We propose that in Huh7 cells hepcidin modulation leads to an unfavourable intracellular environment for HCV replication. (microbiologyresearch.org)
ERFE1
By suppressing hepcidin, ERFE increases the function of the cellular iron export channel, ferroportin. (wikipedia.org)
Erythroferrone8
Erythroferrone is produced by erythroblasts, inhibits the production of hepcidin in the liver, and so increases the amount of iron available for hemoglobin synthesis. (wikipedia.org)
Erythroferrone is a hormone that regulates iron metabolism through its actions on hepcidin. (wikipedia.org)
Erythroferrone inhibits hepcidin synthesis by binding bone morphogenetic proteins and thereby inhibiting the bone morphogenetic protein pathway that controls hepcidin expression. (wikipedia.org)
Mice deficient in the gene encoding erythroferrone have transient maturational hemoglobin deficits and impaired hepcidin suppression in response to phlebotomy with a delayed recovery from anemia. (wikipedia.org)
We must remind here the role of hepcidin and particularly the role of erythroferrone in certain forms of anemia characterized by accelerated and ineffective erythropoiesis. (haema-journal.gr)
Role of erythroferrone and hepcidin in iron absorption in normal situation. (haema-journal.gr)
Mice bearing LC-06-JCK were administered rat anti-mouse IL-6 receptor antibody MR16-1 and their serum hepcidin levels and hematological parameters were determined. (biomedcentral.com)
LC-06-JCK-bearing mice showed decreased body weight and serum albumin with increased serum amyloid A. MR16-1 treatment showed significant inhibition of decreased body weight and serum albumin levels, and suppressed serum amyloid A level. (biomedcentral.com)
Serum hepcidin and ferritin levels were statistically elevated in mice bearing LC-06-JCK. (biomedcentral.com)
Administration of MR16-1 to mice bearing LC-06-JCK significantly suppressed levels of both serum hepcidin and ferritin, with increased values of MCV and MCH. (biomedcentral.com)
Hepcidin secretion is regulated by iron stores, oxygenation, and inflammatory signals. (biomedcentral.com)
RESULTS: ASP significantly reduced hepcidin expression by inhibiting the expression of signal transducer and activator of transcription 3/5 (STAT3/5) and mothers against decapentaplegic protein 4 (SMAD4) in liver and stimulating the secretion of erythropoietin, which further down-regulated hepcidin by repressing CCAAT/enhancer-binding protein α (C/EBPα), SMAD4, and the phosphorylation process of STAT3/5. (alexbotsaris.com.br)
Ferritin1
We also found that RNAi-mediated knockdown of the key Fe modulator hepcidin increased intracellular ferritin and inhibited HCV replication. (microbiologyresearch.org)
Inflammatory2
Inflammatory cytokines suppress erythropoiesis in the BM and stimulate hepcidin production in the liver, which impacts iron absorption and mobilization negatively. (haaselab.org)
Inflammatory cytokines stimulate hepcidin production in the liver and lead to reduced ferroportin surface expression and hypoferremia. (haaselab.org)
Erythroid1
Uremic toxins have been shown to suppress erythroid colony formation in vitro as well as EPO transcription in hepatoma cells, the latter indicating possible suppressive effects on hepatic and renal EPO production in vivo (indicated by red line). (haaselab.org)
AIM OF THE STUDY: Previous study indicated that Angelica sinensis polysaccharide (ASP) may promote plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver. (alexbotsaris.com.br)
STAT31
Finally, we demonstrated that hepcidin is modulated at the mRNA level by alpha interferon through STAT3. (microbiologyresearch.org)
Liver2
Its mechanism of action is to inhibit the expression of the liver hormone, hepcidin. (wikipedia.org)
Hepcidin is a 25-amino acid peptide hormone produced mainly in the liver that regulates intestinal iron absorption by causing degradation of the enterocyte iron transporter ferroportin, iron recycling by macrophages, and iron release from hepatic stores [ 4 , 6 ]. (biomedcentral.com)
Production5
These factors suppress hepcidin production leading to increased iron absorption from the intestine and to iron release from macrophages. (haema-journal.gr)
A mechanism linking cancer-related anemia and IL-6 through hepcidin production is suggested. (biomedcentral.com)
We have demonstrated in numerous preclinical studies that DISC-0974 potently suppresses hepcidin production and are developing DISC-0974 to treat anemias of inflammation. (discmedicine.com)
Hepcidin is also maintained at higher levels by decreased errythroferrone production (dotted blue line), which is secondary to a reduction in erythroblast numbers due to EPO deficiency in renal failure. (haaselab.org)
Conclusions1
CONCLUSIONS: ASP can suppress the expression of hepcidin in normal rats, and may be used in the treatments of hepcidin-induced diseases. (alexbotsaris.com.br)
Iron5
A Histone Demethylase Inhibitor Exhibits Cell-Specific Iron Suppression and Neuroprotection in Parkinson's Disease Model. (edu.hk)
2. Try to correct iron hyper absorption which is associated with low levels of hepcidin. (haema-journal.gr)
Our results suggest that overproduction of hepcidin by IL-6 signaling might be a major factor that leads to functionally iron-deficient cancer-related anemia in the LC-06-JCK model. (biomedcentral.com)
Release of iron into the circulation occurs via ferroportin (FPN), which is hepcidin-regulated but also HIF-inducible. (haaselab.org)
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. (mcmaster.ca)
Clarify2
To clarify the hypothesis that overproduction of IL-6 elevates hepcidin levels and contributes to the development of cancer-related anemia, we evaluated anti-IL-6 receptor antibody treatment of cancer-related anemia in an IL-6-producing human lung cancer xenograft model. (biomedcentral.com)
The present study aims to clarify the inhibitory effect of ASP on hepcidin expression as well as the involved mechanisms. (alexbotsaris.com.br)
Erythropoiesis1
More recently, the Haase lab investigated the role of HIF in the regulation of hepcidin and was able to show that the hypoxic suppression of hepcidin occurs indirectly through HIF-2-mediated stimulation of erythropoiesis. (haaselab.org)
Expression3
DISC-0974 is a first-in-class, injectable mAb that inhibits signaling through hemojuvelin (HJV), a co-receptor required for hepcidin expression. (discmedicine.com)
Disturbance in the interval between the HBS1L and MYB suppresses MYB expression and gives rise to the increased level of Hb F [7]. (scirp.org)