• Chen CC, Simard MJ, Tabara H, Brownell DR, McCollough JA, Mello CC. A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans. (umassmed.edu)
  • For the remainder of this investigation you are going to focus on one superfamily present in FtaA, the Nucleotidyltransferase domain family (CATH code: 3.30.420.40). (cathdb.info)
  • The next step is to investigate one of the domains in the CATH superfamily 3.30.420.40 using both CATH and Gene3D. (cathdb.info)
  • The name CATH derives from the initials of the top four levels of the classification - Class, Architecture, Topology and Homologous Superfamily. (cathdb.info)
  • The capping enzyme is part of the covalent nucleotidyl transferases superfamily, which also includes DNA ligases and RNA ligases. (wikipedia.org)
  • DNA ligase belongs to the nucleotide transferase superfamily, including RNA ligases and mRNA capping enzymes. (microbenotes.com)
  • NAD + dependent ligases have a central ligase catalytic core which is composed of oligonucleotide binding fold domain and nucleotidyltransferase domain. (microbenotes.com)
  • What is the type of fold members of this superfamily adopt? (cathdb.info)
  • The enzymes of this superfamily share the following similarities: Conserved regions known as motifs I, II, III, IIIa, IV, V and VI, which are arranged in the same order and similar spacing A lysine containing motif KxDG (motif I) A covalent lysyl-NMP intermediate The capping enzyme is composed of two domains, a nucleotidyl transferase (NTase) domain and a C-terminal oligonucleotide binding (OB) domain. (wikipedia.org)
  • If you look at the homologous superfamily level (the H-level) you will see that the domain has the code 3.30.420.40. (cathdb.info)
  • [4] This classification initially identified 48 families of inhibitors that could be grouped into 26 related superfamily (or clans) by their structure. (wikipedia.org)
  • Click on this level to view the structures of other known domains from this homologous superfamily. (cathdb.info)
  • We will then investigate the superfamily of one of these domains further by looking at the types of biological functions and how the superfamily is distributed across different biological kingdoms. (cathdb.info)
  • Homologous Superfamily refers to domains that are believed to be related by a common ancestor. (cathdb.info)
  • A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. (cam.ac.uk)
  • My work in computational biology at NIH has been dedicated to four main activities: exploring the evolution of viruses, detecting conserved motifs in proteins, predicting new protein functions and characterizing protein families and superfamilies, and undertaking the comparative analysis of complete bacterial genomes. (nih.gov)
  • The characterization of LinB enabled its classification as a member of a nucleotidyltransferase superfamily, along with nucleotide polymerases and aminoglycoside nucleotidyltransferases, and this relationship offers further support for the LinB mechanism. (rcsb.org)
  • The enzymes of this superfamily share the following similarities: Conserved regions known as motifs I, II, III, IIIa, IV, V and VI, which are arranged in the same order and similar spacing A lysine containing motif KxDG (motif I) A covalent lysyl-NMP intermediate The capping enzyme is composed of two domains, a nucleotidyl transferase (NTase) domain and a C-terminal oligonucleotide binding (OB) domain. (wikipedia.org)
  • Bacillus halodurans (𝐵ℎ) ribonuclease H (RNase H) belongs to the nucleotidyl-transferase (NT) superfamily and is a prototypical member of a large family of enzymes that use two-metal ion (Mg 2+ or Mn 2+ ) catalysis to cleave nucleic acids. (ias.ac.in)
  • Radical SAM superfamily [Interproscan]. (ntu.edu.sg)
  • 15. Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication. (nih.gov)
  • In the present study, a functional nucleotidyltransferase gene from Arabidopsis encoding a 58.3 kDa GlcNAc1pUT-1 (N-acetylglucosamine-1-phosphate uridylyltransferase) was identified. (rhea-db.org)
  • These include, for example, a novel nucleotide-binding motif shared by eukaryotic translation initiation factor eIF-2B and a variety of nucleotidyltransferases, and another motif that is conserved in splice-junctions of self-splicing proteins and in the hedgehog family of development regulators. (nih.gov)