• A small number of patients have mutations in the hepcidin (HAMP) gene. (wikipedia.org)
  • expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). (affbiotech.com)
  • Hepcidin levels in the liver are dramatically depressed in these knockout animals. (wikipedia.org)
  • Our results suggest sexually dimorphic protein expression in the liver, with female mice demonstrating lower inflammation and increased oxidative stress defenses. (biomedcentral.com)
  • The ability to distinguish proliferative hepatocytes from hepatocellular carcinoma (HCC) and normal liver tissues and comparison of their gene expression profiles will aid us in understanding the mechanisms underlying aberrant proliferative signaling in malignant cells. (biomedcentral.com)
  • We propose that in Huh7 cells hepcidin modulation leads to an unfavourable intracellular environment for HCV replication. (microbiologyresearch.org)
  • There are three critical promoter elements responsible for transcriptional activation in skeletal muscle (the tissue that has the highest level of RGMc expressesion per weight), comprising paired E-boxes, a putative Stat and/or Ets element, and a MEF2 site, and muscle transcription factors myogenin and MEF2C stimulate RGMc promoter function in non-muscle cells. (wikipedia.org)
  • This strategy treats the anemia and suppresses endogenous erythropoiesis so that extramedullary hematopoiesis and skeletal changes are suppressed. (medscape.com)
  • These mutations primarily point mutations that affect transcriptional control, translation, and splicing of the Hb B gene and gene product [2]. (scirp.org)
  • Epub 2013 Oct 30.Differential miRNA expression in repeated recurrence of nasopharyngeal carcinoma.Wang LJ1, Chou YF2, Chen PR2, Su B3, Hsu YC4, Chang CH5, Lee JW6. (welgene.com.tw)
  • The perturbed expression was associated with disease progression and poor prognosis. (wikipedia.org)
  • CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). (affbiotech.com)
  • Conclusions The results indicate that estradiol tightly regulates calreticulin expression in normal human T cells and the dynamics are different between activated and resting T cells. (academicediting.org)
  • The receptor does not actually interact with the DNA but rather stabilizes the protein complex and helps recruit additional transcriptional regulators.46 47 Estrogen upregulates SP-1 in human T cells and increases SP-1 binding to the cyclic AMP response element modulator α.48 Results from the present study suggest that estradiol regulates calreticulin expression in normal T cells and this regulation is altered in SLE T cells. (academicediting.org)
  • Taken together our results suggest that estradiol tightly regulates calreticulin expression in normal human T cells. (academicediting.org)
  • We also found that RNAi-mediated knockdown of the key Fe modulator hepcidin increased intracellular ferritin and inhibited HCV replication. (microbiologyresearch.org)
  • However previous studies suggest a 1.6-fold increase of calreticulin expression can increase intracellular calcium storage Iguratimod (T 614) and decrease store-operated calcium influx.38 Calreticulin is upregulated by estradiol during activation and we hypothesize that this prepares T cells for the sustained calcium elevation that follows antigen encounter.5 8 Deregulation of calreticulin is expected to affect signal transduction and cytokine profiles in SLE T cells. (academicediting.org)
  • Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. (affbiotech.com)
  • Nkc2.5) increases calreticulin expression in the heart while chicken ovalbumin upstream promoter-transcription factor 1(COUP-TF1) binds to the Nkx2.5 binding CACNG1 site and suppresses transcription from the calreticulin promoter.43 44 In the present study calreticulin expression markedly decreases at 24 h of estradiol stimulation suggesting this decline is due to the presence of an inhibitory factor. (academicediting.org)
  • The tumor-suppressing mechanisms mediated by menin remain unclear, although menin was shown to be involved in the regulation of gene transcription, cell proliferation, apoptosis, and genome stability 54. (publiguia.net)
  • Epub 2014 Feb 3.A supervised network analysis on gene expression profiles of breast tumors predicts a 41-gene prognostic signature of the transcription factor MYB across molecular subtypes.Liu LY1, Chang LY2, Kuo WH3, Hwa HL2, Chang KJ4, Hsieh FJ5. (welgene.com.tw)
  • Gene expression profiles of individual cells in HCC and para-carcinoma tissues can be effectively obtained using the single-cell RNA sequencing (scRNA-Seq) technique. (biomedcentral.com)
  • Gene expression profiles between the two types of proliferative hepatocytes were compared. (biomedcentral.com)
  • Compared to males, females demonstrated significantly lower inflammatory protein expression (ICAM-1, MCP-1, COX-2), along with lower expression of the DNA damage marker, Gadd153, and the oxidative stress marker, HO-1. (biomedcentral.com)
  • RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. (wikipedia.org)
  • Analysis of Genome-Wide Monoallelic Expression Patterns in Three Major Cell Types of Mouse Visual Cortex Using Laser Capture Microdissection. (welgene.com.tw)
  • Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). (affbiotech.com)
  • Calreticulin expression decreased in activated SLE T cell samples and increased in approximately 50% of resting T cell samples. (academicediting.org)
  • Furthermore, aberrant expression of RGMs was indicated in breast cancer. (wikipedia.org)
  • Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lα expression during ER stress. (affbiotech.com)
  • A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. (mcmaster.ca)
  • The goal of long-term hypertransfusional support is to maintain the patient's hemoglobin level at 9-10 g/dL, thus improving his or her sense of well being while simultaneously suppressing enhanced erythropoiesis. (medscape.com)
  • Finally, we demonstrated that hepcidin is modulated at the mRNA level by alpha interferon through STAT3. (microbiologyresearch.org)
  • Disturbance in the interval between the HBS1L and MYB suppresses MYB expression and gives rise to the increased level of Hb F [7]. (scirp.org)
  • Thus, our work identifies significant changes in the protein content of PIEZO1-HX erythrocytes, revealing a "PIEZO1 signature" and identifying potentially targetable pathways in this disease characterized by a heterogeneous clinical expression and contra-indication of splenectomy. (bvsalud.org)
  • A small number of patients have mutations in the hepcidin (HAMP) gene. (wikipedia.org)
  • The core of his lab s research since the mid-1990s has been to map gene expression in the erythroid lineage. (nih.gov)
  • 2022. Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs. (nih.gov)
  • Hepcidin has been suggested to act as a modifier gene in genetic hemochromatosis. (wjgnet.com)
  • The role of gender in the regulation of human hepcidin gene expression in the liver is unknown. (wjgnet.com)
  • Thermogenic gene expression was decreased in these mice as well. (bvsalud.org)
  • ABCD1 deficiency impaired VLCFA homeostasis and prolonged pro-inflammatory gene expression upon LPS treatment. (biomed.news)
  • In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. (genetex.com)
  • Bacillus paralicheniformis TRQ65 reprograms the gene expression patterns associated with systemic response to potentially facilitate its colonization and stimulate cell growth and plant biomass. (tuberculosistest.net)
  • A soluble form of HJV may be a molecule that suppresses hepcidin expression. (wikipedia.org)
  • However it has been demonstrated that hemojuvelin interacts with bone morphogenetic protein (BMP), possibly as a co-receptor, and may signal via the SMAD pathway to regulate hepcidin expression. (wikipedia.org)
  • Downregulation of miR-340 inhibited GC cell proliferation, arrested cell cycle, and facilitated apoptosis through upregulating SOCS3 expression to suppress JAK-STAT3 signaling pathway. (cusabio.com)
  • DNA microarray analysis was performed to analyze the expression of genes in the NF-κB signaling pathway. (bmj.com)
  • After transcriptional profiling of the TGF- b superfamily members in erythroblasts, GDF15 stood out among 54 genes. (nih.gov)
  • 6. The SMILE transcriptional corepressor inhibits cAMP response element-binding protein (CREB)-mediated transactivation of gluconeogenic genes. (nih.gov)
  • Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. (cusabio.com)
  • Ways in which PPARs may reduce oxidative stress involve modulation of mitochondrial uncoupling protein (UCP) expression (thus reducing reactive oxygen species, ROS), optimising forkhead box class O factor (FOXO) activity (by improving whole body insulin sensitivity) and suppressing NFkB (at the transcriptional level). (westminster.ac.uk)
  • Transcriptional regulation of cell growth and reprogramming of systemic response in wheat (Triticum turgidum subsp. (tuberculosistest.net)
  • Sex and genetic background have also been shown to modulate hepcidin expression in mice. (wjgnet.com)
  • 3. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. (nih.gov)
  • 19. Supranutritional selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1α expression in male Sprague-Dawley rats. (nih.gov)
  • So it regulates iron s uptake from food through the peptide hepcidin, which hinders iron absorption via enterocyte cells in the gut. (nih.gov)
  • In contrast, VLCFAs provoked pro-inflammatory responses through scavenger receptor CD36-mediated uptake, cumulating in JNK signalling and expression of matrix-degrading enzymes and chemokine release. (biomed.news)
  • Here, whole transcriptome sequencing of X-ALD macrophages indicated that VLCFAs prime human macrophage membranes for inflammation and increased expression of factors involved in chemotaxis and invasion. (biomed.news)
  • RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. (wikipedia.org)
  • May play an apoptotic role by transctivating BIRC5 expression under LEP activation. (cusabio.com)
  • Importantly, we identify the epigenetic reactivation of argininosuccinate synthase (ASS1), a urea cycle enzyme suppressed in primary ccRCC, as a crucial event for metastatic renal cancer cells to acquire the capability to generate arginine, invade in vitro and metastasize in vivo. (biomed.news)
  • [37] Angiogenesis Co-culture experiment of 2 cell lines Electrolyzed reduced H2 water inhibited lumen formation via suppression of VEGF expression in cultured cells. (researchgate.net)
  • Furthermore, aberrant expression of RGMs was indicated in breast cancer. (wikipedia.org)
  • The use of microRNA mimics to suppress EMT has expanded to other cancer cell lines and holds potential for clinical drug development. (micrornamimic.com)