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  • hyperalgesia
  • When applied intrathecally, BTX-A (1U/kg) reduced diabetic hyperalgesia within 24h supporting the assumption of retrograde axonal transport of BTX-A from the peripheral site of injection to central nervous system. (nih.gov)
  • 6 In a patient, such hyperexcitability of pain processing is expressed as increased pain for a given stimulus, a phenomenon termed hyperalgesia in the absence of modality shifts. (asahq.org)
  • The presence of hyperalgesia has a major impact on primary and secondary pain processing by the brain, with these changes having the potential to be both adaptive and maladaptive. (asahq.org)
  • First, hyperalgesia tends to increase the amount of pain the patient experiences-an unwanted outcome of itself-because of greater amplification of given noxious inputs. (asahq.org)
  • Finally, abnormal persistence of nervous system sensitization subsequent to nociception, i.e. , excitatory neuroplasticity expressed as hyperalgesia and increased pain, is now considered a major candidate mechanism for the development of chronic pain. (asahq.org)
  • The very definition of hyperalgesia-more pain accompanying a given stimulus-makes it clear that its detection is based on construction and comparison of stimulus-response curves before and after nociception or drug application. (asahq.org)
  • noxious
  • A key insight has been that nervous system processing of nociception and pain is not hardwired, and that the gain of the nervous system can change as a result of noxious sensory inputs or the drugs used to modulate these. (asahq.org)
  • pediatrics
  • Individual panel members were selected to include individuals from diverse disciplines and positions from across Canada, including organizations involved in pediatric medicine (the Canadian Paediatric Society, Toronto Public Health) and immunization (the Canadian Center for Vaccinology) and clinicians, policy-makers and scientists involved in pediatrics, pain, evidence-based medicine, education, health policy, knowledge translation and methodology for guideline development. (cmaj.ca)
  • intensity
  • This represents enhanced central tolerance to pain rather than decreased pain intensity, yet it enables patients to become significantly more comfortable and functional in their lives. (practicalpainmanagement.com)
  • Pain intensity scores were significantly reduced when subjects took part in the more cognitively demanding interference task of the counting Stroop than in the less demanding neutral task. (ox.ac.uk)
  • thermal
  • After peripheral application, BTX-A (5 and 7U/kg) reduced mechanical and thermal hypersensitivity not only on ipsilateral, but on contralateral side, too. (nih.gov)
  • reduction
  • The results presented here demonstrate the long-lasting pain reduction after single BTX-A injection in the animals with diabetic neuropathy. (nih.gov)
  • The bilateral pain reduction after unilateral toxin application and the effectiveness of lower dose with the faster onset after the intrathecal injection suggest the involvement of the central nervous system in the antinociceptive action of BTX-A in painful diabetic neuropathy. (nih.gov)
  • Joint
  • Therefore, the use of CBD in topical form is a useful alternative for those who wish to avoid the psychoactive effects of THC and those who would like options besides the over-the-counter steroid-based creams typically used for arthritis, joint pain, and similar ailments. (therajoypharma.com)
  • while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. (shop.com)
  • Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. (shop.com)
  • An aminomonosaccharide (a combination of the amino acid - glutamine and a sugar - glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. (shop.com)
  • illness
  • When chronically ill individuals struggle to adjust, and make sense of their disease, they are likely to benefit from participating in illness support groups. (springer.com)
  • These three concepts suggest that support groups assist with regulating emotions, belonging, and integrating chronic illness into one's identity. (springer.com)
  • Although attachment theory highlights important aspects of coping with chronic illness, it is framed in dyadic terms, which is ill-fitting for support groups. (springer.com)
  • Practical applications of these evolutionary concepts for chronic illness support groups are discussed. (springer.com)
  • I have a well-documented illness that explains the cause of my pain. (nap.edu)
  • surgical
  • But carpal tunnel syndrome that sends shooting pains into both of her hands and an aversion to conventional steroid and surgical treatments is prompting her to consider some new options. (therajoypharma.com)
  • typically
  • Second, more pain typically means more patient stress in the postoperative period, with the possibility of negative consequences for a variety of complications and outcomes. (asahq.org)
  • Patient
  • That is the worst part of being a pain patient. (nap.edu)
  • Section 4305 of the 2010 Patient Protection and Affordable Care Act required the Secretary, Department of Health and Human Services (HHS), to enter into an agreement with the Institute of Medicine (IOM) for activities "to increase the recognition of pain as a significant public health problem in the United States. (nap.edu)
  • results
  • In contrast, many areas of the pain matrix (i.e. thalamus, insula, cognitive division of the ACC) displayed reduced activation, supporting the behavioural results of reduced pain perception. (ox.ac.uk)
  • Once experiments with animals have been approved, the suffering, pain and number of animals required for each test must be reduced to the greatest possible extent without jeopardising the validity of the experimental results. (bund.de)
  • effect
  • In this study, we aimed to assess the effect of adaptive support ventilation (ASV) on atelectasis in patients undergoing cardiac surgery. (anesthpain.com)
  • Androgen deprivation therapy (ADT), or androgen suppression therapy, is a hormone treatment that reduces the effect of androgen. (moreliaclinic.com)
  • demonstrate
  • Recent surveys of chronic pain after surgery demonstrate that this problem is much more common than previously thought, with some types of surgery ( e.g. , thoracotomy, mastectomy, limb amputation) being associated with chronic pain incidences of more than 50% at 1 yr postoperatively. (asahq.org)
  • Methods
  • One of the most important methods for reducing pulmonary complications is supportive care with protective ventilation strategies. (anesthpain.com)
  • suffer
  • During the many years that I directed the UCLA Pain Control Unit, one of the most valuable things I learned was that it is possible for someone to have pain and yet not suffer. (practicalpainmanagement.com)
  • health
  • Most regretted various choices they made that led to the pain experience, and many tearfully mourned their loss of health, function, purpose, meaning, income and relationships. (practicalpainmanagement.com)
  • Conversely, minimizing pain during childhood vaccination can help to prevent distress, development of needle fears and subsequent health care avoidance behaviours, such as nonadherence with vaccination schedules. (cmaj.ca)
  • In light of the prevalence of pain during vaccine injections and the potential for substantial short-term and long-term adverse sequelae, we identified a need for a national guidance document to address this important public health issue. (cmaj.ca)
  • Modern social context and economic view of health services, the needs of the pharmaceutical market and the recognition that research on medicinal plants used in folk medicine represents a suitable approach for the development of new drugs [ 2 , 3 ] have led to an increase in the number of publications in this field, and private and governmental institutions are now financially supporting research programs worldwide. (biomedcentral.com)
  • The annual economic cost of chronic pain in adults, including health care expenses and lost productivity, is $560-630 billion annually according to a new estimate developed for this study (see Appendix C ). (nap.edu)
  • Accordingly, HHS, through the National Institutes of Health (NIH), requested that the IOM conduct a study to assess the state of the science regarding pain research, care, and education and to make recommendations to advance the field. (nap.edu)
  • patients
  • When two patients were admitted with similar diagnoses, histories, demographics, and objective findings, we would often find tremendous variability in how well they were coping with pain and its consequences. (practicalpainmanagement.com)
  • The highly coping patients reported much greater tolerance to pain in general, as well as a consistently positive attitude and focus on the future. (practicalpainmanagement.com)
  • Pain tolerance can have a huge impact on how patients respond to any type of medical treatment. (practicalpainmanagement.com)
  • Guided imagery techniques enabled us to best meet our remaining three goals, and they became one of the most effective ways to help our patients reduce suffering even when "nothing more (medically) can be done. (practicalpainmanagement.com)
  • Moradian S T, Saeid Y, Ebadi A, Hemmat A, Ghiasi M S. Adaptive Support Ventilation Reduces the Incidence of Atelectasis in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial, Anesth Pain Med. (anesthpain.com)
  • 7-9 ] Recent studies have shown that the production of such mediators is highly increased in patients with discogenic back pain, implicating their biologic activity in the pathogenesis of this condition. (chiro.org)
  • activation
  • Experimental studies suggest that bile and enteric reflux, and intravenous free fatty acid (FFA) infusion initiate pancreatitis by an interstitial mechanism whereas hyperstimulation with caerulein or organophosphates, pancreatic duct obstruction and choline deficient ethionine supplemented diet (CDE diet) result in intracellular activation. (vin.com)
  • care
  • 1 The quotations throughout this report come from the committee's survey on pain care, testimony received at public workshops, committee member comments, and published sources, as noted. (nap.edu)
  • Consistent
  • Consistent with BPI scoring, items will be averaged to create a composite score that had a possible range of 0 to 10 with higher scores indicating greater pain. (clinicaltrials.gov)
  • help
  • We convened an interdisciplinary guideline development panel, the Help ELiminate Pain in KIDS (HELPinKIDS) Team, to develop the guideline. (cmaj.ca)
  • Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. (westernkentuckyvsfloridaintllive.us)
  • common
  • Injections for vaccinations, the most common source of iatrogenic pain in childhood, 1 are administered repeatedly to almost all Canadian children throughout infancy, childhood and adolescence. (cmaj.ca)