Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). (wikipedia.org)
A large pore is formed by transmembrane proteins. (tcdb.org)
Interferon-induced transmembrane proteins (IFITMs) are antiviral factors that act uniquely and early in viral replication cycles to restrict the entry of a diverse range of primarily enveloped viruses into cells ( 1 ). (life-science-alliance.org)
Cytosolic1
ERAD enables ER processing to distinguish the properly and improperly folded proteins in the ER lumen and then extracts them through membrane channels (dislocation or retrotranslocation) in an energy-dependent manner for delivery to cytosolic proteasomes. (eu.org)
Lumen1
C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)
Inhibition1
These transporters are sensitive to inhibition by N-ethylmaleimide . (guidetopharmacology.org)
Gene1
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene. (wikipedia.org)
MRNA1
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
Budding yeast1
In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
Endoplasmic reticulum2
VCP complexes are involved in many cellular processes, particularly in the endoplasmic reticulum (ER)‐associated degradation (ERAD) process for protein quality control, membrane trafficking, and DNA damage response. (eu.org)
The Endoplasmic Reticulum (ER) is an important eukaryotic cell organelle that has various functions, including the synthesis of proteins for export and quality control of nascent proteins. (eu.org)
Synthesis1
Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
Bind1
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)
Cellular2
Ter94 in fly, CDC48 in yeast) is a hexameric multidomain protein belonging to the functionally highly diverse AAA+ (ATPases Associated with diverse cellular Activities) superfamily of proteins. (eu.org)
The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
Receptor1
Syntaxins serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis. (wikipedia.org)
Functional1
A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
Degradation3
The ERAD (ER-Associated Degradation) mechanism acts as a protein quality control and removes these misfolded proteins. (eu.org)
Nearly all ERAD substrates are ubiquitinated prior to their degradation and these ubiquitin chains provide a binding site for VCP (Valosin-Containing Protein). (eu.org)
And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)
Distinct2
Most peroxisomal membrane proteins do not have PTS1 or PTS2, and insertion requires several peroxins distinct from those required for import of soluble matrix proteins. (tcdb.org)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
Depends1
Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)
Mechanism2
They catalyze glucuronidation reactions in various aglycone substrates, contributing significantly to the body's chemical defense mechanism. (mdpi.com)
Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y + ), apparently as an exchange mechanism. (guidetopharmacology.org)
Family1
IFITMs belong to the CD225/pfam04505 or "dispanin" protein superfamily ( http://pfam.xfam.org/family/PF04505 ) ( 3 ) that contains more than 2,000 members, including both prokaryotic and eukaryotic proteins, all of which encode a conserved CD225 protein domain. (life-science-alliance.org)
Expression1
The effects of an imidazoline compound (BL11282) on protein expression in rat pancreatic islets were investigated with a proteomic approach. (researchgate.net)
Domain1
The N-terminal domain of VCP acts as a binding site for a group of adaptor proteins through their Arg/Lys-rich peptide motifs. (eu.org)
Humans1
We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)
Essential2
Thus ERAD is essential for ER homeostasis and correct functioning by degrading misfolded proteins ( Hwang,2018 ). (eu.org)
TGF-β, especially TGF-β1 as an uppermost isoform of TGF-β superfamily, may play a very essential role in the development of insulin resistance and obesity and finally, diabetes. (frontiersin.org)
Cell3
Proteins targeted to the peroxisome (in plants called glyoxisomes) are synthesized in the cytoplasm of the cell and are targeted to the peroxisome post-translationally, possibly via multiple pathways. (tcdb.org)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
As their name suggests, IFITMs are membrane proteins, allowing them to police the cell surface and endocytic membranes that viruses must cross to invade cells. (life-science-alliance.org)
Found2
Intrinsically disordered regions in Pex13 and Pex5 resemble those found in nuclear pore complex proteins. (tcdb.org)
Here, we found that an uncharacterized protein REGULATORY PARTICLE NON-ATPASE 1a-like in peanut (AhRPN1a-like), located in the nucleus and cytoplasm, directly interacted with type I metacaspase in peanut (AhMC1). (bvsalud.org)
High1
RUNX3 occurs to Runx protein Defects in the physical( high) blood of the RUNX1 heat, making C-terminal cysteine( Spender et al. (evakoch.com)
Large1
The peroxisomal protein import machinery, which shares similarities with chloroplasts, is unique in transporting folded and large (up to 10 nm in diameter) protein complexes into peroxisomes. (tcdb.org)