ParkinsonismParkinson'sCorticobasal degenerationOphthalmoplegiaGazeDementiaClinicalAmyotrophic-lateral-sLate-onset neurodegenerative diseaseSteele-RichardsDiagnosisMultiple systemSymptomsDystoniaBrainCerebralAlzheimer'sNeurological diseaseSyndromeDysfunctionParkinsonianCognitiveMultimodalAtrophyUpgazeNeuropathologicSubtypesDisordersAxialDescriptorExaminationDiseaseCorticalAbstractPatientsPrimary progres
Parkinsonism5
- A 56 year old woman presented with parkinsonism associated with apathy, cognitive impairment, vertical supranuclear gaze palsy, walking difficulties, postural instability with falls and dysarthria . (omicsonline.org)
- An atypical variant of progressive supranuclear palsy (PSP), a rare late-onset neurodegenerative disease, by prominent early parkinsonism (tremor, limb bradykinesia, axial and limb rigidity) rather than falls and cognitive change. (nih.gov)
- Follow this link to review classifications for Progressive supranuclear palsy-parkinsonism syndrome in Orphanet. (nih.gov)
- Dejerine and Thomas first used the term olivopontocerebellar atrophy (OPCA) in 1900 when they described 2 patients with a degenerative disorder leading to progressive cerebellar dysfunction and parkinsonism. (medscape.com)
- Some members may present primarily with amyotrophy, and others may present with primary supranuclear gaze palsy, parkinsonism, schizophrenialike thought disorder, or progressive aphasia and/or apraxia. (medscape.com)
Parkinson's5
- Progressive supranuclear palsy (PSP) is a life-limiting progressive neurological disease which can be mistaken for Parkinson's disease early in its course. (bmj.com)
- We agree with Andrew Lees on the value of the applause sign (i.e. ask a PSP patient to clap 3 times, and they typically perseverative by clapping more than 3 times) and a lack of decrement on hypokinesia tests (e.g. sequential finger tapping or in micrographic writing, without a progressive reduction in amplitude) to differentiate Progressive Supranuclear Palsy from Parkinson's disease. (bmj.com)
- Progressive supra-nuclear palsy (PSP) is a debilitating and rapidly progressing form of atypical Parkinson's disease. (mdsabstracts.org)
- Discriminating progressive supranuclear palsy from Parkinson's disease using wearable technology and machine learning. (ox.ac.uk)
- BACKGROUND: Progressive supranuclear palsy (PSP), a neurodegenerative conditions may be difficult to discriminate clinically from idiopathic Parkinson's disease (PD). (ox.ac.uk)
Corticobasal degeneration3
- They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP ), corticobasal degeneration (CBD) and Dementia with Lewy bodies (DLB). (parkinson.ca)
- To address these issues, we examined the morphology and differential distribution of pathologic lesions in three disorders: progressive supranuclear palsy, Pick's disease, and corticobasal degeneration. (elsevierpure.com)
- The Society for Progressive Supranuclear Palsy, is a 501(c)3 organization dedicated to increasing awareness of progressive supranuclear palsy and corticobasal degeneration, advancing research toward a cure, educating health professionals, and providing support, education and hope for persons with PSP and CBD and their families. (rareshare.org)
Ophthalmoplegia4
- Supranuclear ophthalmoplegia is a condition that affects the movement of the eyes. (medlineplus.gov)
- People with supranuclear ophthalmoplegia are unable to move their eyes at will in all directions, especially looking upward. (medlineplus.gov)
- Tests will be done to check for diseases linked with supranuclear ophthalmoplegia. (medlineplus.gov)
- Treatment depends on the cause and symptoms of the supranuclear ophthalmoplegia. (medlineplus.gov)
Gaze3
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease (see the image below) whose characteristics include supranuclear, initially vertical, gaze dysfunction accompanied by extrapyramidal symptoms and cognitive dysfunction. (medscape.com)
- Although progressive supranuclear palsy is defined by its akinetic rigidity, vertical supranuclear gaze palsy and falls, cognitive impairments are an important determinant of patients' and carers' quality of life. (cardiff.ac.uk)
- Possible PSP requires the presence of a gradually progressive disorder with onset at age 40 or later, either vertical supranuclear gaze palsy or both slowing of vertical saccades and prominent postural instability with falls in the first year of onset, as well as no evidence of other diseases that could explain these features. (neurology.org)
Dementia4
- Progressive supranuclear palsy is a rare, degenerative central nervous system disorder that progressively impairs voluntary eye movements and causes bradykinesia, muscular rigidity with progressive axial dystonia, pseudobulbar palsy, and dementia. (msdmanuals.com)
- Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
- Pick disease (named after Arnold Pick) is a progressive dementia defined by clinical and pathologic criteria. (medscape.com)
- Two types of primary progressive aphasia are identified: (1) semantic dementia, in which meaning systems are lost from language, and (2) nonfluent primary progressive aphasia. (medscape.com)
Clinical6
- Mithridion, Inc. a privately-owned clinical stage drug development company focusing on serious Central Nervous System (CNS) disorders, announces that the US Food and Drug Administration (FDA) has awarded orphan drug designation for MCD-386CR, its lead drug candidate, for the treatment of Progressive Supranuclear Palsy (PSP). (pharmabiz.com)
- The clinical definition of multiple system atrophy (MSA) is a progressive, idiopathic, degenerative process beginning in adulthood. (medscape.com)
- We recruited 23 patients with progressive supranuclear palsy (using clinical diagnostic criteria, nine with subsequent pathological confirmation) and 22 age- and education-matched controls. (cardiff.ac.uk)
- To improve the specificity and sensitivity of the clinical diagnosis of progressive supranuclear palsy (PSP, Steele-Richardson-Olszewski syndrome), the National Institute of Neurological Disorders and Stroke (NINDS) and the Society for PSP, Inc. (SPSP) sponsored an international workshop to develop an accurate and universally accepted set of criteria for this disorder. (neurology.org)
- Objective: To describe clinical features and identify prognostic predictors in progressive supranuclear palsy (PSP). (ncl.ac.uk)
- Ling H. Clinical approach to progressive supranuclear palsy. (medlineplus.gov)
Amyotrophic-lateral-s1
- Primary lateral sclerosis Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei. (msdmanuals.com)
Late-onset neurodegenerative disease1
- Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain. (wikipedia.org)
Steele-Richards1
- Progressive supranuclear palsy (PSP), also called Steele-Richardson-Olszewski syndrome, is one of the most common atypical parkinsonian syndromes. (neurology.org)
Diagnosis3
- Progressive Supranuclear Palsy (PSP) is a rare primary tauopathy, e.g. a disorder caused by the deposit of abnormal tau protein in the brain (tau is a protein that stabilises neuron cells in the nervous system), neurodegenerative disease that usually affects people in their 50s, 60s and 70s, and is generally fatal within 5-7 years of diagnosis. (vivli.org)
- A diagnosis of Progressive Supranuclear Palsy is not to be given lightly, as for any other disease. (bmj.com)
- Methods: Record-based diagnosis according to National Institute of Neurological Disorders and Stroke-Society for Progressive Supranuclear Palsy criteria was performed in 187 cases of PSP. (ncl.ac.uk)
Multiple system1
- Multiple System Atrophy (MSA) is a progressive brain disorder caused by loss of nerve cells in specific areas of the brain. (parkinson.ca)
Symptoms2
- Symptoms of progressive supranuclear palsy usually begin in late middle age. (msdmanuals.com)
- Symptoms for Progressive Supranuclear Palsy has not been added yet. (rareshare.org)
Dystonia1
- Dystonia is a common symptom of cerebral palsy and several neurodegenerative conditions. (clevelandclinic.org)
Brain5
- Ayurvedic Treatment of Progressive Supranuclear Palsy Introduction Herbal Remedies About Progressive Supranuclear PalsyProgressive supranuclear palsy is a disorder of the brain, which has a serious impact on the balance of the body, eye movements, gait and walking. (planetayurveda.com)
- There is no cure for progressive supranuclear palsy (PSP), a brain disorder marked by walking and balance difficulties. (medicalxpress.com)
- PSP is a progressive brain disease in which neurons degenerate in regions of the brain vital for eye movements, balance, walking, speech, and cognition. (pharmabiz.com)
- This article is an overview of a rare brain disorder called Progressive Supranuclear Palsy (PSP). (seniornavigator.org)
- Progressive Supranuclear Palsy is a rare degenerative disorder involving the gradual deterioration and death of selected areas of the brain. (rareshare.org)
Cerebral1
- 2020) found that 44.4% of Swedish children with cerebral palsy used a form of AAC either exclusively or to supplement their speech. (asha.org)
Alzheimer's2
- It consists of residues K 254 -F 378 of 3R tau, while other taupathies (including Alzheimer's disease, progressive supranuclear palsy, and corticobasal ganglionic degeneration) either have 4Rtau or a combination of 3R and 4Rtau. (medscape.com)
- Initial letter and semantic category fluency in Alzheimer's disease, Huntington's disease, and progressive supranuclear palsy. (bvsalud.org)
Neurological disease1
- This book illustrates the neurological disease progressive supranuclear palsy (PSP) told through the eyes of a child whose grandmother is inflicted with this disease. (psp.org)
Syndrome3
- Using Downgaze Palsy Progression Rate to Model Survival in Progressive Supranuclear Palsy-Richardson Syndrome. (uchicago.edu)
- Introduction: In the present study, midbrain atrophy and the pons-to-midbrain area ratio (P/M ratio) were investigated as diagnostic markers for presymptomatic progressive supranuclear palsy-Richardson's syndrome (Pre-PSP-RS). (elsevierpure.com)
- Primary progressive aphasia is a focal atrophy syndrome that may be associated with Pick disease, Alzheimer disease, or other pathology. (medscape.com)
Dysfunction2
- Additionally, the H2 haplotype, combined with vascular dysfunction, seems to be a factor of vascular progressive supranuclear palsy. (wikipedia.org)
- Accumulation of abnormal protein leads to progressive neuronal dysfunction and loss. (medscape.com)
Parkinsonian1
- Assessment of these square-wave jerks and diminished vertical saccades is especially useful for diagnosing progressive supranuclear palsy, because these movements set PSP patients apart from other parkinsonian patients. (wikipedia.org)
Cognitive1
- Cortical synapse loss, the probable substrate of cognitive impairment in Alzheimer disease (AD), has not previously been evaluated in progressive supranuclear palsy (PSP). (bvsalud.org)
Multimodal1
- We conclude that patients with progressive supranuclear palsy have a multimodal deficit in social cognition. (cardiff.ac.uk)
Atrophy2
- Sagittal T1-weighted image shows atrophy of midbrain, preservation of pontine volume, and atrophy of the tectum, suggestive of progressive supranuclear palsy (Steele-Olszewski-Richardson disease). (medscape.com)
- This deficit is due, in part, to progressive atrophy in a network of frontal cortical regions linked to the integration of socially relevant stimuli and interpretation of their social meaning. (cardiff.ac.uk)
Upgaze1
- Patients tend to have difficulty looking down (a downgaze palsy) followed by the addition of an upgaze palsy. (wikipedia.org)
Neuropathologic1
- We investigated the validity and reliability of diagnoses made by eight neuropathologists who used the preliminary NINDS neuropathologic diagnostic criteria for progressive supranuclear palsy (PSP) and related disorders. (nih.gov)
Subtypes1
- New evidence supports the observation that, over time, different subtypes of progressive supranuclear palsy (PSP) converge to a common phenotype. (neurodiem.tw)
Disorders1
- Disorders of supranuclear control of ocular motility. (medlineplus.gov)
Axial1
- Enfermedad degenerativa del sistema nervioso central caracterizada por dificultades en el equilibrio, TRASTORNOS DE LA MOTILIDAD OCULAR (oftalmoplejia supranuclear), DISARTRIA, dificultades de la deglución y DISTONÍA axial. (bvsalud.org)
Descriptor1
- Supranuclear Palsy, Progressive" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Examination1
- Progressive supranucelar palsy (SPS) is diagnosed following a neurological examination by a medical consultant. (manchesterneurophysio.co.uk)
Disease3
- Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease that lacks any disease modifying therapy. (movementdisorders.org)
- Disease course and treatment patterns in progressive supranuclear palsy: A real-world study. (uchicago.edu)
- Progressive supranuclear palsy (PSP) is a rare, rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. (unict.it)
Cortical1
- Cortical synapse loss in progressive supranuclear palsy. (bvsalud.org)
Abstract2
- Abstract: Objectives: Progressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter (GM) of deep nuclei and cerebellum. (cam.ac.uk)
- Exercise and physical activity for people with Progressive Supranuclear Palsy [abstract]. (mdsabstracts.org)
Patients6
- Hypometabolism in the fronto-mesial cortex and in the anterior cingulate cortex were reported in patients with progressive supranuclear palsy (PSP). (omicsonline.org)
- We report here that 18 F-FDG PET could demonstrate brainstem changes in patients with progressive supranuclear palsy (PSP). (omicsonline.org)
- In patients with progressive supranuclear palsy (PSP), previous reports have shown a severe white matter (WM) damage involving supra and infratentorial regions including cerebellum. (maastrichtuniversity.nl)
- But, patients with Progressive Supranuclear Palsy have suffered disproportionately from delays and diagnostic hesitation, often long past any reasonable doubt. (bmj.com)
- This impairment of social cognition is important to consider for those managing and caring for patients with progressive supranuclear palsy. (cardiff.ac.uk)
- We describe the results of a study of the spinal cord of 5 patients with progressive supranuclear palsy (PSP). (uni-luebeck.de)
Primary progres1
- 60-80%) and semantic variant of primary progressive aphasia (svPPA). (medscape.com)