Surgery cold ischemia. Medical search. Frequent questions

Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? (hindawi.com)
This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI). (hindawi.com)
Although a large number of drugs and agents (including Ca 2+ -channel blockers, mannitol, acadesine, adenosine, Na + /H + -exchange inhibitors, and N-acetylcysteine (an antioxidant)) have been shown to protect against ischemia-reperfusion injury (IRI) in the kidney in vitro and in vivo (in either rat or mouse), all have failed in either large animal or human trials [ 5 - 8 ]. (hindawi.com)
The central role of lung ischaemia-reperfusion injury in pulmonary dysfunction after cardiac surgery, particularly thoracic organ transplantation, has been well recognised. (ersjournals.com)
Post-operative pulmonary dysfunction following the use of cardiopulmonary bypass is a frequently observed phenomenon that is associated with lung ischaemia-reperfusion injury 2 , 3 . (ersjournals.com)
Unlike any other organ in the human body, the lung possesses two blood supply networks with extensive anastomotic connections and a total of three potential sources of lung tissue oxygenation, thus making lung ischaemia-reperfusion injury more intriguing to study 2 . (ersjournals.com)
Since the mid-1980s, the role of neutrophils, free radicals and other inflammatory mediators in ischaemia-reperfusion injury has been extensively investigated 4 . (ersjournals.com)
Nevertheless, these mediators appear to contribute only in part to lung ischaemia-reperfusion injury. (ersjournals.com)
The current review highlights the latest research findings in apoptosis after acute lung ischaemia-reperfusion injury. (ersjournals.com)
Tissue necrosis after lung ischaemia-reperfusion injury has been recognised to be associated with significantly worsened lung function, related to the high degree of inflammation. (ersjournals.com)
Quercetin and curcumin up-regulate antioxidant gene expression in rat kidney after ureteral obstruction or ischemia/reperfusion injury. (cryonet.org)
Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. (holyh2.com)
Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. (holyh2.com)
Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. (holyh2.com)
Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. (holyh2.com)
Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. (holyh2.com)
Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. (holyh2.com)
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. (holyh2.com)
The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. (akjournals.com)
The process, however, contributes to ischemia/reperfusion injury, inflammatory damage that occurs when blood flow is interrupted until the liver is transplanted. (wustl.edu)
most recently, a study in the American Journal of Transplantation reported that CD47 blockade reduces ischemia-reperfusion injury. (wustl.edu)

Outcomes following robotic surgery compared favorably to conventional transplantation. (medscape.com)
Robotic surgery may therefore enable obese patients with ESRD to access kidney transplantation and may thereby reduce health disparities in groups with a high prevalence of obesity and ESRD. (medscape.com)
A pharmacological agent that could reduce the risk of IRI and prolong the "safe" warm ischemia time would cause a global transformational change in the utilization of partial nephrectomy, with broader implications for renal transplantation, cardiac surgery, and the myriad other surgeries that involve IRI. (hindawi.com)
Those injuries sometimes remain undetected during the surgery, which can lead to serious problems for the patients, said study first author Dr. Ali Zarrinpar, an assistant professor of surgery in the Division of Liver and Pancreas Transplantation. (vetscite.org)
Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures. (nih.gov)
The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
Damage to organs during transplantation occurs in 2 phases: first, the warm ischemic phase, then the cold ischemic phase. (medscape.com)
Ischaemia-reperfusion-induced pulmonary dysfunction is a significant clinical problem in cardiac surgery and, particularly, lung transplantation 1 . (ersjournals.com)
Pulmonary ischaemia-reperfusion can cause cellular breakdown and death of lung epithelial tissue, which may contribute to the magnitude and duration of pulmonary dysfunction seen after cardiopulmonary bypass and lung transplantation 2 , 4 . (ersjournals.com)
In experimental studies of rodent single-lung transplantation, a short duration of ischaemia (20 min) and reperfusion was associated with neither increased cellular necrosis nor apoptosis of the transplanted lung compared with the pre-retrieval lungs 12 . (ersjournals.com)
BACKGROUND: Cold ischemia and reperfusion during renal transplantation result in release of reactive oxygen species. (cryonet.org)
BACKGROUND: Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. (cryonet.org)
Buemi A, Duisit J, Musuamba F, Darius T, De Meyer M, Aydin S, Kanaan N, Devresse A, Goffin E, Mourad M. Donor Age and Ischemia Time Are Independent Factors Affecting Graft Survival after En Bloc Kidney Transplantation from Donors Less than Three Years of Age. (lidsen.com)
En bloc kidney transplantation from donors aged less than one year was associated with high early graft loss and poor long-term survival rates. (lidsen.com)
The extracorporeal life support systems (ECLS) have been lifesaving and facilitating complex cardiothoracic surgeries, and the ESOP technology has the potential to increase the number of the transplantable donor organs, and to improve the outcomes of transplantation. (frontiersin.org)

2. Self-retaining barbed suture reduces warm ischemia time during laparoscopic partial nephrectomy. (nih.gov)
7. The use of self-retaining barbed suture for inner layer renorrhaphy significantly reduces warm ischemia time in laparoscopic partial nephrectomy: outcomes of a matched-pair analysis. (nih.gov)
Zero ischaemia', sutureless laparoscopic partial nephrectomy for renal tumours with low nephrometry score. (unifi.it)
in the present paper, a ' zero ischaemia ' , sutureless laparoscopic partial nephrectomy for renal tumours with low nephrometry score is possible and can overcome the ischaemic obstacle. (unifi.it)

Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). (holyh2.com)
Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. (holyh2.com)
Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. (holyh2.com)
Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (nih.gov)

Since the late 1990s, scientists have recognised that the different processes following ischaemia-reperfusion, although closely related, cause lung injury by activation of different inflammatory pathways 2 , 4 , 6 . (ersjournals.com)
1) Cold: The invasion of cold air causes changes in blood circulation, vasoconstriction, ischemia, and inflammatory changes in local fibrous tissues. (legiralmassagegun.com)

10. Use of self-retaining barbed sutures decreases cold ischemia time in open nephron-sparing surgery. (nih.gov)
However, while the majority of cancers are suitable for partial nephrectomy, concern about the warm ischemia time has meant that only around 25% of small kidney cancers are treated with nephron-sparing surgery [ 3 ]. (hindawi.com)

Trends in the incidence, treatment, and outcomes of acute lower extremity ischemia in the United States Medicare population. (msdmanuals.com)

Eleven variables available on admission to the ICU can be used for the prediction of 30-day mortality after cardiac surgery. (perfusion.com)
Volume 36, Number 4 Published by W.. B. Saunders Company Hypothermia for General and Cardiac Surgery With Techniques of Some Open Intracardiac Procedures Under Hypothermia HENRY SWAN, M.D., F.A.C.S.* For many years there have been sporadic attempts to explore the value of lowering body temperature as a therapeutic modality. (nih.gov)
The prevention and successful treatment of this complication com- Hypothermia for General and Cardiac Surgery 1011 prise an essential step in the safe management of the hypothermic indi- vidual. (nih.gov)

OBJECTIVES: This study compared clinical and transmission electron microscopic aspects of myocardial protection during mitral valve replacement using warm retrograde perfusion in empty beating versus arrested heart with cold blood anterograde cardioplegia. (fiocruz.br)
METHODS: Randomized study to evaluate myocardial cellular ischemia-reperfusion of both techniques to replace the mitral valve. (fiocruz.br)

A new study suggests that the amount of time donated blood is stored can substantially affect patients getting blood transfusions during heart surgery. (perfusion.com)
BNKT recipients had longer cold ischemia time, required more ICU care, increased blood transfusions and longer hospital stays. (nih.gov)
This is a time-critical step due to the critical ischemia period of renal tissue. (hindawi.com)
The two key factors that contribute to postoperative loss of renal function are ischemia time and degree of parenchymal loss [ 2 ]. (hindawi.com)
Current clinical data support a "safe" warm ischemia time of 25 minutes, or a cold ischemia time (when the kidney is placed on ice slush) of 35 min while up to two hours can be tolerated [ 4 ]. (hindawi.com)
UCLA researchers have discovered an optimal way to image the bile ducts during gallbladder removal surgeries using a tested and safe dye and a real-time near-infrared florescence laparoscopic camera, a finding that will make the procedure much safer for the hundreds of thousands of people who undergo the procedure each year. (vetscite.org)
Cold ischemia time was 17 hours and warm ischemia time was 30 minutes. (bvsalud.org)
The surgery lasted 5 hours and 10 minutes and the total anesthesia time was 6 hours. (bvsalud.org)
In order to shorten the hot ischemia time and improve the patient's cosmetic outcome, a minor oblique incision in the left, lower quadrant was prepared in advance of the laparoscopic donor nephrectomy for use as a site for the autograft to be procured through the retroperitoneal space and as a transplant site for the autograft. (biomedcentral.com)
No significant difference was observed between the groups regarding recipient age, time on dialysis, ischemia time, human leukocyte antigen matching, the time needed to reach serum creatinine levels of ≤2 mg/mL, and patient survival. (lidsen.com)
In a multivariate analysis, donor age ( p = 0.01) and ischemia time ( p = 0.02) were independent factors affecting graft survival. (lidsen.com)
Variables analyzed included: age, sex, comorbidities, type of diabetes, types of pancreas transplants, time in waiting list, preservation solution, time of cold and warm ischemia (CI and WI), hospital and ICU length stay, complications and overall patient's and graft's survival. (tts2022.org)
Currently donated livers are flushed with a cold preservation solution and iced down at the time the organ is recovered. (wustl.edu)
Frostbite - Occurs when the skin is exposed to cold for a long time, causing the freezing of the skin or other underlying tissue. (physio-pedia.com)

Ischemia occurs when the narrowed coronary artery may reach a point where it cannot supply enough oxygen-rich blood to meet your heart's needs. (cesarnahasmd.com)
However, coronary artery disease can progress to a point where ischemia occurs even while you rest. (cesarnahasmd.com)

So, traditionally, most centers will do either clamping with cold ischemia, where the kidneys packed in ice, or clamping with warm ischemia. (urologytimes.com)

Journal of Thoracic and Cardiovascular Surgery. (wustl.edu)

Hydrogen as additive of HTK solution fortifies HTK's preservation efficacy for cardiac grafts subjected to prolonged cold ischemia by inhibiting cold ischemia-induced up-regulation of oxidative stress, inflammation mediators, and apoptosis. (perfusion.com)
However, during ischemia the activity of the antioxidant enzymes is diminished, leading to an increase in the formation of superoxide radicals and oxidative stress at reperfusion [ 9 ]. (hindawi.com)
Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion Hinjury. (holyh2.com)

It was first described by Maurice Raynor 1862 who referred to "local asphyxia of the extremities" and "episodic digital ischaemia provoked by cold and emotion. (breastfeedingnetwork.org.uk)

The initiation phase corresponds to the period of exposure to ischemia or nephrotoxins. (medscape.com)
The controversy has been that some in the field have argued that exposure to that ischemia, that timeframe where there's no blood flow, that it might predispose the kidney to progressive longitudinal decline and function. (urologytimes.com)
And specifically, is exposure to ischemia really one of the major risk factors? (urologytimes.com)
And is it related to exposure of ischemia versus other factors? (urologytimes.com)
These symptoms, known as the Four E's, occur most commonly during Exertion (activity),Eating, Excitement and Exposure to cold. (cesarnahasmd.com)

Frostbite may also cause a thermal burn by indirect cellular injury from crystallization of water in tissue, ischemia, and reperfusion, leading to skin necrosis and deep tissue injury. (spirewrite.org)
It is due to direct cellular injury from the crystallisation of water in tissue and indirect injury from ischemia [5] . (physio-pedia.com)

Transplant surgery chief William Chapman, MD, examines a liver for normo-thermic machine perfusion. (wustl.edu)
While the donated liver is on the normothermic perfusion pump system, we can check parameters of function and have confidence determining whether the organ is going to work effectively, and then you can say, 'OK, we know whether we can use it,'" says Transplant Surgery Chief William Chapman, MD, the Eugene M. Bricker Chair of Surgery. (wustl.edu)

Obviously, many degrees of hypothermia are possible, the range for From the Department of Surgery, University of Colorado School of Medicine, Denver, Colorado. (nih.gov)
Professor and Head, Department of Surgery, University of Colorado School of Medicine. (nih.gov)

Extracorporeal circulation (ECC) systems, including cardiopulmonary bypass, and extracorporeal membrane oxygenation have been an irreplaceable part of the cardiothoracic surgeries, and treatment of critically ill patients with respiratory and/or cardiac failure for more than half a century. (frontiersin.org)
Extracorporeal circulation systems (ECC), have been an essential part of life-support in critically ill patients and cardiothoracic surgeries ( 1 ). (frontiersin.org)
He was the chairman of cardiothoracic surgery at Loma Linda and has performed more pediatric heart transplants than almost anyone else in the world. (levelshealth.com)
Can you talk a little bit about how, after doing thousands of heart surgeries and being deep in the cardiothoracic surgery world, you decided to leave and realized you could possibly make a bigger impact by helping people understand their diets and their holistic health? (levelshealth.com)

Most intrinsic ARF cases are associated with ATN from prolonged ischemia or toxic injury, and the terms ischemic and nephrotoxic ATN are frequently used synonymously with ischemic or nephrotoxic ARF. (medscape.com)
Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury. (hindawi.com)

Pathologically, ATN is characterized by varying degrees of tubule cell damage (see Pathophysiology) and by cell death that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. (medscape.com)
Unlike heart disease, diabetes or cancer, sepsis is usually the result of something else, like a cut or scrape, surgeries or invasive devices. (cdc.gov)

Acute peripheral arterial occlusion is characterized by severe pain, cold sensation, paresthesias (or anesthesia), pallor, and pulselessness in the affected extremity. (msdmanuals.com)

Recent studies suggest that lung apoptosis following ischaemia-reperfusion could be equally important in the development of post-operative lung dysfunction. (ersjournals.com)
or one could achieve prolonged safe regional or general ischemia for technical operative purposes. (nih.gov)

Most recently, transplant surgeons at Barnes-Jewish Hospital are participating in a national trial comparing traditional cold storage vs. normothermic machine perfusion (NMP) for donor organs. (wustl.edu)

Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. (cryonet.org)
Chapman led an animal study showing that NMP improved organ function in donation-after-cardiac death (DCD) livers and published findings in the journal Surgery. (wustl.edu)

The current literature on the mechanism and pathways involved in pulmonary dysfunction and, in particular, its relationship with apoptosis after lung ischaemia-reperfusion is briefly reviewed here. (ersjournals.com)
The final pathways, after lung ischaemia and reperfusion, leading to cellular damage, necrosis or apoptosis of the pulmonary epithelium remain to be fully elucidated. (ersjournals.com)
Recently, the mechanisms involved in pulmonary apoptosis following lung ischaemia-reperfusion have begun to be understood 5 . (ersjournals.com)
However, the complex relationship between ischaemia-reperfusion and lung apoptosis is only beginning to emerge. (ersjournals.com)
After prolonged periods (up to 18 h) of cold ischaemic lung preservation without reperfusion, a high percentage of cell necrosis (but not apoptosis) can be observed 12 , 13 . (ersjournals.com)

In the theory of sports rehabilitation, fascial medicine has a history of decades, and myofascial relaxation surgery is the use of the fascial system to promote the human body's mechanical, neurophysiological, and adaptive potential operating concepts and therapeutic philosophy. (legiralmassagegun.com)
Compartment Syndrome Compartment syndrome is increased tissue pressure within a closed fascial space, resulting in tissue ischemia. (msdmanuals.com)

Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. (nih.gov)

A total of 52 en bloc kidney graft transplantations were performed. (lidsen.com)

Annals of Plastic Surgery. (wustl.edu)

The etiology of rhabdomyolysis is diverse and includes hereditary (metabolic diseases, dystrophinopathies, channelopathies) and acquired disorders (excessive muscular stress, ischemia, toxic damage, infections). (medlink.com)

Additionally, the muscles receive direct injury from the current flow, which may result in cardiac ischemia, arrhythmias, cardiac arrest and myoglobinuria with subsequent acute kidney injury (Friedstat, Brown, & Levi, 2017). (spirewrite.org)

However, its effectiveness and accuracy for guiding blood glucose management in major surgeries remains unclear. (biomedcentral.com)
Sometimes there is a lump in the blood vessels and the feet may get cold. (nashaband.com)
Relaxation surgery will quickly affect the local blood and tissue viscosity through the nervous system, so you can quickly feel the changes in tissue softness (relaxation). (legiralmassagegun.com)
Treatment is usually continued for 4 to 24 hours, depending on severity of ischemia and signs of thrombolysis (relief of symptoms and return of pulses or improved blood flow shown by Doppler ultrasonography). (msdmanuals.com)

Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. (hindawi.com)
Beyond this period, critical ischemia ensues, where renal cells are irreversibly injured, eventually resulting in nephron loss and chronic kidney disease in 5-17% patients [ 4 ]. (hindawi.com)
The aim of this study was to describe our experience of perioperative treatment of pediatric patients undergoing en bloc kidney transplant. (bvsalud.org)
METHODS: Between September 2002 and August 2004, 43 dialysis dependent cadaveric kidney recipients were enrolled into a study using Oxy-Q which contains 480 mg of curcumin and 20 mg of quercetin, started after surgery and taken for 1 month. (cryonet.org)

Lung tissue necrosis after prolonged ischaemia is known to worsen lung function, which was believed to be due largely to adjacent tissue inflammation. (ersjournals.com)

The treatment of nutcracker syndrome by retroperitoneal laparoscopic nephrectomy with ex vitro repair and autotransplantation is a simpler and less invasive procedure than open surgery. (biomedcentral.com)

The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia (approximately 60% spontaneous survival), and poor prognoses with drug-induced ALF, hepatitis B, and indeterminate cases (approximately 25% spontaneous survival). (nih.gov)

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. (holyh2.com)
The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. (holyh2.com)

Thermal burn injuries are caused by external heat sources (hot or cold), scalds (hot liquids), as a result of energy transfer, hot solid objects, steam and cold objects. (physio-pedia.com)

However, understanding of the complex pathophysiology of ischaemia-reperfusion-induced lung injury remains incomplete. (ersjournals.com)
The aim of this study is to examine whether cold storage induced cell injury can be ameliorated by adding flavonoids directly to preservation solutions. (cryonet.org)
CONCLUSION: Cold storage induced injury of renal tubular cells was substantially ameliorated by adding selected flavonoids directly to preservation solutions. (cryonet.org)
Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. (cryonet.org)
Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. (cryonet.org)

Another set of symptoms associated with coronary artery disease may be caused by a condition called ischemia. (cesarnahasmd.com)
Ischemia may be present without any warning symptoms. (cesarnahasmd.com)

An unknown but certainly significant number of patients have colostomies following surgery for cancer, ulcerative colitis, Crohn's disease, diverticulitis, and other serious bowel conditions. (aafp.org)
Patients with arterial ulcers should not be treated with compression therapy, but will often need vascular surgery. (coloplast.us)
The purpose of this study was to perform minimal-incision technique surgery without a specific incision length cutoff on a cohort of nonselected, consecutive THA patients to determine if patient height, weight, body mass index, gender, type of femoral fixation, and/or age correlated with incision length. (jsoaonline.com)
With his extensive experience, research contributions, and dedication to his patients, Dr. Bunger is recognized as a leading expert in vascular surgery. (airomedical.com)

Thrombotic causes are now more common due to aging populations and advancements in vascular surgery. (libsyn.com)
He obtained his medical license in Hamburg in 1997 and went on to specialize in surgery at Rostock University Medical Center, with additional specializations in endovascular and vascular surgery. (airomedical.com)
His research has focused on various aspects of vascular surgery, including using local hemostatic and antiplatelet agents in carotid endarterectomies and the vascular response to absorbable sirolimus-eluting polymeric scaffolds. (airomedical.com)
Currently, Dr. Bunger serves as the Head Doctor of the vascular surgery department at the Vivantes Hospital Humboldt in Berlin-Reinickendorf, Germany. (airomedical.com)
He is a founding member of the North German Vascular Doctors and a member of prestigious professional associations such as the German Society of Vascular Surgery and the Association of German Surgeons. (airomedical.com)

Indeed, it remains of utmost importance to explore new ways to face this surgical step, in order to minimize or even eliminate the detrimental effect of renal ischaemia. (unifi.it)

It is then treated with angioplasty, stenting or bypass surgery. (nashaband.com)
Treatment consists of embolectomy (catheter or surgical), thrombolysis, or bypass surgery. (msdmanuals.com)

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