TransplantCombined with autologous bone marrow traAllogeneic boneFollowed by autologous stem cell transBiopsyHigh-doseBlood and marrow transplantationMultiple myelomaConventionalCyclophosphamideDisease-free survivalRegimensIntensiveEvent-free survivalClinicalRadiotherapy for boneRelapseComplete remissionProgenitor cellCancersAutologous peripheral-bloodAcuteTherapiesSpleenRadiation or chemotherapyPrognosisRefractorySequential chemotherapyCell transplantationInvolve chemotherapyInduction chemotherapyTransplantsAspirationMalignantPercentage of boneTreatmentAplasticOverall survivalMulticenter studyLymphoidHodgkin'sGraftABMTInfectionsMutationsUndergoDoseLeukemiasDonorsLeukemiaHematopoietic cellsStem cellsAllograftASCTPeripheralEfficacy
Transplant11
- Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, in addition to supportive care and palliative care as needed. (wikipedia.org)
- Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALL R1 trial. (ox.ac.uk)
- Its prognosis despite therapy is generally poor, and treatment may involve chemotherapy and stem cell transplant. (the-medical-dictionary.com)
- MRC AML 10 tested the role of bone marrow transplantation following four blocks of intensive chemotherapy and found that while both allogeneic bone marrow transplant (allo-BMT) and autologous bone marrow transplant (A-BMT) significantly reduced the relapse risk (RR), this did not translate into a significant improvement in overall survival (OS). (ox.ac.uk)
- It is important to know whether the survival of patients receiving an allogeneic bone marrow transplant (BMT) is better than that of patients receiving "conventional" treatment and, if BMT is better, to know how much better. (ox.ac.uk)
- Studies conducted have revealed the benefits derived from cord blood transplant when compared to bone marrow in non-cancerous and cancerous disorders. (yoursdailynews.com)
- Approximately 190 cord blood patients meant for transplantation were compared with 123 patients recommended for matched donor transplant. (yoursdailynews.com)
- They also suggested that cancer patients provided with higher dosage of pre-transplant radiotherapy or chemotherapy should be recommended with cord blood as the preferred stem cell transplant source. (yoursdailynews.com)
- In research presented in Bone Marrow Transplantation , investigators examined whether the time interval from ending induction therapy to receiving an autologous hematopoietic stem cell transplant (AHSCT) impacted outcomes in patients with multiple myeloma (MM). Lead author, Charalampos Charalampous, MD, noted that the last cycle of induction therapy is typically completed two to four weeks before transplantation. (bloodcancerstoday.com)
- 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
- Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
Combined with autologous bone marrow tra1
- SEATTLE--French researchers have recently concluded a study of multiple myeloma in which high-dose chemotherapy combined with autologous bone marrow transplantation (HDC/ABMT) resulted in a significant improvement in response rate and overall survival, compared with conventional chemotherapy. (cancernetwork.com)
Allogeneic bone5
- Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
- Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
- The associations of cytogenetics with complete remission (CR) rates, overall survival (OS), and outcomes after CR were studied in 609 previously untreated AML patients younger than 56 years old in a clinical trial comparing 3 intensive postremission therapies: intensive chemotherapy, autologous transplantation (ABMT), or allogeneic bone marrow transplantation (alloBMT) from matched related donors. (elsevierpure.com)
- Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
- History of prior allogeneic bone marrow progenitor cell or solid organ transplantation. (astrazenecaclinicaltrials.com)
Followed by autologous stem cell trans1
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
Biopsy4
- Diagnosis is typically made by blood tests or bone marrow biopsy. (wikipedia.org)
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- A bone marrow biopsy is usually performed to estimate the percentage of bone marrow occupied by plasma cells. (the-medical-dictionary.com)
- The workup for AML includes blood tests, bone marrow aspiration and biopsy (the definitive diagnostic tests), and analysis of genetic abnormalities. (medscape.com)
High-dose16
- However, in a recent COG report, the authors demonstrated that intensive multimodal therapies-including high-dose chemotherapy, radiation, and bone marrow transplantation-have enabled improved efficacy for curing patients with regional extraocular retinoblastoma (87% event-free survival [EFS] at 36 months) and metastatic retinoblastoma not involving the CNS (79% EFS at 36 months), while rates for patients with CNS disease continue to be dismal (8% EFS at 36 months). (aao.org)
- To improve these results, a high-dose chemotherapy regimen usingmelphalan (Alkeran) was developed for the treatment of aggressivemultiple myeloma, and has been anecdotally reported to inducean improved response, including some complete remissions, in patientsrefractory to conventional dosages. (cancernetwork.com)
- At diagnosis, 200 patients under age 65 with intermediate or hightumor mass (stage II/III DS), previously untreated multiple myelomawere randomized to receive either a conventional chemotherapeuticregimen of VMCP/BVAP or high-dose therapy, consisting of melphalan(140 mg/m²) and total body irradiation, supported with unpurgedautologous bone marrow, collected after two cycles of VMCP/BVAP.Maintenance with alpha-interferon was used in both arms. (cancernetwork.com)
- At a median follow-up of 40 months, the 5-year postdiagnosis probabilityof survival was 52% for the high-dose regimen vs 12% for conventionaltherapy. (cancernetwork.com)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
- These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
- Treatment of various cancers increasingly involves cytoreductive therapy, including high dose chemotherapy or radiation therapy. (justia.com)
- After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
- Anthracycline-related cardiotoxicity remains a concern and the current MRC AML 15 trial tests the feasibility of reducing anthracycline dosage without compromising outcome by comparing standard MRC anthracycline-based consolidation with high-dose ara-C. MRC studies suggest that the role of allo-BMT is limited in 1st CR and that there may be a ceiling of benefit from current or conventional chemotherapy. (ox.ac.uk)
- Treatment involves maximal safe tumor resection, craniospinal irradiation, and high-dose chemotherapy. (biomedcentral.com)
- We determined the incidence and the prognostic significance of HZ and its correlation with VZV serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with ASCT. (nature.com)
- Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
Blood and marrow transplantation1
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Multiple myeloma3
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- Impact of the time interval between end of induction and autologous hematopoietic transplantation in newly diagnosed patients with multiple myeloma. (bloodcancerstoday.com)
- Cilta-cel improved survival outcomes compared with standard care in patients with lenalidomide-refractory multiple myeloma. (bloodcancerstoday.com)
Conventional5
- Dr. Attal said that conventional chemotherapy for multiple myelomahas proved disappointing, with a median overall survival rateof only 2 to 3 years and few, if any, complete remissions. (cancernetwork.com)
- These two therapeutic compounds both indirectly activate p53, thereby presenting a combinational non-genotoxic p53 activation strategy, in contrast to conventional chemotherapy and bone marrow transplantation. (uib.no)
- CONCLUSION: The combination of immunotherapy and tyrosine-kinase inhibitors is at least as effective as a tyrosine-kinase inhibitor alone, and superior to conventional chemotherapy for treating metastatic RCC of unknown primary origin. (bvsalud.org)
- A therapeutic regimen that combined the GO with conventional three-drug chemotherapy was associated with improved survival in children with AML who underwent bone marrow transplantation. (cancertherapyadvisor.com)
- Most studies that have attempted to define the value of BMT have been subject to varying degrees of bias because of the problems of identifying a "conventional chemotherapy" control group with which the outcome of patients who have received BMTs can be compared. (ox.ac.uk)
Cyclophosphamide3
- Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
- Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)
- Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
Disease-free survival3
- Although these treatments prolonged pancytopenia, they decreased induction failures and substantially improved disease-free survival. (medscape.com)
- The development of acute graft-versus-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P=.04) and improved disease-free survival (P=.11). (umn.edu)
- A common bias arises when disease-free survival of BMT patients is compared with that of all other remitters. (ox.ac.uk)
Regimens5
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
- METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
- The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. (chop.edu)
- The study reviewed the duration and dosing of participants' induction regimens, the date of final chemotherapy, and any biochemical response achieved before transplantation. (bloodcancerstoday.com)
- Current standard chemotherapy regimens cure only a minority of patients with AML. (medscape.com)
Intensive3
- Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
- Research suggests that while treatments such as intensive chemotherapy and allogeneic stem cell transplantation may be curative for younger people, they are less likely to be effective in older individuals. (medicalnewstoday.com)
- People who undergo intensive chemotherapy may need to stay in the hospital for 3-5 weeks . (medicalnewstoday.com)
Event-free survival5
- Event-free survival was 40% at 5 years for children over 26 weeks but under 10% for younger children. (nih.gov)
- The donor group had a non-significant eight-year event-free survival (EFS) advantage of 8%, (95% confidence interval -9%-24%) over the no donor group. (ox.ac.uk)
- Adding gemtuzumab ozogamicin to standard therapy improved event-free survival improved in children with de novo acute myeloid leukemia. (cancertherapyadvisor.com)
- It was conducted to demonstrate cord blood transplantation outperformed bone marrow concerning event-free survival, treatment related mortality and graft failure. (yoursdailynews.com)
- It resulted in EFS (Event-free survival) of over 90% at one year. (yoursdailynews.com)
Clinical7
- this clinical situation requires adjuvant chemotherapy and radiation therapy. (aao.org)
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- overall survival (OS), response rates, duration of clinical benefit and safety were the secondary endpoints. (bvsalud.org)
- Indolent clinical course , with median survival of 7 to 8 years. (oncolink.org)
- This article reviews the genetics, clinical approach, and treatment options for retinoblastoma focussing on advances in chemotherapy for intraocular retinoblastoma (chemoreduction), as well as improvement in survival in advanced retinoblastoma with surgery, chemotherapy, radiotherapy, and bone marrow transplantation. (jiaps.com)
- Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
- Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. (biomedcentral.com)
Radiotherapy for bone2
- The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
- 8. Subjects are allowed to receive palliative radiation therapy (including brain radiotherapy for symptomatic brain metastases and radiotherapy for bone metastases), but the radiotherapy must be completed at least 1 week before enrollment, and the toxicity related to radiotherapy should be restored to less than or equal to 1 degree (CTCAE 5.0, excluding hair loss). (who.int)
Relapse7
- Patients who do not respond with a complete remission or who relapse within 6 to 12 months following initial chemotherapy, have a very poor prognosis. (nethealthbook.com)
- Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. (umn.edu)
- A prospective, randomized trial of maintenance chemotherapy with oral methotrexate and mercaptopurine did not demonstrate improvement in relapse risk or survival for those assigned maintenance chemotherapy (P=.7). (umn.edu)
- These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. (umn.edu)
- MRC AML trials employ a short course of triple intrathecal chemotherapy alone for CNS-directed treatment and CNS relapse is uncommon. (ox.ac.uk)
- Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
- Much lower relapse rate in patients having received cord blood transplantation procedure. (yoursdailynews.com)
Complete remission2
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- Overall, COP chemotherapy causes complete remission in about 70% of dogs with lymphoma for a median of 130 days. (vin.com)
Progenitor cell1
- The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
Cancers5
- Leukemia (also spelled leukaemia and pronounced /luːˈkiːmiːə/ loo-KEE-mee-ə) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. (wikipedia.org)
- these include an annual physical examination, with an assessment of the skin to identify second-primary skin cancers, as well as education regarding the signs and symptoms of bone and soft-tissue sarcomas. (aao.org)
- The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
- Blood cancers represent about 10% of all cases of cancer each year in the U.S. Blood cancers can be fatal, with varying survival rates based on multiple factors including the specific type of blood cancer diagnosed. (fda.gov)
- Stem cell transplantation is a common treatment for blood cancers. (fda.gov)
Autologous peripheral-blood1
- A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitory cell transplantation. (nature.com)
Acute10
- Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
- The survival rate of acute lymphoblastic leukemia (ALL) depends on the age of the patient and the response to chemotherapy. (medicinenet.com)
- BACKGROUND: Although reinduction rates are good for children with relapsed acute lymphoblastic leukaemia there is no consensus on whether bone marrow transplantation (BMT) is the most effective treatment to prolong second remission. (ox.ac.uk)
- AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
- Acute myeloid leukemia is a blood cancer but, for many patients, the cancer may originate from an unusual source: a mutation in their bone cells. (cancertherapyadvisor.com)
- Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. (wikigenes.org)
- Acute myelogenous leukemia (AML) is a type of cancer that involves the bone marrow. (medicalnewstoday.com)
- AML is the most common type of acute leukemia in adults, and it happens when the bone marrow begins making myeloblasts, also called blasts. (medicalnewstoday.com)
- However, of the forms of acute leukemia that affect adults, AML currently has the shortest length of survival. (medicalnewstoday.com)
- Acute myelogenous leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
Therapies5
- These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
- Studies examining the survival and toxicity of therapies administered to treatment-refractory pediatric MB patients will be included. (biomedcentral.com)
- Although applying multi-modal therapies (radiation, chemotherapy, and surgery) has increased 5-year survival amongst standard-risk MB patients, overall survival (OS) rates seem to have plateaued. (biomedcentral.com)
- This first-ever symposium featured leading researchers from around the world sharing their current research on improving survival after hematopoietic transplantation, adoptive cell therapy, gene therapy and hybrid therapies. (fredhutch.org)
- This process may include undergoing therapies such as radiation or chemotherapy, both of which may weaken an individual's immune system. (fda.gov)
Spleen3
- Involvement of other organs, such as spleen, liver, or bone marrow is an indication of advanced disease. (vin.com)
- The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
- Second, the rapid proliferation of these cells, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)
Radiation or chemotherapy1
- This is defined by their ability to repopulate an individual whose hematopoietic system has been destroyed by radiation or chemotherapy. (justia.com)
Prognosis3
- Children with intraocular retinoblastoma who have access to modern medical care have a very good prognosis for survival (>95% in industrialized countries). (aao.org)
- Historically, children with extraocular retinoblastoma had a very poor prognosis for survival. (aao.org)
- Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. (bvsalud.org)
Refractory2
- Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
- NCT04131621), patients relapsed or refractory after platinum-based chemotherapy received nivolumab and ipilimumab following TMBhigh vs. TMBlow stratification. (bvsalud.org)
Sequential chemotherapy1
- 110 dogs were treated with a sequential chemotherapy protocol that used the above drugs (Madison-Wisconsin Protocol or AMC protocol). (vin.com)
Cell transplantation13
- These are sometimes added when patients require additional therapy, such as stem cell transplantation, or when a temporary access situation develops (as when an indwelling central line is removed because of infection). (medscape.com)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Sometimes stem cell transplantation is curative. (msdmanuals.com)
- Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
- Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
- The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
- 184 had no cardiac events after stem cell transplantation. (slideshare.net)
- Discussion Stem cell transplantation is well and truly underway in South East Asia. (slideshare.net)
- Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation. (fda.gov)
- The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
- Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
- The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
Involve chemotherapy1
- Standard treatments involve chemotherapy and radiotherapy. (wikipedia.org)
Induction chemotherapy3
- If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
- One treatment option is induction chemotherapy, which involves several drugs. (medicalnewstoday.com)
- Consolidation chemotherapy can follow induction chemotherapy to treat any remaining leukemia cells that are not visible in the blood or bone marrow. (medicalnewstoday.com)
Transplants6
- Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
- Cord Blood Transplants or Bone Marrow Transplants - Which one to choose? (yoursdailynews.com)
- Several studies have been conducted to compare bone marrow and cord blood transplants. (yoursdailynews.com)
- Also are faced greater re\lapse chances, graft failure and high mortality related to bone marrow transplants. (yoursdailynews.com)
- Researchers were said to have compared the results of double-unit cord blood and matched bone marrow transplants conducted in adults. (yoursdailynews.com)
- There were higher chances to develop graft vs. host disease with bone marrow unlike cord blood transplants. (yoursdailynews.com)
Aspiration1
- Our work-up included laboratory tests, radiographic examinations, analysis of bone marrow aspiration, and histopathologic evaluations. (the-medical-dictionary.com)
Malignant5
- Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
- Dr. E. Donnall Thomas and his colleagues discovered a way to treat advanced leukemia by eradicating malignant white blood cells in the bone marrow using high doses of chemotherapy and radiation, and then replacing them with healthy donor cells. (fredhutch.org)
- A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
- The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
- Over the past 40 years, chemotherapy resulted in a progressive improvement in survival rates of patients with malignant neoplasms 1 . (bvsalud.org)
Percentage of bone2
- Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
- 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
Treatment17
- After transplantation, most febrile episodes require in-patient treatment and observation until profound neutropenia and clinically significant infection resolves. (medscape.com)
- Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
- In stage I and II treatment of Hodgkin's disease consists of local radiation, which can abort Hodgkin's disease with very good long-term survival rates. (nethealthbook.com)
- Prostate Cancer Unmasked analyzes 9 different treatment varieties of prostate cancer and their 10-year survival data. (nethealthbook.com)
- Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
- The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
- Survival rates continue to improve with newer and improved treatment modalities. (medicinenet.com)
- Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
- Analysis by treatment received gave similar results, with BMT patients having a 5% (P = 0.8) eight-year EFS advantage over patients who received chemotherapy. (ox.ac.uk)
- Cytotoxic chemotherapy drugs have become the main treatment in recent decades, especially in patients with NSCLC without EGFR, ALK, and ROS gene mutations. (biomedcentral.com)
- This study explores the combination of intestinal microecological regulation and chemotherapy to provide new treatment strategies and basis for lung cancer patients. (biomedcentral.com)
- Despite treatment with chemotherapy and radiation, the patient died of his disease 6 months later. (the-medical-dictionary.com)
- While the results of MRC AML 12 remain immature, there appears to be no survival advantage for a fifth course of treatment. (ox.ac.uk)
- Among postremission patients, survival from CR varied significantly among favorable, intermediate, and unfavorable groups (P= .0003), with significant evidence of interaction (P = .017) between the effects of treatment and cytogenetic risk status on survival. (elsevierpure.com)
- The goal of treatment of this tumor at the distal radius is complete removal of the tumor and reconstruction of the bone defect in order to preserve maximum function of the wrist joint. (jbstjournal.com)
- Over the course of my unique dual training, I developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. (chop.edu)
- Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
Aplastic1
- Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
Overall survival1
- however, there was not a significant difference in overall survival. (bloodcancerstoday.com)
Multicenter study1
- The safety and effectiveness of Omisirge was supported by a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in subjects between the ages of 12 and 65 years. (fda.gov)
Lymphoid3
- Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
- A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. (lookformedical.com)
- Lymphoid leukemia (lymphoid or lymphoblastic leukemia) arises from the lymphoid line of cells in the bone marrow. (medicinenet.com)
Hodgkin's4
- Stage III and IV patients of these patients with low-grade Hodgkin's disease were first treated with combination chemotherapy and then with radiotherapy, if indicated. (nethealthbook.com)
- In selected patients, who will withstand the initial high chemotherapy dosage to wipe out the Hodgkin's cells in the system, a bone marrow transplantation can yield cure rates in more than 50% of patients. (nethealthbook.com)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
Graft4
- Long term follow up will be needed to assess temporal complications and long term survival of the graft. (jbstjournal.com)
- We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
- Similar to all approved umbilical cord products , the label carries a Boxed Warning for infusion reactions, graft versus host disease (GvHD - a condition that occurs when donor bone marrow or stem cells attack the graft recipient), engraftment syndrome (characterized by a noninfectious fever and rash), and graft failure (occurs when new cells do not produce white blood cells, red blood cells and platelets). (fda.gov)
- from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
ABMT1
- Patients with favorable cytogenetics did significantly better following ABMT and alloBMT than with chemotherapy alone, whereas patients with unfavorable cytogenetics did better with alloBMT. (elsevierpure.com)
Infections3
- This type of cancer can also cause serious and damaging effects to the body and lead to symptoms such as fatigue, bone and joint pain, night sweats, infections, weakness, weight loss and fever. (fda.gov)
- The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
- Bacterial or fungal infections by 100 days following transplantation were seen in 39% of subjects receiving Omisirge versus 60% of subjects in the control group who received umbilical cord blood. (fda.gov)
Mutations1
- These mutations can stop bone marrow cells from maturing normally and may cause cells to grow out of control. (medicalnewstoday.com)
Undergo2
- Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
- In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
Dose1
- For subjects with recent chemotherapy or experimental therapy the first dose of study drug must occur after 5 times the half-life of the agent(s). (astrazenecaclinicaltrials.com)
Leukemias2
- This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias: In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (wikipedia.org)
- In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
Donors3
- For patients with suitable donors, transfer to a center capable of performing stem cell transplantations is usually necessary. (medscape.com)
- Early failures are then automatically assigned to the chemotherapy group even if they have donors and so would have gone on to a BMT had they not relapsed or died. (ox.ac.uk)
- The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)
Leukemia2
- In children under 15 in first-world countries, the five-year survival rate is greater than 60% or even 90%, depending on the type of leukemia. (wikipedia.org)
- Leukemia is a cancer of the blood cells and bone marrow. (medicinenet.com)
Hematopoietic cells1
- Patients are simultaneously given supportive care until their bone marrow achieves hematologic remission and is again producing normal hematopoietic cells. (medscape.com)
Stem cells4
- However, the fate of stem cells under chemotherapy has not been fully elucidated. (ijbs.com)
- In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
- This abnormal cell growth often begins in the bone marrow, which is made up of stem cells that form into different types of blood cells with specific functions in the body. (fda.gov)
- G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
Allograft2
- PATIENTS AND METHODS: Analyses comparing the outcome of related donor allogeneic BMT (related allograft) with chemotherapy are unreliable because of selection biases. (ox.ac.uk)
- CONCLUSIONS: Related allograft was not found to be significantly better than chemotherapy, but there was the possibility of a moderate EFS benefit with related allograft. (ox.ac.uk)
ASCT3
- The occurrence of varicella zoster virus (VZV) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (HZ) after autologous SCT (ASCT). (nature.com)
- Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
- Our data indicate that VZV reactivation after ASCT is a frequent event carrying a significant disease burden and it is associated with improved survival. (nature.com)
Peripheral1
- Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
Efficacy2
- This study will seek to investigate the efficacy of "Microbiota modulation of the Gut-Lung Axis" combined with chemotherapy in patients with advanced NSCLC. (biomedcentral.com)
- Based on the theoretical basis of "intestinal and lung axis microecological adjustment", combined with traditional platinum-containing two-drug chemotherapy, the efficacy of the new therapy on patients with advanced NSCLC was observed. (biomedcentral.com)