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  • metabolism
  • Interestingly, although IGF-I has been traditionally regarded as a promoter of skeletal muscle hypertrophy , several studies have observed that IGF-I based interventions can also increase the oxidative metabolism of dystrophic muscles, and increase contractile capacity over the course of a repetitive recruitment test (Gregorevic et al. (fitness-vip.com)
  • Of the various PPAR isoforms, PPAR-delta is particularly strongly expressed in the skeletal muscle, and especially in the more fatigue-resistant and oxidative metabolism-favoring type I fiber population (Wang et al. (fitness-vip.com)
  • 2004). Transgenic mice expressing an activated PPAR-delta construct, and animals administered a PPAR-delta activating agonist have been shown to demonstrate varying degrees of increasingly induced gene expression associated with a 'fast-to-slow' muscle fiber type transformation which encompasses increased oxidative metabolism and importantly, considerably improved fatigue resistance under exercise (Wang et al. (fitness-vip.com)
  • 2008). Animals that express increased levels of the PPAR coactivator peroxisomes-proliferator-activated receptor-gamma coactivator 1 alpha (PGC1-alpha)-1a have also been shown to exhibit increased fatigue resistance attributes, further substantiating the importance of the PPAR-associated mechanisms as key regulators of metabolism and muscle fiber phenotype (Lin et al. (fitness-vip.com)
  • fibers
  • 1998). Reduced fatigue resistance may be a consequence of the reduced number of functional fibers present within a given muscle being tasked with a comparatively greater work requirement compared with the myofiber/myofibril population in a non dystrophic muscle, although increased inflammatory cell activity and altered metabolic status also appear to contribute to this deleterious phenotype. (fitness-vip.com)
  • functional
  • 2008). Such a statement should be qualified by acknowledging that exercise adaptations affect multiple organs as well as the nerve-vasculature- tendon -muscle interactions, though it is plausible to suggest that at least a degree of functional benefit could be derived via an intervention designed to increase the activation of PPAR-delta in the muscles of dystrophic mice and patients. (fitness-vip.com)
  • Expression
  • As mentioned earlier, supplementation of muscle NO levels via increased expression of NOS could be a viable approach to enhance fatigue resistance. (fitness-vip.com)
  • 2008). That pharmacological restoration of cGMP-mediated signaling can counter the increased susceptibility to fatigue observed in dystrophic muscles supports this argument, and serves as justification for further investigation into the potential to ameliorate fatigue susceptibility in dystrophic muscles via interventions that can increase NOS expression (Kobayashi et al. (fitness-vip.com)
  • A different intervention that could enhance the abilities of muscles to sustain contractile capacity with repeated exertion may be based around the cellular mechanisms influenced by the expression and activation of the peroxisome proliferator activated receptor (PPAR) family of transcription regulators. (fitness-vip.com)
  • mice
  • Several groups have shown that nNOS deficient mice (dystrophic and otherwise) exhibit reduced force-producing capacity with repeated contraction (Kobayashi et al. (fitness-vip.com)
  • function
  • Therefore, intervention strategies with the potential to reduce the susceptibility of muscles to fatigue could be valuable in increasing/sustaining muscle function. (fitness-vip.com)
  • delayed onset mu
  • It's been so effective with our athletes that we have several reports of it preventing delayed onset muscle soreness (DOMS) after particularly intense workouts. (athleanx.com)
  • protein synthesis
  • It can help speed recovery time between training sessions due to an increase in nitrogen levels in the muscle cells which assists in protein synthesis. (athleanx.com)
  • 2016). Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults. (delisiolab.ca)
  • Apparently, skeletal muscle has both surface receptors and nuclear receptors for D3 that augment calcium flux during contraction (from surface receptors) and have steroid-like effects at the nuclear level WRT protein synthesis. (diigo.com)
  • Increases in muscle protein synthesis occurring in response to resistance training can be attributed to pre-translational (increase in mRNA abundance) mechanisms [ 7 ], as muscle-specific gene expression is up-regulated in order to provide an ample supply of mRNA template to meet translational (increases in protein synthesis/unit of mRNA) demands. (biomedcentral.com)
  • This process is critical since skeletal myocytes are multi-nucleated and each myonucleus controls both mRNA and protein synthesis over a finite sarcoplasmic volume (aka. (biomedcentral.com)
  • Those who have taken a BCAA supplement have reported a significant decrease in the feelings of muscle soreness and fatigue, and its promotion of muscle protein synthesis could significantly contribute muscles recover from exercise, injury, or discomfort. (34-menopause-symptoms.com)
  • peak
  • No significant reduction in force output was determined for BR relative to PL for the peak contraction, the mean or the end force, and no significant time effect was found over the course of the supplementation period. (biomedsearch.com)
  • 14 ] found that 15 days of 400 mg per day of ATP supplementation increased minimum peak torque for the final two sets of a dynamometer test. (biomedcentral.com)
  • Three 30s Wingate tests (WAnT) were conducted before, in the middle, and after the training and the supplementation interventions, with peak power, mean power, and fatigue index obtained during WAnT, and blood lactate and heart rate obtained after WAnT. (biomedcentral.com)
  • exercise
  • In a double-blind, randomized, crossover design, eight participants received 0.5 l/day of nitrate-rich (BR) or nitrate-depleted (PL) beetroot juice for 15 days and completed an exercise protocol consisting of 50 MVCs at 2.5 h, 5 days and 15 days after the beginning of the supplementation period. (biomedsearch.com)
  • There was a reduction in the mean PCr cost of exercise averaged over the BR supplementation trials, but this did not reach statistical significance for end exercise (BR 15.10 ± 4.14 mM, PL 17.10 ± 5.34 mM, P = 0.06) or the mean throughout the protocol (BR 15.96 ± 4.14 mM, PL 17.79 ± 4.51 mM, P = 0.06). (biomedsearch.com)
  • Despite increasing research, a comprehensive and critical review on polyphenol supplementation and exercise is still lacking. (springer.com)
  • Polyphenol supplementation in exercise studies included mainly extracts (multicomponent or purified), juices, infusions or an increased intake of polyphenol-rich foods. (springer.com)
  • Pericyte response to contraction mode-specific resistance exercise training in human skeletal muscle. (delisiolab.ca)
  • In rehabilitation, exercise instructions are multi-modal and can include a focus of increasing mean activity of a target muscle and inhibiting aberrant synergistic muscle activity, particularly during shoulder exercises, such as the prone horizontal abduction (PHA). (biomedsearch.com)
  • This study determined the effects of 28 days of heavy resistance exercise combined with the nutritional supplement, NO-Shotgun ® , on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers. (biomedcentral.com)
  • Thigh muscle cross-sectional area increased following resistance exercise, with no additive effect of creatine. (biomedsearch.com)
  • The present study aimed to compare the effects of zinc supplementation, yoga exercise, and zinc supplementation plus yoga exercise on serum apelin level and kidney function among women with type II diabetes mellitus. (mcjbums.com)
  • and zinc supplementation plus yoga exercise. (mcjbums.com)
  • Eight-week yoga exercise and zinc supplementation are useful to women with type II diabetes mellitus. (mcjbums.com)
  • vastus
  • Muscle biopsies (vastus lateralis) were analyzed for fiber type-specific SCs, myonuclei, and fiber cross-sectional area (CSA). (forskningsdatabasen.dk)
  • Fiber segments, obtained from vastus lateralis muscle of human subjects by needle biopsy, were mechanically skinned, and their Ca(2+) release and contractile apparatus properties were characterized. (biomedsearch.com)
  • tissue
  • Throw in its additional researched ability to prevent the breakdown of muscle tissue after intense training, and your ability to tip the balance of muscle growth in your favor just grew by leaps and bounds with ReconstruXion. (athleanx.com)
  • Muscle injury causes tissue disruption and subcellular damage followed by cytokine release and a rapid invasion of leukocyte subpopulations into the muscle [ 5 - 7 ]. (hindawi.com)
  • The objective of this study was to investigate the effects of a normal salt diet on tissue aldehyde conjugates, cytosolic [Ca 2+ ] i and blood pressure in DSS rats and to determine whether lipoic acid supplementation prevents the increase in blood pressure and biochemical changes. (springer.com)
  • It is stored in the liver, as well as fat and muscle tissue. (34-menopause-symptoms.com)
  • The benefits one derives from creatine supplementation depends upon how much his or her tissue crea-tine levels increase. (forresthealth.com)
  • Creatine supplementation can increase tissue concentrations to a level that is unobtainable through diet alone. (forresthealth.com)
  • maximal
  • Dorsiflexor muscles of the left limb in all animals were exposed 3 times per week for 4.5 weeks to a protocol of 80 maximal SSCs (60 deg/s, 50 deg range of motion, 14 exposures) per exposure in vivo. (cdc.gov)
  • Increases
  • LCLT also increases androgen receptors in the muscle cells, which means more testosterone is recruited to build muscle. (athleanx.com)
  • Specifically, there is a tight coupling between oxygen demand in skeletal muscle and increases in blood flow. (biomedcentral.com)
  • Studies on this potent nootropic show it not only boosts mood and focus, but also increases the "mind muscle connection. (priceplow.com)
  • It is not certain if the higher body mass reflected increases in muscle or simply excess water weight, which may give the impression of bigger muscles. (encyclopedia.com)
  • Rather, NO-Shotgun ® effectively increases muscle strength and mass, myofibrillar protein content, and increases the content of markers indicative of satellite cell activation. (biomedcentral.com)
  • human
  • Consequently, we sought to characterize what effects carnosine, at levels attained by supplementation, has on human muscle fiber function, using a preparation with all key EC coupling proteins in their in situ positions. (biomedsearch.com)
  • body composition
  • The main outcome measurements included muscle strength (one repetition maximum), energetics ((31)P magnetic resonance spectroscopy), composition and size (magnetic resonance imaging), as well as total body composition (dual-energy X-ray absorptiometry). (biomedsearch.com)
  • significant
  • Significant proportion of locomotor diseases is caused by muscle weakness or wasting, but the biological mechanisms involved in these processes are not completely understood. (biomedcentral.com)
  • performance
  • We also sought to determine the effects of ATP on muscle protein breakdown, cortisol, and performance during an overreaching cycle. (biomedcentral.com)
  • The scientific evidence suggests that creatine may not have much usefulness as a muscle-enhancing agent, though it does appear to moderately improve performance in exercises or sports that require short, repeated bursts of high-energy activity. (encyclopedia.com)
  • It has far-reaching consequences, and affecting the performance of the muscles is no exception. (34-menopause-symptoms.com)
  • These vitamins, which act as antioxidants in the body, have been shown to have a positive effect on muscle performance and overall energy levels. (34-menopause-symptoms.com)
  • doses
  • Evidence is insufficient to make recommendations for or against the use of polyphenol supplementation (neither specific polyphenols nor specific doses) for either recreational, competitive or elite athletes. (springer.com)
  • responses
  • Although research of antioxidants has become popular within the past ten years, there have been only two known studies to investigate the effect of cherry ingestion on inflammatory responses of muscles and prevention of symptoms of muscle damage. (ommegaonline.org)
  • intense
  • The protein is used by the body to make a chemical compound called adenosine triphosphate (ATP), the immediate fuel source used by muscles during short but intense bursts of activity. (encyclopedia.com)