• In the healthcare setting, "alcohol" refers to two water-soluble chemical compounds-ethyl alcohol and isopropyl alcohol-that have generally underrated germicidal characteristics 482 . (cdc.gov)
  • Contact insecticides can also be organic insecticides, i.e. organic chemical compounds, synthetically produced, and comprising the largest numbers of pesticides used today. (allaboutchemistry.net)
  • In 1961, Frenkel and Hirsch described strains of streptococci isolated from cases of bacterial endocarditis that grew only in the presence of other bacteria, around which they formed satellite colonies, or in media enriched with sulfhydryl compounds, such as cysteine. (cdc.gov)
  • THPP is also useful for the removal of protecting groups from S-protected cysteine, the deoxygenation of sulfoxides, N-oxides, and other sulfur and nitrogen compounds 5 . (strem.com)
  • Ellman's Reagent (5,5′-dithio-bis-[2-nitrobenzoic acid]) is used to estimate sulfhydryl groups in a sample by comparing to a standard curve of a sulfhydryl-containing compound such as cysteine. (meltingpointathens.com)
  • Exogenous sulfhydryl compounds including GSH and cysteine partially blocked the induction of cystine transport by DSF or DDC, suggesting that the induction might be mediated through a sulfhydryl reaction between DSF and some cellular components. (uthscsa.edu)
  • Ananas comosus ) is a kind of plant protease, a group of compound cysteine sulfhydryl proteolytic enzymes extracted from the pineapple plant of the genus Bromelain, which is divided into stem enzymes and fruit enzymes according to the different parts of separation and extraction. (china-sinoway.com)
  • Although the mechanism of action has not been fully elucidated, thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins. (medindex.am)
  • It is the sulfhydryl (thiol) group (SH) of cysteine that serves as protein-donor and is responsible for the biochemical activity of glutathione. (immunocal.com.my)
  • N-acetyl cysteine (NAC) is a sulfhydryl-containing amino acid that is commonly used to support liver health. (mywelllabs.com)
  • Ellman's reagent is a versatile, water-soluble compound for quantifying free sulfhydryl groups in solution. (gbiosciences.com)
  • In 1959, Ellman introduced 5,5′-dithio-bis-(2-nitrobenzoic acid), also known as DTNB, as a versatile water-soluble compound for quantitating free sulfhydryl groups in solution. (meltingpointathens.com)
  • Glutathione dihydrogenase acts on the reabsorbed portion and produces free sulfhydryl groups. (drugbank.com)
  • These free sulfhydryl groups bind acrolein in the bladder, allowing effective excretion and prevention of toxic effects. (drugbank.com)
  • This work has proposed an MOA involving formation of sufficient levels of reactive trivalent metabolites which interact with critical free sulfhydryl groups, leading to cytotoxicity and regenerative cell proliferation, implying a non-linear, threshold dose-response relationship for both non-cancer and cancer end points of exposure to iAs. (semanticscholar.org)
  • A number of enzymes in carbohydrate and lipid metabolism depend upon glutathione and other sulfhydryl compounds such as coenzyme A for their activity. (erowid.org)
  • As an active tripeptide with important physiological functions, Glutathione is the most important non-protein sulfhydryl compound in organisms. (yrspec.com)
  • [ 5 ] GSTs catalyse the conjugation of reduced glutathione - via a sulfhydryl group - to electrophilic centers on a wide variety of substrates. (leparisien.fr)
  • GSTs contribute to this type of metabolism by conjugating these compounds (often electrophilic and somewhat lipophilic in nature) with reduced glutathione to facilitate dissolution in the aqueous cellular and extracellular media, and, from there, out of the body. (leparisien.fr)
  • It is the sulfur in cysteine's "thiol" (sulfhydryl) group that imparts NAC's unique properties, including its critical role as a building block of Glutathione - our body's most powerful, internally-produced protective compound. (procapslabs.com)
  • At usual doses, it is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is eventually excreted by the kidneys. (pharmacycode.com)
  • Glutathione participates directly in the neutralization of free radicals, reactive oxygen compounds, and maintains exogenous antioxidants such as vitamins C and E in their reduced (active) forms. (immunocal.com.my)
  • In addition, through direct conjugation, glutathione plays a role in the detoxification of many xenobiotics (foreign compounds) both organic and inorganic. (immunocal.com.my)
  • Whilst iron (Fe), copper (Cu), chromium (Cr), vanadium (V) and cobalt (Co) undergo redox-cycling reactions, for a second group of metals, mercury (Hg), cadmium (Cd) and nickel (Ni), the primary route for their toxicity is depletion of glutathione and bonding to sulfhydryl groups of proteins. (pubmed.pro)
  • All Benzisothiazolinones contain active N - S bonds, which will react with proteins, enzymes or amino acids containing - SH group in the cell membrane to open a loop, and then react with amino and sulfhydryl groups, amino acids and amino compounds contained in the cell membrane or cell, thus destroying the normal metabolism of cells, inhibiting or killing cells. (irobiocide.com)
  • A thiol compound, diamide [azodicarboxylic acid bis (dimethylamide)] causes protein cross-linking with exposed sulfhydryl residues of denatured proteins. (kribb.re.kr)
  • Since denatured proteins expose normally well-hidden sulfhydryl groups, these will be preferentially cross-linked by diamide. (kribb.re.kr)
  • It should be also mentioned that arsenic has the ability to bind to reduced thiols including sulfhydryl organizations in some proteins (2). (molecularcircuit.com)
  • mPEG-MAL can be used to modify proteins, peptides and other materials or small molecules containing sulfhydryl groups. (bocsci.com)
  • Free radicals as an effect of oxidative metabolism can cause tissue damage by reacting with polyunsaturated fatty acids in cellular membranes, nucleotides in DNA, and critical sulfhydryl bonds in proteins [ 4 , 5 ]. (hindawi.com)
  • The figures below show the boiling and melting point for organic sulfur compounds as sulfides, disulfides, thiols (mercaptans) and thiophenes , together with the molecular structures of the different compounds. (engineeringtoolbox.com)
  • The effect of NaCl on the level of reduced sulfur compounds in rat liver. (krakow.pl)
  • Divalent sulfur compounds, such as thiols and thioethers, are extremely potent odorants. (duke.edu)
  • It reacts with a free sulfhydryl group to yield a mixed disulfide and 2-nitro-5-thiobenzoic acid (NTB), a measurable yellow colored product at 412nm. (gbiosciences.com)
  • A solution of this compound produces a measurable yellow-colored product when it reacts with sulfhydryls. (meltingpointathens.com)
  • DTNB reacts with a free sulfhydryl group to yield a mixed disulfide and 2-nitro-5-thiobenzoic acid (TNB). (meltingpointathens.com)
  • DTNB (Ellman's Reagent) (5,5-dithio-bis-(2-nitrobenzoic acid) Thermo Scientific Pierce Ellman's Reagent (DTNB) reacts with sulfhydryl groups to yield a colored product, providing a reliable method to measure reduced cysteines and other free sulfhydryls in solution. (meltingpointathens.com)
  • Mal selectively reacts with free mercaptan, sulfhydryl or sulfhydryl groups through Michael addition to form stable carbon sulfur bonds. (bocsci.com)
  • The part of a compound that reacts with another compound is called the functional group. (scienceoxygen.com)
  • This toxic metabolite reacts with sulfhydryl groups. (pharmacycode.com)
  • Oxidation occurs when an organic compound reacts with an oxidizing agent. (englishreally.com)
  • Reduction occurs when an organic compound reacts with a reducing agent. (englishreally.com)
  • Antioxidants--but not thiol redox active compounds--inhibited both oxidative stress and necrosis in hepatocytes. (elsevier.com)
  • Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. (t3db.ca)
  • The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. (greenmedinfo.com)
  • Some investigations have emphasized how the lipid compounds are altered due to oxidative deterioration [2]. (thefreelibrary.com)
  • Mercury compounds reacting with sulfhydryl groups inhibit a variety of enzymes. (cdc.gov)
  • It also maintains several enzymes in their active sulfhydryl form. (erowid.org)
  • We demonstrate that silver ions inactivate enzymes by binding sulfhydryl (thiol) groups in amino acids and promote the release of iron with subsequent hydroxyl radical formation by an indirect mechanism likely mediated by reactive oxygen species. (unifr.ch)
  • This enzyme carries out a specific chemical reaction called S-methylation of a group of molecules known as aromatic and heterocyclic sulphydryl compounds. (medlineplus.gov)
  • At this time, 1951, many applications had been submitted to me for approval, or to be more precise, these were medications for cancer therapy with the sulfhydryl group (sulfur-containing protein compounds). (healingcancernaturally.com)
  • Through official channels I had the right to ask the companies questions relative to how they wanted to substantiate how this substance (sulfhydryl group) could help with cancer. (healingcancernaturally.com)
  • Everybody knows the sulfur-containing protein compound of the sulfhydryl group can be detected in all breathing tissues. (healingcancernaturally.com)
  • However another partner must be present in the interplay with this sulfhydryl group, because the self-active oxygen consumption in the living system is executed in a zig zag curve. (healingcancernaturally.com)
  • The target of DTNB in this reaction is the conjugate base (R-S-) of a free sulfhydryl group. (meltingpointathens.com)
  • Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side chain constitute an interesting avenue of research for the study of new taxoid compounds. (ewha.ac.kr)
  • It is easy to form stable thioether bond with sulfhydryl group in pH 6.5-7.5. (bocsci.com)
  • It was found that all the six compounds **2** structures are similar, Visit Your URL for the oxidation of a CCC-COOH to a phenyl group. (takepharmacologyexam.com)
  • A functional group is defined as an atom or group of atoms within a molecule that has similar chemical properties whenever it appears in various compounds. (scienceoxygen.com)
  • Functional groups are groups of atoms in a compound, such as the hydroxyl group in an alcohol, that determine the chemical behavior of the compound. (scienceoxygen.com)
  • An atom/group of atoms joined in a specific manner which is responsible for the characteristics chemical properties of the organic compounds is called a functional group. (scienceoxygen.com)
  • Chemical modification of the maleimido group on each of these derivatives allowed specific conjugation with a sulfhydryl group at the hinge region of an antibody molecule and conjugation with other peptides. (memphis.edu)
  • Compounds in this group are often applied against household pests . (allaboutchemistry.net)
  • CoA consists of a nucleotide head (adenine + ribose + phosphate), a vitamin B5 body, and a beta-mercaptoethylamine tail which contains a sulfhydryl group. (humandynamics.se)
  • CoA is bound to a sulfhydryl group (-SH) and diffuses away to eventually combine with another acetyl group. (assignmentpoint.com)
  • Thiols are organosulfur compounds that contain a free sulfhydryl group (-SH). (transcriptionfactor.org)
  • The role of homocyst(e)ine in the conversion of Met sulfur to Cys (the transsulfuration pathway by which the sulfhydryl group of Hcy replaces the hydroxyl group of serine to form Cys) was studied in the years to follow, and investigators showed that homocyst(e)ine could support the growth of animals fed diets deficient in Cys, Met, or choline. (basicmedicalkey.com)
  • Both Hcy and Cys have a free sulfhydryl group. (basicmedicalkey.com)
  • The first antidote to heavy metal poisoning, and the basis for chelation therapy today, was British Anti-Lewisite (BAL, or dimercaprol), a large molecule with sulfhydryl groups that bind arsenic, as well as other metals, to form stable covalent bonds that can then be excreted by the body. (stevenjwong.com)
  • It can modify a variety of drugs, such as protein drugs, peptide compounds, organic small molecule drugs and so on. (bocsci.com)
  • The Intellectual Property encompasses the inhibition of tumor growth using compounds that inhibit QSOX1 enzymatic activity and, specifically, to anti-neoplastic compounds targeting QSOX1 (the parent molecule referred to as SBI-183). (ipscio.com)
  • Definition and Performance Characteristics Silane coupling agent is a class of organosilicone compounds containing two different chemical groups in the molecule at the same time. (rooloong.com)
  • The activated form then binds covalently with sulfhydryl groups of cysteines in the H + K + -ATPase, irreversibly inactivating the pump molecule. (pocketdrugguide.com)
  • during the a sulfur-containing molecule attached to toxin in order produce compound that can be excreted out of body. (mywelllabs.com)
  • Measure peptide cysteines or other free, reduced sulfhydryls (-SH groups) in solution using this thiol-reactive, colored compound (Amax 412nm). (fishersci.com)
  • Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a similar interaction. (wikipedia.org)
  • Another study demonstrated that increased the barrier of protective mucus and the protein sulfhydryl content in the glandular stomachs of the rats (Rafatulla et al 1990). (rhythmofhealing.com)
  • In nature, vitamin C, ascorbic acid is presented, as well as its derivatives: dehydroascorbic acid and askorbigenom.The first derivative is formed by the recovery of ascorbic acid compounds containing sulfhydryl bond.Ascorbigen formed by joining the amino acid to ascorbic acid or protein substrates.All of these modifications of vitamin C are readily soluble in water and possess biological activity. (healthtipsing.com)
  • The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl groups in the muscle. (wikipedia.org)
  • These o-quinones are the mediators of cytotoxicity believed to impair the melanocytes' metabolism by combining with sulfhydryl-containing entities crucial to the cell cycle such as DNA polymerase. (gla.ac.uk)
  • Many commercial grade detergents contain elevated levels of sulfhydryl oxidizing agents, peroxides, salts and carbonyl compounds. (gbiosciences.com)
  • G-Biosciences' Proteomic Grade Detergent Solutions contain reduced peroxides and carbonyl compounds. (gbiosciences.com)
  • Tris(3-hydroxypropyl)phosphine (THPP) and Tris(2-carboxyethyl)phosphine, hydrochloride (TCEP) are water soluble compounds that are used as neutral sulfhydryl reducing agents. (strem.com)
  • 7 , 25 , 47 , 48 Administration of bismuth thioglycollate and its related water soluble compounds, triglycollamate and trithioglycollamate, were responsible for the kidney failure, which occurred with as little as one or two treatments. (mhmedical.com)
  • Sulfhydryl-containing compounds can be useful as antidotes for such overdose related toxicity of paracetamol. (pharmaxchange.info)
  • Out of all sulfhydryl containing molecules, N-acetylcysteine is the most widely used for paracetamol toxicity. (pharmaxchange.info)
  • The generation of inorganic or organic trivalent arsenic forms offers important implications with regard to the toxicity of this agent as such compounds are more harmful to the cells and show more carcinogenic properties (2 3 Therefore many of the effects of exposure to arsenic as discussed below are the result of the activities and toxicities of the various metabolic products of arsenic compounds. (molecularcircuit.com)
  • Based on these study results, it is expected that both 1,3-BDDMA and 1,4-BDDMA will be rapidly hydrolyzed to MAA in vivo and therefore, both compounds would be expected to have similar toxicity potential. (europa.eu)
  • Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally administered, metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. (bjorklundnutrition.net)
  • These versatile compounds help rid the body of damaging oxidizing agents, and with a processed food supply that has put us in a record state of "energy toxicity", antioxidants have become increasingly popular. (priceplow.com)
  • Most protein labeling reagents have similar reactive sites, such as succinimidyl ester (NHS) for amino groups and maleimide or bromoacetamide for sulfhydryl groups. (dojindo.com)
  • These results suggest that DNA could be a target for Acrylamide-inducedinhibition of topoisomerase II.Furthermore, preliminary results seem to indicate the possibility that another mode of action ofacrylamide is related to its affinity for topoisomerase II sulphydryl groups, according to recentevidences reporting that thiol-reactive compounds can induce DNA damage through a nongenotoxicmechanism, such as the thiolation of the nuclear protein topoisomerase II. (unipa.it)
  • Sometimes, protein labeling with NH 2 -reactive compounds is not favorable because of the potential blockage of the protein's active site. (dojindo.com)
  • The second most common labeling method is the use of SH-reactive compounds. (dojindo.com)
  • Then, SH-reactive compounds such as maleimide and bromoacetyl compounds are applied in labeling the protein's SH groups. (dojindo.com)
  • After reduction of the disulfide to sulfhydryl (thiol) groups the resulting thiol-modified γ DNA molecules were reacted on silanized coverslip. (elsevier.com)
  • Compounding Balkan Pharmaceuticals Dianabol 10mg pharmacies intentionally overfill the injectable have sulfhydryl groups which bond together to Signature Pharmaceuticals Dianabol for disulfide bridges. (baconandbrine.com)
  • Kit-SH additionally contains reducing agents for converting disulfide groups to sulfhydryl groups (SH). (dojindo.com)
  • The accumulation of volatile flavour constituents in liquid cultures of three Kluyveromyces lactis strains was studied after cultivation on defined culture media containing glucose as carbon source, yeast extract, vitamines, and different additional nitrogen compounds. (degruyter.com)
  • Sulfhydryl Compounds/pharmacology* Unithiol* Substances. (stevenjwong.com)
  • These constructs combine an antibody against a target of interest with a compound that adds interesting pharmacology, such as cytotoxicity. (pharmtech.com)
  • belongs to the class of inorganic compounds known as other non-metal halides. (t3db.ca)
  • These are inorganic compounds containing 'other non-metals' and halogen. (t3db.ca)
  • These can be inorganic insecticides, which are metals and include the commonly used sulfur , and the less commonly used arsenates , copper and fluorine compounds. (allaboutchemistry.net)
  • Dihydrolipoic acid has two sulfhydryl groups and it can undergo further oxidation reaction forming lipoic acid. (balkanmedicaljournal.org)
  • The number of sulfhydryl groups in the Escherichia coli ribosome has been measured by titration with 5,5′-dithiobis(2-nitrobenzoic acid). (elsevier.com)
  • An organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties. (medindex.am)
  • This compound is modelled on serine, an amino acid residue phosphorylated by the MAP kinase enzyme. (gla.ac.uk)
  • Acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. (pocketdrugguide.com)
  • In the last step of the citric acid cycle, oxaloacetate-the starting four-carbon compound-is regenerated by oxidation of malate. (assignmentpoint.com)
  • The range of analytical data listed on the ADS depends on the type of product, as methods for analyzing amino acid derivatives (and very short peptides), peptides, and "non-peptidic" compounds differ somewhat. (bachem.com)
  • In conclusion we believe that the combination of the lipophilic nature of the tertiary amides and the close structural resemblance to the parent compound (iii) provided the series (iv) with better antimelanoma activity than the other two series (v) and (vi). (gla.ac.uk)
  • Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with sulfate and glucuronide, and then excreted by the kidneys. (pharmacycode.com)
  • Methods are described for synthesizing compounds useful for detecting nucleic acids, and in particular, the hybridization of nucleic acids. (freepatentsonline.com)
  • The more highly reduced form a thiol-containing compound has, the more stronger antioxidative activity it exerts. (balkanmedicaljournal.org)
  • [ 11 ] However, some endogenous compounds, e.g., bilirubin, can inhibit the activity of GSTs. (leparisien.fr)
  • An organic compound is any compound that contains carbon and another element. (scienceoxygen.com)
  • Hydrocarbon solvents hydrocarbons Organic compounds that contain only two elements, hydrocarbons and carbon, are called hydrocarbons. (rooloong.com)
  • Methylisothiazolinone (MIT), is an organic compound, chemical formula is C 4 H 5 NOS, molecular weight is 115.15. (irobiocide.com)
  • Lipid oxidation causes loss of nutritional and sensory values, as well as the formation of potentially toxic compounds that compromise meat quality and reduce its shelf life [ 3 ]. (hindawi.com)
  • Therefore, you will deal with oxidation and reduction separately, as they apply to organic compounds. (englishreally.com)
  • Note that equations for the oxidation of organic compounds are often left unbalanced. (englishreally.com)
  • Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. (greenmedinfo.com)
  • As the results of this study show, the pungent principle of ginger, the so-called 6-gingerol, makes the level of the enzyme sulfhydryl oxidase 1 in saliva increase 16-fold within a few seconds. (doctorclean.com.cn)
  • The enzyme Quiescin Sulfhydryl Oxidase 1 (QSOX1) is a master regulator of extracellular matrix remodeling, and its overexpression by tumor cells. (ipscio.com)
  • Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. (who.int)
  • This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. (who.int)
  • Benzisothiazolinone belongs to one of the biosynthesis inhibitors and it is a heterocyclic compound. (irobiocide.com)
  • Alcohols, alkyl halides, and aromatic compounds commonly undergo substitution reactions, as shown in these examples. (englishreally.com)
  • Extremely research centered on the usage of arsenic compounds in the treatment of human diseases remains highly Temsirolimus promising and it is an area of active investigation. (molecularcircuit.com)
  • In consideration of the systemic nature of arsenic compounds carcinogenicity, route-to-route extrapolation from the data obtained from drinking water studies to the dermal route is considered justified. (europa.eu)
  • Friedel, R. A. and M. Orchin (1951) Ultraviolet Spectra of Aromatic Compounds. (photochemcad.com)
  • These compounds exhibited strong biofilm sugar-independent bactericidal activity on in vitro-grown biofilms and prevented murine Staphylococcus epidermidis implant infection in vivo with slow release of silver ions and limited transient leukocyte cytotoxicity. (unifr.ch)
  • Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl homeostasis. (pubmed.pro)
  • For instance, the two Fab' fragments, through their hinge-region sulfhydryl groups, could covalently attach to a homobifunctional chelator via thioether linkage to generate a Fab'-S-chelator-S-Fab' immunoconjugate. (memphis.edu)
  • Our programme of research involved the synthesis of three sets of target compounds modelled on the lead compound designed as substrates for Tyrosinase. (gla.ac.uk)
  • The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. (muni.cz)
  • Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. (muni.cz)
  • Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (drugbank.com)
  • Once inside the body, thiopurine drugs are converted to toxic compounds that kill immune system cells in the bone marrow. (medlineplus.gov)