• Given the health risks associated with vitamin D deficiency, the American Academy of Family Physicians (AAFP) supports coverage of vitamin D supplementation by third party payers. (aafp.org)
  • Vitamin D deficiency, including cases of rickets, continues to be diagnosed in infants in the United States. (aafp.org)
  • Vitamin D could potentially fill this role, as it is a critical modulator of immune activity and earlier findings have suggested that RA could be tied to vitamin D deficiency. (news-medical.net)
  • These findings suggest that targeting vitamin D deficiency could potentially be key to helping patients achieve and maintain RA remission. (news-medical.net)
  • According to the results obtained, we have observed that vitamin D deficiency is associated with the activity of [RA],' said Jose Luis Garcia de Veas Silva, PhD, a coauthor of this study. (news-medical.net)
  • Researchers have found that deficiency in vitamin D may predispose people to infection, and thus vitamin D has been labeled as antibiotic vitamin [ 5 ]. (hindawi.com)
  • Vitamin D deficiency if severe leads to chest wall deformity, hypotonia, poor chest wall compliance, atelectasis, and fibrosis [ 9 ]. (hindawi.com)
  • All these factors contribute to a higher incidence of pneumonia in children with severe vitamin D deficiency. (hindawi.com)
  • along with substantial conflicting findings from individual studies, conducted in settings with potentially varying levels of maternal vitamin A deficiency and infant mortality. (nutraingredients.com)
  • Therefore, maternal vitamin A deficiency may result in a deficiency among infants. (nutraingredients.com)
  • Vitamin A deficiency is considered a major public health problem in low and middle income countries and globally 9.8 million pregnant women are affected by night blindness - one of the major consequences. (nutraingredients.com)
  • Vitamin A deficiency (VAD) is a public health problem all around the world, affecting more than 100 countries [1]. (who.int)
  • The solution for correcting vitamin A deficiency lies in improving the child's diet - through increased consumption of vitamin A-rich foods, naturally rich or commercially fortified foods such as processed oils or sugar. (who.int)
  • Vitamin A deficiency is a common condition in low- and middle-income countries that can cause stunting, anemia, dry eyes (the leading cause of preventable childhood blindness), susceptibility to infection, and death. (givewell.org)
  • VAS involves treating all children aged approximately six months to five years in areas at high risk for vitamin A deficiency with high-dose vitamin A supplements, usually twice per year. (givewell.org)
  • We think this grant will lead to an increase in the number of children with vitamin A deficiency receiving VAS, which will, in turn, lead to reduced mortality and other health and income-related benefits during the rest of these children's lives. (givewell.org)
  • Nutrition International's program will increase the number of children with vitamin A deficiency that receive vitamin A supplements. (givewell.org)
  • Vitamin D supplementation should be reserved for those who are at risk of deficiency such as elderly people in residential care, people with darkly pigmented skin and people who receive little direct sunlight e.g. women who are veiled. (bpac.org.nz)
  • 4 Individuals within communities may display wide variations in circulating levels of vitamin D. Therefore, unless severe deficiency is suspected, testing serum levels is not recommended and clinical decisions regarding supplementation can usually be made by assessing individual risk factors. (bpac.org.nz)
  • To compare the safety and efficacy of high-dose vitamin D supplementation tailored to baseline deficiency levels with conventional vitamin D supplementation in women with early breast cancer. (naturalmedicinejournal.com)
  • Overall, vitamin and antioxidant deficiency should be considered in the management of cancer, including individually tailored assessment and repletion strategies. (naturalmedicinejournal.com)
  • Compliance with high-dose discontinuous vitamin D supplementation (T arm) was measured as the number of vials reported taken divided by the prescribed number of vials (3, 5, or 6 vials, according to the vitamin D deficiency), reported as a percentage. (naturalmedicinejournal.com)
  • Percent deficiency values of folate, vitamin B6 and vitamin B12 were 39.7%, 52.8% and 6.6% respectively. (unboundmedicine.com)
  • There is already solid evidence that testing and correcting vitamin D deficiency is much more complex than monitoring hydroxyvitamin D levels and vitamin D3 supplementation. (wakeup-world.com)
  • So, if supplemented with high doses of vitamin D in the presence of vitamin K deficiency, the long-term results could be disastrous. (wakeup-world.com)
  • Vitamin D deficiency has been associated with the development of food allergy in infants. (bmj.com)
  • Vitamin D is likely to play a role in early infant immune health, with emerging evidence that early life vitamin D deficiency increases the risk of developing childhood diseases such as food allergy 1 lower respiratory infections (LRIs) 2 and eczema. (bmj.com)
  • Results from epidemiological studies suggest that vitamin D (VD) deficiency (VDD) may be a cause of hypertension (HTN). (escholarship.org)
  • Further support for vitamin C supplementation arose from a published report that suggested hypertrophic osteodystrophy (HOD), a bone disease of young dogs, might be due to a deficiency of vitamin C within the body, based on a report that found similarities between bone abnormalities found in HOD and scurvy (vitamin C deficiency) in humans. (seniorpetproducts.com)
  • Vitamin D deficiency has been associated with several adverse health outcomes, including abnormal bone mineralization, heart disease, and premature mortality. (medscape.com)
  • Conversion of circulating 25D to 1,25D occurs primarily in the kidneys and is upregulated during states of vitamin D deficiency. (medscape.com)
  • Oral calcium either as dietary intake or supplement should be routinely used in conjunction with vitamin D in the treatment of Vitamin D deficiency regardless of age or weight. (medscape.com)
  • Although routine 25OHD screening is not recommended for healthy children, children at risk of osteoporosis or vitamin D deficiency (with factors/conditions that reduce vitamin D synthesis or intake) should have their vitamin D status ascertained by measurement of a serum 25OHD concentration. (medscape.com)
  • However, new research casting doubt on the benefits of vitamin D supplementation is sparking a debate on whether healthy Americans should bother being tested for vitamin D deficiency or taking a supplement. (lablynx.com)
  • Twenty percent of the participants were black, a group among which vitamin D deficiency is more common. (lablynx.com)
  • Participants were not selected based on whether they had vitamin D deficiency, low bone mass, osteoporosis, or other bone health issues. (lablynx.com)
  • Therefore, newborns have a high risk of suffering from vitamin E deficiency. (parentingscience.today)
  • Colostrum, which is the earliest milk produced in the lactation stage, contains α-tocopherol, so breastfeeding is the safest way to prevent a possible vitamin E deficiency in infants. (parentingscience.today)
  • Because the effects of higher intakes are not well known but include complicating the diagnosis of vitamin B((12)) deficiency, care should be taken to keep total folate consumption at less than 1 mg per day, except under the supervision of a physician. (cdc.gov)
  • Increased concentrations of methylmalonic acid in plasma or serum and excessive urinary excretion of MMA are believed to be direct measures of tissue stores of cobalamin (vitamin B12) and to be the first indication of cobalamin deficiency. (cdc.gov)
  • Vitamin A deficiency also affects about 19 million pregnant women, mostly from the World Health Organization (WHO) regions of Africa and South-East Asia. (bvsalud.org)
  • In a meta-analysis of 21 randomized clinical trials including a total of 83,291 patients, vitamin D supplementation was not associated with a reduction in cardiovascular events or death. (nature.com)
  • Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: a meta-analysis. (nature.com)
  • Their study involved 38 men and women with rheumatoid arthritis and 32 healthy men participating in two independent 12-week randomized clinical trials of vitamin E supplementation. (yourhealthbase.com)
  • However, the results of randomized clinical trials (RCTs) designed to address the impact of VD supplementation on reducing blood pressure (BP) remain equivocal. (escholarship.org)
  • To determine whether regulating vitamin C (ascorbic acid: AA) intake to achieve higher or lower plasma concentrations was associated with improved clinical outcome. (bmj.com)
  • Vitamin C (ascorbic acid: AA) is an important aqueous phase antioxidant in cells and plasma. (bmj.com)
  • Dr. Marc McRae from the National University of Health Sciences in Lombard, Illinois reviewed the effect of vitamin C (ascorbic acid) supplementation on LDL (bad) and HDL (good) cholesterol, as well as triglycerides in patients with hypercholesterolemia. (thecamreport.com)
  • Vitamin C, or ascorbic acid, is required for the formation of collagen. (seniorpetproducts.com)
  • Unless inadequate amounts are synthesized by the liver or there is an unusually high metabolic requirement, supplementation of the diet with ascorbic acid is unnecessary. (seniorpetproducts.com)
  • However, when combined with other antioxidants such as vitamin E and butylated hydroxytoluene, ascorbic acid has been shown to work cooperatively with these antioxidants. (seniorpetproducts.com)
  • Vitamin C requirements do increase with stress and many pet owners, breeders, and veterinarians believe that stressed animals may be unable to manufacturer sufficient ascorbic acid themselves to deal with stressful situations. (seniorpetproducts.com)
  • Later evidence showed that the two conditions were not the same disorder and controlled studies on the efficacy of supplementing with vitamin C in the treatment of HOD failed to support the concept that low levels of ascorbic acid were a cause of HOD. (seniorpetproducts.com)
  • Ascorbic acid supplementation in dogs and cats, on the other hand, may be detrimental under certain circumstances since any excess ascorbic acid is excreted as oxalate in the urine. (seniorpetproducts.com)
  • For this reason, avoidance of ascorbic acid supplementation is currently recommended for the prevention of calcium oxalate urinary crystals or bladder stones. (seniorpetproducts.com)
  • is a meta-analysis of randomized controlled trials looking at a variety of vitamins, both multivitamins and specific vitamins, and their relationship to cardiovascular disease, stroke, and all-cause mortality. (sciencebasedmedicine.org)
  • This article summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation to prevent cancer and cardiovascular disease and the supporting scientific evidence. (nih.gov)
  • June 21, 2022 - The U.S. Preventive Services Task Force released today a final recommendation statement on vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease (CVD) and cancer. (uspreventiveservicestaskforce.org)
  • The high levels of plasma homocysteine could indicate a reason for mass micronutrient supplementation to prevent the high incidence of cardiovascular disease observed in Pakistani population. (unboundmedicine.com)
  • Hundreds of research studies suggest that vitamin D can help prevent a multitude of conditions, from osteoporosis to autoimmune disorders, immune function, cardiovascular disease, cancer and more. (wakeup-world.com)
  • Vitamin D gets my vote for the nutrient of the decade with it being linked in research to an amazing amount of positive effects in the body, including reducing cardiovascular disease, cancer, autoimmune diseases, infections, promoting DNA repair, as well as increased bone density. (drweitz.com)
  • Therefore, the AAFP recommends that breastfed infants whether exclusive or partial) receive 400 IU of vitamin D supplementation daily starting soon after birth until one year of age. (aafp.org)
  • Formula-taking infants should receive vitamin D supplementation until they are taking in more than 32 ounces of formula per day. (aafp.org)
  • Additional analysis of data for all infants from 11 studies also revealed no evidence of a significant reduction in the risk of infant mortality at six months among babies supplemented with vitamin A compared with the control. (nutraingredients.com)
  • In a recent study, the effects on bone mass did not differ between groups of infants with different levels of vitamin D supplementation. (contemporarypediatrics.com)
  • A higher dose of vitamin D supplementation is not associated with advantages in bone mass for infants born with 25-hydroxyvitamin D (25[OH]D) concentrations less than 50 nmol/L, according to a recent study. (contemporarypediatrics.com)
  • Vitamin D status at birth is reflective of 25(OH)D, with concentrations of under 50 nmol/L in mothers associated with increased risk of vitamin D insufficiency in infants. (contemporarypediatrics.com)
  • Public health policies in North America to suggest vitamin D supplementation be initialized in breastfed infants shortly after birth. (contemporarypediatrics.com)
  • However, it is unknown if infants born with low 25(OH)D have compromised bone mineral content (BMC), or if increased vitamin D dosage is needed for improved vitamin d stores and bone health. (contemporarypediatrics.com)
  • To evaluate outcomes in infants with serum 25(OH)D concentrations below 50 nmol/L receiving vitamin D supplementation when aged 1 to 12 months, investigators conducted a secondary analysis of a double-blinded, parallel, randomized clinical trial from March 2016 to March 2019. (contemporarypediatrics.com)
  • Infants in 1 trial group were given 400 IU of oral vitamin D3 supplementation daily, while those in the other trial group were given 1000 IU. (contemporarypediatrics.com)
  • Vitamin D3 supplementation was given to infants from ages 1 to 12 months. (contemporarypediatrics.com)
  • However, the proportion of infants with sufficient vitamin D status did not differ from baseline in both trial groups. (contemporarypediatrics.com)
  • This showed an absence of effects from vitamin D supplementation on bone mass in infants born with 25(OH)D concentrations under 50 nmol/L. (contemporarypediatrics.com)
  • Effect of vitamin D supplementation on bone mass in infants with 25-hydroxyvitamin D concentrations less than 50 nmol/L: aprespecified secondary analysis of a randomized clinical trial. (contemporarypediatrics.com)
  • With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6-8 weeks to 12 months of age, we have started a double-blind, randomised, placebo-controlled trial of daily 400 IU vitamin D supplementation during the first year of life, VITALITY. (bmj.com)
  • Methods nd analysis Infants (n=3012) who are fully breastfed and not receiving vitamin D supplementation will be recruited at the time of their first immunisation, from council-led immunisation clinics throughout metropolitan Melbourne, Australia. (bmj.com)
  • Vitamin E thus strengthens infants' defenses against oxidative stress. (parentingscience.today)
  • Vitamin K toxicity is rare but is most common in formula-fed infants. (msdmanuals.com)
  • Besides these, nutritional supplementations such as zinc and vitamin A supplementation have been tried, though the results have been unfavorable [ 3 , 4 ]. (hindawi.com)
  • The older the woman, the more likely it is that consistent use of calcium and vitamin-D supplements will play a role in reducing her risk for osteoporosis, according to the results of a large national clinical trial conducted as part of the Women's Health Initiative (WHI). (sciencedaily.com)
  • Despite recommendations that women should ensure adequate calcium plus vitamin-D intake for postmenopausal bone health, the role of these supplements on reducing fractures has been conflicting. (sciencedaily.com)
  • This meta-analysis is a good opportunity to step back and reconsider our basic approach to vitamins and supplements, in terms of both practical implications and underlying philosophy. (sciencebasedmedicine.org)
  • This study highlights the possibility of interaction between supplements and adds to the growing body of evidence to the fact that high-dose supplementation with a single vitamin may not be desirable. (yourhealthbase.com)
  • For most vitamins and mineral supplements, more research is needed to make a recommendation for or against taking them to prevent CVD and cancer. (uspreventiveservicestaskforce.org)
  • Many doctors and nutritionists routinely prescribe supplements with high doses of vitamin D, ranging from 2,000-10,000 IU (international units) per day to 50,000 IU per week. (wakeup-world.com)
  • If you've just started building your supplement stack, you may be wondering which popular vitamins and supplements you really need to improve your overall health and wellness. (transcend.me)
  • So, the children of the women who took vitamin E supplements received a greater amount of α-tocopherol through breast milk. (parentingscience.today)
  • The researchers, led by David Torgerson from the University of York, England, calculated that the vitamin K supplements were associated with a consistent reduction in all fracture types. (rejuvenation-science.com)
  • Vitamins/supplements were the focus of 15% of articles in men's magazines and 11% in women's magazines. (cdc.gov)
  • PCPs reported on their recommendation of fall prevention approaches including general exercise, Tai Chi, medication adjust- ments, home safety modifications, vitamin D supplements, assistive devices, alarm systems, and referral to physical therapy, foot specialist, or vision specialist. (cdc.gov)
  • Higher doses of vitamin D, 600 IUs or higher, might be required to produce a statistically significant benefit to bone health. (sciencedaily.com)
  • As a matter of fact, a clinical study found no change in coagulant activity in patients with coronary artery disease who were taking warfarin and 100-400 IU/day of vitamin E. It is, however, possible that patients with low vitamin K status could experience a decrease in coagulation time if warfarin therapy is combined with large doses (800-1200 IU/day) of vitamin E. (yourhealthbase.com)
  • In countries where this remains a public health problem, and while food-based solutions are gradually being implemented and scaled-up to reach those populations, giving children 6 to 59 months of age two doses of vitamin A per year can impact a child's health. (who.int)
  • The warfarin doses before vitamin K were not significantly different between the 3 groups and, in fact, the absolute mean dose was lower in the GG group than in the GA or the AA group (3.23 mg, 4.52 mg, and 3.50 mg, respectively). (clotcare.com)
  • The warfarin doses after the addition of vitamin K also were not significantly different (mean daily doses of 4.05 mg, 4.86 mg, and 3.50 mg for GG, GA, and AA, respectively) - and the mean dose for the "resistant" group remained lower than the mean dose for the "average" (GA) group. (clotcare.com)
  • Safety of oral doses of vitamin D 3 and calcium (unspecified form) given in the study was assessed by descriptive analysis. (naturalmedicinejournal.com)
  • Random supplementation with high doses of vitamin D without knowing and understanding the person's entire health profile or the condition of other minerals and vitamins involved in biochemical balance can be even dangerous. (wakeup-world.com)
  • These findings suggest that there is no benefit of high-dose vitamin D supplementation for bone health, a finding that has been evidenced in other studies such as the clinical trial by Burt et al [3], which was designed to investigate the effects of daily supplementation of vitamin D in high doses on bone density and strength. (imsociety.org)
  • In conclusion, vitamin D supplementation is recommended due to their beneficial effects for the prevention and treatment of osteoporosis, however, in high doses an additional benefit on bone health has not been found and on the contrary adverse effects have been suggested. (imsociety.org)
  • There is need for more studies to evidence the effectiveness/risk of high doses of vitamin D3 supplementation. (imsociety.org)
  • According to the US Department of Agriculture , the following foods are vitamin D-rich and, when consumed as part of a healthy diet, allow adults to reach their desired daily vitamin D level, without the need for supplemental doses. (lablynx.com)
  • Antioxidants, in particular vitamin C, have been suggested to decrease oxidative DNA damage. (nih.gov)
  • Vitamin E is considered one of the best antioxidants due to its protective effect against oxidative processes that produce free radicals. (parentingscience.today)
  • A recent study in the United European Gastroenterology Journal found that when patients with Crohn's Disease were supplemented with 2000 IU of vitamin D3 per day for three months, several markers of disease progression were reduced, as well as their symptoms, as compared to placebo. (drweitz.com)
  • For treatment of nutritional rickets per the most recent Global Consensus Recommendations, the minimal recommended dose of vitamin D is 2000 IU/d (50 μg) for a minimum of 3 months. (medscape.com)
  • A post hoc analysis of the AMATERASU randomized, double-blind, placebo-controlled trial of postoperative vitamin D3 supplementation (2000 IU/day) in 417 patients with stage I to stage III digestive tract cancer from the esophagus to the rectum was conducted. (bvsalud.org)
  • Thus, it would appear that supplementation with a high dose of vitamin E does indeed reduce body stores of vitamin K. The vitamin E supplementation had no effect on prothrombin time (INR) and its effect on PIVKA-II was insignificant when compared with the effect of warfarin - a powerful vitamin K destroyer. (yourhealthbase.com)
  • It was hypothesized that a higher dose of vitamin D would have a positive effect on HR-pQCT measurements of volumetric density and strength at the distal radius and tibia. (imsociety.org)
  • Vitamin D testing is expensive and there is no consensus on the optimal vitamin D serum level. (bpac.org.nz)
  • In New Zealand, vitamin D serum levels are lowest during winter. (bpac.org.nz)
  • Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study. (naturalmedicinejournal.com)
  • Calcium and vitamin D serum levels were obtained at baseline and during follow-up (6, 12, 18, and 24 months). (naturalmedicinejournal.com)
  • Secondary measures included percentage by arm of patients with a normal vitamin D value at 12, 18, and 24 months and percentage of 25(OH)D serum normalization after 6 months of crossover in the C arm population. (naturalmedicinejournal.com)
  • To determine the plasma/serum levels of homocysteine, and vitamins folate, B6 and B12, in Pakistani healthy adults. (unboundmedicine.com)
  • Mean concentrations of plasma/serum folate, vitamin B12 and PLP were found to be 5+/-3.9 ng/ml, 522+/-296 pg/ml and 21.6+/-14 nmol/l, respectively. (unboundmedicine.com)
  • Dr. McRae concludes, "Supplementation with at least 500 mg/day of vitamin C, for a minimum of 4 weeks, can result in a significant decrease in serum LDL cholesterol and triglyceride concentrations. (thecamreport.com)
  • Main outcome measures included concentrations of DBP, vitamin D metabolites, and bioavailable 25-hydroxyvitamin D (25D) in pre- and posttreatment serum samples. (medscape.com)
  • Conclusion Changes after vitamin D2 supplementation involve acute rise in serum DBP and 24,25D, both of which may attenuate the rise in bioavailable 25D and 1,25D. (medscape.com)
  • Vitamin D Supplementation Regulates Postoperative Serum Levels of PD-L1 in Patients with Digestive Tract Cancer and Improves Survivals in the Highest Quintile of PD-L1: A Post Hoc Analysis of the AMATERASU Randomized Controlled Trial. (bvsalud.org)
  • Because vitamin D responsive elements have been found to be located in the PD-L1 gene , vitamin D supplementation was hypothesized to regulate serum PD-L1 levels and thus alter survival time of cancer patients . (bvsalud.org)
  • Vitamin D supplementation significantly (p = 0.0008) up-regulated serum PD-L1 levels in the lowest quintile (Q1), whereas it significantly (p = 0.0001) down-regulated them in the highest quintile (Q5), and it did not either up- or down-regulate them in the middle quintiles (Q2-Q4). (bvsalud.org)
  • Vitamin D supplementation significantly reduced the risk of relapse / death to approximately one-third in the highest quintile of serum PD-L1. (bvsalud.org)
  • Particularly, food supplementation should include micronutrients and anti-oxidants in balanced amounts, exploiting their synergistic actions. (mdpi.com)
  • The rate of major adverse cardiovascular events (the primary end point of the meta-analysis) was not reduced with vitamin D supplementation compared with placebo (risk ratio (RR) 1.00). (nature.com)
  • Study leaders say that even the slight benefits demonstrated by the trial involving more than 36,000 participants suggest calcium and vitamin-D supplementation provides an overall public health benefit to postmenopausal women. (sciencedaily.com)
  • The findings from the calcium and vitamin-D supplementation arm of the WHI are published in the Feb. 16 issue of the New England Journal of Medicine. (sciencedaily.com)
  • The calcium-with-vitamin-D trial found a small but significant 1 percent higher hip bone density for women taking calcium combined with vitamin D compared to other women taking placebo. (sciencedaily.com)
  • Half of the 36,282 participants in the supplementation trial received a daily dose of 1,000 milligrams of calcium carbonate combined with 400 international units (IUs) of vitamin D, while the other half received placebo. (sciencedaily.com)
  • Vitamin D is required by everyone to regulate the body's calcium balance. (bpac.org.nz)
  • Women with known hypersensitivity reaction to vitamin D or calcium compounds, known comorbidities affecting vitamin D-calcium balance or bone health, or concomitant vitamin D supplementation were excluded from the study. (naturalmedicinejournal.com)
  • 67% of the T arm and 68.4% of the C arm reported taking at least 80% of the planned daily oral calcium supplementation. (naturalmedicinejournal.com)
  • Vitamin D and calcium supplementation was well-tolerated, with no difference in treatment-related toxicity between the arms (1 case of asymptomatic hypercalciuria was reported in each arm). (naturalmedicinejournal.com)
  • Vitamin D and calcium exist in a delicate balance. (wakeup-world.com)
  • So there is a very strong connection between calcium and vitamin K, and if we are deficient in vitamin K, calcium can accumulate and deposit in the soft tissues of the body. (wakeup-world.com)
  • Vitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as neurocognitive. (bmj.com)
  • Vitamin D is essential for optimal musculoskeletal health because it promotes calcium absorption, mineralization of osteoid tissue formation in bones, and the maintenance of muscle function [1]. (imsociety.org)
  • Therapy includes antiresorptive agents such as bisphosphonates (eg, alendronate, risedronate, pamidronate, zoledronic acid) as well as calcium and vitamin D supplementation. (medscape.com)
  • The human body can only absorb calcium and phosphorus, the primary components of bone, when vitamin D is present. (lablynx.com)
  • Meryl LeBoff, MD, chief of the Calcium and Bone Section in the Endocrine Division at Brigham and Women's Hospital and professor of medicine at Harvard Medical School, led the largest vitamin D randomized controlled trial ever conducted. (lablynx.com)
  • The results, published in the New England Journal of Medicine in July 2022 6 , showed that supplemental vitamin D without co-administered calcium did not result in a significantly lower risk of fractures than a placebo, suggesting that generally healthy adults may see no benefit in taking the supplement for the purpose of bone health. (lablynx.com)
  • The researchers indicated that the benefit behind vitamin K's influence was from modification of a protein called osteocalcin which is required to bind calcium to the bone matrix. (rejuvenation-science.com)
  • The mechanism behind the benefits is proposed to be due to vitamin K's influence on the secondary modification of osteocalcin, a protein needed to bind calcium to the bone matrix. (rejuvenation-science.com)
  • Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers. (oregonstate.edu)
  • After 6 d of supplementation, plasma d3- and d6-alpha-tocopherol concentrations did not differ significantly between groups. (oregonstate.edu)
  • We evaluated whether sesame lignans (sesamin/episesamin = 1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. (ccsenet.org)
  • PIVKA-II concentrations in patients on warfarin are around 750 ng/mL or 140 times higher than that experienced in healthy men taking 1000 IU/day of vitamin E. (yourhealthbase.com)
  • Recent studies in childhood cancer suggest that maternal vitamin supplementation may reduce the risk of leukaemia, neuroblastoma and certain types of childhood brain tumours. (bmj.com)
  • Recall of exposures, including maternal vitamin supplement use, however, may be difficult and subject to error. (bmj.com)
  • The impact that misclassification of maternal vitamin supplement use may have had on the observed ORs in this study was quantified. (bmj.com)
  • Is Maternal Vitamin E Supplementation Good for Breastfed Children? (parentingscience.today)
  • Effect of Maternal Supplementation with Vitamin E on the Concentration of α-tocopherol in Colostrums. (parentingscience.today)
  • In 2016, a group of Brazilian researchers from Natal City decided to perform a trial titled "Effect of Maternal Supplementation with Vitamin E on the Concentration of α-tocopherol in Colostrums," which was published in Jornal de Pediatria and widely discussed by the medical community in Latin America. (parentingscience.today)
  • Maternal vitamin E supplementation increases the supply of α-tocopherol, which benefits newborns. (parentingscience.today)
  • A recent systematic review and meta-analysis assessed the benefits and harms of vitamin D supplementation in patients with attention-deficit/hyperactivity disorder (ADHD). (chadd.org)
  • In this systematic review and meta-analysis, we have shown that supplementation with [vitamin K] phytonadione and menaquinone, particularly MK-4, is associated with increased bone mineral density (BMD) and reduced fracture incidence," wrote lead author Sarah Cockayne. (rejuvenation-science.com)
  • Eradicating pathogens and improving immunity can correct the dysfunctional metabolism of vitamin D and can resolve inflammatory symptoms. (wakeup-world.com)
  • Nitric oxide bioavailability increases following nitrate supplementation wherein oral microbiota facilitate the metabolism and absorption of nitrate. (wku.edu)
  • Objective Examine acute changes in vitamin D metabolism and bioavailability after vitamin D2 supplementation. (medscape.com)
  • CONCLUSION: Population screening and universal supplementation for vitamin D insufficiency are cost-effective strategies in community-dwelling older women and men. (duke.edu)
  • The dose-response effects of daily vitamin D supplementation (400, 4,000, 10,000 IU) on total volumetric bone mineral density (BMD) and bone strength in 287 healthy older adults (55 to 77 years) were explored. (imsociety.org)
  • The clinical expression of vitamin D overdose includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues [5]. (imsociety.org)
  • The popularity of vitamin-mineral supplementation in the human health field, and in particular the prevalence of vitamin C supplementation, is unquestionable. (seniorpetproducts.com)
  • The most common adverse effect of the supplementation was kidney stones, which were reported by 449 women in the supplement group, compared to 381 women in the placebo group. (sciencedaily.com)
  • Nutrition International is committed to supporting vitamin A supplement (VAS) programs for children 6 to 59 months of age in settings where VAD is a public health problem, as one of the most cost-effective ways to improve child survival. (who.int)
  • Over the past decade, vitamin D has distinguished itself as a miracle supplement. (wakeup-world.com)
  • Uncertainty analysis was used to calculate ORs adjusted for inaccurate reporting of vitamin supplement use under assumed probability distributions for exposure misclassification parameters. (bmj.com)
  • Avid vitamin and supplement users may even inform you that increasing your intake of vitamin D reduces the risk of cancer and other diseases and prevents infection. (lablynx.com)
  • But vitamin D is also a commercially produced supplement projected to be valued at $1.3 billion by 2025. (lablynx.com)
  • 2 Reuters Health 3 reports nearly one in five US adults take supplemental vitamin D, and nearly half of all American adults take a multi-vitamin supplement that contains vitamin D. 4 Supplemental dosage can vary among vitamin users, with some taking three to 10 times the RDA. (lablynx.com)
  • Their findings, announced today at the 70th AACC Annual Scientific Meeting & Clinical Lab Expo, indicate that vitamin D supplementation could significantly improve quality of life for RA patients. (news-medical.net)
  • At the end of the study the authors concluded that among healthy adults, treatment with vitamin D for 3 years at a dose of 4,000 IU per day or 10,000 IU per day, compared to 400 IU per day, resulted in a statistically significant lower radial BMD and tibial BMD was significantly lower only with the 10,000 IU daily dose. (imsociety.org)
  • The combination of Vitamin C and Vitamin E significantly reduced painful periods, pain with intercourse, and overall pelvic pain for women with endometriosis. (fertilitycenter.com)
  • Statistical analysis of 25(OH)D measurements showed that, overall, the RA patients had low 25(OH)D concentrations compared to healthy individuals, with only 33% of RA patients displaying adequate vitamin D levels. (news-medical.net)
  • Context Changes in vitamin D binding protein (DBP) concentrations and catabolism of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D (24,25D) after vitamin D2 supplementation may alter concentrations and bioavailability of circulating 25-hydroxyvitamin D (25D). (medscape.com)
  • [ 9 ] In response to variations in exposure ( e.g., sunlight, diet) and exogenous supplementation, counter regulatory mechanisms are in place that maintain appropriate concentrations of 1,25-hydroxyvitamin D (1,25D) and its precursor 25-dihydroxyvitamin D (25D). (medscape.com)
  • When comparing the α-tocopherol concentrations in the colostrum samples collected immediately after the first lactation and twenty-four hours later, the women who did not receive supplementation (i.e., the control group) had similar concentrations in both samples. (parentingscience.today)
  • A new meta-analysis shows no benefit from multivitamins or routine supplementation. (sciencebasedmedicine.org)
  • [ 16 ] It is unknown, however, whether and to what extent vitamin D supplementation affects DBP levels following routine supplementation. (medscape.com)
  • Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. (yourhealthbase.com)
  • Statistics suggest that a large number of adults and children do not have enough vitamin D in the body. (wakeup-world.com)
  • Scholars@Duke publication: Comparison of cost-effectiveness of vitamin D screening with that of universal supplementation in preventing falls in community-dwelling older adults. (duke.edu)
  • OBJECTIVES: To compare the cost-effectiveness of population screening for vitamin D insufficiency with that of universal vitamin D supplementation in community-dwelling older adults. (duke.edu)
  • Nevertheless, daily supplementation with 400 IU/day of vitamin E has been found safe in numerous studies and is highly unlikely to affect prothrombin time or bleeding tendency in patients taking warfarin. (yourhealthbase.com)
  • To investigate the antioxidant effect of vitamin C in terms of oxidative DNA damage measured by the comet assay and DNA repair measured by expression of OGG1 mRNA in blood cells of male smokers given 2 x 250 mg vitamin C daily as plain or slow release tablets combined with plain release vitamin E 2 x 91 mg, or placebo for 4 wk. (nih.gov)
  • The bottom line of this report is that those with the "resistant" genotype (GG) who typically require a higher dose of warfarin show the greatest fall in the INR (or require the largest upward dose adjustment of warfarin) when daily vitamin K supplementation (150 mcg) is initiated to help stabilize the INR. (clotcare.com)
  • On the other hand, those who are more sensitive to warfarin (GA and AA genotype), show less of a change - or no change - in the INR with daily vitamin K supplementation. (clotcare.com)
  • Although a variety of other factors may influence the response to vitamin K supplementation, the mean increase in warfarin dose that was required was 25% for resistant (GG) patients, 8% for GA patients, and 0% for sensitive AA patients following the implementation of daily vitamin K supplementation. (clotcare.com)
  • The vitamin D supplied by human milk is not adequate for infant daily intake. (contemporarypediatrics.com)
  • All patients in the C arm received daily 400 IU vitamin D 3 . (naturalmedicinejournal.com)
  • These results suggest SVE supplementation could safely alleviate daily fatigue and oxidative stress. (ccsenet.org)
  • Interestingly, findings from 12 RCTs indicate that daily or weekly supplementation, as opposed to large bolus dosing, results in the reduction of BP in VD-deficient hypertensive patients. (escholarship.org)
  • Vitamin B6 (no more than 100 mg daily) has been shown to decrease nausea in early pregnancy. (medlineplus.gov)
  • A recent randomized, triple-blind, placebo-controlled trial found that vitamin supplementation can improve endometriosis symptoms. (fertilitycenter.com)
  • however, there is no conclusive data regarding the direct effect of vitamin D supplementation in acute pneumonia. (hindawi.com)
  • Given the high burden of death among children younger than five years of age in low and middle income countries, and the fact that mortality in infancy is a major contributory cause, it is critical to obtain sound scientific evidence of the effect of vitamin A supplementation during the neonatal period on infant mortality and morbidity. (nutraingredients.com)
  • We observed similar results for infant mortality at 12 months of age with no significant effect of vitamin A compared with control. (nutraingredients.com)
  • Chen Hu, from the Chongqing Hospital of Traditional Chinese Medicine in China, and colleagues conducted a systematic review of randomized controlled trials exploring the effect of vitamin D for migraine patients. (physiciansweekly.com)
  • In May 2023, GiveWell recommended a $6 million grant to Nutrition International to renew support for its vitamin A supplementation (VAS) program in Chad. (givewell.org)
  • In different reviews it has been shown that randomized controlled trials, with 800 IU/day of vitamin D, the levels of 25[OH]D reach the threshold of sufficiency of 50 nmol/L, being safe and effective levels in correcting insufficient levels of vitamin D [5]. (imsociety.org)
  • MONDAY, Jan. 10, 2022 (HealthDay News) - Vitamin D supplementation could reduce headache attacks per month and headache days per month among migraine patients, according to a review published in the December issue of The American Journal of Emergency Medicine . (physiciansweekly.com)
  • Few studies have assessed the therapeutic efficacy of vitamin D supplementation as an adjunctive to antibiotics and supportive measures in treating childhood pneumonia. (hindawi.com)
  • Unlike the evidence favoring a prophylactic effect, there is no clear evidence to support or refute the therapeutic efficacy of vitamin D in acute pneumonia. (hindawi.com)
  • Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. (bmj.com)
  • However, there is no evidence to support the preventive efficacy of such supplementation. (seniorpetproducts.com)
  • The researchers found that vitamin D supplementation could reduce headache attacks per month, headache days per month, and migraine disability assessment questionnaire scores (mean differences, −2.74, −1.56, and −5.72, respectively) compared with controls, but it had no obvious effect on attack duration or headache severity. (physiciansweekly.com)
  • Does Vitamin D Supplementation Reduce ADHD Symptoms? (chadd.org)
  • Vitamin D supplementation resulted in a small but statistically significant improvement to ADHD symptoms. (chadd.org)
  • This led a research group helmed by Tomas De Haro Muñoz, MD, of Hospital Universitario Campus de la Salud in Spain, to investigate the relationship between vitamin D levels and the severity of RA symptoms. (news-medical.net)
  • These authors speculate that the combination of Vitamins C and E may have reduced some of the inflammation and oxidative damage induced by endometriosis, thereby resulting in a reduction of symptoms. (fertilitycenter.com)
  • If you have more questions about how vitamin supplementation can improve endometriosis symptoms or if you are having difficulty conceiving, please contact us for a free consultation. (fertilitycenter.com)
  • Ingestion of the vitamin formulation with plain release only indicated a damage-reducing effect 4 h after intake of a single tablet, and the effect was more apparent on endonuclease III than formamidopyrimidine DNA glycosylase sites. (nih.gov)
  • However, factors that interfere with vitamin E supplementation have not been investigated, particularly vitamin E and fat intake during pregnancy, which can be considered a study limitation. (parentingscience.today)
  • BACKGROUND: Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture. (rejuvenation-science.com)
  • For example, in tissue culture models of vitamin D receptor signaling, exogenous addition of DBP to culture media dramatically reduces bioavailability of both 25D and 1,25D. (medscape.com)
  • Now, based on the WHI, we have better data to address these issues," said Rebecca Jackson, lead author of the journal article about supplementation and fractures and Ohio State University Medical Center's principal investigator for the WHI. (sciencedaily.com)
  • The trial aimed to determine whether 2,000 IU/day of supplemental vitamin D would result in a lower risk of fractures than placebo among generally healthy middle-aged and older Americans. (lablynx.com)
  • Supplementation of vitamin K (MK-4) resulted in reductions in hip fractures of 77 percent, vertebral fracture of 60 percent, and all non-vertebral fractures of 81 percent. (rejuvenation-science.com)
  • OBJECTIVE: To assess whether oral vitamin K (phytonadione and menaquinone) supplementation can reduce bone loss and prevent fractures. (rejuvenation-science.com)
  • Further research is required to understand the impact of supplementation regimen and population on the physiological effects of dietary nitrate. (wku.edu)
  • Concurrent nitrate and AA supplementation did not elicit additional increases to nitric oxide compared to nitrate ingestion alone. (wku.edu)
  • However, the low coverage of vitamin A supplementation is a persistent problem in low- and middle-income countries. (lu.se)
  • The coverage of vitamin A supplementation should be improved, especially for children 6-23 months old, in most countries, particularly where the consumption of vitamin-A-rich foods is inadequate. (lu.se)
  • No previous studies, however, have assessed how vitamin D levels impact the clinical course of this condition. (news-medical.net)
  • No clinical trials or epidemiologic studies have ever reported an association between vitamin E supplementation and increased risk of bleeding or hemorrhagic stroke - not even in patients taking warfarin. (yourhealthbase.com)
  • From a clinical perspective, the results of this review suggest that patients at risk for fracture should be encouraged to consume a diet rich in vitamin K, which is chiefly obtained from green leafy vegetable and certain vegetable oil," concluded the researchers. (rejuvenation-science.com)
  • This study suggests that long-term vitamin C supplementation at high dose, i. e. 500 mg together with vitamin E in moderate dose, 182 mg, decreases the steady-state level of oxidative DNA damage in mononuclear blood cells of smokers. (nih.gov)
  • Recent research suggests that almost every cell in our body has receptors for vitamin D, which indicates a much stronger role for this vitamin than previously thought. (wakeup-world.com)
  • Furthermore, vitamin D was not associated with significant reductions in any of the secondary end points: myocardial infarction (RR 1.00), stroke (RR 1.06), CVD mortality (RR 0.98) or all-cause mortality (RR 0.97). (nature.com)
  • A new systematic review states there is no indication that vitamin A supplementation among babies at birth reduces mortality during the first six or 12 months of life. (nutraingredients.com)
  • But according to the review, data from three studies for children born at full term did not show a statistically significant effect on the risk of infant mortality at six months in the vitamin A group compared with the control group. (nutraingredients.com)
  • We believe that vitamin A supplementation is likely to reduce child mortality. (givewell.org)
  • Because vitamin D sufficiency has been associated with improved mortality risk in women with breast cancer, vitamin D repletion should be an important goal. (naturalmedicinejournal.com)
  • 6 Being severely deficient in vitamin D is associated with a more than twofold increased risk of developing dementia. (bmj.com)
  • The findings suggest that vitamin D supplementation does not confer cardiovascular protection and is not indicated for this purpose," conclude the researchers. (nature.com)
  • Scientists have discovered that in rheumatoid arthritis (RA) patients, lower levels of vitamin D are associated with increased disease severity. (news-medical.net)
  • They measured levels of 25-hydroxyvitamin D (25(OH)D)-;a marker of vitamin D status-;in blood samples from 78 patients with RA and 41 healthy controls. (news-medical.net)
  • Patients with active disease had lower levels of vitamin D than those with disease in remission. (news-medical.net)
  • The area is of high interest because babies have very low levels of vitamin A stored in the liver at birth and are dependent on breast milk as a source of vitamin A during the first few months of life. (nutraingredients.com)
  • Plasma vitamin E was unaltered in the first 12 h after ingestion of a single tablet, suggesting that the antioxidant effect was mediated by vitamin C. Differences in plasma vitamin C levels at steady state could not explain the difference between the two vitamin C formulations, whereas wider amplitudes of plasma vitamin C were seen after ingestion of plain release formulation compared to slow release formulation. (nih.gov)
  • Assessment of OGG1 mRNA levels by RT-PCR did not indicate increased expression of this DNA repair gene after 4 wk of vitamin supplementation. (nih.gov)
  • Despite the increasing focus on vitamin D levels and claimed associations with many health conditions, there is no evidence to support blanket supplementation of the general population. (bpac.org.nz)
  • Vitamin D supplementation at recommended levels is safe, however, there is emerging evidence that sustained, high levels of vitamin D are associated with adverse effects. (bpac.org.nz)
  • Monitoring vitamin D levels is also considered unnecessary. (bpac.org.nz)
  • In recent years low vitamin D levels have been associated with a host of non-musculoskeletal conditions, such as cancer, autoimmune diseases, diabetes, multiple sclerosis and heart disease, although studies often produce mixed results. (bpac.org.nz)
  • Requests by patients to have vitamin D levels assessed are also increasing despite a lack of evidence that vitamin D improves any non-musculoskeletal outcomes. (bpac.org.nz)
  • Studies have shown that females have lower vitamin D levels than males, Māori have lower levels than Europeans and levels in Pacific peoples are lower still. (bpac.org.nz)
  • Vitamin D levels were measured as circulating 25-hydroxyvitamin D 2 (25[OH]D 2 ) and 25(OH)D 3 to provide total circulating 25(OH)D levels. (naturalmedicinejournal.com)
  • Without investigating these influences, clinicians lose sight of the causes of aberrant fluctuations in vitamin D levels and cannot apply a proper balancing and healing protocol. (wakeup-world.com)
  • Some studies suggest that this is a real possibility when vitamin D levels become too high. (wakeup-world.com)
  • It should be noted that not all the patients achieved the target Vitamin D levels, which means that they required higher dosages. (drweitz.com)
  • No adverse events relating to SVE supplementation were confirmed. (ccsenet.org)
  • Re 'Drugs for prostate cancer' (WDDTY vol 16 no 1, page 7), a recent study revealed that vitamin D could cut a man's risk of prostate by almost half. (healthy.net)
  • In this view there is little downside and no risk to taking vitamins "as insurance," even if they are not strictly needed. (sciencebasedmedicine.org)
  • The researchers conclude that high-dose vitamin E supplementation does reduce vitamin K status, but are uncertain whether this interaction is immaterial, beneficial (reduced stroke risk) or harmful (loss of bone density). (yourhealthbase.com)
  • Vitamin D supplementation could optimise infant immune health in the first year of life reducing the risk of allergic disease and respiratory diseases. (bmj.com)
  • VD supplementation for five years or more may reduce the risk of developing HTN specifically among those with VDD. (escholarship.org)
  • Some research studies over the last 50 years have suggested that vitamin D may also reduce the risk of multiple sclerosis, decrease the chance of heart disease, reduce the severity of flu and COVID-19 infections, support immune health, regulate mood, reduce depression, and even support weight loss. (lablynx.com)
  • Nurse practitioners were more likely to suggest home modification [aOR: 2.1 (1.3-3.4)] and less likely to suggest vitamin D [aOR: 0.6 (0.4-1.0)] than internists. (cdc.gov)
  • One trial used a single 100,000 unit of oral vitamin D3 at the onset of pneumonia. (hindawi.com)
  • Oral vitamin D supplementation does not help children under-five with acute pneumonia. (hindawi.com)
  • Beetroot Juice and Vitamin C Supplementation on Oral Microbiota" by Jeffrey Li, Keonabelle K. Paniagua et al. (wku.edu)
  • Moreover, our understanding on how the oral microbiome responds to nitrate supplementation is limited, especially in women. (wku.edu)
  • In a randomised controlled trial, no significant benefits or harmful effects were associated with treatment allocation to higher or lower AA supplementation throughout the first 28 days of life. (bmj.com)