LymphocyteMoleculesAPCsCD48Chimeric antigenDifferentiationTumor necrosMacrophagesLigandMoleculeProteinsCapture antigenSuperfamilyDendritic cellsInhibitoryImmunological synapseInteractionsCCR5LymphocytesRosette formationAffinityBindsCellsExtracellularSolubleErythrocyte receptorCD47MigrateGeneActivationExpressionInteractionRecognizeSignals via
Lymphocyte9
- It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. (wikipedia.org)
- Human cell surface receptor CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), plays a critical role in the early stages of immune response through interacting with CD2. (bvsalud.org)
- Mouse monoclonal to CD2.This recognizes a 50KDa lymphocyte surface antigen which is expressed on all peripheral blood T lymphocytes,the majority of lymphocytes and malignant cells of T cell origin, including T ALL cells. (irjs.info)
- CD58 , or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages . (wikidoc.org)
- CD2 interacts with lymphocyte function-associated antigen (LFA-3/CD58) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. (ptglab.com)
- The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
- A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
- B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
- This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells . (wikidoc.org)
Molecules8
- 5-7 These molecules are important components of the immunological synapse (IS), which enables antigen-dependent communication between T cells and antigen-presenting cells (APCs). (ashpublications.org)
- Adhesion molecule pairs, such as CD2-CD58 and CD11a-CD54, induce a transient adhesion of T cells to APCs, after which the T-cell receptor (TCR) scans the cell surface for antigens presented in the context of human leukocyte antigen (HLA) molecules. (ashpublications.org)
- Upon antigen recognition, F-actin polymerization enables stabilization of the mature IS with a central region that contains the TCR-HLA molecules and interacting adhesion molecules in the periphery. (ashpublications.org)
- IL-10 controls inflammatory processes by suppressing the expression of proinflammatory cytokines, chemokines, adhesion molecules as well as antigen-presenting and costimulatory molecules in monocytes/macrophages, neutrophils, and T cells. (angioproteomie.com)
- This is realized by downregulation of constitutive and IFN¿-induced cell surface levels of MHC class II, of costimulatory molecules such as CD86, and of some adhesion molecules such as CD58. (angioproteomie.com)
- LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
- When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation. (rush.edu)
- T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
APCs4
- CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in mice and CD58 in humans, that are present on antigen-presenting cells (APCs). (bvsalud.org)
- This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation , when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. (wikidoc.org)
- The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
- [ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
CD482
- However, both CD48 and CD58 are also expressed on T cells. (bvsalud.org)
- CD2-CD48 interactions on T cells enabled more robust T cell receptor (TCR) signals, including protein tyrosine phosphorylation. (bvsalud.org)
Chimeric antigen2
- Tisagenlecleucel is a chimeric antigen receptor T-cell (CAR-T) treatment-a type of therapy in which patients' own T cells are harvested, reprogrammed to target a protein called CD19 that is expressed on the surface of cancer cells, and returned to the patient to fight ALL and lymphoma. (aacr.org)
- Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Differentiation4
- CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. (wikipedia.org)
- SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation. (uchicago.edu)
- A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. (bvsalud.org)
- In molecular biology , CD4 ( cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells , monocytes , macrophages , and dendritic cells . (wikidoc.org)
Tumor necros6
- Macrophages are the main source of IL-10, and its secretion can be stimulated by endotoxin (via Toll-like receptor 4, NF-¿B dependent), tumor necrosis factor TNF-a (via TNF receptor p55, NF-¿B-dependent), catecholamines, and IL-1. (angioproteomie.com)
- A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN . (nih.gov)
- Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
- This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
Macrophages2
- CD58 expression correlated with infiltrations of CD4+ lymphocytes, NK cells, and macrophages cells. (bvsalud.org)
- IL-10 inhibits the capacity of monocytes and macrophages to present antigen to T cells. (angioproteomie.com)
Ligand2
- The major ligand for CD2 is CD58 (also known as LFA-3). (biolegend.com)
- The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
Molecule1
- The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
Proteins3
- In this study, Pulsipher and colleagues investigated the predictive value of flow cytometry-a technique that interrogates proteins on the cell surface-and next-generation DNA sequencing minimal residual disease (NGS-MRD) monitoring, using blood and bone marrow samples collected from the ELIANA and ENSIGN phase II clinical trials at one, three, six, nine, and 12 months after tisagenlecleucel infusion. (aacr.org)
- Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
- [ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
Capture antigen1
- [ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
Superfamily2
- CD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. (biolegend.com)
- Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)
Dendritic cells6
- Langerhans cells (LCs) are antigen-presenting dendritic cells located in the skin. (transhumanist.ru)
- NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
- The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
- Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
- Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
- Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
Inhibitory3
- High CD58 expression is implicated in T cell-mediated immune responses as an immunosuppressive factor and affect inhibitory immune checkpoint genes. (bvsalud.org)
- Killer cell inhibitory receptors. (embl.de)
- CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
Immunological synapse3
- However, the CD2-CD58 axis, an important component of the immunological synapse, remains unknown in LGG. (bvsalud.org)
- Hodgkin tumor cells extensively interact with rosetting CD4 + T cells by immunological synapse formation involving HLA class II and CD58. (ashpublications.org)
- 00:14.1 Today, I'm going to talk to you about 00:16.1 the immunological synapse, 00:17.2 Part 1 - antigen recognition. (ibiology.org)
Interactions4
- Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. (uchicago.edu)
- The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
- To analyze the interactions between M. tuberculosis and immune cells, human peripheral blood monocyte-derived immature DCs were infected with M. tuberculosis H37Rv wild type strain and flow cytometry was used to analyse cell surface expression markers. (biomedcentral.com)
- The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (antibodies-online.com)
CCR51
- These co-receptors are chemokine receptors CCR5 or CXCR4 . (wikidoc.org)
Lymphocytes5
- Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, neither do common ALL cells. (irjs.info)
- Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3. (ox.ac.uk)
- The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
- CD2 is a cell surface glycoprotein present on a majority of thymocytes, all mature T cells and subset of NK cells but not on B lymphocytes. (ptglab.com)
- A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Rosette formation1
- Intriguingly, the level of CD58 expression correlated with the extent of rosette formation, and CD58 knockout or CD2 blockade reduced both rosette formation and T-cell activation. (ashpublications.org)
Affinity3
- The intraepidermal nerve fibers and subepidermal nerve plexus were identified by immunohistochemistry of protein gene product 9.5 (PGP 9.5) and tropomyosin-receptor kinase (Trk) A, the high affinity nerve growth factor receptor. (transhumanist.ru)
- A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
- CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
Binds1
- It binds to CD2 (LFA-2) [3] [4] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. (wikidoc.org)
Cells15
- Recent research identified CD58 as a surface marker of colorectal cancer (CRC), which can upregulate the Wnt pathway and promote self-renewal of colorectal tumor-initiating cells (CT-ICs) by degradation of Dickkopf 3. (bvsalud.org)
- In conclusion, T-cell rosetting in HL is established by formation of the IS, and activation of rosetting T cells critically depends on the interaction of both TCR-HLA-II and CD2-CD58. (ashpublications.org)
- The results demonstrate that the motility of LGLs depends on the type of receptor in the opposing bilayer, the receptor mobility in the bilayer, and the activation of the cells. (ox.ac.uk)
- [5] . Genomic region containing the single-nucleotide polymorphism rs1335532, associated with high risk of multiple sclerosis , has enhancer properties and can significantly boost the CD58 promoter activity in lymphoblast cells. (wikidoc.org)
- Because the CD19 receptor is also expressed on normal B cells, treatment causes B-cell aplasia-the depletion of a patient's B cells. (aacr.org)
- Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
- LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
- Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
- CAR T cell therapy for hematological cancers can be highly effective, but is currently limited to antigens that are only expressed by tumor cells or by lineages that are non-essential. (acir.org)
- Targeting antigens expressed by all tumor cells is often associated with on-target/off-tumor toxicities to normal hematopoietic cells. (acir.org)
- Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
- Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. (uchicago.edu)
- Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. (musc.edu)
- DCs comprise a family of antigen presenting cells that act like 'conductors' of the immune response in their capacity to orchestrate signals derived from the different parts of the immune system [ 2 ]. (biomedcentral.com)
- CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)
Extracellular1
- CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
Soluble1
- In addition, it enhances the production of anti-inflammatory mediators such as IL-1RA and soluble TNF-a receptors. (angioproteomie.com)
Erythrocyte receptor1
- It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. (wikipedia.org)
CD471
- Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Migrate1
- After antigen uptake, DC rapidly migrate to the draining secondary lymphoid organ. (biomedcentral.com)
Gene1
- Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis . (wikidoc.org)
Activation4
- MetaSape pathways analysis revealed the involvement of CD58 in regulating T cell activation, leukocyte-mediated immunity, and the positive regulation of cell activation in WHO grade II and III. (bvsalud.org)
- However, it is unknown whether this synapse is fully assembled and leads to T-cell activation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class II (HLA-II). (ashpublications.org)
- Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation. (rndsystems.com)
- and this enhances antigen-specific T-cell activation. (bvsalud.org)
Expression2
- RESULTS: The expression of the CD2-CD58 axis was found to be elevated with increasing of WHO grade (p (bvsalud.org)
- The ESTIMATE algorithm indicated that patients with high CD58 expression had significantly higher immune scores compared with low CD58 expression in WHO grade II/III, but no statistical difference was observed in WHO grade IV (p (bvsalud.org)
Interaction1
- The extension of our findings to primary HL tissue by immunohistochemistry and proximity ligation assays showed interaction of CD2 with CD58 and of TCR-associated CD4 with HLA-II. (ashpublications.org)
Recognize1
- TCRs can recognize fragments of antigen attached to MHC on the surface of an APC. (medscape.com)
Signals via1
- The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)