Sulfur pathway and hydrogen sulfide. Medical search. Frequent questions

He is an avid researcher and has published several peer-reviewed papers covering sulfur metabolism, glyphosate, cancer, and other topics. (betterhealthguy.com)
Research Foci: Chemical biology of hydrogen sulfide signaling, regulation of mammalian sulfur metabolism in health and disease, structural enzymology of human B 12 trafficking proteins. (umich.edu)
The enzymes involved in sulfur metabolism are richly dependent on multiple B vitamins for their catalytic functions including vitamin B6, folic acid and B 12 . (umich.edu)
Because of this central role in cellular metabolism, a precise knowledge of the biosynthetic pathways that are responsible for homeostatic regulation of methionine and AdoMet in plants has practical implications, particularly in herbicide design. (rhumbarlv.com)
The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. (genome.jp)
Exposure to high level of NH 3 can alter several amino acid pathways and neurotransmitter systems, cerebral energy metabolism, nitric oxide synthesis, oxidative stress, and signal transduction pathways in the brain [ 9 ]. (hindawi.com)
Parents of autism children also are subject to impairment in sulfur metabolism [ 20 - 22 ]. (hindawi.com)
Potential projects focused on this theme are (1) investigating the contributions of metabolism to prognosis in tick-borne diseases like Lyme's, and (2) the effect of metal contamination on sulfur metabolism of the gut microbiome. (wisc.edu)
With regard for the pathways of central carbon metabolism, hydrogen metabolism at the same time as dissimilatory sulfur oxidation and assimilatory sulfate reduction, the transcriptomic and proteomic responses matched in most instances substantiating the incubation instances too selected (Weissgerber et al. (dna-alkylating.com)
What is being dealt with is sulfur metabolism and utilization. (metabolichealing.com)
As a result of sulfur metabolism, a number of intermediate metabolites are produced downstream of CBS. (metabolichealing.com)

Reactive sulfur species (RSS) are a family of sulfur-based chemical compounds that can oxidize and inhibit thiol-proteins and enzymes. (wikipedia.org)
The health consultation analyzes the available data for exposure via the air pathway to contaminants including hydrogen sulfide, sulfur dioxide and volatile organic compounds (VOCs). (cdc.gov)
Paracoccus) oxidize such sulfur compounds as hydrogen sulfide (sulfides) thiosulfates and inorganic sulfur etc. (microscopemaster.com)
Anaerobic sulfate reduction by bacteria and certain amino acid degradation pathways will produce sulfur-containing compounds that emanate malodor. (mdgbio.com)
Deamination often releases carbon dioxide, hydrogen, and a variety of odor-causing compounds such as VFAs and ammonia . (mdgbio.com)
Black smokers produce a great amount of heat, methane, and sulfur compounds. (kenyon.edu)
The results revealed a differential expression of the SOX sulfur oxidation pathway (soxCDYZ and soxABXYZ) in response to the two different sulfur compounds. (uni-greifswald.de)
Oxidation of sulfur compounds. (cdc.gov)
The formation of bonds between arsenic and sulfur atoms also helps break down arsenic-containing compounds. (the-scientist.com)
The researchers also substituted carbon monoxide for methane and found that the Archaea could oxidize that as well and produce these sulfur compounds. (phys.org)
mediation of sulfur ion transfer to cyanide or to other thiol compounds. (researchwap.net)
The resulting data sets permitted us to recognize parallel and distinct response patterns, represented by conserved patterns on each the metabolic as well as the gene and protein expression levels, across all sulfur compounds.1.2 g l-1 in all circumstances. (dna-alkylating.com)

Also, some sulfur bacteria use hydrogen sulfide as the hydrogen source for their photosynthesis. (cid-inc.com)
Sulfur bacteria - These bacteria (e.g. (microscopemaster.com)
Hydrogen bacteria - Such bacteria as Hydrogenovibrio marinus and Helicobacter pylori oxidize hydrogen as a source of energy under microaerophilic conditions. (microscopemaster.com)
The most common bacteria that lead to corrosion of steel can use sulfur as an energy source, and even a small amount of sulfur present in the steel or on surfaces can be enough. (emlab.com)
The bacteria use the hydrogen in the water to reduce sulfates, sulfites, thiosulfates, and sulfur to hydrogen sulfide, which then reacts with metal to form metal sulfides. (emlab.com)
Some bacteria can synthesize methionine using organic sulfur through transsulfuration of O-succinyl-L-homoserine with L-cysteine to form L-cystathionine. (rhumbarlv.com)
They include certain groups of bacteria such as sulfur-oxidizing gamma proteobacteria epsilon proteobacteria and neutrophilic iron-oxidizing bacteria and certain archaea such as methanogenic archaea. (microblife.in)
For example bacteria living in active volcanoes oxidize sulfur to produce their own food. (microblife.in)
The Archaea take in the methane and produce a methyl sulfide, and then the sulfur-reducing bacteria eat the methyl sulfide and reduced it to sulfide. (phys.org)

Members of the marine Roseobacter clade can degrade dimethylsulfoniopropionate (DMSP) via competing pathways releasing either methanethiol (MeSH) or dimethyl sulfide (DMS). (beilstein-journals.org)
methyl mercaptan and volatile dimethyl sulfide is associated with rotting cabbage odor, while ethyl mercaptan is noted as pungent garlic or skunk-like odor. (mdgbio.com)
They then tried the methyl sulfides, methanethiol (methyl mercaptan) and dimethyl sulfide, to see if they reduced methane oxidation. (phys.org)

The main backbone is derived from aspartic acid, while the sulfur may come from cysteine, methanethiol, or hydrogen sulfide. (rhumbarlv.com)
Methanethiol is converted into hydrogen sulfide (15). (metabolichealing.com)

Little is known, however, about the metabolic pathways that allow the Campylobacteria to dominate the bacterial community at Crab Spa. (uni-greifswald.de)
To address this fundamental question, a two-pronged approach was taken consisting of first determining the dominant metabolic pathways in situ, and second to study those same metabolic pathways and their controls in more detail under defined conditions in vitro in the model campylobacterium Sulfurimonas denitrificans. (uni-greifswald.de)
This allowed to identify the dominant organisms and their major metabolic pathways sustaining the microbial community at Crab Spa. (uni-greifswald.de)
Conversely, proteins related to electron donor-associated metabolic pathways accounted for less than 0.1% of the metaproteome, possibly in response to the high concentration of the electron donor. (uni-greifswald.de)
Current genome annotations do not account for the multiplicity of functions one gene may perform nor do they include atypical metabolic pathways. (wisc.edu)
Simplified picture showing homocysteine involvement in different metabolic pathways, as well as the role of vitamins B-6, B-12, and folate as a co-factors in this pathway. (medscape.com)

In the case of hydrogen sulfide, the compound undergoes oxidation to release electrons and hydrogen ions (referred to as protons given that they are separated from the compound and electrons and gain a positive charge). (microscopemaster.com)
in the body, arsenic ions bind to hydrogen sulfide groups in proteins, crippling important physiological functions. (the-scientist.com)
Since it is the same on both sides, it makes sense to cancel it out, just as we would for water, hydrogen ions, or electrons. (cavemanchemistry.com)

In this context, the intervention of the TRX and glutathione (GSH)/GRX reducing systems in the sulfur signaling/trafficking pathways is examined as both the TRX and GSH/GRX systems might modulate STR function and in particular be central to the formation of hydrogen sulfide, a molecule susceptible to trigger redox signalling cascades in several physiological situations. (hal.science)
Now it's time to meet its sister molecule, hydrogen sulfide (H2S). (healthworkscollective.com)
If hydrogen were the interspecies transfer molecule, than an abundance of hydrogen would turn off the methane oxidation. (phys.org)

Besides hydrogen sulfide, elemental sulfur has the potential to serve as an important electron donor at Crab Spa. (uni-greifswald.de)
However, up to know no information was available on how Campylobacteria might be able to utilize elemental sulfur. (uni-greifswald.de)
The energy source for chemosynthesis may be elemental sulfur hydrogen sulfide molecular hydrogen ammonia manganese or iron. (microblife.in)
Chemosynthetic autotrophs are the organisms which can synthesize their energy from oxidation of inorganic substances like elemental sulfur nitrates nitrites etc . (microblife.in)
Sulfide (4 mM), thiosulfate (10 mM) ?or 50 mM elemental sulfur [obtained from Riedel-de Haen, consisting of 30 cyclo-octasulfur and 70 polymeric sulfur (Franz et al. (dna-alkylating.com)
When elemental sulfur was the substrate, incubation was prolonged to 24 h. (dna-alkylating.com)
2014). Development conditions have been also identical for global transcriptomic profiling, having said that, incubation instances right after addition of substrates were PDE9 Inhibitor custom synthesis shorter in this case (1, 2 and 3 h hours on sulfide, thiosulfate and elemental sulfur, respectively). (dna-alkylating.com)

The fact is that if you dip a strip of zinc metal in dilute sulfuric acid, the zinc will be oxidized to zinc sulfate and the sulfuric acid will be reduced to hydrogen gas. (cavemanchemistry.com)
The reaction would be the same for nitrate, sulfate, acetate--any ion which forms a soluble compound with both hydrogen and zinc. (cavemanchemistry.com)
It perennially discharges cold (~ 7 °C), hypersaline (7-8% salinity), anoxic (~ 0.04 ppm O 2 ), and highly reducing (~ − 430 mV) brines rich in sulfate (2.2 g.L −1 ) and sulfide (9.5 ppm), making Gypsum Hill an analog to putative sulfate-rich briny habitats on extraterrestrial bodies such as Mars. (biomedcentral.com)
Sulfate reduction was dominated by hydrogen-oxidizing chemolithoautotrophic Desulfovibrionaceae sp. (biomedcentral.com)
We detected Mars-relevant metabolisms including hydrogenotrophic sulfate reduction, sulfur reduction, and sulfide oxidation, which indicate the potential for microbial life in analogous S-rich brines on past and present Mars. (biomedcentral.com)
For photoorganoheterotrohic growth on malate with sulfate as sole sulfur source, "0" medium was mixed with 22 mM malate (pH 7.0 of malate stock resolution was reached by the addition of NaOH). (dna-alkylating.com)

In addition to the canonical mitochondrial sulfide oxidation pathway, we have recently discovered a new pathway for clearing H 2 S, which involves hemeproteins. (umich.edu)
14. Pillich R.T., Scarsella G., Risuleo G. Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-L-carnitine to mouse fibroblasts in culture. (nogr.org)

There are three major ones known: nitric oxide (quite popular for heart health), hydrogen sulfide (topic of discussion), and carbon monoxide (also a toxic gas, but it is not known if screwing with the carbon monoxide in your body is a good thing to do or not). (healthworkscollective.com)
Both nitric oxide (NO) and hydrogen sulfide (H 2 S) act as gaseous signaling molecules with similar physiological effects. (chemistryviews.org)
Moreover, molecules involved in nitric oxide signaling, such as H 2 S and S -nitrosothiols (molecules with an -S-N=O group), readily react with zinc-sulfur bonds that form important structural units whose modification in proteins leads to functional change. (chemistryviews.org)

Ammonia (NH 3 ) and hydrothion (hydrogen sulphide, H 2 S) have long been known for their poisoning effect to human central nervous system and may cause psychological disturbances and behavioral disorders. (hindawi.com)

The role of DMSP degradation pathways for MeSH and DMS formation was further investigated by using the synthetic analogue DMTeP as a probe in feeding experiments with the wild-type strain and knockout mutants. (beilstein-journals.org)

The pathway also supplies important precursor metabolites including 2-oxoglutarate. (easyomics.org)
Additionally, H 2 S-related sulfur metabolites are also involved in some mental disorders. (hindawi.com)
This hypothesis suggests that with or without CBS up-regulation, there can be elevated accumulation of certain sulfur metabolites. (metabolichealing.com)
The reduced ability to detoxify these metabolites may result in significant sulfur sensitivities. (metabolichealing.com)

This article is a follow-up, based upon my own current hypotheses as well as literature-cited observations regarding these complex yet seemingly critical discussions regarding CBS (cystathionine beta synthase) and the transsulfuration pathway. (metabolichealing.com)
Homocysteine is metabolized by means of 2 pathways: remethylation and transsulfuration. (medscape.com)

The remethylation pathway comprises 2 intersecting biochemical pathways and results in the transfer of a methyl group (CH 3 ) to homocysteine from methylcobalamin, which receives its methyl group from S-adenosylmethionine (SAM), from 5-methyltetrahydrofolate (an active form of folic acid), or from betaine (trimethylglycine). (medscape.com)

The metaproteomic analyses confirmed that the active microbial community was dominated by Campylobacteria, carrying out carbon fixation via the reductive TCA cycle predominantly fueled by the oxidation of sulfide and sulfur with nitrate and oxygen. (uni-greifswald.de)
Fouling issues: Operators has for a long time encountered a fouling rich in carbon and sulphur, which clogs up several unit operations, such as wastewater treatment facilities. (umd.edu)
Hydrogen sulfide (H2S) - At sustained and high enough levels, hydrogen sulfide is a poisonous substance, and nervous system toxicant compared in toxicity to carbon monoxide (2). (metabolichealing.com)

Knockout of relevant genes from the known DMSP demethylation pathway to MeSH showed in both species a residual production of [ 2 H 3 ]MeSH, suggesting that a second demethylation pathway is active. (beilstein-journals.org)
Sulfhydration by a hydrogen sulfide anion and electrophile thiolation by reactive sulfur species (RSS) such as persulfides/polysulfides (e.g. (elsevierpure.com)
All chemosynthetic organisms use energy released by chemical reactions to make a sugar but different species use different pathways. (microblife.in)
Timothy H. Warren, Georgetown University, Washington, D.C., USA, and colleagues have been able to stabilize, isolate, and characterize two of the species tied to these signaling pathways through binding to a zinc complex. (chemistryviews.org)
This extremely reactive species is so unstable, however, that its biochemistry and discrete reaction pathways are very difficult to determine. (chemistryviews.org)

Using a combination of structural, spectroscopic and kinetic approaches we are studying allosteric regulation in the trafficking pathway for cofactor delivery with high fidelity. (umich.edu)
Role of Hydrogen Sulfide and Sulfur-Containing Amino Acids in Regulation of Tone of Smooth Muscles of the Vascular Wall in Rats. (nogr.org)

More specifically, CBS activates the sulfuration process, the biosynthesis of the sulfur-containing amino acid cysteine, and the fate of residual sulfur byproducts through various downstream processes. (metabolichealing.com)
Cysteine is the sulfur-containing amino acid that performs some critical functions in the body, including the formation of thiol-bearing antioxidants such as glutathione and metallothionein. (metabolichealing.com)

P. abyssi and other archaea found in these thermal vents convert these products into energy by chemosynthesis and sulfur reduction. (kenyon.edu)
In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. (genome.jp)
We observed a minimal reduction in the rate of methane oxidation, and conclude that hydrogen does not play an interspecies role in anaerobic oxidation of methane," the researchers say. (phys.org)

In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. (easyomics.org)
In the second half-reaction, hydrogen is gaining electrons, that is, it is being reduced . (cavemanchemistry.com)
Instead of releasing the energy of the reaction in the form of heat as the electrons are transferred, perhaps we could set up a pathway for the electrons to be tranferred by an indirect route and require them to do some electrical work along the way. (cavemanchemistry.com)
The candidate will develop computational chemistry models to identify the extent of possible reaction pathways towards value-added products for H2S conversion. (umd.edu)

What is the connection between glyphosate and sulfur pathways? (betterhealthguy.com)

These results suggest that the smallest differences in the course of physiological signaling pathways can lead to different output signals that ultimately result from the interplay between NO and H 2 S. (chemistryviews.org)

A redox cycle with complex II prioritizes sulfide quinone oxidoreductase dependent H 2 S oxidation. (umich.edu)

Depending on the organism, or the type of sulfur compound being used, the oxidation process takes place in several stages. (microscopemaster.com)
Researchers now have evidence that the two microbes that accomplish this feat do not simply reverse the way methane-producing microbes work, but use a sulfur compound instead. (phys.org)

This instability actually holds up in the body, and it seems that these molecules (there are many molecules in garlic that adhere to the following) can either be used by an enzyme to liberate sulfur or they just degrade and release sulfur. (healthworkscollective.com)
Three arms exist in the ER stress response: the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 (IRE1) pathways, where each of the sensor proteins is a membrane protein ( Figure 1 ). (encyclopedia.pub)
The mammalian ER stress response consists of three arms: the inositol-requiring enzyme 1 (IRE1), protein kinase R (PKR)-like ER kinase (PERK), and activating transcription factor 6 (ATF6) pathways. (encyclopedia.pub)

Genome-resolved metagenomics and metatranscriptomics were utilized to describe an active microbial community containing novel metagenome-assembled genomes and dominated by sulfur-cycling Desulfobacterota and Gammaproteobacteria . (biomedcentral.com)
We identified a rare surficial chemolithoautotrophic, sulfur-cycling microbial community active in a unique anoxic, cold, hypersaline Arctic spring. (biomedcentral.com)

Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. (easyomics.org)
ALD of sulfide materials typically uses metalorganic precursors and hydrogen sulfide (H 2 S). As in oxide ALD, the precursor chemistry is critical to controlling both the film growth and properties including roughness, crystallinity, and impurity levels. (osti.gov)

The same questions and strategies apply to sulfurtransferases, enzymes that catalyze the transfer of a sulfur atom from sulfur donors to nucleophilic sulfur acceptors (trans-persulfidation) by forming themselves persulfides. (hal.science)
Proteins involved in electron acceptor-related pathways, in particular denitrification, accounted for up to 20% of the whole metaproteome, which could be seen as an adaptation to the scarcity of electron acceptors at Crab Spa. (uni-greifswald.de)

Figure 1: The different photosynthetic pathways in plants. (cid-inc.com)

The breakdown of sulfur-containing amino acids is known to release hydrogen sulfide (rotten egg odor) and mercaptans. (mdgbio.com)
NOTE for the hydrogen sulphide emmissions (the rotten egg smelling vapours): keep your camera lens covered when not in use as sulphur is corrosive. (maremmaguide.com)

In some of the organisms, for instance, inorganic sulfur will be stored until they are required for use. (microscopemaster.com)
The cannulae bundle together to allow multiple cells to be connected [X]. This archaeum is a chemolithoautotroph and uses Hydrogen as an electron donor and Sulfur as an electron acceptor to perform inorganic redox reactions in extreme conditions. (kenyon.edu)

Essentially, CBS links the two pathways together, through its conversion of homocysteine into cystathionine. (metabolichealing.com)

For our research projects, we employ biochemical, biophysical, spectroscopic and structural biology approaches with *Populus trichocarpa* and *Arabidopsis thaliana* as model organisms to explore (i) the roles of the antioxidant/detoxification systems in the physiology of plants subject to environmental constraints and (ii) the maturation and roles of iron-sulfur proteins in plant organelles. (hal.science)
We hope to unravel new redox-regulated cellular processes or signaling pathways in poplar and more generally in plants which are controlled by redox reactions such as thiol-disulfide exchanges and understand how the functions of these proteins are controlled at the cellular level by TRX and GRX. (hal.science)
We have been elucidating novel enzymatic functions of the individual proteins and the thermodynamics and kinetics of protein-protein interactions in the pathway that guide B 12 delivery without dilution into the cellular milieu. (umich.edu)

1979. Preliminary measurements of biogenic sulfur-containing gas emissions from soils. (cdc.gov)
In nature, H2S is produced primarily by the in determining where H2S-induced olfactory lesions occur decomposition of organic matter and is found in natural gas, since air streams flowing through the nasal passages during petroleum, and volcanic and sulfur-spring emissions. (cdc.gov)

PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. (pi3k-inhibitors.com)
Moreover, PI3K/Akt-mammalian target of rapamycin (mTOR) is one of the two detrimental signaling pathways that control autophagy. (springeropen.com)

Instead they make food using energy from chemical reactions often combining hydrogen sulfide or methane with oxygen. (microblife.in)
Despite low oxygen availability, sulfide oxidation was primarily attributed to aerobic chemolithoautotrophic Halothiobacillaceae . (biomedcentral.com)

It is my current hypothesis that many of the sulfur sensitivities experienced by most people are due to aberrations in sulfur detoxification, downstream of CBS. (metabolichealing.com)

Pyrodictium abyssi is a chemolithiautotroph that gains energy from sulfur respiration utilizing hydrogen as an electron donor. (kenyon.edu)

Hydrogen sulphide (H2S) is a major impurity in oil and gas production as well as many bio-based processes. (umd.edu)

Vesicant Chemical-Warfare Agents Vesicants are chemical-warfare agents that cause blistering (vesicles) and include Mustards, including sulfur mustard and nitrogen mustards Lewisite Phosgene oxime (technically an urticant and. (msdmanuals.com)

such as sulfur mustard, Lewisite, and phosgene oxime (which also affect the skin) as well as military smokes, products of combustion, and many toxic industrial chemicals. (msdmanuals.com)

This Account highlights the attributes of ALD chemistry that are unique to metal sulfides and surveys recent applications of these materials in photovoltaics, energy storage, and photonics. (osti.gov)
As a result, we consider challenges that must be addressed prior to implementing ALD metal sulfides into future device architectures. (osti.gov)

While the majority of ALD processes identified to date produce metal oxides, novel applications in areas such as energy storage, catalysis, and nanophotonics are motivating interest in sulfide materials. (osti.gov)

The only by-product found was Hydrogen sulfide, which can be beneficial to environments and ecosystems, but due to the isolation of Pyrodictium abyssi this production is probably irrelevant. (kenyon.edu)
Surprisingly hydrogen sulfide has some beneficial, biological-signaling effects at low enough concentrations. (metabolichealing.com)

Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly. (mcw.edu)

He has spoken at the Conference on the Physics, Chemistry, and Biology of Water which takes place annually in Europe, where he has educated researchers from around the world about the unique role of sulfur in the maintenance of water structure in the body. (betterhealthguy.com)
HSNO may, thus, play a key role in the overlap of these signaling pathways. (chemistryviews.org)

Anatomy1

Organisms4

Diseases2

Chemicals and Drugs33

Phenomena and Processes2

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Humanities2

Geographicals2

Metabolism11

Compounds12

Bacteria9

Dimethyl sulfide3

Methanethiol2

Metabolic pathways6

Ions3

Molecule3

Elemental sulfur7

Sulfate6

Mitochondrial2

Nitric oxide3

Ammonia1

Degradation pathways1

Metabolites4

Transsulfuration2

Biochemical pathways1

Carbon3

Species5

Regulation2

Amino acid2

Reduction3

Reaction4

Glyphosate1

Physiological1

Oxidoreductase1

Compound2

Enzyme3

Microbial community2

Precursors2

Acceptors2

Photosynthetic1

Rotten egg2

Inorganic2

Homocysteine1

Proteins3

Emissions2

MTOR2

Oxygen2

Detoxification1

Electron donor1

Impurity1

Nitrogen1

Mustard1

Metal sulfides2

Processes1

Beneficial2

Activates1

Role2