• As a member of the sulfatase family, arylsulfatase A is encoded by the ARSA gene and required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). (bio-techne.com)
  • Recombinant mouse ARSA corresponds to the mature chain and has sulfatase activity as described in Activity Assay Protocol. (bio-techne.com)
  • The human arylsulfatase A (ARSA) protein is a critical enzyme involved in the metabolism of sulfated compounds. (creativebiomart.net)
  • The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. (thermofisher.cn)
  • Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. (wikipedia.org)
  • Juvenile and adult metachromatic leukodystrophy: partial restoration of arylsulfatase A (cerebroside sulfatase) activity by inhibitors of thiol proteinases. (nih.gov)
  • The metabolism of sulfatide, which synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and specifically degraded by a sulfatase (arylsulfatase A), is very simple compared to that of many gangliosides. (go.jp)
  • It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B). (curehunter.com)
  • 4. Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. (nih.gov)
  • Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide. (nih.gov)
  • Previous studies have shown a deficiency of steroid sulfatase (STS) in skin fibroblasts and a marked elevation of plasma cholesterol sulfate in patients with X-linked ichthyosis. (medscape.com)
  • Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. (curehunter.com)