Ampicillin and Sulbactam for Injection, USP is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and intramuscular administration. (nih.gov)
Therefore, mixed infections caused by ampicillin-susceptible organisms and beta-lactamase producing organisms susceptible to UNASYN should not require the addition of another antibacterial. (pfizermedicalinformation.com)
The dose of ampicillin and sulbactam for injection in such patients should be administered less frequently in accordance with the usual practice for ampicillin (see DOSAGE AND ADMINISTRATION section). (nih.gov)
Sodium6
Ampicillin sodium is derived from the penicillin nucleus, 6-aminopenicillanic acid. (nih.gov)
Sulbactam sodium is a derivative of the basic penicillin nucleus. (nih.gov)
Ampicillin and Sulbactam for Injection, USP, ampicillin sodium/sulbactam sodium parenteral combination is available as a white to off-white dry powder for reconstitution. (nih.gov)
Ampicillin and Sulbactam for Injection, USP dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per mL and 125 mg sulbactam per mL. (nih.gov)
1.5 g of Ampicillin and Sulbactam for Injection, USP (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) parenteral contains approximately 115 mg (5 mEq) of sodium. (nih.gov)
Multiple studies of ceftriaxone plus ampicillin in E faecalis valve endocarditis supported those of smaller earlier ones. (medscape.com)
For individuals at risk for these side effects, intravenous ampicillin 2 g every 4 hours plus intravenous ceftriaxone 2 g every 12 hours appears to provide a reasonable alternative. (medscape.com)
A recent study of ceftriaxone plus ampicillin in E faecalis valve endocarditis supported those of smaller earlier one. (medscape.com)
Intravenous1
Immediately after completion of a 15-minute intravenous infusion of ampicillin and sulbactam for injection, peak serum concentrations of ampicillin and sulbactam are attained. (nih.gov)
Infections2
To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection and other antibacterial drugs, ampicillin and sulbactam for injection should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
While UNASYN is indicated only for the conditions listed above, infections caused by ampicillin-susceptible organisms are also amenable to treatment with UNASYN due to its ampicillin content. (pfizermedicalinformation.com)
Penicillin1
For most isolates, the MIC of ampicillin is 2- to 4-fold lower than that of penicillin. (medscape.com)
Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations, and the total dose of sulbactam should not exceed 4 grams per day. (pfizermedicalinformation.com)
Effectiveness1
[ 37 , 38 ] Combining various antibiotics with daptomycin may restore the effectiveness of daptomycin against enterococci that have become resistant to it. (medscape.com)
Susceptible1
Ampicillin is the drug of choice for monotherapy of susceptible E faecalis infection . (medscape.com)
Patients1
In patients with impaired renal function the elimination kinetics of ampicillin and sulbactam are similarly affected, hence the ratio of one to the other will remain constant whatever the renal function. (nih.gov)
Infection1
These compounds are used in combination with the primary anti-infective agent, but not for their direct effects on the infection itself, but since they enhance or restore the activity of the drug. (infectiologyjournal.com)
Range1
The corresponding mean peak serum levels for sulbactam range from 48 to 88 mcg/mL and 21 to 40 mcg/mL, respectively. (nih.gov)
Hours1
Approximately 75 to 85% of both ampicillin and sulbactam are excreted unchanged in the urine during the first 8 hours after administration of ampicillin and sulbactam for injection to individuals with normal renal function. (nih.gov)
Drug1
Boosters are substances which are used in combination with a primary therapeutic agent (drug), not for their direct effects on the pathogenic organisms or viruses themselves, but because they enhance or restore the activity of the anti-infective agent. (infectiologyjournal.com)
Imipenem3
This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. (nih.gov)
Time-kill studies showed a bactericidal effect for colistin but not for imipenem, rifampicin or sulbactam/ampicillin used as single agents. (nih.gov)
Synergism was observed with combinations of rifampicin+imipenem or sulbactam/ampicillin for all isolates and with colistin+rifampicin for isolates showing higher minimum inhibitory concentrations for rifampicin. (nih.gov)
Antibacterial2
To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection, USP and other antibacterial drugs, ampicillin and sulbactam for injection, USP should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
This inhibition restores the antibacterial activity of beta-lactam antibiotics against? (arlakbiotech.com)
Antibiotics2
[ 37 , 38 ] Combining various antibiotics with daptomycin may restore the effectiveness of daptomycin against enterococci that have become resistant to it. (medscape.com)
Treatment involves antibiotics and giving the rabbit fluids and food to help restore its energy. (oxfordpets.com)
Resistant1
In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii. (nih.gov)
Fluids1
If your rabbit is showing signs of a stomach virus, such as vomiting and diarrhea, give them plenty of fluids and electrolytes (like salt) to help restore their balance. (oxfordpets.com)
Single2
Ampicillin and sulbactam for injection Pharmacy Bulk Package is a bottle containing a sterile preparation of ampicillin sodium and sulbactam sodium for parenteral use that contains many single doses. (nih.gov)
Ampicillin and Sulbactam for Injection, pharmacy bulk package is a vial containing a sterile preparation of ampicillin sodium and sulbactam sodium for parenteral use that contains many single doses. (nih.gov)
Combination2
Ampicillin and sulbactam for injection parenteral combination, is available as a white to off-white, crystalline powder for reconstitution. (nih.gov)
Combination therapy with a cell wall-active agent (eg, ampicillin, vancomycin) and an aminoglycoside (eg, gentamicin, streptomycin) has long been regarded as the standard of care for E faecalis native valve endocarditis. (medscape.com)
Natural1
Haloperidol decanoate is a long-acting form of psychiatric medication (antipsychotic-type) that works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain. (oceanpharmaproducts.com)
Functions1
although it still had scars, its functions were restored. (bvsalud.org)