Surface proteins. Medical search. Frequent questions

The approach, devised by Xin Zhou at the Dana-Farber Cancer Institute in Boston, Massachusetts, and her colleagues, involves using modified antibodies they call TransTACs to join a surface protein to another common protein that is involved in transporting iron into cells. (newscientist.com)
We show that antibodies against proteins belonging to the antigen 85 complex were the most abundant in the serum of M. tuberculosis infected patients, and that secreted lipoproteins were the most immunogenic proteins in term of high antibody to protein amount ratio were lipoprotein, illustrating the importance of this group of proteins for serodiagnostic development. (uib.no)
Rising demand for biopharmaceutical products including antibodies, vaccines, proteins, and drugs is another major factor driving the growth of the cell culture protein surface coating market. (prnewswire.co.uk)
The production of biopharmaceutical products such as monoclonal antibodies and recombinant proteins is carried out by using cell culture technique. (prnewswire.co.uk)
The following protocol describes combined surface and intracellular protein staining with TotalSeq™-B antibodies, with or without TotalSeq™-B hashtag antibodies using the Single Cell 3' v3.1 Feature Barcoding technology from 10x Genomics. (biolegend.com)
This protocol has been validated solely for the detection of surface or intracellular protein expression with the corresponding TotalSeq™-B antibodies. (biolegend.com)
This includes TotalSeq™ antibodies targeting intracellular proteins of interest. (biolegend.com)
Optimization of antibody staining concentration is essential to obtain good quality data in antibody-based applications such as surface and intracellular staining using TotalSeq™ antibodies. (biolegend.com)
Enzymatic digestion may result in alterations of surface protein epitopes and impact staining with TotalSeq™ antibodies. (biolegend.com)
Many of the most promising medicines under development are proteins, often antibodies, to help patients fight disease. (udel.edu)
The systems are presently evaluated for selection of affinity proteins, i.e. affibody molecules and domain antibodies, using surface-displayed libraries. (kth.se)
Full-length trimeric protein enables detection of more antibodies against SCoV2-S, than shorter protein constructs (e.g. (baltymas.lt)
EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)
One group of these proteins is called immunoglobulins, or antibodies, that are produced by specialized cells called B cells. (sciencedaily.com)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)

Surface modification involves the fundamentals of physicochemical interactions between the biomaterial and the physiological environment at the molecular, cellular and tissue levels (reduce bacterial adhesion, promote cell adhesion). (wikipedia.org)
In various biomedical applications of developing implantable medical devices (such as pacemakers and stents), surface properties/interactions of proteins with a specific material must be evaluated with regards to biocompatibility as it plays a major role in determining a biological response. (wikipedia.org)
These results add to the growing evidence that specific Ca2+-protein-lipid interactions are important in determining both the structure and function of extracellular lung surfactant fractions. (nih.gov)
In this webinar the critical role of electrostatic interactions between proteins and surface charges at solid-liquid interfaces will be examined. (anton-paar.com)
Specific examples of protein-surface interactions related to fill-finish operations for antibody formulations will be shared along with container-protein interaction applications. (anton-paar.com)
A theoretical description of individual filaments that incorporates information from molecular dynamic simulations has identified that filament curvature, monomer twist, surface attachment and lateral interactions between monomers are enough to describe, using Monte Carlo simulations, some of the structures that we observe experimentally. (cea.fr)
In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. (nature.com)
Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)
Although protein-protein interactions (PPIs) are promising targets, drugging them is one of the key challenges in drug discovery 19 . (nature.com)
Our studies suggest that controlling hydrophobicity and roughness, in addition to electrostatics, as independent parameters could provide a means to tune desirable or undesirable protein interactions with surfaces. (aip.org)
Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)
Of specific interest is the role that nanoscale cell-surface interactions play in the biocompatibility of neural implants. (frontiersin.org)
We designed a medium throughput approach to systematically test for interactions between these pneumococcal surface proteins and host proteins (extracellular matrix proteins, circulating proteins or immunity related proteins). (biomedcentral.com)
Interactions were tested in a solid phase assay, which led to the identification of 23 protein-protein interactions among which 20 are new. (biomedcentral.com)
Deciphering protein–protein interactions. (crossref.org)
In this study, we address the issue of the interactions of plasma proteins with polymer coated surfaces. (unict.it)
Protein-Protein interactions in electrolytes solutions. (lu.se)

Results from one-dimensional gel electrophoresis show the presence of polymer layers around the particles affects the adsorption of protein onto the TiO 2 surface. (rsc.org)
Understanding the heterogeneous dynamics of protein adsorption on surfaces with varying roughness is experimentally challenging. (aip.org)
In this work, we use single-molecule fluorescence microscopy to study the adsorption of α-lactalbumin protein on the glass substrate covered with a self-assembled monolayer (SAM) with varying surface concentrations. (aip.org)
Protein adsorption and transport on solid surfaces are common but complicated phenomena. (aip.org)
1,2 In 2019, the National Academies of Sciences challenged researchers to design new surface materials as part of understanding protein adsorption and dynamics in realistic complex environments. (aip.org)
Physical adsorption isotherms were experimentally determined for these engineered proteins, allowing for direct calculation of the available ligand density present on coated surfaces. (frontiersin.org)
A team of engineers has shown that surface diffusion in protein transport into ion-exchange beads depends on adsorption affinity - a measure of attraction between the two materials. (udel.edu)
One reason for this is that the nanoparticle physicochemical properties fall short for handling the complexity of biological environments and for preventing nonspecific protein adsorption. (unict.it)
Quartz Crystal Microbalance with dissipation was used to monitor the polymer adsorption kinetics and to evaluate the resistance to protein adsorption. (unict.it)
Adsorption characteristics of 18 proteins, with different sizes and isoelectric points, to a titanium oxide surface were studied. (elsevierpure.com)

Affibody molecules are based on a 58-amino acid protein domain, derived from staphylococcal protein A, which has served as scaffold for construction of combinatorial libraries from which affibody binding proteins can be selected to desired target proteins. (kth.se)
Among aquatic organisms, fish share many target proteins for human medicines. (janusinfo.se)

Mapping of proteins exported by the pathogen to the extracellular environment is necessary to understand the biology of the pathogen and for identification of novel drug targets and vaccine candidates to eliminate the disease. (uib.no)
A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)

Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42) and p32 which have a role in initial steps of protein import. (nih.gov)
Membrane proteins play a key role in the cell's energy metabolism and in its signalling and communication with its environment. (lu.se)
More than half of all drugs that are in use today target membrane proteins. (lu.se)
The main aim of the course is to enable students to acquire specialised knowledge and understanding of membrane biochemistry and the molecular structure, topology and functional mechanisms of membrane proteins. (lu.se)

The serotype of influenza A virus is determined by the hemagglutinin (HA) and neuraminidase (NA) proteins present on its surface, and there are at least 18 subtypes of HA in influenza A. (scienceboard.net)
The virus' hemagglutinin (HA) surface proteins are depicted in blue. (cdc.gov)
It displays part of hemagglutinin (HA), an influenza protein, on the surface of a microscopic nanoparticle made of nonhuman ferritin. (medscape.com)
The virus' hemagglutinin (HA) and neuraminidase (NA) surface proteins were displayed in semi-transparent blue, sticking out of the surface of the virus. (cdc.gov)

Recombinant monoclonal antibody to Pvs25 Surface Protein. (absoluteantibody.com)
This antibody binds to Pvs25, a Plasmodium surface protein constiting of a triangular arrangement of four epidermal growth-factor-like domainst tether on the cell by a glycosylphosphatidylinositol anchor. (absoluteantibody.com)

As proteins are made up of different sequences of amino acids, proteins can have various functions as its structural shape driven by a number of molecular bonds can change. (wikipedia.org)
Thus, attachment of molecules with different protein for example, those containing Arginine-Glycine-Aspartate (RGD) sequences are expected to modify the surface of tissue scaffolds and result in improvement of cell adhesion when placed into its physiological environment. (wikipedia.org)
Availability of genome sequences facilitated the identification of pneumococcal surface proteins bearing characteristic motifs such as choline-binding proteins (Cbp) and peptidoglycan binding (LPXTG) proteins. (biomedcentral.com)
Several mutations in the N terminus of the G-protein-coupled receptor rhodopsin disrupt NXS/T consensus sequences for N-linked glycosylation (located at N2 and N15) and cause sector retinitis pigmentosa in which the inferior retina preferentially degenerates. (jneurosci.org)
Protein sequences are a far cry from the Jurassic Park vision of a genetic blueprint for dinosaurs, because they do not contain all the information in the genome. (newscientist.com)
Although the samples contained little protein, he was able to reconstruct the amino acid sequences of seven collagen fragments. (newscientist.com)

Neuraminidase, or NA, is another influenza surface protein. (medscape.com)
This term refers to influenza viruses that have surface proteins (haemaggluttinin alone or haemaggluttinin and neuraminidase together) that are very different from those found on existing human influenza viruses. (who.int)

We make use of a highly flexible multi-step cloning strategy in order to allow for the rapid synthesis of new recombinant proteins that can introduce many different biofunctionalities. (frontiersin.org)

A total of 20 serological reactive proteins were identified, including 4 novel antigens. (uib.no)
We conclude that whether peptidoglycan binding proteins do not appear to be major adhesins, most of the choline-binding proteins interact with host proteins (elastin and C reactive proteins are the major Cbp partners). (biomedcentral.com)

The effects of divalent cations on the structure and surface activity of this protein-lipid mixture were investigated by following (1) the state of lipid dispersion by changes in turbidity and by electron microscopy and (2) the ability of the surfactant lipids to form a surface film from an aqueous subphase at 37 degrees C. The protein complex markedly increased the rate of Ca2+-induced surfactant-lipid aggregation. (nih.gov)
The threshold Ca2+ concentration required for rapid lipid aggregation was reduced from 13 to 0.5 mM by the protein complex. (nih.gov)
This protein-facilitated lipid aggregation did not occur if Mg2+ was the only divalent cation present. (nih.gov)
Similarly, 5 mM Ca2+ but not 5 mM Mg2+ improved the ability of the protein-lipid mixture to form a surface film at 37 degrees C. Extensive aggregation of the surfactant lipids without protein by 20 mM Ca2+ or 20 mM Mg2+ did not promote rapid surface film formation. (nih.gov)
Protein aggregation remains a significant problem in E. coli expression systems. (iucr.org)

The protein surface coating provides improved adhesion and proliferation of cells in vitro. (prnewswire.co.uk)
We have used supported lipid bilayers and controlled orientation of FtsZ monomers in vitro to study their GTP-dependent self-assembling on surfaces with atomic force microscopy in solution, providing single molecule information of the dynamic structure of filaments and their aggregates [2-4]. (cea.fr)

Surface morphology, in addition to hydrophobic and electrostatic effects, can alter how proteins interact with solid surfaces. (aip.org)

Over the past 20 years, the importance of proteins for S. pneumoniae virulence has become clear. (biomedcentral.com)
Altogether, this work frames the relative importance of the P5 and Hap surface proteins in NTHi virulence. (qub.ac.uk)

RNA genome can be translated to an individual polyprotein precursor which can be processed to create 10 adult proteins by co- and post-translational digesting (Rice and Lindenbach, 2003). (findadig.com)
2. Methods and Materials 2.1 Components The DENV2 NS2B-NS3pro expression plasmid encoding the protease precursor found in this research provides the hydrophilic domains of NS2B cofactor (48 proteins) as well as the NS3pro domains (185 residues) (Yon et al. (findadig.com)
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. (nih.gov)
The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins. (nih.gov)

Proteins from the lipid phase were precipitated by ethanol. (uib.no)
The spike protein encoded mRNA and the lipid nanoparticles that in case the mRNA are the only ingredients in these vaccines. (cdc.gov)

Here, we develop a biological nanopore sensor for single-molecule detection of proteins and PDIs using the pore-forming toxin YaxAB. (nature.com)
The reaction of the spike protein with Au enabled single-molecule protein circuits, by connecting the spike S1 protein between two Au nano-electrodes using the scanning tunnelling microscopy-break junction (STM-BJ) technique. (rsc.org)

According to the expressed construct, purified SCoV2-rSα protein should be trimer in the stabilized prefusion conformation. (baltymas.lt)
AlphaFold2 (AF2) program developed by DeepMind predicted, with unprecedented success, the three-dimensional conformation of proteins using only amino acid sequence information. (sabanciuniv.edu)

however, although protein -based ligands have been proven advantageous as adjuvants, their mechanisms of action, including their ability to undergo structural modifications to achieve optimal immunogenicity, have been explored less thoroughly. (bvsalud.org)
The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)

The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). (nature.com)
Currently, our focus is to determine whether the interaction between NTHi surface proteins and CRL can trigger an immune response, as this information will be valuable in identifying potential vaccine candidates. (lu.se)

Bacterial surface proteins play determining roles in the NTHi-airways interplay, but their specific and relative contribution to colonization and infection of the respiratory tract has not been addressed comprehensively. (qub.ac.uk)
NTHi utilizes a variety of proteins to adhere to and colonize the surface of epithelial cells, which is crucial for its invasion. (lu.se)
We have obtained some preliminary data that suggest a group of NTHi surface proteins are capable of binding to CRL. (lu.se)

Biocompatibility and applicability of surface modification with current uses of metallic, polymeric and ceramic biomaterials allow alteration of properties to enhance performance in a biological environment while retaining bulk properties of the desired device. (wikipedia.org)
The properties of the uppermost molecular layers are critical in biomaterials since the surface layers are in physicochemical contact with the biological environment. (wikipedia.org)
As an additional benefit, it can help to reduce the risk of biological contamination, where food residues on surfaces could potentially provide nutrients for spoilage or pathogenic bacteria to thrive. (neogen.com)
The detection and evaluation of concentration of influenza virus proteins in biological samples is critical in a broad range of medical and biological investigations regarding the concern over potential outbreaks of virulent influenza strains in animals and humans. (omicsonline.org)
N-linked glycosylation is the most prevalent posttranslational modification of plasma membrane and secretory proteins and participates in many important biological roles such as protein folding, intracellular targeting, immune response, cell adhesion, and protease resistance. (jneurosci.org)
The aim of the course is to enable students to acquire a specialised understanding of proteins, focusing on structure and the connection to biological function. (lu.se)

As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways. (bvsalud.org)
As models of TLR4-PBAs, we used hemocyanin from Fissurella latimarginata (FLH) and a recombinant surface immunogenic protein (rSIP) from Streptococcus agalactiae . (bvsalud.org)

The culture filtrate protein mixture of M. tuberculosis used in our first work investigated to identify novel antigens. (uib.no)
Moreover, after enteric digestion, numerous potential antigens are generated at the mucosal surface. (medscape.com)

FtsZ is a cytoskeletal protein that participates in the formation, on the inner side of the cytoplasmic bacterial membrane, of the "septal ring", a protein complex responsible for cell division [1]. (cea.fr)
Furthermore, we suggest a new mechanism for force generation in which the orientation and type of monomer attachment to the surface could play an important role in modulating the force exerted by filament aggregates on the bacterial membrane during cell division [5,6]. (cea.fr)
Tarazona,P. and Vélez, M. "Depolymerization dynamics of individual filaments of bacterial cytoskeletal protein FtsZ" PNAS 109 8133‐8138. (cea.fr)
The present focus is to evaluate bacterial display for protein library applications using fluorescence activated cell sorting (FACS) for library screening. (kth.se)
Additionally, researchers have shown that changing the bacterial composition of the body may have important consequences on the effectiveness of vaccines used to protect the mucosal surfaces of the body against infection. (sciencedaily.com)

Staphylococcus aureus is a major human pathogen that utilises many surface-associated and secreted proteins to form biofilms and cause disease. (sdu.dk)

For instance, surface hydrophobicity or hydrophilicity of a material can be altered. (wikipedia.org)
For this purpose, two different approaches were used to separate the proteins according to their hydrophobicity and pH followed by molecular mass based separation. (uib.no)
Contact angle measurements and atomic force microscopy imaging show that increasing SAM concentration results in both increasing hydrophobicity and surface roughness. (aip.org)
These properties lead to two opposing effects: increasing hydrophobicity promotes longer protein flights, but increasing surface roughness suppresses protein dynamics resulting in shorter residence times. (aip.org)

And it all started with a brainstorm, where Khanal suggested more in-depth investigation of surface diffusion's relationship to binding affinity on the charged surfaces using complementary tools. (udel.edu)
A class of small affinity proteins, denoted affibody molecules, has been developed at our department. (kth.se)
Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establishing a new upper limit for the solution affinity at 2.5 mM. (lu.se)

Additional modifications of the surface could be through attachment of functional groups of 2D or 3D patterns on the surface so that cell alignment is guided and new tissue formation is improved. (wikipedia.org)
Our ultimateaim is to develop an efficient and integrated method that maps transitions between functional conformations of any given folded protein to its energy surface. (sabanciuniv.edu)
To achieve thisaim the first step is to make a comparative study of the methods that disclose reaction coordinates (RC) that manage transitions between different functional structures of proteins. (sabanciuniv.edu)

We have isolated a surfactant-associated protein complex with molecular weight components of 36 000, 32 000, and 28 000 and reassembled it with protein-free lung surfactant lipids prepared as small unilamellar liposomes. (nih.gov)
A molecular dynamic (MD) modeling approach was applied to evaluate the effect of external electric field on gliadin protein structure and surface properties. (mdpi.com)
Two heat-stable globulins constitute 90% of the pulp-derived proteins: beta-conglycinin, which has a molecular weight (MW) of 180,000, and glycinin, which has an MW of 320,000. (medscape.com)
The course deals with both the principles determining these properties and the methods, mainly X-ray crystallography, that is used to study them in modern molecular protein science. (lu.se)

HA are homotrimeric glycoproteins found on the surface of influenza viruses. (scienceboard.net)

Protein surface modification of various types biomaterials (ceramics, polymers, metals, composites) is performed to ultimately increase biocompatibility of the material and interact as a bioactive material for specific applications. (wikipedia.org)
In this work, we present a novel approach to fabricate such coatings, which specifically involves the use of surface-adsorbed, nanoscale-designed protein polymers to prepare reproducible, customized surfaces. (frontiersin.org)
The proteins are synthesized using recombinant, genetic engineering techniques, allowing for the creation of biocompatible polymers with nanoscale precision that impart highly specific protein functionalities. (frontiersin.org)
The present study establishes a correlation between the long-term stability of PEG coated particles in biofluids and the protein resistance of surfaces coated with the same polymers. (unict.it)

Our findings demonstrate that msfGFP is a good candidate fluorescent reporter to consider when studying proteins secreted by the Sec pathway in S. aureus. (sdu.dk)
We determined that rSIP and FLH are partial TLR4 agonists , and depending on the protein agonist used, TLR4 has a unique bias toward the TRIF or MyD88 pathway. (bvsalud.org)

Static electric field strengths of 0.001 V/nm and 0.002 V/nm induced conformational changes in the protein but had no significant effect on its surface properties. (mdpi.com)

Both studies suggest that defects in rhodopsin glycosylation are associated with impairment of protein folding or stability. (jneurosci.org)
111 Pages Report] The market for protein stability analysis is expected to grow from USD 1.2 billion in 2018 to USD 2.1 billion by 2024, at a CAGR of 10.0 % during the forecast period. (marketsandmarkets.com)
The growth of the protein stability analysis market is primarily driven by the growing adoption of open innovation models in pharmaceutical & biotechnology companies and increasing pharmaceutical outsourcing. (marketsandmarkets.com)
However, the high cost of protein stability analysis systems is expected to restrain the growth of this market to a certain extent. (marketsandmarkets.com)
On the basis of products, the protein stability analysis market is divided into reagents & assay kits, instruments, consumables & accessories, and software. (marketsandmarkets.com)
The large share of this market segment can be attributed to the high consumption of reagents and assay kits in protein stability analysis techniques, increasing protein pharmaceutical R&D, and increased government funding for life science research. (marketsandmarkets.com)
The extensive use of protein stability analysis in pharmaceutical & biotechnology companies for drug discovery applications will drive the market during the forecast period. (marketsandmarkets.com)
By end user, the protein stability analysis market is segmented into pharmaceutical and biotechnology companies, contract research organization, and academic & research institutes. (marketsandmarkets.com)
The large share of this segment is primarily due to the extensive use of protein stability analysis in pharmaceutical & biotechnology companies for drug discovery applications. (marketsandmarkets.com)
Stringent regulations for pharmaceutical drug development and manufacturing are also supporting the adoption of protein stability analysis instruments in this end-user segment. (marketsandmarkets.com)
The protein stability analysis market is segmented into four major regions, namely, North America, Europe, the Asia Pacific, and the rest of the World. (marketsandmarkets.com)
The availability of funds for research from various public and private sector organizations and increasing research activities for drug development are the major factors driving the North American market for protein stability analysis. (marketsandmarkets.com)
This research report categorizes the protein stability analysis market based on Product, Technique, End User, and Region. (marketsandmarkets.com)

Recent evidence indicates that altered degradation rate of mutant proteins represents a pathogenic mechanism underlying genetic diseases. (frontiersin.org)

They have also disagreed on how movement at the surface of the material contributes to protein movement when using ion-exchange chromatography, a laboratory and manufacturing method for separating materials based on their charge. (udel.edu)
Proteins can creep into the pores of resin beads used to perform ion-exchange chromatography and bind on the walls, based on charge. (udel.edu)
By understanding and exploiting protein surface diffusion in ion-exchange chromatography, researchers can build upon this work and develop methods to reduce waste during the expensive drug manufacturing process. (udel.edu)
Ion-exchange chromatography of proteins is an absolutely key operation in biopharmaceutical manufacturing," said Lenhoff. (udel.edu)

Formulated with amaranth protein, saw palmetto, lysine and the color vita-complex, the Awaken Protein Styling Spray from Surface strengthens fine hair while working to support a healthy, rejuvenated scalp. (behindthechair.com)

The implication of this work is that monomer flexibility and surface attachment, additionally to filament curvature, could be important in determining the polymorphism and dynamic behavior of filament aggregates. (cea.fr)
We applied this strategy to study coagulase (Coa), a secreted protein and a major contributor to the formation of a fibrin network in S. aureus biofilms that protects bacteria from the host immune system and increases attachment to host surfaces. (sdu.dk)
Glycated proteins differ from non-glycated proteins by the attachment of a sugar moiety(s) at various binding sites by means of a ketoamine bond. (cdc.gov)

Deepened knowledge on the biophysical chemistry of proteins with emphasis on properties rather than methods. (lu.se)

We present a very strong case for the significance of surface diffusion, and we use multiple approaches to corroborate its importance through a simple technique that can be implemented right away," said Khanal. (udel.edu)

Visual reading of a color change indicates the presence of detectable levels of protein. (neogen.com)
A quick, easy visual reading of a color change indicates the presence of detectable levels of protein and the fast results allow immediate corrective action. (neogen.com)

This study demonstrated that it is necessary to gain insight into protein dynamics under external electric field stress, in order to develop the novel food processing techniques that can be potentially used to reduce or eradicate food allergens. (mdpi.com)
The intestinal mucosa damaged by cow's milk proteins may allow increased uptake of the potentially allergenic soy proteins. (medscape.com)

A lower 4 × 10 −6 G 0 conductance is attributed to the spike protein connecting to the STM electrodes from the RBD subunit and the N-terminal domain (NTD). (rsc.org)
At an electric field of 1.5 × 10 8 V m −1 , the original conductance magnitude decreases accompanied by a lower junction yield, suggesting a change in the structure of the spike protein in the electrified junction. (rsc.org)
Above an electric field of 3 × 10 8 V m −1 , the conducting channels are blocked and this is attributed to the spike protein denaturing in the nano-gap. (rsc.org)
Fig. 1a(ii) ), 5-7 MERS-CoV contains 11 S-S bonds, and HCoV-229E spike protein contains 13 S-S bonds. (rsc.org)
8 The SARS-CoV-2 spike protein S1 is composed of three domains, the receptor binding domain (RBD) that contains 4 S-S bridges, the N-terminal domain (NTD) that contains 3 S-S bridges and the S1/S2 cleavage site that contains 3 S-S bridges ( Fig. 1a(iii) ). (rsc.org)
The spike protein is the protein that the messenger RNA codes for. (cdc.gov)
The spike protein is produced and then presented on the surface of the cell. (cdc.gov)
The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)
Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)

As a result, over 100 membrane and membrane-associated proteins were identified including around 50% all predicted lipoproteins in the genome. (uib.no)
In this study, we focused on the ompP5 and hap genes, present in all H. influenzae genome sequenced isolates, and encoding the P5 and Hap surface proteins, respectively. (qub.ac.uk)

The function of surface modification is to change the physical and chemical properties of surfaces to improve the functionality of the original material. (wikipedia.org)

A new kind of medicine that destroys specific proteins on the surface of cells could lead to better therapies for conditions such as cancer. (newscientist.com)
Previous studies have demonstrated that lung-specific proteins are associated with surfactant lipids, particularly the highly surface active subfraction known as tubular myelin. (nih.gov)
These data indicate that this eukaryotic cell-free expression system has a high success rate and that the addition of specific reagents can increase the yield of soluble protein. (iucr.org)
However, rSIP and FLH have a specific pattern of interleukin 6 ( IL-6 ) and interferon gamma-induced protein 10 (IP-10) secretion associated with MyD88 and TRIF recruitment. (bvsalud.org)
Primary Ag NPs were 20 nm in diameter with a 0.3% wt polyvinylpovidone coating (Nano Amor, Inc.). Specific surface area was measured to be 7.54 + / - 0.10 m2/g. (cdc.gov)

Whole expression construct includes: full-length SCoV2-S ectodomain (aa 1 - 1208) w/o transmembrane and cytoplasmic aa, furin cleavage site "RRAR" mutated to "GSAS", C-terminal GSN4 trimerization motif fused to protein sequence, then follows thrombin cleavage site, Strep-tag II and His6-tag. (baltymas.lt)

intestines and lungs are two of the largest mucosal surfaces. (sciencedaily.com)

Indices of lung injury (albumin and lactate dehydrogenase) were increased up to 28 days post exposure, and proteins indicative of inflammation and immune response were altered in the lavage fluid from rats exposed to the high dose. (cdc.gov)

Reciprocally, perturbations of the cell surface were examined for their effects on internal filaments. (rupress.org)
It now appears clearly that cell-surface proteins participate in many stages of the colonization process and/or the disease transition. (biomedcentral.com)

December 7, 2020 -- A new universal influenza vaccine has been developed that targets the stalk portion of the influenza virus surface protein rather than the head portion. (scienceboard.net)
2,3 In 2020, it was reported that the viability of the SARS-CoV-2 virus in aerosol droplets varied on different surfaces. (rsc.org)

The structures of the spike proteins (S1 and S2) of most of the coronaviruses, including SARS-CoV-2 ( Fig. 1a(i) ), revealed that these proteins possess multiple disulfide (S-S) bonds. (rsc.org)
Although there were those who touted this as a solution to the "Protein Folding Problem", since the method is based on the examination of folded proteins of known structures with advanced machine learning techniques, the underlying physics still maintains its secrets. (sabanciuniv.edu)
Our group's research program is based-on predicting the functions of proteins whose three-dimensional structures are known using dynamical information obtained from trajectories and to foretell how the shifts in the environmental conditions will change these functions. (sabanciuniv.edu)

The reduction in particle aggregate size and changes to the particle surface chemistry, following polymer grafting, was found to reduce cellular uptake and diminish cytotoxicity for both human lung cell lines tested. (rsc.org)
SAM-covered areas of substrates are found to promote CTRW, whereas glass surfaces promote localized motion. (aip.org)
Gluten is a storage protein found in wheat, it plays an important role in regulating its baking quality by determining the viscosity, cohesivity, water absorption and elasticity of the dough [ 1 ]. (mdpi.com)
In conclusion, decreased or increased protein expression of several TRPM4 variants linked to cardiac conduction disorders or ventricular arrhythmias were found to be caused by altered TRPM4 half-life compared to the WT form. (frontiersin.org)
Most fossils have been found near the surface where degradation is more likely, he explains. (newscientist.com)
At least 9 proteins with MW ranging from 14,875-54,500 were found to react with human IgE in patients with asthma. (medscape.com)
Ferritin is a natural protein that can be found in cells from all living species. (medscape.com)
This protein is found in all blood cells. (medlineplus.gov)
Glycohemoglobin (GHb) thus contains 1,2-cis-diol groups not found in non-glycated proteins. (cdc.gov)
HER2 is found in large amounts on the surface of some cancer cells where it stimulates their growth. (who.int)

Anatomy14

Organisms58

Diseases16

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care5

Antibodies15

Interactions17

Adsorption10

Target proteins2

Extracellular2

Membrane Proteins4

Hemagglutinin4

Antibody2

Sequences6

Neuraminidase2

Recombinant proteins1

Reactive proteins2

Aggregation5

Vitro2

Electrostatic1

Virulence2

Precursor4

Lipid2

Single molecule2

Conformation2

Structural2

Interaction2

NTHi3

Biological6

Ligand1

Immunogenic2

Antigens2

Bacterial5

Pathogen1

Hydrophobicity4

Affinity3

Functional3

Molecular4

Influenza viruses1

Polymers4

Pathway2

Conformational changes1

Stability13

Pathogenic1

Chromatography4

Amaranth1

Attachment3

Biophysical1

Approaches1

Detectable2

Potentially2

Spike protein9

Genome2

Physical1

Specific5

Motif1

Mucosal1

Immune response1

Cell surface2

20202

Structures3

Found10