Suggests structure ribosomal. Medical search. Frequent questions

Ribosomal protein SA is one of several proteins that make up the small subunit. (medlineplus.gov)
Our findings strongly support the idea of the conceptualization of nucleolus-like structures in bacteria, i.e., rRNA synthesis, ribosomal protein synthesis and subunit assembly occurring in close proximity at the cell poles, facilitating the efficiency of ribosome maturation even under conditions of transient nutrient deprivation. (uni-marburg.de)
We recently showed that a member of the mitochondrial transcription termination factor (MTERF) family of proteins, MTERF4, recruits NSUN4, a 5-methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitochondrial ribosome biogenesis. (rcsb.org)
Here, we report that mutations of an IRES domain that docks in the 40S subunit's decoding groove cause only a local perturbation in IRES structure and result in conformational changes in the IRES-rabbit 40S subunit complex. (janelia.org)
Bud23 is a SAM methyltransferase important for the proper biogenesis of the small ribosomal subunit. (utexas.edu)
Here I will demonstrate that Bud23 methylates G1575 of the small subunit ribosomal RNA (SSU rRNA), and its absence delays export of the SSU rRNA from the nucleolas, and the nucleus, and results in the delayed maturation of the SSU rRNA. (utexas.edu)
The m 7 G-cap of the mRNA is recognized by the 43S translation preinitiation complex comprised of the 40S ribosomal subunit and the eIF2-GTP-Met-tRNAi ternary complex. (biorxiv.org)
Most yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with different subunit composition or specifically-tailored functions. (prolekarniky.cz)
To test this assumption, we are currently developing methods capable of analyzing the structure of 50S ribosomal subunit precursors, which we will obtain directly from cells. (charite.de)
Structural visualization of the formation and activation of the 50S ribosomal subunit during in vitro reconstitution. (charite.de)
Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine the precise orientation of tRNA in the peptidyl-transferase center (PTC). (cnr.it)
Of special interest are the translation initiation factors eIF2, a GTPase that binds methionyl-tRNA to the ribosome, and eIF5B, a second GTPase that catalyzes ribosomal subunit joining in the final step of translation initiation. (nih.gov)
The first step of protein synthesis is binding of the initiator Met-tRNA to the small ribosomal subunit by the factor eIF2, which is composed of three subunits. (nih.gov)
In this study, culture-based methods and small subunit ribosomal RNA gene clone library approach were used to characterize microbial communities in MRF bulk fluid and associated biofilm samples collected from fluid systems in an automobile engine plant. (cdc.gov)

They were used as an autoregulatory mechanism to control the concentration of ribosomal proteins S15. (wikipedia.org)
The structure is located in the 5′ untranslated regions of mRNAs encoding ribosomal proteins S15 (rpsO). (wikipedia.org)
are cellular structures that process the cell's genetic instructions to create proteins. (medlineplus.gov)
Research suggests that it helps the ribosome control the production of certain proteins, many of which are likely important for development before birth. (medlineplus.gov)
The synthesis of proteins in growth cones could afford a mechanism for the alteration of growth cone structure or function. (jneurosci.org)
In general, proteins regulate their activity by changes in either expression or structure, the latter is often triggered by post-translational modifications (PTMs) 5 . (nature.com)
This study provides a molecular explanation for MTERF4-dependent recruitment of NSUN4 to ribosomal RNA and suggests a unique mechanism by which other members of the large MTERF-family of proteins can regulate ribosomal biogenesis. (rcsb.org)
Electron cryomicroscopy, or cryoEM, is an emerging technique for studying the three-dimensional structures of proteins and large macromolecular machines. (janelia.org)
Electron crystallography is a branch of cryoEM in which structures of proteins can be studied at resolutions that rival those achieved by X-ray crystallography. (janelia.org)
and assembly into subunits that takes place in the nucleolus and includes in the association of Ribosomal RNA (rRNA) with ribosomal proteins that are translocated from the site of synthesis in cytoplasm. (globalscienceresearchjournals.org)
Yet, some RNA strands can also fold to form ribozymes, 3D structures that could have guided life's chemical processes the way proteins do now. (elifesciences.org)
Unlike yeast, most mammalian ribosomal proteins are thought to be encoded by a single gene copy, raising the possibility that heterogenous populations of ribosomes are unique to yeast. (prolekarniky.cz)
Ribosome synthesis is a highly controlled process, whereby three distinct RNA polymerases are synchronously coordinated to produce equimolar amounts of four rRNAs and 79 mammalian ribosomal proteins (RPs) [1] - [4] . (prolekarniky.cz)
Crystal structures are available for archaeal and bacterial NAS-like proteins that carry out simpler aminobutanoyl transferase reactions. (bvsalud.org)
Thorough assessment of different randomization methods and statistical scoring algorithms allows determining the significance of concurrent profiles within a complex, therefore providing insights into the conservation of their composition across human cell types as well as the identification of intrinsic structures in complex behavior to determine which proteins orchestrate complex function. (biomedcentral.com)
The delineation of different domains in proteins is important for classification, understanding of structure, function and evolution. (biomedcentral.com)
A spiral rotation of the 3′ end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. (cnr.it)

In this structure, similarities between the rRNA binding site of the S15 ribosomal protein and the S15 ribosomal protein leader binding site were detected. (wikipedia.org)
This suggests that the ribosomal leaders in these organisms function by mimicking the S15 binding site in rRNA. (wikipedia.org)
Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. (nih.gov)
Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. (nih.gov)
Eukaryotic cells transcribe ribosomal RNA and largely assemble ribosomes in a structure called the nucleolus, where chromosomal regions containing rRNA operons are clustered. (uni-marburg.de)
In addition, yeast Nep1 binds to a 6-nt RNA-binding motif also found in 18S rRNA and facilitates the incorporation of ribosomal protein Rps19 during the formation of pre-ribosomes. (rcsb.org)
Therefore, our structures together with previous genetic data suggest that Nep1 is a genuine rRNA methyltransferase. (rcsb.org)
Based on the 23S rRNA structure in the vicinity of A2451, it was further proposed that an altered pKa for A2451 that allows it to perform these catalytic roles was generated through a charge-relay network that mediated through nucleotide bases of G2447 to the phosphate of A2450. (globalscienceresearchjournals.org)
When the insert was modeled "in-context" in the presence of a previously published crystal structure of the T. thermophila ribosomal RNA, we discovered a surprising association between the insert and a highly variable portion of the rRNA, termed expansion segment 7, or ES7. (uri.edu)

This gene provides instructions for making a protein called ribosomal protein SA, which is a component of ribosomes. (medlineplus.gov)
Ribosomes are the cellular structures responsible for the synthesis of protein in all branches of life. (utexas.edu)
We propose that in the absence of a functional SRP or translocon, ribosomes remain jammed at their primary membrane docking site, whereas FtsY-dependent ribosomal targeting to the membrane continues. (rupress.org)
In response to immune induction, uORF-inhibition is alleviated by three Ded1p/DDX3X-homologous RNA helicases which unwind the RNA structures, allowing ribosomes to bypass the inhibitory uORFs and upregulate defence protein production. (biorxiv.org)
The structure, containing l- and d-dimers in a centrosymmetric space group, revealed unexpected homology with bacterial hibernation-promoting factors that bind to ribosomes and suppress translation. (pentelutelabmit.com)

This finding suggests that both subunits of the protein complex likely contribute to RNA recognition. (rcsb.org)
The three-dimensional structures of isolated ribosomal subunits and intact ribosome have recently been solved by X-ray crystallography with atomic resolution1-4. (globalscienceresearchjournals.org)
The structural analyses followed and built on electron microscopy analyses of overall structures of the subunits and functional complexes. (globalscienceresearchjournals.org)
These interactions can lead to a variety of stable or transient states where the complexes display different compositions of their subunits or different structures that are often fine-tuned by post-translational modifications. (biomedcentral.com)
Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism. (cnr.it)

In addition to their role in the ribosome, many RPs, including murine Rpl22, have been shown to have extra-ribosomal functions [16] - [18] . (prolekarniky.cz)
In addition to its multiple extra-ribosomal functions, rpS3 possesses several post-translational modification motifs. (bmbreports.org)

In yeast, ribosomal protein genes are generally duplicated and evidence has emerged that paralogs might have specific roles. (prolekarniky.cz)
Analysis of ribosomal genes and metagenomics revealed that alveolinid symbionts and kleptoplasts belong to the same clade, which suggests a common ancestry. (unige.ch)
In contrast, genes transcribed by Pol II are organized in a more compact, regularly spaced, nucleosomal structure. (asm.org)
Studies of genes transcribed by RNA polymerase II (Pol II) have shown that open and closed chromatin structures are dynamically regulated through multiple mechanisms, including histone modifications, histone variant incorporation, and DNA methylation (reviewed in reference 17 ). (asm.org)
Genome-wide studies in Saccharomyces cerevisiae , for example, have revealed that promoters of most actively transcribed genes are depleted of nucleosomes and that histone density is inversely proportional to the transcription rate within coding regions, suggesting that nucleosomes are dynamically disassembled and reassembled at each passage of the polymerase ( 16 ). (asm.org)
Another trial also reports that Prostamax may exhibit a potential to affect genetic processes in aging cells by modulating chromatin structure and possibly reactivating certain genes. (corepeptides.com)
(3) The trial focused on the potential role of Prostamax in the activation of ribosome genes, decondensation of chromatin, and altering the structure of heterochromatin. (corepeptides.com)
Analysis of 270 families in the DKC registry found that mutations in dyskerin ( DKC1 ), TERT , and TERC only account for 64% of patients, with an additional 1% due to NOP10 , suggesting that other genes associated with this syndrome are, as yet, unidentified. (medscape.com)

We sequenced four genetic markers from the collected specimens, assessed the phylogenetic position of N. ruffoi within the genus, and studied the structure of this species complex using four molecular species delimitation methods. (eawag.ch)
For the above-mentioned reasons, the internal phylogenetic structure of N. ruffoi s. lat. (eawag.ch)
Phylogenetic analysis of 18 ribosomal RNA gene sequences showed that branches next to symbiont-bearing Alveolinidae. (unige.ch)
Overall transition to transversion ratio was 0.76:1.00 and both accumulated linearly in stem and loop regions, suggesting appropriate phylogenetic signal. (unboundmedicine.com)
To resolve phylogenetic relationships among isolates, we sequenced 68 isolates from Europe and North America at 1 chromosomal locus (16S-23S ribosomal RNA spacer) and 3 plasmid loci ( ospC , dbpA , and BBD14). (cdc.gov)

The only known exception to this is the 23S ribosomal RNA in the bacterial ribosome which catalyzes peptide bond formation. (jove.com)

RPSA gene mutations are thought to reduce the amount of functional ribosomal protein SA. (medlineplus.gov)
This may include increasing in the frequency of sister chromatid exchanges and Ag-positive nucleolus organizer regions, indicating enhanced chromosomal exchange activities and changes in ribosomal RNA gene activity as well as reducing the frequency of large segments of C-pericentromeric heterochromatin, suggesting a decondensation action on the chromatin. (corepeptides.com)
This increase might indicate changes in ribosomal RNA gene activity or chromatin structure modifications. (corepeptides.com)

Finally, growth cones that were isolated for 2 d prior to radiolabeling incorporate 3H-leucine in a eukaryotic ribosomal- dependent manner, suggesting that the capacity for translation is long- lived in growth cones. (jneurosci.org)

Thus, we find a specific epigenetic mechanism that regulates axonal regeneration of CNS axons, suggesting novel targets for clinical application. (nature.com)
Despite decades of effort no structure is currently available for any nitrate transport protein and the mechanism by which nitrate is transported remains largely unknown. (janelia.org)
Conservation of the RNA helicases suggests that mRNA structurome remodelling is a general mechanism for stress-induced translation across kingdoms. (biorxiv.org)

The secondary structure of his putative ribosomal leader consists of a hairpin in most species. (wikipedia.org)
Molecular species delimitation methods suggested that N. arolaensis is a single species, while N. ruffoi should be considered as a species complex of three (using ITS) to eight (using COI) putative species. (eawag.ch)
Accordingly, a putative SRP-independent, FtsY-mediated ribosomal targeting pathway has been suggested (Herskovits, A.A., E.S. Bochkareva, and E. Bibi. (rupress.org)

S15 Ribosomal protein leaders perform an important regulatory function in ribosome biogenesis. (wikipedia.org)
This suggests the participation of Nep1 in a methyltransferase reaction during ribosome biogenesis. (rcsb.org)
Recent work constructing protein interaction networks in Saccharomyces cerevisiae suggested the methyltransferase Bud23 was involved in ribosome biogenesis (1). (utexas.edu)

This work presents cryo-EM structures of two active ribosomal ligands in yeast, namely eEF3 and Sec61. (hu-berlin.de)
In addition, interventions leading to reduced translation, such as dietary restriction and reduced 60S ribosomal protein expression, elicits lifespan extension in yeast, worms and files [10] - [13] . (prolekarniky.cz)
We use molecular-genetic and biochemical studies in yeast and human cells to dissect the structure-function properties of translation factors. (nih.gov)

The structures reveal a positively charged substrate-translocation pathway lacking protonatable residues, suggesting that NarK functions as a nitrate/nitrite exchanger and that protons are unlikely to be co-transported. (janelia.org)
Functionally, the mutations decrease IRES activity by inhibiting the first ribosomal translocation event, and modeling results suggest that this effect occurs through an interaction with a single ribosomal protein. (janelia.org)

This factor is essential for the binding of the aminoacyl-tRNA-eEF1A-GTP ternary complex to the A site of the ribosome and has been suggested to do so by facilitating the clearance of deacyl-tRNA from the ribosomal E-site. (hu-berlin.de)
From there the affinity for tRNA in the ribosomal E site could be easily modified. (hu-berlin.de)

Ribosome-nascent chain complexes (RNCs) studied by cryo-EM provided us with "snapshots" of most-stable states of NCs within the ribosomal tunnel 9-13. (biorxiv.org)
Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. (rupress.org)
Remaining to be tested are how such factors as natural selection, low recombination rate, and genetic drift due to geographic structuring contribute to the formation and maintenance of these clonal complexes in natural bacterial populations ( 3 , 4 ). (cdc.gov)

It has been proposed that ribosome scanning and start codon selection are regulated by elements in the 5' leader sequence, such as RNA primary sequences (for example, the Kozak sequence context), upstream open reading frames (uORFs), secondary structures, and RNA modifications 4 - 7 . (biorxiv.org)
The ospC -A clone appeared to be highly prevalent on both continents, and isolates of this clone were uniform in DNA sequences, which suggests a recent trans-oceanic migration. (cdc.gov)

Here, we present the X-ray structure of the Nep1 homolog from the archaebacterium Methanocaldococcus jannaschii in its free form (2.2 A resolution) and bound to the S-adenosylmethionine analog S-adenosylhomocysteine (SAH, 2.15 A resolution) and the antibiotic and general methyltransferase inhibitor sinefungin (2.25 A resolution). (rcsb.org)

This complex process is evolutionary conserved and involves several RNA processing and modification steps required for correct ribosomal RNA maturation. (rcsb.org)
Part of the maturation process involves modification of this ribosomal RNA as processing is carried out. (utexas.edu)

Using the crystal structure of eEF3, a molecular model for eEF3 was generated, which provides the structural basis for the activity of an ABC protein in the context of translation. (hu-berlin.de)
The early and distinct origin of Collodictyon suggests that it constitutes a new lineage in the global eukaryote phylogeny," the authors wrote in in the journal Molecular Biology Evolution . (the-scientist.com)
To date, molecular epidemiologic studies detailing the phylogeographic structure of H. capsulatum in the United States have been limited. (cdc.gov)

This suggests that Prostamax may have a role in enhancing chromosomal exchange activities. (corepeptides.com)

The crystal structure of an inactive PCC, however, shows only a single heterotrimer (monomer) which could also be functional in the active state. (hu-berlin.de)
They furthermore act as control hubs that regulate highly important processes in the cell and exhibit a high functional diversity due to their ability to change their composition and their structure. (biomedcentral.com)
This suggests that the functional role of Rv1738 is to contribute to the shutdown of ribosomal protein synthesis during the onset of nonreplicating persistence of M. tuberculosis. (pentelutelabmit.com)

The biochemical and genetic evidence previously suggested the importance of A2451. (globalscienceresearchjournals.org)
Genetic variability and divergence rates were tested between stem (paired) and loop (unpaired) regions of secondary structure. (unboundmedicine.com)

When large and well-ordered crystals are obtained, the structures of both protein and its surrounding membrane can be determined to atomic resolution. (janelia.org)

Isolated growth cones displayed incorporation of 3H-leucine that was inhibited by treatment with the protein synthesis inhibitors anisomycin and pactamycin, indicating that ribosomal-dependent translation occurs in growth cones. (jneurosci.org)

The cryo-EM structure of the ATP-bound form of eEF3 in complex with an 80S ribosome shows that eEF3 binds the ribosome in the post-translocational conformation using a novel binding site. (hu-berlin.de)
Chromatin structure is dynamic, adopting a more condensed conformation at transcriptionally silent regions (closed chromatin) than at transcriptionally active regions (open chromatin) ( 6 ). (asm.org)

Studies using cryo-EM have shown NC folding within the exit tunnel is largely limited to the formation of rudimentary secondary structure, pre-dominantly α helices within different areas of the tunnel, while β hairpins as well as the formation of small domains in the wider vestibule region of the tunnel 9-13. (biorxiv.org)

Using in planta nucleotide-resolution mRNA structurome probing, we discovered that this stress-induced switch in translation is mediated by highly structured regions detected downstream of uAUGs in TE-up transcripts. (biorxiv.org)

Because outer regions of the nucleoids contain the highest accumulation of RNA polymerase, it has been hypothesized that bacteria contain "nucleolus-like" structures. (uni-marburg.de)

By tracking single molecules of two GTPases that play an essential role in ribosomal folding and processing in Bacillus subtilis, we show that this process takes place at sites of translation, i.e., predominantly at the cell poles. (uni-marburg.de)
2015 . The crystal structure of full-length E. coli YidC revealed that a hydrophilic groove, formed by five transmembrane helices, is a conserved structural feature of YidC, as compared to the previous YidC structure from Bacillus halodurans , which lacks a periplasmic domain. (tcdb.org)

Multiple distinct structural types of S15 ribosomal protein leaders are known in different organisms. (wikipedia.org)
With the rapid progress and improvements in the fields of macromolecular crystallography, Cryo-EM, small angle scattering, electron diffraction and use of XFELs, the new LINXS theme INTEGRATIVE STRUCTURAL BIOLOGY is formed to advance cutting-edge research and to encourage new users to utilize integrative structure biology to address key scientific questions. (lu.se)

The E. coli ribosomal S15 leader is an RNA element that can form two alternative structures found in the ribosomal S15 protein. (wikipedia.org)
Here we report the structure of a bacterial nitrate/nitrite transport protein, NarK, from Escherichia coli, with and without substrate. (janelia.org)

Although it is clear that switching among BESs does not involve DNA rearrangements and that regulation is probably epigenetic, it remains unknown why BESs are transcribed by Pol I and what roles are played by chromatin structure and histone modifications. (asm.org)

Ribosomal protein leader Meyer MM (March 2018). (wikipedia.org)

One study highlights the potential impact of Prostamax on the chromatin structure in lymphocytes. (corepeptides.com)
Prostamax appears to induce notable changes in this chromatin structure. (corepeptides.com)
This redistribution and temperature shift might be linked to a relaxation in the chromatin structure, particularly the 30-nm-thick fiber relaxing into a 10-nm filament. (corepeptides.com)

The nascent chain (NC), emerges into the cellular milieu via the ribosomal exit tunnel, which is an active component that regulates the NC passage. (biorxiv.org)
Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an internal hairpin structure and repressing its expression. (prolekarniky.cz)

However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs. (elifesciences.org)

Moreover, we found a discrepancy between the different nuclear ribosomal DNA markers, indicating a possible recombination with fragments of 28S DNA of N. ruffoi s. lat. (eawag.ch)

Such a lack of apparent secondary structure would be unusual for a ribosomal leader, which makes this candidate ribosomal leader a less certain prediction. (wikipedia.org)

This structure causes translational regulation of the S15 protein. (wikipedia.org)
These results reveal the existence of recurrent supra-ribosomal building blocks forming polysomes and suggest the presence of unexplored translational controls embedded in the polysome structure. (ox.ac.uk)

Phosphoprotein P0 is a highly conserved ribosomal protein that forms the central scaffold of the large ribosomal subunit's "stalk complex", which is necessary for recruiting protein elongation factors to the ribosome. (uri.edu)

These RNC structures reveal a range of pathways adopted by the NC. (biorxiv.org)

More details about protein structure can be achieved by chemical cross-linking or hydrogen-deuterium exchange mass spectrometry [ 5 ]. (biomedcentral.com)
Protein domains are the fundamental units of protein structure, function and evolution. (biomedcentral.com)

Nonetheless, nascent polypeptides with more complex tertiary structure fold close to and outside the tunnel, as found for spectrin - a three-helix bundle protein, and titin, an all beta-sheet immunoglobulin domain 10,13. (biorxiv.org)

Here, we give an overview of these results and integrate them with the mechanisms of ribosomal synthesis. (globalscienceresearchjournals.org)

The pooled RR for the more robust RCTs (3 studies, n = 3056 participants) suggests that, from the available data, there is no statistically significant effect of incentives to prevent smoking initiation among children and adolescents in the long term (RR 1.00, 95% CI 0.84 to 1.19). (who.int)

Dyskenin is composed of 514 amino acids and has a role in ribosomal RNA processing and telomere maintenance. (medscape.com)
This suggests that Prostamax may have a role in modulating the structure of chromatin in aging cells. (corepeptides.com)
Ribosomal protein S3 is a protein component of the ribosome, which is a cellular structure that plays a central role in protein synthesis. (bmbreports.org)
Multiple lines of research suggest that a newly identified organism, Mycobacterium immunogenum (MI), appears to have an etiologic role in hypersensitivity pneumonitis (HP) in case of MRFs exposed workers. (cdc.gov)
Mycobacteria (more specifically MI) were found in all biofilm samples, including biofilms collected from inside the MRF systems and from adjacent environmental surfaces, suggesting that biofilms may play an important role in microbial ecology in MRFs. (cdc.gov)

Within the ribosome, the function of the ribosomal protein SA is unclear. (medlineplus.gov)
The ability of the HCV IRES to manipulate the ribosome provides insight into how the ribosome's structure and function can be altered by bound RNAs, including those derived from cellular invaders. (janelia.org)
Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. (pentelutelabmit.com)

Here, we describe the 3D crystal structure of the human MTERF4-NSUN4 complex determined to 2.9 Å resolution. (rcsb.org)
Crystal structure of a nitrate/nitrite exchanger. (janelia.org)

Evidence in the literature suggests that P0 may be involved in diseases such as malaria and systemic lupus erythematosus. (uri.edu)
He explains: "Much of the information available in the literature suggests that 50S assembly in vivo follows a very similar course to that observed in vitro. (charite.de)

The triplets cooperatively invaded and unraveled even highly stable RNA secondary structures, and support non-canonical primer-free and bidirectional modes of RNA synthesis and replication. (elifesciences.org)

The cryo-EM structure of the active PCC in complex with a translating ribosome shows the hitherto most detailed electron density map for the PCC. (hu-berlin.de)
Coding regions of active rDNA were initially thought to be devoid of nucleosomes, as suggested by electron microscopy and psoralen cross-linking experiments ( 4 ). (asm.org)

Subunit14

Proteins17

RRNA9

Ribosomes5

Subunits5

Extra-ribosomal functions2

Genes8

Phylogenetic5

Peptide bond formation1

Gene3

Eukaryotic1

Mechanism3

Putative3

Biogenesis3

Yeast3

Translocation2

TRNA2

Complexes3

Sequences2

Methyltransferase1

Maturation2

Molecular3

Chromosomal1

Functional3

Genetic2

Membrane1

Incorporation1

Conformation2

Largely1

Downstream1

Bacteria1

Bacillus2

Structural2

Coli2

Roles1

20181

Chromatin structure3

Regulates2

Dependent1

Recombination1

Prediction1

Translational2

Large1

Reveal1

Protein Structure2

Nascent1

Mechanisms1

Initiation1

Role5

Function3

Crystal structure2

Literature suggests2

Secondary structures1

Electron2