Survival signaling. Medical search. Frequent questions

Enhancing HH signaling by decreasing the gene dosage of a negative regulator of the pathway, Ptch1 , decreased cell death and rescued the midface defect in both Tctn2 and Cc2d2a mutants. (elifesciences.org)
Primary cilia function as specialized cellular signaling organelles that coordinate multiple signaling pathways, including the Hedgehog (HH) pathway ( Zaghloul and Brugmann, 2011 ). (elifesciences.org)
Furthermore, siRNA knockdown of ALDH1A1 significantly decreased RAR expression and induced cell apoptosis via suppression of the phosphoinositide 3-kinase (PI3K) pathway and activation of caspase signals.Our findings indicate that ALDH1(+) cells represent a pool of endocrine precursors in the developing human pancreas and that ALDH1 activity is required during endocrine cell differentiation. (bepress.com)
Here, I present two studies utilizing the phenotypic and the target approaches, respectively, to demonstrate that miR-BARTs can inhibit apoptosis and activate the Wnt signaling pathway. (duke.edu)
On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. (duke.edu)
Utilizing a Wnt signaling FLuc reporter TOPflash which measures the Wnt signaling activation, I confirmed that expression of many miR-BARTs that target Wnt signaling inhibitors can indeed upregulate the Wnt signaling pathway. (duke.edu)
Together, my results identified and validated a substantial number of novel targets of miR-BARTs involved in apoptosis and the Wnt signaling pathway, indicating that EBV may employ miR-BARTs to heavily target these two pathways to facilitate chronic infection. (duke.edu)
Altogether, the current data suggest that an imbalanced regulation of the 2 B-cell receptor associated signaling axes (Syk and Akt pathway) in the context of increased tyrosine phosphatase activity could contribute to the breakdown of tolerance and the development and maintenance of autoimmunity in patients with SLE," the authors wrote. (rheumatologyadvisor.com)
Big'-insulin-like growth factor-II signaling is an autocrine survival pathway in gastrointestinal stromal tumors. (ru.nl)
Our data put forth the big-IGF-II/IR isoform A axis as an autocrine survival pathway and potential therapeutic target in GISTs. (ru.nl)
Hedgehog (Hh) signaling is an important survival pathway in CCA. (elsevierpure.com)
Finally, chemical inhibition of TrkB signaling increases apoptosis in HTLV-1 -infected T cells and reduces phosphorylation of glycogen synthase kinase 3 ß ( GSK-3 ß), a downstream target in the signaling pathway. (bvsalud.org)
We found that HBZ promotes a BDNF /TrkB autocrine/ paracrine signaling pathway that is known to enhance the survival and chemotherapeutic resistance of other types of cancer cells . (bvsalud.org)
One potential novel pathway is via the Wnt ligand WNT4, a critical signaling molecule in mammary gland development regulated by the progesterone receptor. (nih.gov)
WNT4 drives a novel signaling pathway in ILC cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. (nih.gov)
Moreover, we showed that p75 NTR signaling is involved in the activation of the hypoxic signaling pathway and is also regulating glioma cell stemness and migration in hypoxia. (lu.se)

This imbalance creates a disruption in the B-cell receptor signaling pathways, leading to enhanced survival of lupus B cells and differentiated plasma cells. (rheumatologyadvisor.com)
Disruption of B-cell receptor signaling pathways in patients with SLE may lead to improper B-cell negative selection, imparting survival advantages to potentially autoreactive B-cells. (rheumatologyadvisor.com)
Here, we investigated the signaling pathways activated in response to the energetic stress created by transient glutamate excitation in cerebellar granule neurons. (jneurosci.org)
To study glioblastoma phenotypic heterogeneity, multi-parametric magnetic resonance images (MRI) of 85 glioblastoma patients from The Cancer Genome Atlas were analyzed to characterize tumor-derived spatial habitats for their relationship with outcome (overall survival) and to identify their molecular correlates (i.e., determine associated tumor signaling pathways correlated with imaging-derived habitat measurements). (oncotarget.com)
Pathscan intracellular signaling array provided the preliminary picture of cell signaling in quiescent and motile rat sperm, indicating upregulation of cell-survival pathways in quiescent sperm, which were downregulated during motility activation. (bioscientifica.com)
Immunofluorescence localized the kinase proteins in the sperm mid-piece region (mitochondria), a known extra-nuclear target for these signaling pathways. (bioscientifica.com)
Click on one of the biological effects of VEGF-VEGF R2 signaling shown in the Explore Pathways box below to see the specific molecules involved in promoting each effect and the phosphorylation sites on VEGF R2 that are necessary for recruitment of key downstream adaptor proteins or kinases. (rndsystems.com)
Considering the central importance of the UPR in regulating cell survival and death, evidence is emerging that cells evolve feedback regulatory pathways to modulate the key UPR executors, however, the precise mechanisms remain to be elucidated. (elsevierpure.com)
Collectively, our data suggest that venetoclax resistance can be mediated through the enrichment of distinct gene signatures and cytokine signaling pathways. (lu.se)

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase signaling cascades. (nih.gov)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
Cholangiocarcinoma (CCA) cells paradoxically express the death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and thus rely on potent survival signals to circumvent cell death by TRAIL. (elsevierpure.com)
Herein, we further examine the mechanisms whereby Hh signaling mediates apoptosis resistance in CCA, revealing a pivotal role for the cell division regulating serine/threonine kinase polo-like kinase 2 (PLK2). (elsevierpure.com)
p38 MAPK Signalling in Endothelial Apoptosis. (lu.se)

Inhibition of ALDH1-mediated retinoid signalling impairs human fetal islet cell differentiation and survival. (bepress.com)
Inhibition of Hh signaling by cyclopamine reduced PLK2, but not PLK1 or PLK3, messenger RNA and protein expression in vehicle-treated and sonic Hh-treated CCA cells, confirming our previous microarray study. (elsevierpure.com)
Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticle s. (cdc.gov)
Inhibition of WNT5A signaling and function in malignant melanoma. (lu.se)

These results reveal that ciliary HH signaling mediates communication between the prechordal plate and the neurectoderm to provide cellular survival cues essential for development of the facial midline. (elifesciences.org)

Distress signals give you the ability to let emergency services and other potential rescuers know where you are. (thesurvivalguide.com)

Intracellular signaling via phosphorylation cascades is quick events that may regulate motility and survival of transcriptionally inactive sperm. (bioscientifica.com)

In systemic lupus erythematosus (SLE), an imbalance between the tyrosine kinase Syk and the serine/threonine kinase Akt may contribute to enhanced B-cell survival, according to research published in Arthritis & Rheumatology . (rheumatologyadvisor.com)
Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
Interactome of signaling proteins involved in motility activation was constructed by Search Tool for the Retrieval of Interacting Genes (STRING) software, which identified mitogen activated protein kinase-p38 (MAPK-p38), AKT, mTOR and their downstream target p70S6K as the key kinases regulating sperm function. (bioscientifica.com)
The liberated HSP60 associates with and activates the IκB kinase (IKK) complex in the cytosol, which consequently induces the NF-κB-dependent expression of survival genes in nucleus. (ewha.ac.kr)
Gene set enrichment analysis (GSEA) showed enrichment of cytokine signaling in all three cell lines which was supported by the phospho-kinase array where STAT5 phosphorylation was found to be elevated in resistant cells. (lu.se)
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. (bvsalud.org)

ILC and ILC-LTED cell lines were used to identify upstream regulators and downstream signaling effectors of WNT4 signaling. (nih.gov)

ASK1 thus appears to mediate signals leading to both differentiation and survival of PC12 cells. (nih.gov)

By taking these factors into account, you can greatly increase the effectiveness of your signal fire and maximize your chances of being noticed by potential rescuers. (survivalneede.com)
Flashlights and strobe signals are great ways to get the attention of airplanes, helicopters or other potential rescuers. (thesurvivalguide.com)

It is over 90% as reflective as glass, yet boasts features you won't find with traditional glass signal mirrors. (camping-gear-outlet.com)
Signal mirrors and emergency whistles become very useful in being seen and heard by Search and Rescue Operations. (survivalsuppliesaustralia.com.au)

Swing the light in front of you to signal for rescue on the ground, or swing it over your head to signal an aircraft. (outdoorlife.com)
Even on overcast days, you can effectively use this signal mirror to obtain rescue. (camping-gear-outlet.com)
Ideally used as a signaling device, the SOS Survival Signal and Light is perfect for rescue and outdoor safety operations. (bestglide.com)
Make sure your kit has the signaling tools you need to make sure you can signal for rescue, for communication, and for finding your way back to your site without worry. (survivalmetrics.com)
When in distress or emergency, increase your chances of attention for rescue and help with signalling tools. (survivalsuppliesaustralia.com.au)
Then when you hear that rescue chopper or airplane getting close, light the end and you've got instant smoke signal. (dailysurvival.info)
Just because you know how to signal an airplane or other means of rescue doesn't necessarily mean they got the message. (thesurvivalguide.com)
LuxoGear Emergency Whistles are highly effective in rescue signaling, allowing you to alert nearby individuals or rescue teams to your presence. (masternetwork.org)
Below you will find links with information about cold water survival and cold water rescue. (cdc.gov)

Down-regulation of either big-IGF-II or IR affected AKT and MAPK signaling and reduced survival in both cell lines. (ru.nl)
PLK2 regulation by Hh signaling appears to be direct, because the Hh transcription factors, glioma-associated oncogene 1 and 2, bind to the PLK2 promotor. (elsevierpure.com)
Regulation of survival and proliferationof human intestinal epithelial cells by leukotriene D4. (lu.se)

It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. (bvsalud.org)

We further demonstrated that GRP78va has the ability to regulate PERK signaling and that GRP78va is able to interact with and antagonize PERK inhibitor P58 IPK . (elsevierpure.com)
T. Reporter-based screening identified pterosin B as a SIK3 signaling-specific inhibitor. (mingsheng88.org)
it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling. (bvsalud.org)

A BDNF /TrkB autocrine/ paracrine signaling loop has additionally been implicated in augmenting the survival of cells representing several human cancers and is associated with poor patient prognosis . (bvsalud.org)
Hypoxic signaling, mediated by the HIF transcription factors, is a cornerstone in the maintenance of cancer stemness in glioblastoma and other cancers. (lu.se)

Data suggest that sperm motility and survival are inversely complementary and critically regulated by intracellular cell signaling. (bioscientifica.com)
4 Intracellular survival of SL1344 or SL1344 in Organic264.7 cells. (mingsheng88.org)

HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. (bvsalud.org)
These effects occur through autocrine and paracrine signaling events initiated by interactions between secreted BDNF and its high-affinity receptor, TrkB . (bvsalud.org)
These results suggest that HBZ contributes to an active BDNF /TrkB autocrine/ paracrine signaling loop in HTLV-1 -infected T cells that enhances the survival of these cells . (bvsalud.org)

From relative intensity of pixels in the 3-dimensional tumor region, "imaging habitats" were identified and analyzed for their association to clinical and genetic data using survival modeling and Dirichlet regression, respectively. (oncotarget.com)
Sixteen distinct tumor sub-regions ("spatial imaging habitats") were derived, and those associated with overall survival (denoted "relevant" habitats) in glioblastoma patients were identified. (oncotarget.com)

Most of these variants impair the normal function of the DLG4 protein by decreasing its ability to interact with the other proteins involved in synaptic plasticity or decreasing its ability to help synapses send signals. (medlineplus.gov)

UNLABELLED Brain-derived neurotrophic factor ( BDNF ) is a neurotrophin that promotes neuronal proliferation, survival , and plasticity. (bvsalud.org)

The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)

Ultra-light signal mirror and emergency whistle for camping, backpacking, and emergency preparedness. (baysboss.com)
In case of an emergency, such as getting lost or injured, the whistle can help you signal for help and increase your chances of being located quickly. (masternetwork.org)

Disruption of big-IGF-II signaling in combination with imatinib had additive cytotoxic effects on GIST882 cells. (ru.nl)

Whether you are kayaking, boating, fishing, camping, hiking, hunting, or simply need a reliable signaling device, these survival whistles are designed to deliver a shrill and loud blast that can be heard from a distance. (masternetwork.org)

We will discuss various techniques and methods for signaling for help in emergency situations. (survivalneede.com)

StarFlash Ultra is the latest advancement in signal mirror technology. (camping-gear-outlet.com)
StarFlash Ultra signal mirror can help you be found, and can save your life. (camping-gear-outlet.com)

a great daytime signaling device and site marker. (survivalmetrics.com)
The water and chemical (ammonium nitrate crystals) inside the majority of instant cold packs can be used to make an excellent signaling device. (dailysurvival.info)
The Channel Master CM-3212HD 2-Way Splitter with Power Passing Capability is a high-quality device designed for splitting TV antenna and cable signals. (robots.net)

Here we show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several mouse models. (nature.com)
By following these steps, you can create a strong and effective signal that increases your chances of being noticed and rescued. (survivalneede.com)
However, sniffing the ground and yawning, which are both considered calming signals, are most often displayed when the distance between the sender and the recipient increases. (wikipedia.org)
Treatment-induced increases in animal survivability were associated with decreased hepatic damage along with reductions in serum cytokines/chemokines, and diminished inflammatory related signaling. (cdc.gov)

Through specific knockdown of endogenous GRP78va by siRNA without affecting canonical GRP78, we showed that GRP78va promotes cell survival under ER stress. (elsevierpure.com)

The molecular mechanisms that suppress sperm motility but increase cell survival during storage in cauda epididymis are not known. (bioscientifica.com)

Therapy resistance remains one of the major challenges for cancer treatment that largely limits treatment benefits and patient survival. (lu.se)

Using FLuc 3'UTR indicator assays, I proved that the 3'UTRs of all seven newly identified anti-Wnt signaling genes were indeed targeted by the relevant miR-BARTs identified by PAR-CLIP. (duke.edu)

Introducing the 13 Best Signal Splitter For TV Antenna for 2023, a comprehensive guide that will help you enhance your television viewing experience. (robots.net)

In contrast to the canonical GRP78 which is primarily an ER lumenal protein, GRP78va is devoid of the ER signaling peptide and is cytosolic. (elsevierpure.com)
Here, we report an unexpected messenger role for heat shock protein 60 (HSP60) as a mitochondrial-releasing protein factor that couples stress-sensing signaling and cell survival machineries. (ewha.ac.kr)
Wiskott-Aldrich syndrome is caused by mutations in the gene that encodes the Wiskott-Aldrich syndrome protein (WASP), a cytoplasmic protein necessary for normal B- and T-cell signaling. (msdmanuals.com)

Whether you're stranded on a desert island or lost in the wilderness, understanding survival signals can greatly increase your chances of being rescued. (survivalneede.com)
Uppercut Tactical offers wilderness survival tips that include foraging, finding food, building shelter, starting a campfire, and signaling for assistance. (engagedpage.com)
Fortunately, learning wilderness survival techniques helps them handle these unexpected situations with confidence and ease. (engagedpage.com)

VOCs play various roles in plant development, survival, and gene expression. (the-scientist.com)

This new understanding of altered negative selection and increased B-cell survival may be a topic for investigation in the development of future therapies targeted against autoreactive B cells. (rheumatologyadvisor.com)
Fleischer SJ, Daridon C, Fleischer V, Lipsky PE, Dörner T. Enhanced tyrosine phosphatase activity underlies dysregulated B-cell receptor signaling and promotes survival of human lupus B-cells . (rheumatologyadvisor.com)
ILC cells co-opted WNT4 signaling by placing it under direct ER control. (nih.gov)
In the latter case, WNT4 expression was driven by activated nuclear factor kappa-B signaling in ILC-LTED cells. (nih.gov)

The crucial role of signal fires in survival situations. (survivalneede.com)
This basic yet crucial technique is often used by beginners in survival situations. (survivalneede.com)
Overall, understanding the importance of signal fire in survival situations is vital. (survivalneede.com)

The lightweight SOS Survival Light Stick has a protective plastic outer casing that remains attached by a 30" lanyard and acts as a handle. (bestglide.com)
A vital component of any survival and emergency kit, signaling devices provide lightweight means to get noticed and get rescued. (survivalmetrics.com)

Together with previous reports indicating that ASK1 functions as a pro-apoptotic signaling intermediate, these results suggest that ASK1 has a broad range of biological activities depending on cell types and/or cellular context. (nih.gov)

We showed that the generation of the cleaved form of the cell surface glycoprotein CD44 leads to the stabilization of the HIFs in the perivascular and the perinecrotic glioma niche, leading to increased hypoxic signaling and glioma cell stemness. (lu.se)
All in all, this thesis elucidated aspects of the glioblastoma microenvironment, namely irradiated and hypoxic astrocytes, and the CD44 and p75 NTR signaling, that can lead to the development of new targeted therapeutic strategies. (lu.se)

Protective clothing in cold water survival. (cdc.gov)
The importance of protective clothing in cold water survival was discussed. (cdc.gov)
Cold water survival involved the avoidance of drowning and dealing with hypothermia. (cdc.gov)

By gaining knowledge of the basic survival signals and techniques, beginners can greatly enhance their chances of being rescued. (survivalneede.com)
The most basic survival shelter is a lean-to, but it is also possible to construct huts and other structures. (engagedpage.com)

The author concludes that the criterion of survival time is the time taken for core temperature to drop to 34 degrees-C (the temperature at which a person is considered unable to activate survival equipment, use radios or signaling devices), time taken to become unconscious, or the time taken for body temperature to drop to the point of causing cardiac arrest. (cdc.gov)

Just a few little tweaks can get your gear working harder and signaling farther. (outdoorlife.com)
According to Zahavi costly signals are harder to fake and are therefore, more believable. (warc.com)

Calming signals, or appeasement signals, are communicative cues used by dogs to de-escalate aggressive encounters or to prevent the development of aggressive encounters completely. (wikipedia.org)

They attribute their survival to the flotation and peace of mind provided by these devices. (cdc.gov)
Flotation devices were critical, but did not guarantee survival. (cdc.gov)

Glioblastoma (GBM) show significant inter- and intra-tumoral heterogeneity, impacting response to treatment and overall survival time of 12-15 months. (oncotarget.com)
Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)

To ensure the success of your signal fire , you need to carefully evaluate your resources and choose the right location and construction methods. (survivalneede.com)

Anatomy8

Organisms8

Diseases54

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Phenomena and Processes37

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science8

Named Groups3

Health Care37

Geographicals1

Pathway16

Pathways9

Apoptosis5

Inhibition4

Mediates1

Distress Signals1

Cascades1

Kinase6

Downstream1

Differentiation and survival1

Rescuers2

Mirrors2

Rescue9

Regulation3

Regulates1

Inhibitor3

Cancers2

Intracellular2

Autocrine3

Tumor2

Proteins1

Neuronal1

Promote Cell Survival1

Whistle2

Disruption1

Whistles1

Emergency situations1

Mirror2

Device3

Increases4

Promotes cell survival1

Mechanisms1

Resistance1

Genes1

20231

Protein3

Wilderness3

Gene expression1

Cells4

Situations3

Lightweight2

Results1

Hypoxic2

Cold water survival3

Basic survival2

Radios1

Harder2

Development1

Flotation2

Overall survival2

Methods1