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  • recombination
  • However, 28-178 was located in the middle of the short arm of Hessian fly chromosome A2 whereas 23-201 was located in the middle of the long arm of chromosome A2, suggesting the presence of severe recombination suppression over its proximal region. (genetics.org)
  • classical genetic
  • Sager is known primarily for using classical genetic methods to demonstrate the presence of a hereditary system in the chloroplasts of plants and for establishing Chlamydomonas reinhardtii as a model organism for the study of chloroplasts. (encyclopedia.com)
  • disorders
  • Xeroderma pigmentosum (XP) is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of DNA restoration. (complextraitgenomics.com)
  • Although the genetic basis of seasonality and seasonal affective disorder (SAD) has not been established so far, there is growing evidence that factors affecting the biological clock, such as gene polymorphisms of the core clock machinery and seasonal changes of the light-dark cycle, exert a marked influence on the behavior of patients affected by mood disorders. (frontiersin.org)
  • seizures
  • In our work with a fragile X mouse model, we've found that genetic manipulation of the mice to either over- or under-express APP both resulted in increased seizures, suggesting that a balance of APP catabolites may be important to suppress seizure activity. (alzforum.org)
  • Mutations in the PRICKLE genes can cause seizures in humans, zebrafish, mice, and flies, suggesting the seizure-suppression pathway is evolutionarily conserved. (prolekare.cz)
  • gene
  • WHEN the preceding viewpoints on the benefits of excess were conveyed by Oscar Wilde and Mae West, it is safe to assume that they were not commenting on genetic methodology after scanning the latest scientific literature, but their sentiments nonetheless ring true with geneticists who have used gene overexpression as part of their research modus operandi . (genetics.org)
  • Genetic removal of Mapt , the gene encoding tau, in AD models overexpressing amyloid-β (Aβ) decreases hyperexcitability and normalizes the excitation/inhibition imbalance. (jneurosci.org)
  • Genetic suppression would therefore also cause the product of the second gene to be inactive. (thesourcenatural.com)
  • phenotypes
  • Because overexpression of wild-type genes can cause mutant phenotypes, it has been exploited by geneticists working in tractable genetic systems as a parallel approach to loss-of-function screens. (genetics.org)
  • This article reviews the history, applications, methods, mechanisms, and interpretation of overexpression phenotypes, focusing on its application in genetic screens but also providing examples of the utility of targeted overexpression. (genetics.org)