• Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • SEATTLE--French researchers have recently concluded a study of multiple myeloma in which high-dose chemotherapy combined with autologous bone marrow transplantation (HDC/ABMT) resulted in a significant improvement in response rate and overall survival, compared with conventional chemotherapy. (cancernetwork.com)
  • High-dose melphalan and autologous stem cell transplantation (HDM/ASCT) is widely used in immunoglobulin light chain (AL) amyloidosis, but the benefit is debated mainly because of the high treatment-related mortality (24% in a randomised study comparing HDM/ASCT with oral melphalan/dexamethasone). (lu.se)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
  • The survival of patients suffering from severe LADI is discussed in this paper. (najah.edu)
  • The approach is to do bone marrow transplantation as soon as possible, however, we report 4 patients suffering from severe LADI, who did not have bone marrow transplantation. (najah.edu)
  • Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
  • The development of acute graft-versus-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P=.04) and improved disease-free survival (P=.11). (umn.edu)
  • These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. (umn.edu)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
  • Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
  • Estimate the post complete/partial remission failure-free survival rate in these patients. (knowcancer.com)
  • Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)
  • OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
  • In selected patients, who will withstand the initial high chemotherapy dosage to wipe out the Hodgkin's cells in the system, a bone marrow transplantation can yield cure rates in more than 50% of patients. (nethealthbook.com)
  • Stem cell transplantation is an increasingly effective form of treatment for patients with blood cancer such as leukemia, lymphoma, and myeloma. (science20.com)
  • However, in a recent COG report, the authors demonstrated that intensive multimodal therapies-including high-dose chemotherapy, radiation, and bone marrow transplantation-have enabled improved efficacy for curing patients with regional extraocular retinoblastoma (87% event-free survival [EFS] at 36 months) and metastatic retinoblastoma not involving the CNS (79% EFS at 36 months), while rates for patients with CNS disease continue to be dismal (8% EFS at 36 months). (aao.org)
  • Determine the effect of sargramostim (GM-CSF) on the progression-free 1-year survival of patients with myelodysplastic syndrome who have undergone T-cell-depleted CD34+ augmented allogeneic bone marrow transplantation. (knowcancer.com)
  • OUTLINE: All patients receive elutriated, CD34+ stem cell augmented donor bone marrow according to another protocol on day 0. (knowcancer.com)
  • At diagnosis, 200 patients under age 65 with intermediate or hightumor mass (stage II/III DS), previously untreated multiple myelomawere randomized to receive either a conventional chemotherapeuticregimen of VMCP/BVAP or high-dose therapy, consisting of melphalan(140 mg/m²) and total body irradiation, supported with unpurgedautologous bone marrow, collected after two cycles of VMCP/BVAP.Maintenance with alpha-interferon was used in both arms. (cancernetwork.com)
  • Mesenchymal stromal cell (MSC) transplantation therapy is a promising therapy for stroke patients. (biomedcentral.com)
  • Low bone mass is extremely common among patients awaiting solid organ transplantation. (medscape.com)
  • Moreover, patients are often exposed to therapeutic agents such as steroids, heparin, or loop diuretics, which promote negative calcium balance and bone loss. (medscape.com)
  • Because patients often wait 2 or more years before transplantation, this represents an opportunity to prevent further bone loss and to help restore what may already have been lost. (medscape.com)
  • Osteoporosis is very common among patients awaiting lung transplantation. (medscape.com)
  • Osteopenia (low bone mass) was noted at those sites in 35% and 31% of patients, respectively. (medscape.com)
  • [ 6 ] In other words, only a minority of patients awaiting transplant had normal bone density. (medscape.com)
  • [ 7 ] Prior to transplantation, BMD was decreased at all sites measured, and 35% of patients awaiting transplant had established osteoporosis, as defined by the World Health Organization (WHO). (medscape.com)
  • Moreover, following lung transplantation, nearly three quarters (73%) of patients were at or below the fracture threshold. (medscape.com)
  • in addition 46 patients received corticosteroid, 38 methotrexate, six anti-CD5 ricin A-immunotoxin, and four T cell-depleted bone marrow. (elsevierpure.com)
  • Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • A very rare form is the primary extramedullary manifestation of AML with normal appearing bone marrow, which comprises less than 1% of all patients with AML [ 6 ]. (biomedcentral.com)
  • Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
  • Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
  • We illustrate the procedures using data from a clinical trial of bone marrow transplant patients with leukemia. (bvsalud.org)
  • In patients with cardiac involvement or multiple organ involvement, survival was significantly shorter, median overall survival 49 and 56 months, respectively. (lu.se)
  • In conclusion, long survival times can be achieved in patients with AL amyloidosis treated with HDM/ASCT, also in smaller centres. (lu.se)
  • The object of the statistical analysis is to compare the actual survival among the patients with the hypothetical counter-factual survival that would have occurred if no tx had been performed. (lu.se)
  • Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
  • Decision support for medical images e.g. whole body bone scintigraphy for prostate cancer patients. (lu.se)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • Dr. Attal said that conventional chemotherapy for multiple myelomahas proved disappointing, with a median overall survival rateof only 2 to 3 years and few, if any, complete remissions. (cancernetwork.com)
  • The 5-year probabilities of overall survival adjusted for interval from diagnosis to transplantation, and performance score was 58% for African Americans and 73% for Caucasians. (aamds.org)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. (umn.edu)
  • The average age at time of diagnosis was 10½ - months (range: 3 to 30 months), one patient was diagnosed post-bone marrow transplantation. (bmj.com)
  • Conclusion Our results (100% survival rate) highlight the importance of high index of suspicion, early diagnosis of PID and BCGitis and promote intervention with anti-TB drugs. (bmj.com)
  • The goal of this regional workshop is to perfectly blend research with clinical care practices and to address newly discovered defects, protocols for diagnosis, and treatments, including newborn screening, bone marrow transplantation and gene therapy. (prnewswire.com)
  • Bone marrow studies are necessary to confirm the diagnosis. (rxmed.com)
  • This study reviews results of a radiation-free preparative regimen consisting of busulfan and cyclophosphamide in 65 unrelated allogeneic bone marrow transplant recipients. (elsevierpure.com)
  • Busulfan/cyclophosphamide is an effective preparative regimen in unrelated bone marrow transplantation permitting adequate engraftment and a low relapse rate. (elsevierpure.com)
  • These two therapeutic compounds both indirectly activate p53, thereby presenting a combinational non-genotoxic p53 activation strategy, in contrast to conventional chemotherapy and bone marrow transplantation. (uib.no)
  • Our data suggest some of the observed survival differences between Caucasians and African Americans may be explained by higher rates of acute GVHD and severity of chronic GVHD. (aamds.org)
  • Multiple myeloma occurs when plasma cells in the bone marrow - the cells that produce antibodies - proliferate out of control and lead to organ failure and death. (weizmann-usa.org)
  • The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)
  • Even before transplantation, bone homeostasis may be adversely influenced by the disease process or diseased organ itself (eg, liver, lung, or kidney failure). (medscape.com)
  • Long-term survival following organ transplantation has improved considerably. (medscape.com)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • Historically, the most effective treatment for XSCID has been bone marrow transplantation, [i.e. hematopoietic stem cell transplantation (HSCT)], where a patient receives healthy blood-forming cells from a matched sibling donor, or a half-matched parental donor. (stjude.org)
  • African Americans and Caucasians were matched for age, donor-recipient HLA match, graft type and transplantation year. (aamds.org)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • CXCR4 mutations cause symptomatic hyperviscosity syndrome and high bone marrow activity characteristic of the disease. (wikipedia.org)
  • In stage I and II treatment of Hodgkin's disease consists of local radiation, which can abort Hodgkin's disease with very good long-term survival rates. (nethealthbook.com)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Four-year survival based on disease was 29 ± 27% for chronic myelogenous leukemia (CML) in chronic phase, 20 ± 9% for chronic myelogenous leukemia in accelerated phase, 0% for chronic myelogenous leukemia in blast phase, 32 ± 40% for acute leukemia, and 38 ± 34% for myelodysplasia. (elsevierpure.com)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • At a median follow-up of 40 months, the 5-year postdiagnosis probabilityof survival was 52% for the high-dose regimen vs 12% for conventionaltherapy. (cancernetwork.com)
  • Thanks to improved transplant survival rates, we have now been able to focus our efforts on examining how the procedure affects key aspects of recipients' overall quality of life, including sexual health," said lead study author F. Lennie Wong, PhD, of City of Hope in Duarte, California. (science20.com)
  • Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
  • Recently, Interferon Alpha has been shown to normalize the bone marrow, and bring about remission. (rxmed.com)
  • Median survival after blast crisis is about 2 mo but can be extended to about 8 to 12 mo if remission is achieved. (rxmed.com)
  • Different factors contribute to residual anemia during eculizumab treatment: underlying bone marrow dysfunction, residual intravascular hemolysis and the emergence of C3-mediated extravascular hemolysis. (frontiersin.org)
  • The survival rate of acute lymphoblastic leukemia (ALL) depends on the age of the patient and the response to chemotherapy. (medicinenet.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • When it is sick and unable to produce the normal healthy blood cells, a patient is considered for a bone marrow transplant where the diseased marrow is replaced with healthy marrow. (apollohospitals.com)
  • The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. (chop.edu)
  • Over the course of my unique dual training, I developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. (chop.edu)
  • Prostate Cancer Unmasked analyzes 9 different treatment varieties of prostate cancer and their 10-year survival data. (nethealthbook.com)
  • Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health. (science20.com)
  • Cell transplantation therapy has emerged as a potential candidate treatment for ischemic stroke. (biomedcentral.com)
  • For other discussions on osteoporosis, see the topics Osteoporosis and Pediatric Osteoporosis , as well as Bone Markers in Osteoporosis and Nonoperative Treatment of Osteoporotic Compression Fractures . (medscape.com)
  • Survival rates continue to improve with newer and improved treatment modalities. (medicinenet.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Treatment with recombinant human granulocyte colony-stimulating factor (GCSF) elevates the granulocyte counts, diminishes the number of new infections and improve survival and quality of life. (lu.se)
  • Ferrari et al also prospectively evaluated changes in bone mass in 21 consecutive lung transplant candidates and confirmed this increased osteoporosis prevalence. (medscape.com)
  • The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)
  • Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
  • They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
  • The clinical focus should be to both optimize bone mass before transplantation and to prevent bone loss in the postoperative period. (medscape.com)
  • They further say that this study is one of the longest and is the most inclusive to date evaluating sexual well-being in blood or bone marrow transplantation (stem cell transplantation, SCT) survivors using rigorous, well-validated sexual function assessment tools. (science20.com)
  • As blood or bone marrow transplantation survival rates have steadily increased, researchers are seeking to study and maximize survivors' quality of life. (science20.com)
  • Biology of Blood and Marrow Transplantation. (umn.edu)
  • Leukemia is a cancer of the blood cells and bone marrow. (medicinenet.com)
  • The bone marrow produces a high number of B-Cells, a type of white blood cell that fights against infection-causing a decrease in healthy blood cells. (medicinenet.com)
  • A group of closely related diseases in which the bone marrow produces very few healthy, functioning red blood cells , white blood cells, platelets, or any combination of the three. (medicinenet.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
  • The stem cells in our bone marrow produce blood cells essential for survival. (apollohospitals.com)
  • Leukemia is a group of malignant disorders which affect the blood and blood-forming tissues in the bone marrow, lymphatic system, and spleen. (bvsalud.org)
  • Leukemia is an abnormal proliferation of white blood cells in the bone marrow, resulting in a large accumulation of abnormal leukemia cells in the blood and bone marrow. (bvsalud.org)
  • In this study, we aimed to clarify whether combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs, SB623 cells, and voluntary exercise with running wheel (RW) could exert synergistic therapeutic effects on a rat model of ischemic stroke. (biomedcentral.com)
  • If complications and intracranial plasmacyto- survival were prolonged, the prevalence of mas with no further discussion of the other leptomeningeal MM might be higher. (who.int)
  • However, it disorders such as hypercalcaemia, urae- does not confirm that a long survival time mia and hyperviscosity or due to periph- might increase the prevalence, and a large eral neuro pathy, spinal cord compression series over several years might be needed to and cranial nerve infiltration [ 5 ]. (who.int)
  • To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. (mendeley.com)
  • Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
  • Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
  • These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
  • No end stage renal or other serious medical illness that may limit survival or the ability to participate in this study. (swog.org)
  • Cancer survivors are at risk for poor bone health, given their numerous endocrine morbidities. (chop.edu)
  • My research program focuses on bone health and body composition abnormalities in childhood cancer survivors. (chop.edu)
  • Here we show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several mouse models. (nature.com)
  • Now the question arises whether such tx improves the survival probability, and an ongoing study is hoped to answer that question. (lu.se)