a doctor tells a patient that she has cancer and has just a year left to live, that patient often hears very little afterward. (hawaiipublicradio.org)
Recent studies have found that cancer patients retain less than half of what their doctors tell them. (hawaiipublicradio.org)
So it's not surprising, perhaps, that a patient with advanced cancer can leave her oncology appointment thinking she has a set amount of time left to live. (hawaiipublicradio.org)
Doctors think of the number as a median, but patients usually understand it as an absolute number, according to Dr. Tomer Levin , a psychiatrist who works with cancer patients and doctors at Memorial Sloan Kettering Cancer Center in New York. (hawaiipublicradio.org)
The best-case scenario helps to preserve hope, and that hope is not simply a warm feeling - 1 in 10 patients do much better than the median survival time for their cancer. (hawaiipublicradio.org)
The goal of the treatment is to cure the cancer," she said to the pretend patient. (hawaiipublicradio.org)
Leading cancer prevention and survival charity, World Cancer Research Fund (WCRF) today announces research findings showing that higher body weight measured by body mass index (BMI) in early to mid-adulthood means a poorer survival rate for both breast and colorectal (more commonly known as bowel) cancer patients. (wcrf-uk.org)
Findings show that for adults aged between 20 and 50, an increase in BMI of 1kg/m 2 meant a 6% increase in death rate for bowel cancer patients. (wcrf-uk.org)
For breast cancer patients, for every 1kg/ m 2 increase in BMI there was a 4% increase in death rate. (wcrf-uk.org)
Findings also showed that although a history of cardiometabolic disease (CMD) such as type 2 diabetes and cardiovascular disease is associated with a 46% increase in risk of death, BMI has a direct effect on cancer survival irrespective of whether the individual also has CMD. (wcrf-uk.org)
It is striking that both BMI and cardiometabolic disease were found to have a direct bearing on survival outcomes independently of each other for bowel and breast cancer patients at two key points in adulthood. (wcrf-uk.org)
World Cancer Research Fund is the UK's only charity solely dedicated to cancer prevention and survival. (wcrf-uk.org)
The result was surprising because it suggests, contrary to conventional wisdom, that isoform ratios provide a more robust molecular signature of cancer patients than overall gene abundance, said Xing, director of UCLA's bioinformatics doctoral program and a member of the UCLA Institute for Quantitative and Computational Biosciences . (uclahealth.org)
Our finding suggests that isoform ratios provide a more robust molecular signature of cancer patients in large-scale RNA-seq datasets," he said. (uclahealth.org)
Previously, patients found to have cT3 prostate cancer were offered radiation or hormone treatment, but not radical prostatectomy. (healthnewstrack.com)
We have confirmed that patients diagnosed with locally advanced prostate cancer can enjoy a long, cancer-free interval. (healthnewstrack.com)
The 80 percent survival rate for cT3 diagnoses at 20 years compares to 90 percent for cT2, or cancer confined to the prostate. (healthnewstrack.com)
Treatment with beta-blockers can help reduce the spread of cancer in patients with breast tumours, a researcher will tell the seventh European Breast Cancer Conference (EBCC7) in Barcelona on Friday. (ecancer.org)
The scientists believe that they are the first in the world to have investigated the effect of beta-blockers in breast cancer patients. (ecancer.org)
In collaboration with Professor Frank Entschladen's group at Witten University, Germany, Dr. Powe looked at three groups of breast cancer patients: those who were already being treated for hypertension by beta-blockers, those whose hypertension was treated by other medications, and those who did not suffer from hypertension and were therefore not taking any treatment for it. (ecancer.org)
We will be looking for funding and collaborators to test the effectiveness of beta-blocker treatment on patients diagnosed with breast cancer. (ecancer.org)
ABSTRACT The 5-year survival rate of female breast cancer cases in Jordan and some of the factors that affected survival were measured. (who.int)
RÉSUMÉ Le taux de survie à cinq ans chez les femmes atteintes d'un cancer du sein en Jordanie et certains des facteurs ayant eu une influence sur la survie ont été mesurés. (who.int)
Toutes les femmes jordaniennes chez lesquelles un nouveau diagnostic de cancer du sein avait été posé en 1997-1998 ont été incluses. (who.int)
Is it worthwhile for patients with pancreatic cancer to seek care at a high-volume institution? (medscape.com)
Results are not reported for the nonoperative group of patients, but presumably travel to a distant center would have less overall survival benefit for the nonoperable patients-the largest group of patients with pancreatic cancer. (medscape.com)
Cite this: Pancreatic Cancer Patients 'Going the Extra Mile' for Improved Survival - Medscape - Oct 12, 2017. (medscape.com)
Survival of 48866 cancer patients: results from Nantong area, China. (bvsalud.org)
Patients with cancer registered between 2007 and 2017 in the Nantong rural area were followed up. (bvsalud.org)
The starting date for survival calculation was the date of the first diagnosis of cancer at the Nantong Tumor Hospital , and the closing date was December 31, 2020. (bvsalud.org)
DNA and RNA from tumor and normal colon were used from cancer patients grouped according to death, survival or Dukes A, B, C and D tumor stage. (lu.se)
Normal colon tissue from cancer patients displayed gains in chromosome 19 and 20. (lu.se)
Looking at breast cancer survival on a population level can tell us how effective our public health and health care systems are at early diagnosis, delivery of evidence-based treatment, and management of follow-up care. (cdc.gov)
For breast cancer, 5-year survival for all women was high-around 90%-but survival was more than 10% lower among black women compared with white women. (cdc.gov)
Improving equity in breast cancer treatment and survival requires a coordinated team approach with doctors, nurses, patient navigators, social workers, and others. (cdc.gov)
Soon after breast cancer diagnosis, it is important that each patient understands her disease and treatment plan. (cdc.gov)
Identifying and addressing barriers, educating patients on healthy lifestyles, and improving comorbid conditions can help women have the best opportunity to receive the cancer treatment they need. (cdc.gov)
Oncology nurses are in a particularly good position to educate, navigate, and advocate for cancer patients. (cdc.gov)

In order to reveal the inherent molecular mechanism, NIDCM patients were divided into sinus rhythm (SR) group and VA group and differentially expressed genes (DEGs) were identified via bioinformatic methods. (hindawi.com)
METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
METHODS: Patients with localised invasive cutaneous melanoma diagnosed in 1990-2021 with data on tumour thickness were identified from the population-based Swedish Melanoma Registry. (lu.se)

A team of investigators evaluated records of 2,773 confirmed COVID-19-positive patients admitted to five hospitals in the Mount Sinai Health System in New York City (The Mount Sinai Hospital, Mount Sinai West, Mount Sinai Morningside, Mount Sinai Queens, and Mount Sinai Brooklyn) between March 14 and April 11, 2020. (mountsinai.org)

There is actually quite good evidence from multiple studies that suggest that these therapies - including nutrition, certain supplements, physical activity, and stress reduction - actually do have a major effect on survival," he said. (medscape.com)
A number of studies have demonstrated that a combination of alternative therapies could even have greater effect on survival. (medscape.com)
Stage, laterality and grade had a significant effect on survival rate. (who.int)

A nomogram based on this log-normal model is presented to facilitate calculation of median survival time and 10th and 90th percentile of survival time. (rand.org)

Time from ed symptom onset to healthcare facility admission and 2) t symptom onset to healthcare facility admission was not as- cycle threshold (C ), which can serve as an approximation t sociated with survival, but viral load in the first Ebola virus- of viral load, at the time of EVD diagnosis. (cdc.gov)
This analysis evaluates the impact of early diagnosis and iron removal on survival and complications in hereditary hemochromatosis. (nih.gov)
Among the total of 5,594 patients with NSCLC included in the analysis, 795 (14.2%) were never-smokers, 3,308 (59.1%) were former smokers, and 1,491 (26.7%) were current smokers at time of diagnosis. (ascopost.com)
CONCLUSIONS: The Swedish updated population-based prognostic instrument, predicts MSS survival up to 10 years after diagnosis. (lu.se)
Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)
American Indian/Alaska Native women are more often diagnosed at younger ages and have worse survival after diagnosis. (cdc.gov)

While treatment uptake and survival outcomes were generally comparable across ethnicity and district health boards, dnMBC survival outcomes were considerably poorer than expected, earmarking this subset of patients with ABC for more in-depth research. (hindawi.com)
Among ever-smokers, doubling the years of smoking cessation was associated with significantly prolonged survival (HR = 0.96, 95% CI = 0.93-0.99, P = .003), whereas doubling of smoking pack-years was associated with nonsignificantly poorer survival (HR = 1.03, 95% CI = 0.98-1.07, P = .21). (ascopost.com)

Exploratory endpoints include patient-reported outcomes, biomarkers and safety. (businesswire.com)

Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma. (nih.gov)

Let's say these patients are going to live for 25 years and not 5 years. (medscape.com)
He noted that the patients in the four trials were still elderly (average age 75.4 years) with a short life expectancy. (medscape.com)
Objective: To develop and validate a model estimating the survival time of hospitalized persons aged 80 years and older. (rand.org)
Results: A total of 1266 patients were enrolled over a 10-month period, (median age 84.9, 61% female, 68% with one or more dependency), and 505 (40%) died during an average follow-up of more than 2 years. (rand.org)
All patients had an ECOG performance status between 0 and 1, confirmed adenocarcinoma, and were at least 20 years of age. (curetoday.com)
In comparison, bortezomib and the IMiDs improved median survival to 4 to 5 years. (ajmc.com)
Patients with PDP or OCC had OS that was 10% higher at 1 year and 6% higher at 3 years compared with patients without coverage. (ajmc.com)
Five years after treatment, 46.9 percent of chemoradiation-plus-surgery patients were still living, while 24.9 percent of chemotherapy-plus-surgery patients survived. (hopkinsmedicine.org)
Despite improvements in treatment options and survival outcomes in recent years, NZ ABC mortality rates continue to exceed the OECD average [ 1 ]. (hindawi.com)
The probability of survival is also displayed as a percentage for one year, two years, and three years for both nonresponders and responders. (wolfram.com)
In each case, we can see that the probability of survival at one, two, and three years is significantly higher for responders as compared to nonresponders. (wolfram.com)
Data from 2053 glioblastoma patients were analyzed (male/female ratio 1.5, median age 64 years). (springer.com)
Over the last few years, we have observed an improvement in survival rates for patients with hematologic malignancies. (onclive.com)
More studies with follow-up periods of no less than 10 years are needed to determine the true survival and success rates of dental implants in patients with a history of periodontal disease. (bvsalud.org)
Survival was significantly higher in younger patients than in older patients , with 5-year OSs of 69.26% and 19.84% in those aged 20-29 and 90-99 years, respectively. (bvsalud.org)
Overall survival improved over the years, although the improvement at some sites was not significant. (bvsalud.org)
When treated with chemotherapy, half of the patients will be in remission 10 years after being diagnosed. (medlineplus.gov)
145 cases were in patients around 21 years of age, and 55 of these cases were laboratory confirmed. (cdc.gov)

The multivariate analysis showed that the risk of mortality was significantly higher for the non-progressive patients who stopped at 6 cycles (standard protocol) than those who continued the treatment, hazard ratio = 1.5 (95% CI 1.2-1.9). (springer.com)

For the fittest patients with advanced stage NSCLC, first-line immunotherapy with or without platinum-based doublet chemotherapy (PDC) is now established as the standard of care treatment. (news-medical.net)
However, more than 40% of advanced stage NSCLC patients are in poor health and are often elderly with significant medical co-morbidities. (news-medical.net)
The trial sought to establish the efficacy , safety and overall survival rate of first-line immunotherapy treatment with atezolizumab compared with single-agent chemotherapy in advanced stage NSCLC patients. (news-medical.net)

SOUTH SAN FRANCISCO, Calif.--( BUSINESS WIRE )-- Exelixis, Inc. (NASDAQ:EXEL) today announced that its global phase 3 CELESTIAL trial met its primary endpoint of overall survival (OS), with cabozantinib providing a statistically significant and clinically meaningful improvement in median OS compared to placebo in patients with advanced hepatocellular carcinoma (HCC). (businesswire.com)

These findings identified 5 key variables primarily associated with worse overall survival outcomes for patients with hematologic malignancies: lack of access to health insurance, treatment at a non-academic research institution, economic instability, low education level, and marital status. (onclive.com)
We encourage clinicians to identify patients with hematologic malignancies who present with [socio-economic] disadvantages [associated with worse survival] and implement some socially targeted interventions," Marisol Miranda-Galvis, DDS, MS, PhD, said. (onclive.com)
Patients with idiopathic pulmonary fibrosis (IPF), a rare lung disease that causes shortness of breath and low oxygen levels because of lung scarring, have worse outcomes if they live in poor neighborhoods, according to research presented at the ATS 2021 International Conference. (medicalxpress.com)

To determine whether 2 readily available indicators pre- beyond capacity, which often forced clinicians to make dif- dicted survival among patients with Ebola virus disease in ficult decisions about how to triage patients and how to Sierra Leone, we evaluated information for 216 of the 227 manage patient and family expectations regarding prob- patients in Bo District during a 4-month period. (cdc.gov)
The epidemic of Ebola virus ( Zaire ebolavirus ) disease to-outcome data for all identified EVD patients during a (EVD) in West Africa began in eastern Guinea in De- 4-month period in Bo District, Sierra Leone, we explored cember 2013 ( 1 ) and quickly spread into Liberia and Sierra the extent to which these indicators predicted outcome. (cdc.gov)
Target lesions on baseline and initial post-therapy contrast-enhanced CT examinations were evaluated by CT texture analysis before and after image filtering in patients with stable disease per Response Evaluation Criteria in Solid Tumors (RECIST) on initial post-therapy images. (prweb.com)
A total of 676 HLA-A*0201-positive patients with unresectable stage III or IV melanoma, whose disease had progressed while they were receiving therapy for metastatic disease, were randomly assigned, in a 3:1:1 ratio, to receive ipilimumab plus gp100 (403 patients), ipilimumab alone (137), or gp100 alone (136). (nih.gov)
Measurements: A log-normal model of survival time up to 711 days was developed with the following variables: patient demographics, disease category, nursing home residence, severity of physiologic imbalance, chart documentation of weight loss, current quality of life, exercise capacity, and functional status. (rand.org)
We continually strive to identify new treatment options for this deadly disease and bring hope and encouraging options to our patients. (news-medical.net)
These properties account for 69% of longevitiy in patients with the familiar version of disease, according to PLOS Biology paper. (genengnews.com)
It has been shown that in about 20% of ALS patients who have a family history of ALS, the underlying mutation causing the disease is a change in the gene for SOD1, according to the scientists. (genengnews.com)
PD1 and PD-L1 inhibitors are often used in patients who are ineligible for cisplatin, as maintenance therapy after platinum-based chemotherapy, or as second-line therapy for relapsed or refractory disease. (esmo.org)
Patients were randomized 2:1 to receive 60 mg of cabozantinib once daily or placebo and were stratified based on etiology of the disease (hepatitis C, hepatitis B or other), geographic region (Asia versus other regions) and presence of extrahepatic spread and/or macrovascular invasion (yes or no). (businesswire.com)
In the entire group, disease-specific death occurred in 125 patients (5.5%) during an average follow-up time of 92 months. (thyroid.org)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Armed with that knowledge, scientists might eventually be able to target the isoforms associated with shorter survival times in order to suppress them and fight disease, Xing said. (uclahealth.org)
With a disease like IPF, which has a very high mortality, we are more able to demonstrate the substantial impact that these neighborhood-level factors can have on survival and transplant outcomes. (medicalxpress.com)
Patient disease stabilization was high at 70%, with increased survival, which approximately doubled. (nutraceuticalsworld.com)
Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
The proportion with advanced disease was 40.4% of Black patients and 29.2% of White patients ( P =.004). (oncologynurseadvisor.com)
FAQs on Guidance for Managers and Workers Handling Untreated Sewage from Patients with Suspected or Confirmed Ebola Disease in the U.S. (cdc.gov)
The World Health Organization (WHO) states sanitary sewers may be used for the safe disposal of waste, such as feces, urine, or vomit, from patients with Ebola disease. (cdc.gov)
Why can sanitary sewers be used for waste disposal from Ebola disease patients? (cdc.gov)
These workers should follow the guidelines provided in the CDC Guidance for Managers and Workers Handling Untreated Wastewater from Suspected or Confirmed Patients with Ebola Disease in the U.S. to prevent exposure to an ebolavirus when working with untreated wastewater. (cdc.gov)
Despite the disadvantage of having more advanced disease, travel to a high-volume center was associated with a 25% improved survival benefit ( P = .01) as well as a reduction in morbidity and a reduced hospital stay ( P = .01). (medscape.com)
Aim: The main aim of this literature review was to determine the survival rates of dental implants in patients with a history of periodontal disease. (bvsalud.org)
Among the 89 patients included, 78.7% had cardiac involvement and 42.7% were diagnosed with 2004 Mayo stage III disease , while 75.3% of patients achieved a hematological response, including 37.1% with complete response and a median response time of 1 month. (bvsalud.org)
For example, nosocomial Ebola virus disease infections mostly occur in adults working on hospital wards, and children are not usually caregivers for Ebola virus disease patients. (cdc.gov)

Survival in noncirrhotic and nondiabetic patients and in patients diagnosed between 1982 and 1991 was identical with rates expected. (nih.gov)
The composite median overall survival (medOS) of women in NZ with ABC was 16 months, while one-year and five-year survival rates were documented at 46% and 12%, respectively. (hindawi.com)
The Sepsis Core Elements are intended to be a "manager's guide" to organizing staff and identify the resources that will help bring sepsis rates down and survival rates up. (cdc.gov)
The rates of life-threatening nonhematologic toxicity were similarfor both groups of patients (2.6% for the combined treatment;3.0% for radiation therapy alone). (cancernetwork.com)
1 Therefore, developing new antitumor strategies for reducing mortality rates and improving patients' quality of life are urgently needed. (nature.com)
There was no difference in CSS rates between patients who received radioactive iodine therapy and those who did not when examining the entire group or the matched group. (thyroid.org)
They specifically looked at survival rates for patients placed on blood thinners versus those not placed on blood thinners. (mountsinai.org)
Although the continued development of novel treatment strategies and the emergence of new agents have improved survival outcomes for patients with hematologic malignancies, socio-economic disparities could affect survival rates for different patients in the United States, according to a systemic review evaluating social determinants of health and patient survival outcomes. (onclive.com)
Most studies found that patients who had public insurance, such as Medicaid, Medicare, or another government insurance, had lower survival [rates] compared with patients who had private or military insurance. (onclive.com)
In terms of economic stability and education levels, patients with lower median income and a lower education level presented with lower survival rates. (onclive.com)

Policies and legislation that promote more equitable environments and reduce the burden of poverty in our society may help to alleviate the disparities we see in outcomes of patients with IPF. (medicalxpress.com)
The observed survival varies from region to region, reflecting differences in the patterns of major sites, disparities in proportions of hospitalization , and demographic characteristics. (bvsalud.org)

Ebola treatment units (ETUs) have shown that C values ing patient or family expectations. (cdc.gov)
Treatment with standard PDC is not suitable for many of these patients because of poor tolerance or toxicity concerns, leaving them with limited treatment options. (news-medical.net)
Treatment-related adverse events (AEs) of any grade were experienced by 42.7 percent of patients treated with Opdivo compared with 26.7 percent of those in the placebo arm. (curetoday.com)
Demographic, diagnostic, treatment, and survival data were extracted from electronic records for statistical analysis. (hindawi.com)
Three patients in the combined group had treatment- related deaths(two pulmonary and one renal). (cancernetwork.com)
The authors wrote in the background that more than 50% of patients with metastatic urothelial carcinoma are ineligible for cisplatin treatment, and those who receive chemotherapy typically have progression within a few months. (esmo.org)
we are committed to studying cabozantinib in a range of tumor types as part of our mission to deliver medicines that improve treatment outcomes and give patients hope for the future. (businesswire.com)
At the seven-year descriptive OS analysis, 67% of LYNPARZA patients were alive versus 47% of placebo patients (44% of whom had a subsequent PARP inhibitor), and 45% of LYNPARZA patients versus 21% of placebo patients were alive and had not received a first subsequent treatment. (merck.com)
Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
One paper has shown the dissemination of RT-temozolomide combination as the treatment standard across countries, and a modest survival gain at the population level [ 17 ]. (springer.com)
What extent of combined RT-temozolomide treatment did patients receive (concomitant phase only, initiation of adjuvant phase, 6 cycles of temozolomide in maintenance or more)? (springer.com)
Of the COVID-19 patients analyzed, 786 (28 percent) received a full-treatment dose of anticoagulants-a higher dose than what is typically given for blood clot prevention, and one that is usually given to those who already have clots or are suspected to have clots. (mountsinai.org)
We then classified survival according to treatment-related outcomes and then identified the impact of each social determinant on the survival of those patients. (onclive.com)
If that had been the case, we would have seen similar survival benefits in patients receiving other forms of treatment for hypertension," says Dr. Powe, "but we did not. (ecancer.org)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)

We demonstrate that improved perfusion occurs only in a subset of patients in cediranib-containing regimens, and is associated with improved overall survival in these nGBM patients. (mit.edu)

CELESTIAL is a randomized, global phase 3 trial of cabozantinib versus placebo in patients with advanced HCC who have been previously treated with sorafenib. (businesswire.com)

The parametric Royston-Parmar (RP) method was used to estimate melanoma-specific survival (MSS) probabilities. (lu.se)
The prognostic instrument gives more representative and up-to-date prognostic information for Swedish patients with primary melanoma than the present AJCC staging. (lu.se)

So you pick the very best patients and say we are doing as good or better than surgical patients, but these findings do not apply to all-comer patients at low surgical risk," said Sondergaard, who coauthored an editorial with Giulia Costa, MD, University of Copenhagen, that accompanies the paper. (medscape.com)
Despite observable gains in survival outcomes over the 15-year period, the BCFNZR findings were disappointing. (hindawi.com)

In daily practice and at whole country level, oncological care management for glioblastoma patients is not completely known. (springer.com)

In a multivariate analysis, Hispanic ethnicity was independently associated with improved survival. (oncologynurseadvisor.com)

These functions were derived and developed in [1] as an improvement over the traditional NIH risk stratification equation to predict survival probability for PAH patients. (wolfram.com)

Exelixis will discuss the trial results with regulatory authorities and determine next steps for the trial, including offering patients currently receiving placebo the opportunity to cross over to cabozantinib. (businesswire.com)
We are doing a much better job of identifying and expanding candidates for surgery, which results in better, longer outcomes for so many of our patients," says R. Jeffrey Karnes, M.D., of Mayo Clinic's Department of Urology. (healthnewstrack.com)
I am looking forward to validating these results in a larger and more diverse population of patients with IPF and other forms of fibrotic ILD," stated Dr. Goobie. (medicalxpress.com)

Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, markers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia. (cdc.gov)

This report shows a reduced morbidity and a clear survival advantage for patients undergoing pancreaticoduodenectomy (Whipple procedure) at a high-volume center. (medscape.com)

Anatomy9

Organisms9

Diseases54

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Phenomena and Processes36

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Humanities1

Information Science8

Named Groups2

Health Care34

Publication Characteristics1

Geographicals2

Progression-free sur9

Prognosis12

Long-term survival7

Colorectal Cancer11

Cohort11

Newly diagnosed glioblastoma1

Chemotherapy in patients1

Multiple myeloma3

Pediatric patients8

Better survival2

Cancers7

Study57

Kaplan-Meier2

Underwent2

Treatments9

Bevacizumab5

Clinical17

Improve survival rates3

Longer survival2

Researchers9

Prognostic factors2

Adult patients4

Cancer70

Methods3

20201

Effect on survival3

Median survival time1

Diagnosis6

Poorer2

Endpoints1

Overall Survival in Patients1

Years18

Significantly higher1

NSCLC3

Clinically meaningful1

Worse3

Disease25

Rates10

Disparities2

Treatment17

Subset of patients1

Previously treated1

Melanoma2

Findings2

Glioblastoma patients1

Multivariate Analysis1

Predict survival1

Results3

Biomarkers1

Clear survival advantage1