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  • treatment
  • CV extracts showed antiprolife-rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. (spandidos-publications.com)
  • Furthermore CV-45 treatment resulted in alterations of gene expression of PDCD5, MTDH and TNFRSF10b in MTC as well as in SI-NET cells. (spandidos-publications.com)
  • radiation
  • Aurintricarboxylic Acid (ATA) is a chemical compound that in laboratory tests was shown to block the chemical cascade that otherwise allows glioblastoma cells to invade normal brain tissue and resist both chemo and radiation therapy, according to a TGen-led report published today in the scientific journal Oncotarget . (cityofhope.org)
  • Irradiation combined with adding the substance reduced the self-renewal capability of tumor stem cells and delayed their growth significantly better than radiation treatment alone. (dkfz.de)
  • These potentially harmful effects can be avoided by delivering the radiation more precisely to the targeted tissues leading to immediate sterilization of residual tumor cells. (wikipedia.org)
  • While IORT was first used in clinical practice in 1905, the modern era of IORT began with the introduction of electron IORT in the mid-1960s by transporting patients from the OR after the tumor was removed to the radiation department to receive their electron IORT. (wikipedia.org)
  • Electron IORT has the advantages of being able to carefully control the depth of radiation penetration while providing a very uniform dose to the tumor bed. (wikipedia.org)
  • The rationale for TARGIT is to deliver a high dose of radiation precisely to the tumour bed. (wikipedia.org)
  • Radiosurgery uses computer modelling to focus minimal radiation doses at the exact location of the tumor, while minimizing the dose to the surrounding healthy brain tissue. (wikipedia.org)
  • Tumor removal surgeries have been documented in ancient Egypt, hormone therapy and radiation therapy were developed in the late 19th Century. (wikipedia.org)
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • For tumors that could not be completely removed, radiation therapy may also be recommended. (wikipedia.org)
  • In cases of progressive or recurrent disease, or when maximal surgical removal has been achieved, the medical team will consider radiation therapy. (wikipedia.org)
  • neoplasms
  • These tumors are the most frequently recognized malignant or potentially malignant neoplasms of dogs. (caninecancer.com)
  • It is performed for a variety of reasons, including: Inflammation Necrotising pancreatitis Chronic pancreatitis with pain Trauma Neoplasms Adenocarcinoma (85%) Cystadenoma (mucinous/serous) Cystadenocarcinoma Islet cell tumors (neuroendocrine tumors) Papillary cystic neoplasms Lymphoma Acinar cell tumors Severe hyperinsulinemic hypoglycemia The most common surgical procedure involving removal of a portion of the pancreas is called a pancreaticoduodenectomy. (wikipedia.org)
  • terriers
  • Brachycephalic breeds are particularly susceptible to developing the tumors including Bulldogs, Boxers and Boston Terriers. (doghealthinsider.com)
  • Dog breeds that may be more at risk for this tumor include Bulldogs, American Pit Bull Terriers, American Staffordshire Terriers, Scottish Terriers, Greyhounds, Boxers, and Boston Terriers. (wikipedia.org)
  • adenomas
  • Chief cells in parathyroid adenomas also display acid phosphatase activity. (wikipedia.org)
  • There is no rigorous definitional separation from insulinoma, other than the original emphasis that was placed on the observed precise histological recapitulation of normal islet cell structure within the adenomas, which lacked microscopic features of aggressivity. (wikipedia.org)
  • Basal
  • Basal cell tumors are normally located on the neck and head often affecting older dogs (over the age of seven). (doghealthinsider.com)
  • Other tumors that this may be include a basal cell tumor but these are much less common in dogs then in people, or a melanoma. (justanswer.com)
  • Watson J, Depasquale K, Ghaderi M, Zwillenberg S. Nevoid basal cell carcinoma syndrome and fetal rhabdomyoma: a case study. (wikipedia.org)
  • Hardisson D, Jimenez-Heffernan JA, Nistal M, Picazo ML, Tovar JA, Contreras F. Neural variant of fetal rhabdomyoma and naevoid basal cell carcinoma syndrome. (wikipedia.org)
  • histological
  • No significant associations were found between STS mRNA expression and age, menopausal status, tumor size, histological grade, estrogen receptor status, or postoperative adjuvant therapy. (aacrjournals.org)
  • diagnosis
  • Early diagnosis plays an important role in increasing disease-free survival and reducing mortality in patients with various tumor types, and noninvasive diagnostic procedures are more acceptable and have a higher compliance than invasive screening programs. (hindawi.com)
  • brain
  • However, the proclivity of glioblastoma to invade adjacent brain tissue prevents the surgical removal of all tumor cells. (cityofhope.org)
  • Previous TGen-led studies have identified how the binding of molecules TWEAK and Fn14 stimulate glioblastoma cells to migrate, invade and survive in healthy brain tissue. (cityofhope.org)
  • In the mouse model, this combination therapy was found to be more effective in slowing down the growth of such malignant brain tumors and to prolong survival of the animals. (dkfz.de)
  • Glioblastoma is regarded as the most malignant form of brain tumor. (dkfz.de)
  • In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. (dkfz.de)
  • The main manifestation of the condition is the development of symmetric, benign brain tumors in the region of the cranial nerve VIII, which is the "auditory-vestibular nerve" that transmits sensory information from the inner ear to the brain. (wikipedia.org)
  • Fibrillary astrocytomas also called low grade or diffuse astrocytomas, are a group of primary slow growing brain tumors. (wikipedia.org)
  • As the alternative name of "diffuse astrocytoma" implies, the outline of the tumour is not clearly visible in scans, because the borders of the neoplasm tend to send out tiny microscopic fibrillary tentacles that spread into the surrounding brain tissue. (wikipedia.org)
  • However, they are low grade tumors, with a slow rate of growth, so that patients commonly survive longer than those with otherwise similar types of brain tumour, such as glioblastoma multiforme. (wikipedia.org)
  • citation needed] Possible side effects of surgical intervention include brain swelling, which can be treated with steroids, and epileptic seizures. (wikipedia.org)
  • Pleomorphic xanthoastrocytoma (PXA) is a brain tumor that occurs most frequently in children and teenagers. (wikipedia.org)
  • Nine medical institutions in the United States have formed a Pediatric Brain Tumor Consortium, which "is dedicated to the development of new and innovative treatments for children with progressive/recurrent brain tumors not responsive to standard therapies. (wikipedia.org)
  • Stage IV Wilms tumor is defined as the presence of hematogenous metastases (lung, liver, bone, or brain), or lymph node metastases outside the abdomenopelvic region. (wikipedia.org)
  • Tissue
  • These tumors most often are noticed in the skin and subcutaneous tissue. (acvs.org)
  • Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. (dkfz.de)
  • The investigators first studied glioblastoma cells in tissue samples taken during surgical removal of the tumors. (dkfz.de)
  • Tissue studies showed that, under the combination therapy, tumors grew more slowly and less invasively and showed a lower density of newly formed blood vessels. (dkfz.de)
  • Is a soft tissue tumor and a soft tissue calcifaction the same thing? (healthtap.com)
  • You can get calcification in soft tissue without a tumor also, depends on the context. (healthtap.com)
  • Cytology is the examination and study of blood or tissue cells under a microscope that can be done in dogs and other animals. (petplace.com)
  • Cytology may follow an abdominal ultrasound examination or surgical procedure that reveals abnormal organ tissue. (petplace.com)
  • These types of tumors are caused when large cells that are located in a dog's normal connective tissue start to spread and disperse throughout the internal organs and subcutaneous tissue (nodules will sometimes appear). (doghealthinsider.com)
  • Ependymomas are tumors arising from the ependyma, an epithelium-like tissue of the central nervous system. (wikipedia.org)
  • The mass spectrometer detection, mainly from cell membranes and similar tissue, specifically, of complex lipids from similar tissue, however, yields surprising results. (wikipedia.org)
  • This reaction includes T cells, which then attack nervous tissue. (wikipedia.org)
  • The tumor may be seen within the subcutaneous tissues (below the skin), mucosal surfaces or in soft tissue. (wikipedia.org)
  • A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. (wikipedia.org)
  • polypoid
  • GCT can present as a polypoid tumor causing recurrent postobstructive pneumonia. (hindawi.com)
  • Several endobronchial biopsies were obtained from the large polypoid tumor located in bronchus intermedius and from the lesion in left main bronchus. (hindawi.com)
  • The tumors are well defined, non-specific usually solitary masses, but when seen in the head and neck (or genital region), they may be polypoid. (wikipedia.org)
  • abdominal
  • These same factors can also effect the gastrointestinal tract causing ulcers resulting in clinical signs such as vomiting, lack of appetite, melena (bloody stool), anemia (low red blood cells), and abdominal pain. (acvs.org)
  • Play media The first sign is normally a painless abdominal tumor that can be easily felt by the doctor. (wikipedia.org)
  • microenvironment
  • Many of these mechanisms are due to perturbations in the tumor microenvironment that co-opt innate immunity to favor tumor initiation and progression ( 7 ). (jimmunol.org)
  • In these studies, mice with heightened levels of IL-1β or IL-6 in the tumor microenvironment accumulated MDSC with enhanced suppressive activity ( 8 , 9 , 11 ), and bone marrow stem cells cultured with PGE 2 or other E-prostanoid receptor agonists differentiated into MDSC ( 10 ). (jimmunol.org)
  • common
  • These tumors may develop anywhere on the body surface as well as in internal organs, but the limbs, especially the posterior upper thigh, ventral abdomen, and thorax are the most common sites. (caninecancer.com)
  • The tumor is more common in third and fourth decade of life and our patient is the oldest patient, according to our knowledge, to have a GCT. (hindawi.com)
  • We now show that this population of immature myeloid cells induced by a given tumor share a common phenotype regardless of their in vivo location (bone marrow, spleen, blood, or tumor site), and that Gr1 high CD11b high F4/80 − CD80 + IL4Rα +/− Arginase + MDSC are induced by the proinflammatory proteins S100A8/A9. (jimmunol.org)
  • Where appropriate, it carries certain advantages -including the reduction of infection risk, and the provision of more functional cells not subjected to the significant storage durations common among banked allogenic (separate-donor) blood products. (wikipedia.org)
  • Karyotyping of a small number of these tumors revealed a common loss of chromosomes 9 and 11. (wikipedia.org)
  • The most common type is germ cell tumors which are divided into seminomas and nonseminomas. (wikipedia.org)
  • They are the second most common cancerous cause of hypercalcaemia (high serum calcium) in dogs, following T-cell lymphoma. (wikipedia.org)
  • structures that are common amongst other contractile cells. (wikipedia.org)
  • The most common type is transitional cell carcinoma. (wikipedia.org)
  • Spontaneous regression is common in these tumors, and it is mediated by infiltration of CD8-expressing T cells followed by expression of Type 1 T helper cell cytokines (such as Interferon-gamma) and recruitment of antitumour effector cells[disambiguation needed]. (wikipedia.org)
  • glioblastoma
  • Plus, invasive glioblastoma cells show resistance to TMZ, resulting in the cancer's eventual return and the patient's death, often within a year. (cityofhope.org)
  • The scientific paper, Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells , was funded by The Ben & Catherine Ivy Foundation, and by grants from the National Institutes of Health (NIH). (cityofhope.org)
  • Glioblastoma cells often produce large amounts of a growth factor called TGF-β (transforming growth factor beta). (dkfz.de)
  • In addition, the factor seems to support the self-renewal capability of glioblastoma stem cells. (dkfz.de)
  • However
  • however, the mechanisms by which specific inflammatory mediators contribute to tumor growth remain unclear. (jimmunol.org)
  • However, other kidney tumors can cause hypertension by secreting renin. (wikipedia.org)
  • However, irrespective of histologic type, these tumors almost never show necrosis or increased mitoses. (wikipedia.org)
  • The patient will, however, need repeated MRIs to monitor for tumor re-growth. (wikipedia.org)
  • However, after the drug was stopped, the tumors regrew. (wikipedia.org)
  • However, the patient is still at risk for, and often develops, new tumors arising from subependymal nodules elsewhere in the ventricular system. (wikipedia.org)
  • found
  • Fibrillary astrocytomas arise from neoplastic astrocytes, a type of glial cell found in the central nervous system. (wikipedia.org)
  • Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells. (wikipedia.org)
  • progression
  • MDSC impair tumor immunity and thereby facilitate carcinogenesis and tumor progression by inhibiting T and NK cell activation, and by polarizing immunity toward a tumor-promoting type 2 phenotype. (jimmunol.org)
  • We ( 8 , 9 , 10 ), and others ( 11 , 12 ), recently reported that inflammation also promotes tumor progression by blocking adaptive immunity through the induction of myeloid-derived suppressor cells (MDSC), which prevent the activation of CD4 + and CD8 + T cells. (jimmunol.org)
  • anal
  • It may also affect the horse's ability to turn their head from side to side and eat and drink comfortably if the tumor is on the throat latch area, or cause faecal impaction if tumor is on the anal region. (wikipedia.org)
  • Histiocytosis
  • It is an abnormal growth in the skin of histiocytes (histiocytosis), a cell that is part of the immune system. (wikipedia.org)
  • A similar disease in humans, Hashimoto-Pritzker disease, is also a Langerhans cell histiocytosis. (wikipedia.org)
  • melanoma
  • An equine melanoma is a tumor that results from the abnormal growth of melanocytes in horses. (wikipedia.org)
  • Since 80% of grey horses will develop a melanoma tumor at some point in their lives, it is important to know what kind of treatments are available. (wikipedia.org)
  • secretion
  • Between 25 and 40 percent of dogs with these tumors will also develop hypercalcaemia through secretion of parathyroid hormone-related protein by the tumor. (wikipedia.org)