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  • glycoprotein
  • Laminin is a heterotrimeric extracellular glycoprotein, consisting of an α, a β and a γ chain (Ehrig et al. (springer.com)
  • To resolve the controversy concerning the ability of exogenous GAGs to modulate neurite growth, we examined the effects of a panel of structurally different GAGs on the growth of postnatal rat cerebellar granule neurons and embryonic rat dorsal root ganglia (DRG) neurons on substrates of either laminin or the L1 glycoprotein. (jneurosci.org)
  • They suggest that while CS and KS GAGs may not exert strong negative influences over axonal growth in regions of the developing CNS where the L1 glycoprotein is abundant, these GAGs are capable of inhibiting the growth of axons that extend within an environment rich in laminin. (jneurosci.org)
  • chain
  • 1997 ). However, the major constituent of the basal lamina of adult skeletal muscle is not laminin 111, but laminin 211 (Sanes 2003 ), in which the α chain is LAMA2 (α2). (springer.com)
  • effect
  • Conversely, when AChR patching was blocked by treatment with anti-AChR antibody mAb 35, agrin was still able to effect patching of laminin and HSPG. (semanticscholar.org)
  • growth
  • On L1 surfaces, however, these GAGs are either extremely weak inhibitors of neurite extension or, in the case of CS4, a modest stimulator of neurite growth. (jneurosci.org)
  • muscle
  • A major constituent of the basal lamina of adult skeletal muscle is Laminin 211 (also known as merosin). (springer.com)