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  • bone
  • The myeloproliferative neoplasms (MPNs), previously termed the myeloproliferative disorders , are characterized by the clonal proliferation of one or more hematopoietic cell lineages, predominantly in the bone marrow, but sometimes in the liver and spleen. (clevelandclinicmeded.com)
  • CLL is a disorder of morphologically mature but immunologically less mature lymphocytes and is manifested by progressive accumulation of these cells in the blood, bone marrow, and lymphatic tissues. (cancer.gov)
  • myeloid
  • Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. (medscape.com)
  • Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants. (uni-muenchen.de)
  • At the same time, recent large-scale sequencing studies have also revealed that acquisition of clonally restricted somatic mutations in MDS-associated genes in hematopoietic cells is not limited to individuals with MDS or related myeloid neoplasms. (bloodjournal.org)
  • The two types of Leukemia cells are Lymphocytic and Myeloid. (smore.com)
  • Myeloid leukemia affect the growth of granulocytes, which are a form of white blood cell. (smore.com)
  • graft
  • Personalizing rabbit anti-thymocyte globulin therapy for prevention of graft-versus-host disease after allogeneic hematopoietic cell transplantation: is there an optimal dose? (helsinki.fi)
  • He is also a member of the Dendritic Cell Biology and Therapeutics Group at the Anzac Research Institute, and, with Professor Derek Hart, is involved in developing new approaches for treatment of graft-versus-host disease based on a better understanding of the role of dendritic cells in this disease. (edu.au)
  • Until recently, myeloablative in conjunction with immunosuppressive conditioning was considered mandatory for the elimination of malignant hematopoietic cells and to prevent graft rejection. (clinicaltrials.gov)
  • The rationale behind the NST strategy is to induce optimal graft-versus-leukemia (GVL) effects for the elimination of all malignant cells by alloreactive immunocompetent cells from a matched donor as an alternative to standard high-dose myeloablative chemo radiotherapy. (clinicaltrials.gov)
  • It was also used in stem-cell transplantation (SCT) for the same purposes (e.g. for generation of tolerance and rejection preclusion) as well as a treatment for graft-versus-host disease (GVHD). (clinicaltrials.gov)
  • IM380 cells are radioresistant in vivo and mice with established tumors can be allogeneically transplanted to analyze graft-versus-tumor effects of transplanted T cells. (jove.com)
  • cancer
  • This cancer causes the white blood cells to multiply rapidly with an abnormal shape. (smore.com)
  • Chan, Amanda L. 'White Blood Cells May Play Role In Spread Of Cancer. (smore.com)
  • P-glycoprotein mediates ceritinib resistance in anaplastic lymphoma kinase-rearranged non-small cell lung cancer. (or.jp)
  • These traits make the IM380 model very valuable for the study of B cell lymphoma pathophysiology and for the development of innovative cancer therapies. (jove.com)
  • To better understand the interaction of cancer cells with the pancreatic microenvironment, we demonstrate an orthotopic model of pancreatic cancer that permits non-invasive monitoring of cancer progression. (jove.com)
  • Luciferase-tagged pancreatic cancer cells are resuspended in Matrigel and delivered into the pancreatic tail during laparotomy. (jove.com)
  • Matrigel solidifies at body temperature to prevent leakage of cancer cells during injection. (jove.com)
  • Primary tumor growth and metastasis to distant organs are monitored following injection of the luciferase substrate luciferin, using in vivo imaging of bioluminescence emission from the cancer cells. (jove.com)
  • Blood
  • Polycythemia vera is a clonal disorder characterized by the overproduction of mature red blood cells. (clevelandclinicmeded.com)
  • 2 ] In this disorder, lymphocyte counts in the blood are usually greater than or equal to 5,000/mm 3 with a characteristic immunophenotype (CD5- and CD23-positive B cells). (cancer.gov)
  • Although myelodysplastic syndromes (MDS) are defined by cytopenias, dysplastic morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging will never develop MDS. (bloodjournal.org)
  • The purpose of the stem cell infusion is to restore blood production, which will be severely impaired by the Cyclophosphamide, Fludarabine and CAMPATH-1H, and to produce a normal immune system that will no longer attack the body. (clinicaltrials.gov)
  • r-ATG is developed by injecting horses with a type of human white blood cells called thymocytes. (clinicaltrials.gov)
  • monoclonal B-cell lymphocytosis
  • Therefore, acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dysplastic hematopoiesis can be considered clonal hematopoiesis of indeterminate potential (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis, which are precursor states for hematologic neoplasms but are usually benign and do not progress. (bloodjournal.org)
  • lymphomas
  • This model bears several advantages over other models as it is genetically induced and mimics the translocation that is detectable in a number of human B cell lymphomas. (jove.com)
  • Infection
  • Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model. (or.jp)