Superfamily of proteins complexes are found carrier proteins. Medical search. Frequent questions

Clustering of NCS2/NAT family members on the phylogenetic tree is complex, with bacterial proteins and eukaryotic proteins each falling into at least three distinct clusters. (wikipedia.org)
More than half of all eukaryotic proteins are glycoproteins, and 90 % of those are N- glycosylated [ 33 ]. (biomedcentral.com)
VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). (embl.de)

Furthermore, chromatophore-localized biosynthetic pathways as well as multiprotein complexes include proteins of dual genetic origin, suggesting that mechanisms evolved that coordinate gene expression levels between chromatophore and nucleus. (frontiersin.org)
A common feature appears to be involvement in multiprotein complexes. (embl.de)

We focused on 8 single-nucleotide polymorphisms (SNPs) in 2 candidate genes important in the innate immune response to influenza infection and for which national prevalence estimates were available: the gene for tumor necrosis factor superfamily, member 2 (official symbol TNF ) and the mannose-binding lectin gene (official symbol MBL2 ). (cdc.gov)

Expression analyses showed that the mRNA expression, biosynthesis, intracellular sorting and proteolytic processing of Cln5 were not affected, whereas the depletion of mature Cln5 protein was due to increased proteolytic degradation by cysteine proteases in Cln7 ko lysosomes. (kentlandsinitiative.org)
CLN7 belongs to a group of atypical solute carriers of MFS type which are located at the plasma membrane and/or in intracellular compartments (14). (kentlandsinitiative.org)
Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. (embl.de)
The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). (biolegend.com)

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
However, unlike typical ABC transporters (E.I. Sun & M.H. Saier, unpublished results), they use small integral membrane proteins that are postulated to capture specific substrates. (tcdb.org)
These membrane proteins are homologues to ABC-2 exporters. (tcdb.org)
Fas-activated DCs increase the expression of MHC II, B7 co-stimulatory molecules, and DC-lysosome-associated membrane proteins (DC-LAMP), and secrete proinflammatory cytokines such as IL-1β and TNF-α. (biolegend.com)

This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)
Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
CD3ε is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T cell receptor (α/β or γ/δ) heterodimer. (stem-immune.com)
Cloned in the 80s, the GR has become one of the best-studied and clinically most relevant members of the nuclear receptor superfamily. (uni-ulm.de)
The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)
We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. (biolegend.com)
In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)

There are over 300 alleles (one of two or more forms of a gene that produce variations in a given trait) for the hemoglobin gene, part of the globin gene superfamily. (icr.org)
Apparently these chromatophore-targeted proteins evolved convergently to plastid-targeted expression regulators and are likely involved in gene expression control in the chromatophore. (frontiersin.org)
The origin of the eukaryotic N- glycosylation pathway is not unique and less straightforward than previously thought: some basic components likely have proteoarchaeal origins, but the pathway was extensively developed before the eukaryotic diversification through multiple gene duplications, protein co-options, neofunctionalizations and even possible horizontal gene transfers from bacteria. (biomedcentral.com)
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. (nih.gov)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Expression of truncated bio transport operons, each with one gene deleted, resulted in stable BioMN complexes but revealed only low amounts of BioMY and BioNY aggregates in the absence of the respective third partner. (tcdb.org)
LRRK2 is a large gene spanning a genomic region of 144 kb with 51 exons and encodes a multidomain protein consisting of 2527 amino acids. (biomedcentral.com)

underlying on the sequence today of the complex, about glycolysis of the directly 400 use insertions are ligated and these are the mutations impaired of skeletal eIF5B: transmembrane phosphorylation and described educators. (erik-mill.de)
2023 ). (1) the BioMNY complex with ATPase (BioM) and transmembrane protein (BioN). (tcdb.org)
Some transporters have a conserved transmembrane protein and two nucleotide binding proteins similar to those of ABC transporters. (tcdb.org)
Possibly, these two transmembrane proteins comprise the pathway for transmembrane transport. (tcdb.org)
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. (cathdb.info)

We found that the loss of Cln7 results in alterations in lysosomal soluble proteins under steady state conditions. (kentlandsinitiative.org)
There are two major P450 classes in terms of the native RP systems, namely, the prokaryotic Class I P450 consisting of three stand-alone components (redoxin reductase/redoxin/P450) that are all cytosolically soluble proteins and the two-component eukaryotic Class II P450 comprised of P450 and cytochrome P450 reductase (CPR), both of which are membrane-bound proteins. (nature.com)

Here we report a dual strategy for assessing genetic variation overlooked by those prior efforts: low-frequency protein-coding variants genotyped by large-scale exome-focussed arrays and high-density X-chromosome single-nucleotide polymorphism (SNP) genotyping and imputation. (nature.com)
Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a central role in the maintenance of DNA methylation. (cipsm.de)
This provided new data about the genetic make-up of each parasite that the team analysed to find out how they are related to one another. (elifesciences.org)
Genome-wide association studies have been designed primarily to capture common variation and so far some 10,000 common genetic variants have been robustly associated with a wide range of complex diseases ( 1 ). (frontiersin.org)
There has been much debate as to the role of rare genetic variation on complex traits ( 2 - 4 ) and how rare variant studies complement GWASs ( 5 ). (frontiersin.org)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
To date, at least 23 loci and 19 disease-causing genes for parkinsonism have been found, but many more genetic risk loci and variants for the sporadic phenotype have been identified in various association studies [ 13 ]. (biomedcentral.com)
Pneumocyclicin cassettes were mainly of one genetic cluster and largely found among seven major pneumococcal clonal complexes. (biomedcentral.com)
Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. (cdc.gov)

In proteins belonging to the c-type cytochrome family [ 1 ], the heme group is covalently attached by thioether bonds to two conserved cysteine residues located in the cytochrome c center. (expasy.org)
To recognize c-type cytochrome family proteins we have developed 4 profiles. (expasy.org)

It shares mechanistic similarities based on the use of polyisoprenol lipid carriers with other glycosylation pathways involved in the synthesis of bacterial cell wall components (e.g. peptidoglycan and teichoic acids). (biomedcentral.com)
The comparison of several polyisoprenol-based glycosylation pathways from the three domains of life shows that most of the implicated proteins belong to a limited number of superfamilies. (biomedcentral.com)
The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. (tamu.edu)

To explore this superfamily, we have used bioanalytical, biochemical, synthetic, computational, and enzymatic approaches that have been applied to three distinct projects. (duke.edu)
TNFRSF13B rs4792800 was found to be significantly associated with biochemical recurrence even after adjustment for clinical predictors and false discovery rate correction (adjusted hazard ratio 1.78, 95% confidence interval 1.16-2.71, p = 0.008), and the G allele was associated with higher TNFRSF13B expression ( p = 0.038). (biomedcentral.com)
Biochemical assays revealed that the BioM, N, and Y proteins form stable complexes in membranes of the heterologous host. (tcdb.org)
The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles. (tamu.edu)

The plant and animal proteins cluster loosely together, but the fungal proteins branch from one of the three bacterial clusters forming a tighter grouping. (wikipedia.org)
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. (cathdb.info)

CD23 belongs to the C\type (calcium\dependent) lectin\like (CTLD) superfamily of proteins and is a trimer in its membrane\bound form. (treatmentforprostatecancer.info)
In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)

Previously undetected bacterial homologues were identified for# plant pathogenesis-related proteins, Pad1, von Willebrand factor type A, src homology 3 and YWTD repeat-containing domains. (embl.de)

NLRP3 ( CIAS1 ) mutations are gain-of-function mutations that cause constitutive activation of the inflammasome, a complex with pro-IL-1-processing activity, and macrophage necrosis. (medscape.com)
In addition we also find that there is a significant enrichment of genes annotated for disease-causing mutations in the OMIM database, suggesting that in complex diseases such as SLE, such mutations may be involved in subtle or combined phenotypes or could accelerate specific organ abnormalities found in the disease. (frontiersin.org)
It would be very unexpected to find rare variants that could have substantial effect sizes and therefore high penetrance contributing to complex traits, being more likely to have mutations with modest effects. (frontiersin.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Structure of the functional domain of the LRRK2 protein and the pathogenic mutations associated with PD. (biomedcentral.com)
The enormous variants and mutations found mean that we are still far from being able to concretely clarify a genotype-phenotype relationship. (bvsalud.org)

Cryopyrin (also called NALP3, PYPAF1, or NACHT, leucine-rich repeat [LRR], and PYD domains-containing protein 3) is a member of the APAF-1/NOD1-like protein family, which regulates apoptosis and inflammation. (medscape.com)

CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. (stem-immune.com)
Immunoglobulin E (IgE) is usually a glycosylated protein belonging to the immunoglobulin family and plays Ginsenoside Rg3 a central role in allergic disease, exerting its effector functions through two receptors: FcRI and CD23 [2]. (treatmentforprostatecancer.info)

Families 2.A.88 and 2.A.87 which are part of a superfamily, and 3.A.1.26, are homologous but function as secondary versus primary active transporters, respectively. (tcdb.org)
When evidence suggests that homologous membrane transport proteins of the ABC2 type couple transport to ATP hydrolysis using a homologue of the ABC-type ATPases, we list these proteins in the ABC superfamily. (tcdb.org)

As an example of one of the complex transformations on this pathway, the figure below shows the structure of the pyrimidine synthase catalyzing the complex rearrangement of aminoimidazole ribotide (left) to the thiamin pyrimidine (right). (tamu.edu)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)

Through a series of minimally complex analogs, we determined non-proteinogenic amino acids and the N-acyl fatty acid moiety are essential for bioactivity. (duke.edu)

Cytochrome c, an electron carrier protein located in the mitochondrial matrix. (expasy.org)
An iron-sulfur protein which serves as an electron carrier in enzymatic steroid hydroxylation reactions in adrenal cortex mitochondria. (lookformedical.com)

In healthy individuals, cryopyrin and apoptosis-associated speck-like protein (ASC) interact via the oligomerization of ASC to induce both apoptosis and activate nuclear factor (NF)-kappa B. (medscape.com)
[ 2 , 5 ] MEFV mutation leads to formation of pyrin-marenostrin complex, which interacts with ASC and disrupts the cryopyrin-ASC interaction and specifically inhibits apoptosis and NF-kappa B activation. (medscape.com)
Cytochromes c typically function in electron transfer, but c-type cytochrome centers are also found in the active sites of many enzymes, and in eukaryotic cells, cytochrome c has also a role in apoptosis [ 2 ]. (expasy.org)

It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. (stem-immune.com)
The 397 amino acid recombinant protein has a predicted molecular mass of approximately 44.7 kD. (biolegend.com)
BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)

In a study on vertebrate globins, Jay Storz and his colleagues wrote, "The retention of the proto- Hb and Mb genes in the ancestor of jawed vertebrates permitted a physiological division of labor between the oxygen-carrier function of Hb [hemoglobin] and the oxygen-storage function of Mb [myoglobin]. (icr.org)
The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. (uni-ulm.de)
We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and genes. (biomedcentral.com)
We explored the genes disrupted by these variants from joint analysis of protein-truncating variants (PTVs), missense variants and copy number variants (CNVs) in a cohort of 63,237 individuals. (cdc.gov)

In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. active proteins [ 3 - 5 ]. (omicsonline.org)
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic elimination of many drugs and potentially associated drug-drug interactions. (aspetjournals.org)
The carrier-mediated hepatic uptake process not only represents the first step of hepatic drug elimination but is also an active drug delivery system for many statins to the liver as a target organ ( Sai and Tsuji, 2004 ). (aspetjournals.org)
In fact, our studies indicated that all uptake porters of the ABC superfamily are of the ABC2 type. (tcdb.org)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)

Cytochrome P450 enzymes (P450s or CYPs) are a superfamily of heme-thiolate proteins widespread in all kingdoms of life 1 . (nature.com)
protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)

Multiheme proteins (prokaryotes). (expasy.org)
BioMNY proteins are considered to constitute tripartite biotin transporters in prokaryotes. (tcdb.org)

Our comparison testing data indicates that when handled and stored as recommended, the liquid format has equal or better stability and shelf-life compared to commercially available lyophilized proteins after reconstitution. (biolegend.com)

ANGPT1 In addition, we found a defect in MK-1775 the ability of Cln7 ko MEFs to adapt to starvation conditions as shown by MK-1775 impaired mammalian target of rapamycin complex 1 reactivation, reduced autolysosome tubulation and increased perinuclear accumulation of autolysosomes compared with controls. (kentlandsinitiative.org)
It involves located that the liver cathepsine transcription 2( SH2 Smart-Growth) of PLC-gamma and of regulatory presenting complexes( mammalian as Negotiating decay and compartment Reversible fibronectin) organize their mRNA toward telomeric differentiation transporters of the FGFR. (erik-mill.de)

Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

The mechanistic data imply (i) that BesD may have evolved from a hydroxylase ancestor either relatively recently or under weak selective pressure for efficient chlorination and (ii) that acquisition of its activity may have involved the emergence of linkage between l-Lys binding and chloride coordination following the loss of the anionic protein-carboxylate iron ligand present in extant hydroxylases. (bvsalud.org)

It imports hundreds of nucleus-encoded proteins, and diverse metabolites are continuously exchanged across the two chromatophore envelope membranes. (frontiersin.org)
The N- glycosylation is an essential protein modification taking place in the membranes of the endoplasmic reticulum (ER) in eukaryotes and the plasma membranes in archaea. (biomedcentral.com)
In eukaryotes, the synthesis of the oligosaccharide core is mediated by a lipid carrier called dolichol-phosphate (Dol-P) which is located in the membranes of the endoplasmic reticulum (ER, Fig. 1a ). (biomedcentral.com)

Furthermore, dysregulated expression of several soluble lysosomal proteins and impaired macroautophagy in the Cln7 ko mice suggest that loss of Cln7 results in lysosomal dysfunction in the brain (19). (kentlandsinitiative.org)
These proteins show similar domain architectures as known organelle-targeted expression regulators of the octotrico peptide repeat type in algae and plants. (frontiersin.org)
Two critical factors during this dauntingly complex process appear to be the establishment of metabolic connectivity between the symbiotic partners, and the evolution of nuclear control over protein expression levels within the organelle. (frontiersin.org)
The CD3 subunits are required for proper assembly, trafficking, and surface expression of the TCR complex. (stem-immune.com)
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H. (stem-immune.com)
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endo. (stem-immune.com)

Phyletic distributions of eukaryotic signalling domains were studied using recently developed sensitive methods for protein sequence analysis, with an emphasis on the detection and accurate enumeration of homologues in bacteria and archaea. (embl.de)

The NCS2/NAT family is a member of the APC Superfamily of secondary carriers. (wikipedia.org)

Furthermore, pyrin interacts with proline-serine-threonine phosphatase-interacting protein (PSTPIP1), also known as CD2-binding protein 1 (CD2BP1), which is a tyrosine-phosphorylated protein involved in cytoskeletal organization and thereby involved in immunologic cellular interactions. (medscape.com)
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). (cathdb.info)

Lysosomal localization of the endogenous CLN7 protein has been demonstrated by proteomic analyses using purified human and rat tritosomes, by immunoblotting of mouse liver tritosomes and by immunohistochemical localization in cultured hippocampal neurons (15C18). (kentlandsinitiative.org)
Here we show by mass spectrometric analyses of enriched insoluble protein fractions that, unexpectedly, nucleus-encoded transporters are not inserted into the chromatophore inner envelope membrane. (frontiersin.org)
2009 identified 21 families of these substrate capture proteins, each with a different specificity predicted by genome context analyses. (tcdb.org)
These detailed genomic analyses revealed a novel pneumocyclicin cassette and a wide variety of blp bacteriocin cassettes, suggesting that competition in the nasopharynx is a complex biological phenomenon. (biomedcentral.com)

The RUNX1: heterodimer carrier represses thus inhibited in IL1 phosphorylation of transcription classical kinases, including GPAM, KCTD6 and AXIN1( Stender et al. (erik-mill.de)
The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)
We have found that phosphorylation of Rab10 blocks primary cilia formation in culture and in certain brain regions and we would like to understand how this leads to Parkinson's disease. (stanford.edu)

Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. (nature.com)
Collectively, these novel variants explain ∼ 0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait. (nature.com)
In particular, like most GWAS for other complex traits, previous GWAS for age at menarche provided poor coverage for low-frequency variants and omitted sex chromosome data. (nature.com)
We identify several new associations between rare protein-coding and X-linked variants with age at menarche in women of European ancestry. (nature.com)
The findings implicate new mechanisms that regulate puberty timing, but collectively these novel variants explained only ∼ 0.5% of the variance, indicating that these often overlooked sources of variation that do not substantially explain the 'missing heritability' of this complex trait. (nature.com)
Whole-exome sequencing is a cost-effective alternative, however one of its obvious drawback is the absence of variants in non-coding regions, which may be especially relevant in the context of complex disease genetics. (frontiersin.org)

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

These diseases were reclassified based on the innate immunity mechanisms and the inflammasome, a protein complex containing caspases involved in the proteolytic cleavage of interleukin (IL)-1 precursors to produce active forms of IL-1 (explaining the pathogenesis of fevers in these individuals) (see Table 1). (medscape.com)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
As a result, a number of conserved mechanisms were proposed, wherein the C8-H of the adenyl moiety was found to play a direct role in the control of phosphoryl transfer [ 2 ]. (biomedcentral.com)

The Nucleobase cation symporter-2 (NCS2) family, also called the Nucleobase ascorbate transporter (NAT) family, consists of over 1000 sequenced proteins derived from gram-negative and gram-positive bacteria, archaea, fungi, plants and animals. (wikipedia.org)
A full list of these proteins can be found in the Transporter Classification Database. (wikipedia.org)
It has been reported that solute carrier (SLC) and the ATP-binding cassette (ABC) transporter super families are the major class of membrane transporters [ 14 , 17 ]. (omicsonline.org)

Proteins of the NCS2 family are 414-650 amino acyl residues in length and probably possess 14 TMSs. (wikipedia.org)
The generalized transport reactions catalyzed by proteins of the NAT/NCS2 family are: Nucleobase (out) H+ (out) → Nucleobase (in) H+ (in). (wikipedia.org)
Several proteins make up the NCS2/NAT family. (wikipedia.org)
A few types of proteins that make up the NCS2/NAT family include: Xanthine permeases, including PbuX (XanP) of Bacillus subtilis (TC# 2.A.40.3.1), involved in cellular xanthine transport. (wikipedia.org)
encodes the lysosomal polytopic CLN7 membrane protein of unknown function which contains sequence similarities with the drug: H+ antiporter family DHA1 of the major facilitator superfamily (MFS) (4,12). (kentlandsinitiative.org)
Furthermore, our mass spectrometric analysis revealed an expanded family of chromatophore-targeted helical repeat proteins. (frontiersin.org)
Because FH1 40S strand across the replication superfamily has negatively absorbed, man can appear without the family that provides fluid of organism diseases. (erik-mill.de)
After the Pol spectra prophase challenge serves broken from the closure, the including treatment complex family( PCNA) is to wound a ' PIP3 induction ' benzene. (erik-mill.de)
These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. (nih.gov)
However, the VUT family member, TrpP of Bacillus subtilis (2.A.88.4.1) and the ThiW ABC membrane protein homologue, 3.A.1.26.2, are clearly related by common descent. (tcdb.org)
This protein belongs to the ROCO (ROC and COR domain) protein family and is made up of five characteristic functional domains: leucine-rich repeats (LRR domain), Rasp of complex proteins (ROC domain), C-terminal of Roc (COR domain), mitogen activated protein kinase kinase kinase (MAPKKK domain), and the WD40 domain. (biomedcentral.com)
A recent large family study that used genealogic databases found an elevated risk for influenza death among relatives of persons who died of influenza ( 3 ). (cdc.gov)

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. (expasy.org)

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)

Through a series of bioactivity assays, we found the transfer to the acyl carrier protein (ACP) in a fatty acyl-AMP ligase (FAAL)-dependent manner determined the specificity of lipids selected in the biosynthetic process. (duke.edu)

2009 have a dedicated energizing module, but in 459 cases distributed among almost 100 gram-positive bacteria, different and unrelated substrate capture proteins share the same energy-coupling module. (tcdb.org)
This kind of RP systems are widely found in bacteria and the mitochondria in plants and animals, which serve many different physiological processes 5 . (nature.com)
Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to attack other bacteria and an immunity protein to protect against self-destruction. (biomedcentral.com)
Bacteriocins are small, ribosomally-synthesised antimicrobial peptides or proteins produced by bacteria to inhibit other bacteria, and the producer strain has a dedicated immunity system that protects it from its own bacteriocin. (biomedcentral.com)

Therefore, selection of substrate, substrate concentration, and in vitro transport system are critical for the conduct of in vitro interaction studies involving individual liver OATP carriers. (aspetjournals.org)
LRRK2 encodes a large protein containing three catalytic and four protein-protein interaction domains. (biomedcentral.com)

This configuration enables conformational changes of the protein so that oxygen molecules can easily load and unload. (icr.org)

It causes been that the download insurgency complex peptide 2( SH2 tRNA) of PLC-gamma and of cyanobacterial shedding features( such as elongating site and necrosis pleiotropic circulation) develop their presence toward post-translational p38 Humans of the FGFR. (erik-mill.de)

A major difference was found between the distributions of enzyme families that are typically found in all three divisions of cellular life and non-enzymatic domain families that are usually eukaryote-specific. (embl.de)
The functionality required for the catalysis and regulation of phosphoryl transfer was found to be conserved within the families or fold-groups. (biomedcentral.com)

Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia. (tamu.edu)

Diseases such as obesity, diabetes, and hypertension have been found to be closely associated with the incidence of NAFLD. (wjgnet.com)
The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. (nih.gov)

Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)

Stock solutions can also be prepared at 50 - 100 µg/mL in appropriate sterile buffer, carrier protein such as 0.2 - 1% BSA or HSA can be added when preparing the stock solution. (biolegend.com)

Anatomy16

Organisms13

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes73

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science6

Health Care2

Eukaryotic proteins3

Multiprotein complexes2

Tumor Necros1

Intracellular4

Membrane proteins4

Receptor9

Gene8

Transmembrane5

Soluble proteins2

Genetic9

Cytochrome family2

Pathways3

Biochemical4

Clusters2

Lectin2

Homology1

Mutations6

Leucine-rich r1

Immunoglobulin2

Homologous2

Pathway2

Amino acids1

Electron carrier2

Apoptosis3

Recombinant3

Genes4

Uptake5

Enzymes2

Prokaryotes2

Reconstitution1

Mammalian2

Heterologous1

Mechanistic1

Membranes3

Expression6

Homologues1

Secondary carriers1

Interacting2

Analyses4

Phosphorylation3

Variants6

Nuclear1

Mechanisms3

Transporter3

Family12

Electrons1

Transcription1

Specificity1

Bacteria4

Interaction2

Molecules1

Peptide1

Families2

Biotechnology1

Diseases2

Ribosomal2

Sterile1