Aldo-keto reductase family 1, member B1 (AKR1B1), also known as aldose reductase, is an enzyme that is encoded by the AKR1B1 gene in humans. (wikipedia.org)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
In this study, iolS, an aldo-keto reductase from Bacillus subtilis 168 was exhibited as a potential biocatalyst, which could catalyze the reduction of diaryl α-keto amide such as 2-oxo-N, 2-diphenyl-acetamide (ONDPA) with moderate S-selectivity (76.1%, ee) and 60.5% conversion. (bvsalud.org)
RNF152-overexpressed tumor cells exhibited a significantly lower level of Aldo-Keto reductase family 1 member 10 (AKR1B10), whereas up-regulation of IRAK1 restored the expression of AKR1B10 in RNF152-overexpressed cells. (bvsalud.org)
Aldo-keto reductase family 1 B10 (AKR1B10) was recently found to be elevated in lung cancer BM. (bvsalud.org)
Aldo-keto reductase family 1 member B10 (AKR1B10) is an inflammatory regulator and is closely related to the prognosis of patients with GC. (portlandpress.com)
Ketones2
It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. (wikipedia.org)
These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
Consists2
The AKR1B1 gene lies on the chromosome location of 7q33 and consists of 10 exons. (wikipedia.org)
AKR1B1 consists of 316 amino acid residues and weighs 35853Da. (wikipedia.org)
Cells1
Western Blot analysis of Hela cells and 293T cells using AKR1B1 Polyclonal Antibody at dilution of 1:350. (elabscience.com)
Aldo-keto reductase family 1, member B1 (AKR1B1), also known as aldose reductase, is an enzyme that is encoded by the AKR1B1 gene in humans. (wikipedia.org)
The active site pocket of human aldose reductase is relatively hydrophobic, lined by seven aromatic and four other non-polar residues. (wikipedia.org)
The mouse Akr1b3 gene is clearly orthologous to human AKR1B1, both coding for aldose reductase, and their gene products show similar tissue distribution, regulation by osmotic stress and kinetic properties. (bvsalud.org)
17. Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins. (nih.gov)
Aldo-keto reductases4
The aldo-keto reductases (AKRs): Overview. (nih.gov)
Aldo-keto reductases (AKRs) are distributed in three families and multiple subfamilies in mammals. (bvsalud.org)
10. Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer. (nih.gov)
20. Aldo-keto reductases-mediated cytotoxicity of 2-deoxyglucose: A novel anticancer mechanism. (nih.gov)
Regulates the expression1
7. β2-AR regulates the expression of AKR1B1 in human pancreatic cancer cells and promotes their proliferation via the ERK1/2 pathway. (nih.gov)
The AKR1B1 gene lies on the chromosome location of 7q33 and consists of 10 exons. (wikipedia.org)
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (nih.gov)
The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. (nih.gov)
4. Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway. (nih.gov)
Dehydrogenases1
There is conservation of the catalytic mechanism with short-chain dehydrogenases/reductases (SDRs) even though they show different protein folds. (nih.gov)
Lipid peroxidation1
It also participates in glucose metabolism and osmoregulation and plays a protective role against toxic aldehydes derived from lipid peroxidation and steroidogenesis. (wikipedia.org)
There are 15 human AKRs of these AKR1B1, AKR1C1-1C3, AKR1D1, and AKR1B10 have been implicated in diabetic complications, steroid hormone dependent malignancies, bile acid deficiency and defects in retinoic acid signaling, respectively. (nih.gov)
Inhibitors3
2. Aldo-keto reductase family 1 member B1 inhibitors: old drugs with new perspectives. (nih.gov)
9. Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment. (nih.gov)
14. Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. (nih.gov)
AKR1B103
6. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111). (nih.gov)
13. Overexpression and enhanced specific activity of aldoketo reductases (AKR1B1 & AKR1B10) in human breast cancers. (nih.gov)
16. AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas. (nih.gov)
Reduction1
This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. (nih.gov)
Enzyme1
The best substrate for the enzyme was pyridine-3-aldehyde. (bvsalud.org)
Expression1
8. The Expression and Clinical Significance of Aldo-Keto Reductase 1 Member B1 in Gastric Carcinoma. (nih.gov)
Member2
1. Role of aldo-keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential. (nih.gov)
19. A Potential Prognostic Biomarker for Glioma: Aldo-Keto Reductase Family 1 Member B1. (nih.gov)
Breast1
11. AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program. (nih.gov)
Role1
18. Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer. (nih.gov)