• This study aimed to evaluate the toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) synthesized by biogenic (BS) and chemical (CH) routes. (mdpi.com)
  • In this dissertation, based on the Molecular Communication (MC) system, a macroscale aqueous-based testbed is used to imitate the propagation of biocompatible drug-loaded Superparamagnetic Iron Oxide Nanoparticles (SPIONs) through a human vessel for drug delivery applications. (kobv.de)
  • Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. (fu-berlin.de)
  • Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. (nature.com)
  • Bovine serum albumin (BSA) conjugated poly(acrylic acid) (PAA) coated SPIONs (BSA@PAA@SPION) were developed for encapsulation of ciprofloxacin and the nanoparticles were tagged with 4-aminophenyl-α-D-mannopyrannoside (mannoside, Man) to target E. coli fimbriae. (itu.edu.tr)
  • Weaker growth inhibition was observed with untargeted nanoparticles, Cip-BSA@PAA@SPIONs, confirming that targeting E. coli fimbria with mannoside-tagged nanoparticles increases the ciprofloxacin efficiency to treat ciprofloxacin-resistant E. coli. (itu.edu.tr)
  • Targeted hyperthermia-induced cancer cell death by gold-coated superparamagnetic iron oxide nanoparticles (SPIONs@Au) conjugated luteinizing hormone-releasing hormone (LHRH). (subr.edu)
  • Superparamagnetic iron-oxide nanoparticles (SPIONs) are promising probes for these purposes, as they are relatively non-toxic and magnetic fields are not attenuated by tissue. (hhs.gov)
  • Despite the success in the use of superparamagnetic iron oxide nanoparticles (SPION) for various scientific applications, its potential in biomedical fields has not been exploited to its full potential. (rsc.org)
  • The glioma-targeting Ad5/3-cRGD gene therapy vector was covalently bound to super-paramagnetic iron oxide (Fe 3 O 4 ) nanoparticles (SPION) to monitor its distribution by MRI. (northwestern.edu)
  • In response to the urgent need for efficient treatment of multidrug-resistant infections, we designed a fimbriae targeting superparamagnetic iron oxide nanoparticle (SPION) delivering ciprofloxacin to ciprofloxacin-resistant E. coli. (itu.edu.tr)
  • Ciprofloxacin-loaded mannoside tagged nanoparticles (Cip-Man-BSA@PAA@SPION) provided high antibacterial activity (97.1 and 97.5%, respectively) with a dose of 32 μg/mL ciprofloxacin against two ciprofloxacin-resistant E. coli isolates. (itu.edu.tr)
  • Superparamagnetic iron oxide nanoparticles (SPION) are extensively explored as T 2 contrast agent due to their excellent biocompatibility, easy biodegradability, potential nontoxicity and distinct magnetic properties [6-8]. (nanobe.org)
  • To highlight the coatings' impact in pulmonary administration, two micellar superparamagnetic iron oxide nanoparticles (SPION) were compared. (researchgate.net)
  • The positive contrast of extremely small iron oxide nanoparticles (ESIONP) in magnetic resonance imaging (MRI) rejuvenates this class of metal nanoparticles (NP).Yet, the current synthesis often lacks the possibility of adjusting the core size (while it is a key element for ESIONP-based MRI contrast behaviour), and also involved multiple complex st. (researchgate.net)
  • One of the specialties at LTP is the synthesis of polycrystalline particles based on the controlled agglomeration or assembly of primary nanoparticles. (epfl.ch)
  • Beside the synthesis und processing of various nanoparticles and powders, their characterization and that of the suspension is another main activity. (epfl.ch)
  • Synthesis of functionalized superparamagnetic iron oxide nanoparticles from a common precursor and their application as heavy metal and actinide sorbents. (cdc.gov)
  • Cytotoxicity assay indicated that nanoparticles have good biocompatibility and low toxicity. (nanobe.org)
  • Magnetite due to its biocompatibility and low toxicity has already been approved by FDA as an MRI contrast agent (Feridex, Combidex) and for treatment of iron deficiency (anemia) in people with chronic kidney failure (Ferumoxytol, Feraheme). (nature.com)
  • In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles. (springer.com)
  • Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. (dovepress.com)
  • Meanwhile, for in vivo applications, surface modification of iron oxide nanoparticles is introduced to increase the dispersity and blood circulation [14, 15]. (nanobe.org)
  • For instance, in previous studies a composite based on γ -Fe 2 O 3 nanoparticles decorated with a BSA coating and immobilized thrombin was described and used in in vivo study as a wound healing material 16 . (nature.com)
  • Another clear ambition of Martin's research is to create, study and promote alternative in vitro models that mimic in vivo environments, in order to gain a mechanistic understanding of how nanoparticles may, potentially, adversely impact human health. (swansea.ac.uk)
  • Maghemite differs from magnetite in that all or most of the iron is in the trivalent state (Fe3+ ) and by the presence of cation vacancies in the octahedral sites. (wikipedia.org)
  • Both magnetite and maghemite nanoparticles are superparamagnetic at room temperature. (wikipedia.org)
  • Nanoparticles were produced by entrapping human thrombin (THR) into a sol-gel derived magnetite matrix followed by grinding to sizes below 200 nm and subsequent colloidization. (nature.com)
  • Incorporation of magnetite nanoparticle clusters in fluorescent silica nanoparticles for high-performance brain tumor delineation. (anaspec.com)
  • Examples include hematite, magnetite and maghemite nanoparticles. (bvsalud.org)
  • The effect of the formation of clusters of nanoparticles, which is either an unwanted side effect of poor colloidal stability of the particles, or a desired for- mulation strategy, has poorly understood consequences on the amount of heat generated by the nanoparticles. (unifr.ch)
  • The objective of this work is to address this problem from the theoretical side by performing detailed simulations to investigate the effect of incorporation of magnetic nanoparticles in clusters on the amount of heat generated as a function of the particle size, cluster size and particles magnetic properties. (unifr.ch)
  • Iron oxide nanoparticles are iron oxide particles with diameters between about 1 and 100 nanometers. (wikipedia.org)
  • We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. (hindawi.com)
  • Ultrasmall (approximately 30 nm), superparamagnetic particles of iron oxide (USPIO) extravasate freely through capillaries and are taken up by tissue-resident inflammatory cells of the reticuloendothelial system [ 21 ]. (hindawi.com)
  • The overall goal of this procedure is to synthesize bacterial nano-cellulose, or BNC, and render it magnetic by impregnating in situ with iron oxide nano-particles. (jove.com)
  • Quantification and 3D localization of magnetically navigated superparamagnetic particles using MRI in phantom and swine chemoembolization models. (polymtl.ca)
  • To accomplish this, we also demonstrate the first successful labeling of PDX cells with iron oxide particles. (biorxiv.org)
  • These results open new horizons for the design of biocompatible water dispersible ferrite nanoparticles with good relaxivity properties via a versatile and easily scalable co-precipitation route. (rsc.org)
  • Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. (researchgate.net)
  • English Magnetic nanoparticles have been the subject of enormous investigations for their potential use as cancer treatment via hyperthermia. (unifr.ch)
  • There are many different parameters that need to be considered when designing the optimal nanoparticle formulation for hyperthermia. (unifr.ch)
  • Applications of iron oxide nanoparticles include terabit magnetic storage devices, catalysis, sensors, superparamagnetic relaxometry, high-sensitivity biomolecular magnetic resonance imaging, magnetic particle imaging, magnetic fluid hyperthermia, separation of biomolecules, and targeted drug and gene delivery for medical diagnosis and therapeutics. (wikipedia.org)
  • Image-guided therapy using nanoparticles have been used for various therapeutic applications such as drug and gene delivery, hyperthermia, and photodynamic therapy. (springer.com)
  • All of these cases lower the hyperthermia efficacy of magnetic nanoparticles. (springer.com)
  • Compared to the magnetic nanoparticles hyperthermia, the precise and local delivery of iron oxide nanoparticles (INOPs) to cancer cells is the main advantage of magnetic composite fibers, which is an ideal hyperthermia treatment method for easily accessible tumors. (springer.com)
  • A combination of injectable polymers with heatable iron oxide nanoparticles for hyperthermia in vertebroplasty has recently been patented. (epfl.ch)
  • Liu Y, Chen Z, Liu C, Yu D, Lu Z, Zhang N. Gadolinium-loaded polymeric nanoparticles modified with anti-VEGF as multifunctional MRI contrast agents for the diagnosis of liver cancer. (springer.com)
  • Symposium on "Multifunctional Nanoparticles for Drug Delivery and Imaging", ACS Annual Fall Meeting, Boston, August 22-26, 2010 (PMSE division). (utah.edu)
  • Carbon Dots (CDs) are luminescent quasi-spherical nanoparticles, possessing water solubility, high biocompatibility, and tunable chemical and physical properties for a wide range of applications, including nanomedicine and theranostics. (researchgate.net)
  • Bin Na H, Song IC, Hyeon T. Inorganic nanoparticles for MRI contrast agents. (springer.com)
  • Feraheme (ferumoxytol) is an intravenously administered, carbohydrate-coated, superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticle inorganic product for treating anemia marketed by Amag Pharmaceuticals. (patentdocs.org)
  • Martin gained his PhD at Edinburgh Napier University in 2009, in Nanoparticle In Vitro Toxicolog. (swansea.ac.uk)
  • Martin's research is focused on the nanoparticle-(mammalian)cell interaction, with a view to determining the mechanistic toxicological, immunological and genotoxic effects that nanoparticles, with varying physico-chemical characteristics, may cause at the cellular level by using advanced, next-level in vitro systems combined with state-of-the-art microscopy and bioanalytical approaches. (swansea.ac.uk)
  • Special focus is also given to creating disease-based in vitro models and the role nanoparticles play in disease onsert and/or exacerbation. (swansea.ac.uk)
  • 100 publications within the field of nanotoxicology and the nanoparticle-cell interaction in vitro . (swansea.ac.uk)
  • This approach yielded the formation of highly crystalline, superparamagnetic MnIOs with good control over their size and bivalent Mn ion crystal substitution. (rsc.org)
  • Synthesized nanoparticles related to iron oxide crystalline structures with magnetic properties useful for biomedical applications. (bvsalud.org)
  • Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
  • Furthermore, the magnetic nanoparticles are locally injected in the tumor tissue and they prefer to leak out from the tumor site due to their small size [ 9 ]. (springer.com)
  • The theranostic efficiency of tumor-specific, pH-responsive, peptide-modified, liposome-containing paclitaxel and superparamagnetic iron oxide nanoparticles. (bvsalud.org)
  • In the present study, the tumor -specific, pH -responsive peptide H7K(R2)2-modified, theranostic liposome -containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7K(R2)2, was prepared by using H7K(R2)2 as the targeting ligand , SPIO NPs as the magnetic resonance imaging (MRI) agent, PTX as antitumor drug . (bvsalud.org)
  • Future Advances in Diagnosis and Drug Delivery in Interventional Radiology Using MR Imaging-Steered Theranostic Iron Oxide Nanoparticles. (polymtl.ca)
  • Fimbria targeting superparamagnetic iron. (itu.edu.tr)
  • Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide-based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. (diabetesjournals.org)
  • In this review, we report and discuss recent advances in nanoparticle-mediated plasmonic photothermal therapy for GBM treatment and discuss the preclinical challenges commonly faced by researchers to develop and test such systems. (frontiersin.org)
  • Here, we summarize the imaging modalities used for image-guided therapies and discuss recent advances on nanoparticle-based image-guided therapies. (springer.com)
  • To study PDX cells preclinically, we used both bioluminescence imaging (BLI) to evaluate cell viability and magnetic particle imaging (MPI), an emerging imaging technology to allow for detection and quantification of iron nanoparticles. (biorxiv.org)
  • In this paper, magnetic hemostatic nanoparticles are shown for the first time to assist in minimally invasive treatment of internal bleeding, implying the introduction directly into the circulatory system followed by localization in the bleeding zone due to the application of an external magnetic field. (nature.com)
  • Relative to cells treated with PLL only, cells labeled with superparamagnetic iron oxide/PLL complexes exhibited differential expression of 1399 genes. (johnshopkins.edu)
  • Szpak A, Fiejdasz S, Prendota W, Strączek T, Kapusta C, Szmyd J, Nowakowska M, Zapotoczny S. T1-T2 dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes. (springer.com)
  • Special interests include the ability for nanoparticle geometry and surface properties to interfere with the human immune system and bloodstream. (swansea.ac.uk)
  • Since iron ion contains five unpaired electrons, the iron oxide nanoparticles can also be used as a T 1 contrast agent and magnetic properties are closely related to their size [9-12]. (nanobe.org)
  • Due to its 4 unpaired electrons in 3d shell, an iron atom has a strong magnetic moment. (wikipedia.org)
  • Gene expression profiling was applied to C17.2 neural stem cells following superparamagnetic iron oxide/PLL (poly- L-lysine) labeling over the course of 1 week. (johnshopkins.edu)
  • Gene ontology analysis of differentially expressed genes showed that genes encoding zinc-binding proteins are enriched after superparamagnetic iron oxide/PLL labeling relative to PLL only treatment, whereas members of the apoptosis/programmed cell death pathway did not display increased expression. (johnshopkins.edu)
  • These results demonstrate that, although early reactions responsible for iron homeostasis are induced, overall neural stem cell gene expression remains largely unaltered following superparamagnetic iron oxide/PLL labeling. (johnshopkins.edu)
  • Another field of interest is the biological functionalisation of nanoparticles for drug and gene delivery and to use these innovative methods as delivery platform for implants, in particular for stents and prostheses. (epfl.ch)
  • In this role, Mr. Healey will develop the strategic plan and build the necessary infrastructure for the launch and commercialization of ferumoxytol as an intravenous iron replacement therapeutic for the treatment of anemia in dialysis-dependent and non-dialysis dependent chronic kidney disease patients (CKD). (salesandmarketingnetwork.com)
  • Mr. Healey will also play a key role in evaluating and prioritizing additional indications for ferumoxytol as an intravenous iron replacement therapeutic. (salesandmarketingnetwork.com)
  • Ferumoxytol, the company's key product candidate, is in Phase III multi-center clinical trials for use as an iron replacement therapeutic in chronic kidney disease patients, whether or not on dialysis. (salesandmarketingnetwork.com)
  • In this work, we developed the targeted magnetic nanoparticles as T 1 -positive magnetic resonance imaging (MRI) contrast agents. (nanobe.org)
  • They have attracted extensive interest due to their superparamagnetic properties and their potential applications in many fields (although cobalt and nickel are also highly magnetic materials, they are toxic and easily oxidized) including molecular imaging. (wikipedia.org)
  • Zhu D, Liu F, Ma L, Liu D, Wang Z. Nanoparticle-based systems for T1-weighted magnetic resonance imaging contrast agents. (springer.com)
  • Superparamagnetic iron oxide nanoparticles with variable size and an iron oxidation state as prospective imaging agents. (springer.com)
  • Both prostate-specific membrane antigen (PSMA) PET/CT and ferumoxtran-10 nanoparticle-enhanced MRI (nano-MRI) are imaging modalities with high potential to identify LN metastases in PCa patients. (snmjournals.org)
  • As a leader in our field, we are dedicated to the development and commercialization of our proprietary nanoparticle technology for use in therapeutic iron compounds to treat anemia, as well as novel imaging agents to aid in the diagnosis of cancer and cardiovascular disease. (salesandmarketingnetwork.com)
  • The goal of this study was to develop the first successful iron labeling method of breast cancer cells derived from patient brain metastases and validate this method with imaging during tumour development. (biorxiv.org)
  • These applications require coating of the nanoparticles by agents such as long-chain fatty acids, alkyl-substituted amines, and diols. (wikipedia.org)
  • A facial electrospinning method of in situ precise fabricating magnetic fibrous membrane composed of polyurethane (PU) nanofibers decorated with superparamagnetic γ-Fe 2 O 3 nanoparticles with simultaneous heat generation in response to alternating magnetic field (AMF) is reported. (springer.com)
  • Relative to unlabeled cells, less than 1% of genes (49 total) exhibited greater than 2-fold difference in expression in response to superparamagnetic iron oxide/PLL labeling. (johnshopkins.edu)
  • NOD/SCID/ILIIrg -/- (n=5) mice received injections of 1×10 6 iron-labeled F2-7 cells into the fourth mammary fat pad (MFP). (biorxiv.org)
  • Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application. (springer.com)
  • Further, the cytocompatibility and blood compatibility evaluations demonstrated excellent cell morphological integrity even at high concentrations of nanoparticles supporting the non-toxic nature of nanoparticles. (rsc.org)
  • Single cell magnetic microscopy with multicolor superparamagnetic probes. (hhs.gov)