• PCI contains a small cysteine-rich module, called a T-knot scaffold, that is shared by several different protein families, including the EGF family.a Because of the structural similarities with EGF, PCI inhibits tumor cell growth.a Mechanism of action is inhibition of receptor dimerization and receptor trans-autophosphorylation induced by epidermal growth factor (EGF). (wikipedia.org)
  • This same folding motif is found in some protein growth factors. (embl-heidelberg.de)
  • Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. (uchicago.edu)
  • A putative protein interaction module, approximately 70 amino acids long, that forms a small five-helix bundle with two large interfaces which may homo- and hetero-oligomerize, or bind non-sterile-alpha motif targets. (nih.gov)
  • Protein interaction motifs of approximately 40 amino acids that usually terminate in TRYPTOPHAN and ASPARTIC ACID . (nih.gov)
  • Surprisingly, the major venom components were neprilysins and uncharacterized peptides, in addition to the well-known ω- and δ-hexatoxins and double-knot peptides. (bvsalud.org)
  • Together, this study expands the existing library of jasmintides and furthers our understanding of the molecular diversity and cystine framework of CRPs as scaffolds and tools for engineering peptides targeting pests. (biomedcentral.com)
  • Consequently, our laboratory has focused on this superfamily of metabolically stable plant-derived peptides, particularly CRPs with molecular weights of 2 to 6 kDa. (biomedcentral.com)
  • The beta chains are proteins of about 100 to 140 amino acid residues which contain the cysteine-knot domain [ ( PUBMED:8202136 ) ], as shown in the following schematic representation. (embl-heidelberg.de)
  • These proteins show very little sequence homology, but they all have an unusual arrangement of six cysteines linked to form a 'cystine-knot' conformation. (embl-heidelberg.de)
  • The sterile alpha motif is present in a wide variety of eukaryotic proteins that function in diverse biological processes. (nih.gov)
  • RNA recognition motif domain [Interproscan]. (ntu.edu.sg)
  • Because of their shape, there appears to be an intrinsic requirement for the cystine-knot growth factors to form dimers. (embl-heidelberg.de)
  • The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. (embl-heidelberg.de)