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  • mice
  • Acute tacrolimus treatment transiently increases hepcidin in wild type mice. (bloodjournal.org)
  • Mice pair-fed with regular and ethanol-containing L. De Carli diets were employed to study the effect of alcohol on BMP signaling and hepcidin transcription in the liver. (hindawi.com)
  • Compared with wild-type mice, Erfe-deficient mice exhibited a more severe anemia, had higher hepcidin levels and consequently lower serum iron concentration on days 14 and 21, and manifested impaired mobilization of iron from stores (liver and spleen). (nih.gov)
  • Erfe -deficient mice had higher hepcidin levels 13 days after injection of BA compared with WT mice (D) (see also supplemental Figure 3A). (nih.gov)
  • Time course of hemoglobin and serum hepcidin concentrations after saline or BA injection in WT and Erfe -deficient mice. (nih.gov)
  • Epoetin alfa (EPO) robustly induced bone marrow erythroferrone ( Fam132b ) mRNA in control and Smad1 fl/fl ;Smad5 fl/fl ;Cre + mice but suppressed hepcidin only in control mice. (bloodjournal.org)
  • In 2001, a research team in France found that when the levels of hepcidin were disrupted in mice, the animals developed iron overload, while mice that were genetically altered to "turn on" the Hepcidin gene to a higher level than normal were severely anemic and died within hours of birth. (nih.gov)
  • In 2002, while studying abnormally high iron storage levels in the liver, using a mouse model of the most common form of inherited iron overload (hereditary hemochromatosis), researchers found that the Hepcidin gene was turned off to a greater extent in the mice with the excess liver iron compared to normal mice. (nih.gov)
  • Courselaud B et al (2004) Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. (springer.com)
  • 5 In Tmprss6 KO mice, with an inappropriately active BMP-SMAD signaling, hepcidin levels are high, despite elevated EPO and ERFE levels. (haematologica.org)
  • Time course analysis of the effect of a single EPO injection on hepcidin and BMP-SMAD target genes in WT and Erfe −/− mice and analysis of chromatin modifications at the hepcidin promoter locus 6 and 9 hours after EPO. (haematologica.org)
  • Finally, we demonstrated, using hepatocytes isolated from Hfe −/− mice, that HFE was not critical for the hepcidin response to holotransferrin but important for basal hepcidin expression. (haematologica.org)
  • 5 The common pathogenic mechanism responsible for these iron disorders, as demonstrated in humans and mice, is hepcidin deficiency. (haematologica.org)
  • Disruption
  • Disruption of FKBP12-ALK2 interaction increases hepcidin and renders the receptor responsive to the inflammatory ligand Activin A. (bloodjournal.org)
  • Of note, liver-specific disruption of Smad4 leads to a decrease in hepcidin expression and accumulation of iron in liver, kidney, and pancreas [ 32 ]. (hindawi.com)
  • Testosterone
  • Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis," Journal of Clinical Endocrinology and Metabolism , vol. 95, no. 10, pp. 4743-4747, 2010. (hindawi.com)
  • expression
  • However, current studies in CuD dams failed to confirm a correlation that hepcidin expression was associated with low transferrin receptor 2 (TfR2) levels and also challenged the dogma that holotransferrin can explain the correlation with hepcidin. (biomedcentral.com)
  • Imatinib and spironolactone suppress hepcidin expression. (nih.gov)
  • The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. (bloodjournal.org)
  • Alcohol downregulates hepcidin expression in the liver, which leads to an increase in duodenal iron transporter expression [ 9 ]. (hindawi.com)
  • Hepcidin gene expression could, however, be re-activated by an additional 24 h of incubation with 10% serum. (haematologica.org)
  • Emerging evidence from studies of inherited defects does however, suggest that hepcidin expression in the liver is influenced by hemojuvelin (HJV), transferrin receptor 2 [TfR2, a recently described liver-specific homolog of transferrin receptor-1 (TfR1)] and HFE. (haematologica.org)
  • thereby
  • Since erythroblasts need iron to make hemoglobin, we reasoned that the increased number of erythroblasts in thalassemia may send stronger messages to the liver to suppress hepcidin and thereby absorb more iron even in the condition of iron overload," says the study's lead author, Toshihiko Tanno, Ph.D., an investigator in Miller's laboratory in the NIDDK's Division of Intramural Research. (nih.gov)
  • disorders
  • Hepcidin in human iron disorders: therapeutic implications. (semanticscholar.org)
  • ALK2 free of FKBP12 becomes responsive to the non-canonical inflammatory ligand Activin A. Our results identify a novel hepcidin regulator and a potential therapeutic target to increase defective BMP signaling in disorders of low hepcidin. (bloodjournal.org)