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Small Ubiquitin-Related Modifier ProteinsSUMO-1 ProteinSumoylationProtein Inhibitors of Activated STATSTAT3 Transcription FactorPhosphatidylethanolamine Binding ProteinUbiquitin-Conjugating EnzymesSTAT1 Transcription FactorSTAT5 Transcription FactorUbiquitin-Protein LigasesUbiquitin-Activating EnzymesSTAT6 Transcription FactorLigasesAmino Acid SequenceMolecular Sequence DataProtein BindingSTAT2 Transcription FactorProton-Translocating ATPasesSTAT4 Transcription FactorMitochondria, HeartSubmitochondrial ParticlesDNA-Binding ProteinsAurovertinsAngioedemaProteinsPolycomb-Group ProteinsHMGA1b ProteinSTAT Transcription FactorsProtein Processing, Post-TranslationalProtein Structure, TertiarySignal TransductionComplement C1 Inactivator ProteinsTrans-ActivatorsCell LineLysinePhosphorylationAndrogen-Binding ProteinMutationEnzyme InhibitorsCattleMilk ProteinsCell NucleusTranscription FactorsUbiquitinCarrier ProteinsRepressor ProteinsAlpha-GlobulinsTranscription, GeneticHeLa CellsKineticsUbiquitinsBinding SitesI-kappa B ProteinsPlacental HormonesIntracellular Signaling Peptides and ProteinsRibonuclease, PancreaticBase SequenceAdenosine TriphosphateUracil-DNA GlycosidaseEndo-1,4-beta XylanasesPlant ProteinsJanus Kinase 2Sequence Homology, Amino AcidJanus KinasesNF-kappa BCells, CulturedElectrophoresis, Polyacrylamide GelModels, MolecularMitochondrial Proton-Translocating ATPasesArabidopsis ProteinsBlotting, WesternAdenosine TriphosphatasesSaccharomyces cerevisiae ProteinsGene Expression RegulationCell Line, TumorEnzyme ActivationProtein ConformationCholesterol Ester Transfer ProteinsPhosphoprotein PhosphatasesRecombinant ProteinsTransfectionJanus Kinase 1Adenylyl ImidodiphosphateProtein Phosphatase 1Molecular WeightRecombinant Fusion ProteinsN-Glycosyl HydrolasesMyosin-Light-Chain PhosphataseArabidopsisNuclear ProteinsCalpainTrypsin InhibitorsCyclin-Dependent Kinase Inhibitor p21ApoptosisPeptide FragmentsComplement C1 Inhibitor ProteinInhibitor of Apoptosis ProteinsSuppressor of Cytokine Signaling ProteinsApolipoproteinsProtein Kinase Inhibitors
LigaseSUMOylationLigasesSignaling pathwayPIASEnzymeReceptorUbiquitin-related modifierPIAS2IC50TherapeuticPhosphorylationProteaseSubcellularVesiclePTMsActivatorPotentAnti-inflammatoryEncodesModificationsMembraneGTPaseHomologuesInteractionCellularHydrophobicActivityVirusesDiscoveryFunctionsHUMANGeneSourceShownEssentialDevelopmentHighlyDomainSimilarCellsArea
Ligase5
  • Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. (wikipedia.org)
  • Additionally, E3 SUMO-protein ligase PIAS is an alternative name for PIAS proteins. (wikipedia.org)
  • We have examined single nucleotide polymorphisms (or SNPs) within three genes from the ubiquitin protein system: the ubiquitin conjugating enzyme E2D1 (UBE2D1) gene, the E3 SUMO-protein ligase protein inhibitor of activated STAT 2 (PIAS2) gene, and the E3 ubiquitin ligase F-box and leucine-rich repeat protein 21 (FBXL21) gene, in a Caucasian case-control population for schizophrenia. (edu.au)
  • SUMO1 N-glycyl-lys MDM2, E3 ubiquitin-protein ligase Mdm2 ecNumber6.3.2. (reactome.org)
  • N106 is an activator of SUMO-activating enzyme, E1 ligase. (biochempartner.com)
SUMOylation7
  • These functions include acting as E3 SUMO-protein ligases during SUMOylation, which is an important process in transcriptional regulation. (wikipedia.org)
  • Modest ubiquitin-related modifier 77337-73-6 References proteins (SUMOs) may be covalently conjugated (SUMOylation) to precise lysine residues of several nuclear receptors (a hundred twenty five). (achrinhibitor.com)
  • Notably, a latest proteomic screening of SUMOylated proteins from pre- and postischemic brains of mice exposed hyper-SUMOylation of GR right after ischemia (24). (achrinhibitor.com)
  • SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
  • Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
  • SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
  • Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
Ligases2
Signaling pathway1
  • Additionally, PIAS proteins are important transcriptional co-regulators of the JAK/STAT signaling pathway. (wikipedia.org)
PIAS19
  • PIAS proteins act as transcriptional co-regulators with at least 60 different proteins in order to either activate or repress transcription. (wikipedia.org)
  • The transcription factors STAT, NF-κB, p73, and p53 are among the many proteins that PIAS interacts with. (wikipedia.org)
  • The seven proteins that belong to the mammalian PIAS family are encoded by four genes: PIAS1, PIAS2 (PIASx), PIAS3, and PIAS4 (PIASy). (wikipedia.org)
  • Homologues of PIAS proteins have been found in other eukaryotes, including Zimp/dPIAS in Drosophila melanogaster and zfPIAS4a in zebrafish. (wikipedia.org)
  • PIAS proteins contain each conserved domain and motif of the PIAS protein family, with a few exceptions. (wikipedia.org)
  • The known functions of these domains and motifs are similar among all PIAS protein family members. (wikipedia.org)
  • Presently, less is known about the higher order structure of PIAS proteins. (wikipedia.org)
  • PIAS proteins have potential applications in cancer treatment and prevention. (wikipedia.org)
  • PIAS proteins were named based on their ability to inhibit STAT. For example, PIAS1 inhibited STAT1, and PIAS3 inhibited STAT3. (wikipedia.org)
  • When it was discovered that PIAS proteins did far more than simply inhibit STATs, it was proposed that the PIAS acronym should stand for Pleiotropic Interactors Associated with SUMO based on their association with SUMO proteins. (wikipedia.org)
  • The table below lists the seven known proteins that belong to the mammalian PIAS protein family. (wikipedia.org)
  • Due to alternative splicing, some PIAS protein-encoding genes encode multiple protein products called isoforms. (wikipedia.org)
  • Homologues of PIAS proteins have been found in other eukaryotes, and several are listed below: Zimp/dPIAS in Drosophila melanogaster zfPIAS4a in zebrafish SIZ1 and SIZ2 in yeast PIAS proteins contribute to the control of gene expression, and may be considered transcriptional co-regulators. (wikipedia.org)
  • In essence, the RING-finger-like zinc-binding domain of the PIAS protein assists in the attachment of a SUMO protein to the target transcription factor. (wikipedia.org)
  • Attachment of a SUMO protein to the target allows for protein-protein interaction between PIAS and the transcription factor. (wikipedia.org)
  • One function of PIAS proteins is to relocate transcriptional regulators to different compartments within the nucleus of the cell. (wikipedia.org)
  • PIAS proteins also play a key role in double-stranded break DNA repair. (wikipedia.org)
  • PIAS protein's interaction with STAT signaling requires tyrosine phosphorylation of STAT proteins. (wikipedia.org)
  • The three-dimensional protein structures of PIAS2, PIAS3, and PIAS-like protein SIZ1 were recently solved using X-ray crystallography. (wikipedia.org)
Enzyme3
  • Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid. (absource.de)
  • This download is the types and cells led from a human assembly target content soccer methylated alongside the set of two interaction localizing enzyme proteins in New Zealand. (evakoch.com)
  • 1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. (targetmol.com)
Receptor7
  • On top of that to inhibiting proinflammatory proteins, 15d-PGJ2 has long been shown to inhibit estrogen receptor alpha (ER ) and androgen receptor (AR) exercise (31, 32) too as GR action (33). (achrinhibitor.com)
  • G protein-coupled receptor 85 [Sour. (gsea-msigdb.org)
  • Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
  • ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
  • Constructing glucagon like peptide-1 receptor fused with derivatives of GFP for visualizing protein-protein interaction in living cells. (leibniz-fli.de)
  • An S protein mediates the CoV entry into host cells by attaching to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), followed by fusion between virus and host cell membranes. (medchemexpress.com)
  • SARS-CoV-2 S Protein RBD (HEK293, His) produced in HEK293 cells is a recombinant SARS-CoV S protein receptor-binding domain (RBD) with His tag. (medchemexpress.com)
Ubiquitin-related modifier1
  • A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein. (reactome.org)
PIAS21
  • The three-dimensional protein structures of PIAS2, PIAS3, and SIZ1 have only recently been solved. (wikipedia.org)
IC506
  • Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. (absource.de)
  • Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. (absource.de)
  • Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. (absource.de)
  • Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. (absource.de)
  • Description: PF-06260933 is a highly selective small-molecule inhibitor of MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) with IC50 values of 3.7 and 160 nM for c. (invivochem.com)
  • Description: GNE-495 is a novel, potent and selective MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) inhibitor with an IC50 of 3.7 nM. (invivochem.com)
Therapeutic2
  • Regarding the rising interest in ubiquitin-related proteins as a therapeutic target in other pathologies such as cancer, further research into the role of ubiquitin pathways in schizophrenia seems topical and timely. (edu.au)
  • Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. (leibniz-fli.de)
Phosphorylation1
Protease3
  • Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV. (absource.de)
  • Genome replication and subgenomic RNA transcription after entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro), PLpro (papain-like protease) and RdRp (RNA-dependent RNA polymerase). (medchemexpress.com)
  • It is worth mentioning that a protease called TMPRSS2 (transmembrane protease, serine 2) play important roles throughout the whole life of CoVs (such as attachment, assembling and release) by cleaving S protein. (medchemexpress.com)
Subcellular1
  • All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment of disease caused by CoVs. (medchemexpress.com)
Vesicle1
PTMs1
  • The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
Activator2
  • Cyclopentenone prostaglandin 15d-PGJ2, an item derived with the cyclo-oxygenase pathway concerned within the resolution of irritation (twenty five), can be a known activator in the anti-inflammatory and cytoprotective Kelch-like ECHassociated protein one (KEAP1) uclear aspect erythroid 2-related issue 2 (NRF2) method (26). (achrinhibitor.com)
  • The anti-inflammatory actions of 15d-PGJ2 are thought to predominantly rely on its skill to activate the PPAR and NRF2 and also to inhibit 465-99-6 In Vivo proinflammatory transcription components, this sort of as nuclear issue B(NFB) and activator protein one (AP-1) (280). (achrinhibitor.com)
Potent4
  • Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. (leibniz-fli.de)
  • GNE0877) is a novel, highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with important biological activity. (invivochem.cn)
  • GNE7915) is a novel, highly potent, selective, and brain-penetrant leucine-rich repeat kinase 2 (LRRK2) inhibitor with anti-PD (Parkinson's disease) activity. (invivochem.cn)
  • GSK-2578215 A) is a novel, highly potent and selective LRRK2 kinase inhibitor with anti-PD (Parkinson's disease) activity. (invivochem.cn)
Anti-inflammatory1
  • Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. (absource.de)
Encodes1
  • Apart from PIAS1, each gene encodes two protein isoforms. (wikipedia.org)
Modifications2
  • SUMO modifications are really dynamic and they are reversed with the existence of members of the relatives of SUMO-specific proteases (twenty). (achrinhibitor.com)
  • Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
Membrane2
  • Deciphering soluble and membrane protein function using yeast systems. (leibniz-fli.de)
  • CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. (medchemexpress.com)
GTPase1
Homologues1
Interaction6
  • PPI spider: a tool for the interpretation of proteomics data in the context of protein-protein interaction networks. (leibniz-fli.de)
  • Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. (leibniz-fli.de)
  • NASCENT: An automatic protein interaction network generation tool for non-model organisms. (leibniz-fli.de)
  • Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets. (leibniz-fli.de)
  • Fault tolerance in protein interaction networks: stable bipartite subgraphs and redundant pathways. (leibniz-fli.de)
  • 10074-G5 is a c-Myc/Max interaction inhibitor. (sparkjadesd.com)
Cellular1
  • DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx. (biochempartner.com)
Hydrophobic1
  • The role of small hydrophobic protein P6, encoded by plum bark necrosis stem pitting associated virus (PBNSPaV), has not been well explored. (techscience.com)
Activity1
  • Previous to conjugation by UBC9 (E2 exercise), the SUMOs call for activation by SAE1 and -2 dimers (E1 activity) (eighteen). (achrinhibitor.com)
Viruses2
  • The very small proteins encoded by plant viruses are often overlooked due to their short sequences and uncertain significance. (techscience.com)
  • For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)
Discovery1
  • The discovery was made while the JAK-STAT pathway was being studied. (wikipedia.org)
Functions1
HUMAN1
Gene1
  • Gene-expression profiling and recent protein studies have shown a decrease in the expression of ubiquitin pathway proteins in the prefrontal cortex of schizophrenia patients. (edu.au)
Source3
Shown1
  • PIAS1, PIAS3, and PIAS4 have been shown to recruit proteins to the site of the damage and promote repair. (wikipedia.org)
Essential1
  • Cbl is an essential distribution for A4 non-canonical and caspase-1 changes. (evakoch.com)
Development1
  • Continued development of an empirical function for predicting and rationalizing protein-protein binding affinities. (leibniz-fli.de)
Highly1
Domain1
Similar2
  • SUMO-2 and -3 are fundamentally equivalent (and they are referred to as SUMO-23 right here), but SUMO-1 is just 50 similar to SUMO23 (16, seventeen). (achrinhibitor.com)
  • Using Argonaute CLIP-seq data, Dr. Rigoutsos and colleagues showed that similar percentages of the two sets of microRNAs were in complex with Argonaute proteins. (pharmaceuticalintelligence.com)
Cells2
Area1
  • Predicting protein-protein interfaces as clusters of optimal docking area points. (leibniz-fli.de)