Suggest that the cysteine protease. Medical search. Frequent questions

Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat. (jci.org)
PSS may be caused by disease-causing variants in multiple genes encoding proteins with crucial functions for cell-cell adhesion: structural proteins forming cell-cell adhesion points (desmosomes, corneodesmosomes) and inhibitors of epidermal proteases that control skin shedding. (rarediseases.org)
In contrast, inhibitors against microtubules or cysteine proteases (CP) showed distinct effects on degradation in phagosomes between these two species. (elsevierpure.com)

In the October 23 Neuron, Gan and colleagues now report that APP mice lacking cystatin C (CysC)-an inhibitor of cysteine proteases including CatB-have lower soluble Aβ levels and reduced Aβ-associated deficits in cognition, behavior, and synaptic plasticity compared to APP/CysC+/+ mice. (alzforum.org)
DPPI Kinetics DPPI is definitely gradually inactivated by E64 (Fig. 3B), which really is a noncompetitive, irreversible inhibitor of cysteine proteases (Barrett min). (careersfromscience.org)

Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. (wikipedia.org)
Mucosal presence and activity of cysteine PI and cathepsin B have also been investigated in the pathogenesis of chemically induced HML. (jci.org)
The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main source of amino acids. (maynoothuniversity.ie)
Here we investigated the importance of pH in regulating the activity and functions of the major cathepsin L protease FheCL1. (maynoothuniversity.ie)
Purpose: Cathepsin L is a lysosomal cysteine protease that plays important roles in cancer tumorigenesis proliferation and chemotherapy resistance. (healthanddietblog.info)
Because some experiments suggest that combining cathepsin L inhibition with regular chemotherapeutics is a promising therapeutic option for cancer therapy19 20 21 we hypothesized that cathepsin L inhibition may also be a promising tool to improve radiation therapy effectiveness. (healthanddietblog.info)
This is also supported in part by phenotypes of cathepsin knockout mice and suggests that several proteases can substitute for each other to degrade or process a given substrate. (canada.ca)
The aspartic protease cathepsin D (Clan AA, Family A1) is expressed in the schistosome gut where it plays an apical role in the digestion of hemoglobin released from ingested erythrocytes. (aber.ac.uk)
In this report, RNA interference approaches were employed to investigate the effects of knockdown of schistosome cathepsin D. Cultured schistosomules of Schistosoma mansoni were exposed by square wave electroporation to double stranded RNA (dsRNA) specific for cDNA encoding S. mansoni cathepsin D. RNAi-mediated reductions in transcript levels led to phenotypic changes including significant growth retardation in vitro and suppression of aspartic protease enzyme activity. (aber.ac.uk)
Off-target effects were not apparent in transcript levels of the gut-localized cysteine protease cathepsin B1. (aber.ac.uk)
These and earlier findings suggest that, given its essential function in parasite nutrition, schistosome cathepsin D could be developed as a target for novel anti-schistosomal interventions. (aber.ac.uk)

We used an inhibitor to examine the function of interleukin-1 beta-converting enzyme (ICE) family proteases during sympathetic neuronal death and to assess the metabolic and genetic status of neurons saved by such inhibition. (rupress.org)
The new gene encodes a 32-kDa putative cysteine protease (CPP32) with significant homology to Caenorhabditis elegans cell death protein Ced-3, mammalian interleukin-1 beta-converting enzyme (ICE), and the product of the mouse nedd2 gene. (deathbase.org)
Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. (deathbase.org)
Cloning of interleukin-1 beta converting enzyme (ICE) and Caenorhabditis elegans death protein CED-3 revealed the structural and functional homology between these two proteases. (deathbase.org)

Along with these, up-regulation of the cysteine protease calpains and cleavage of caspase-12 and caspase-7 were found in the channel-deficient retinas, suggesting an endoplasmic reticulum stress-associated apoptosis. (cipsm.de)
Bocaspartyl(OMe)-fluoromethylketone (BAF), a cell-permeable inhibitor of the ICE family of cysteine proteases, inhibited ICE and CPP32 (IC50 approximately 4 microM) in vitro and blocked Fas-mediated apoptosis in thymocytes (EC50 approximately 10 microM). (rupress.org)
These findings suggest that neuronal apoptosis after cardiac arrest is not primarily initiated by activation of caspases. (asahq.org)
However, substantial apoptosis induced by infection of all three viruses have been documented in infected cells and patient tissues, suggesting a previously unrecognized link between apoptosis cascade and the pathogenesis of coronaviruses. (hku.hk)
In this study, I show that a cysteine-aspartic protease which is the central component involved in apoptosis cascade, caspase-6, serves as an important host factor for efficient coronavirus replication. (hku.hk)
Increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. (elsevierpure.com)
Apoptosis, a form of cellular suicide, involves the activation of CED-3-related cysteine proteases (caspases). (deathbase.org)
The apoptotic activity of CPP32 and its high expression in lymphocytes suggest that CPP32 is an important mediator of apoptosis in the immune system. (deathbase.org)
Recent evidence suggests that mammalian cysteine proteases related to Caenorhabditis elegans CED-3 are key components of mammalian programmed cell death or apoptosis. (deathbase.org)
The high degree of conservation in structure and specific activity and the coexistence of Mch3 alpha and CPP32 in the same cell suggests that the PARP cleavage activity observed during apoptosis cannot solely be attributed to CPP32 but could also be an activity of Mch3 alpha. (deathbase.org)
It also suggested the involvement of ICE-like cysteine proteases in apoptosis. (deathbase.org)

Literature suggests nsp5 and other non-structural proteins are potential targets for a number of antiviral therapies. (stackexchange.com)
Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. (springer.com)
Using COS7 cells transfected with a p94 expression vector and Western blot analyses, we previously detected proteolysis of several proteins, suggesting that p94 prote-olytic activity is readily exerted and that the proteins identified are potential p94 substrates [17]. (ecolowood.com)
Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)

Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. (wikipedia.org)
Leupeptin is an organic compound produced by actinomycetes, which inhibits serine, cysteine and threonine proteases. (wikipedia.org)
Proteases are classified on the basis of catalytic mechanism, and five known distinct classes are described: metallo, aspartic, cysteine, serine, and threonine. (blastocystis.net)
Michaelis-Menten plots of 50 ng of rhKLK4 incubated with raising concentrations of NaF at HA14-1 10 min (C) as well as the irreversible serine protease inhibitor AEBSF (D) had been generated. (careersfromscience.org)

A cysteine proteinase with properties similar to mammalian cathepsins has been found in silkmoth eggs. (elsevierpure.com)
Isolated follicle cells synthesized and secreted cysteine proteinase into the medium. (elsevierpure.com)
Cysteine proteinase is able to degrade vitellin (Vn) and egg specific protein (ESP) in vitro in a profile similar to that found in vivo. (elsevierpure.com)
Cysteine proteinase found in many tissues. (lookformedical.com)
Clinical isolates of E. histolytica release 10- to 1,000-fold more cysteine proteinase activity into the supernatant than E. dispar isolates, although significant day-to-day variability may be seen. (blastocystis.net)

This study demonstrated that reduction of full-length CDP levels in two independent strains of CDP knockout mice increased endogenous MMTV and other mammary-specific cellular genes in undifferentiated mammary glands, suggesting a critical role for CDP in the MMTV life cycle. (utexas.edu)
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes. (canada.ca)
2017). In addition, BES1 and BZR1 regulate the manifestation of thousands of BR-responsive target genes including APETALA2/ETHYLENE RESPONSIVE Element (AP2/ERF) transcription factors, which suggests that AP2/ERF transcription factors likely function along with BES1 to balance BR-regulated growth and stress reactions (Sun et al. (dc-thera.org)
Further investigations showed that H 2 S repressed the expression of ethylene synthesis-related genes AdSAM , AdACS1 , AdACS2 , AdACO2 , and AdACO3 and cysteine protease genes, such as AdCP1 and AdCP3 . (ashs.org)

Here, we have investigated the influence of heparin upon Leishmania mexicana cysteine protease rCPB2.8 activity.Methodology/Principal Findings: the data analysis revealed that the presence of heparin affects all steps of the enzyme reaction: (i) it decreases 3.5-fold the k(1) and 4.0-fold the k(-1), (ii) it affects the acyl-enzyme accumulation with pronounced decrease in k(2) (2.7-fold), and also decrease in k(3) (3.5-fold). (unifesp.br)
Moreover, the interaction of heparin with the N-terminal pro-region of rCPB2.8 significantly decreased its inhibitory activity against the mature enzyme.Conclusions/Significance: Taken together, depending on their concentration, heparin-like glycosaminoglycans can either stimulate or antagonize the activity of cysteine protease B enzymes during parasite infection, suggesting that this glycoconjugate can anchor parasite cysteine protease at host cell surface. (unifesp.br)

Extracellular cysteine proteases cleave immune secretory IgA (facilitating adhesion of the organism (pathogen) to mucosal surfaces), degrade the extracellular matrix, activate complement, and degrade IgG to circumvent the host immune response. (blastocystis.net)

For example, leupeptin could be used in a calpain extraction to keep calpain from being hydrolyzed by specific proteases. (wikipedia.org)
Calpain represents a family group of Ca2+-dependent cytosolic cysteine proteases found in almost all eukaryotes and some bacteria, and is involved in a variety of biological phenomena, including brain function. (ecolowood.com)

The nsp3 gene contains a papain-like protease 2 (PL2pro) domain. (stackexchange.com)

We have shown recently that the CPP32 and Mch2 alpha cysteine proteases cleave the apoptotic markers poly(ADP-ribose) polymerase (PARP) and lamins, respectively. (deathbase.org)
We also provide evidence that CPP32 can efficiently cleave proMch3 alpha, but not the opposite, suggesting that Mch3 alpha activation in vivo may depend in part on CPP32 activity. (deathbase.org)

The gene nsp5 encodes 3CLpro (chymotrypsin-like cysteine protease), so there are differences there. (stackexchange.com)

Therefore, we suggest that Hb degradation is not completed in the gut lumen but that the resulting peptides are absorbed by the gut epithelial cells for further processing by intracellular di- and amino-peptidases to free amino acids that are distributed through the parasite tissue for protein anabolism. (maynoothuniversity.ie)
La présente étude visait à identifier le(s) vecteur(s), le parasite et la composition des espèces des phlébotomes dans le district, de juillet à septembre 2009, à l'aide de techniques d'amplification en chaîne par polymérase. (who.int)

In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. (thermofisher.com)
CDP is proteolytically processed within the homeodomain by a cysteine protease to generate a dominantnegative CDP150 protein that interferes with the DNA-binding and repressor activities of CDP. (utexas.edu)
ATP-dependent Clp protease (ClpP), a mitochondrial matrix protease, plays an important role in regulating mitochondrial protein turnover and bioenergetics activity. (springer.com)
Although native p94 protein is abundant in protein preparations made from skeletal muscles, it disappears as a result of autolysis during purification, suggesting that a skeletal-muscle-specific mechanism for stabilizing p94 prevails [27]. (ecolowood.com)
Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
Because the protein produced from the PSMB8 gene may be involved in the maturation of adipocytes, studies suggest that a shortage of this protein may interfere with the normal development and function of these cells. (medlineplus.gov)
it replaces the amino acid cysteine with a signal to stop protein production prematurely (written as Cys135Ter or C135X). (medlineplus.gov)
The genetic basis of HD is the expansion of a cysteine-adenosine-guanine (CAG) repeat encoding a polyglutamine tract in the N-terminus of the protein product called huntingtin. (medscape.com)

Both poly-(ADP ribose) polymerase and pro-ICE and Ced-3 homolog-1 (ICH-1) appear to be cleaved in a BAF-inhibitable manner, although the majority of pro-CPP32 appears unchanged, suggesting that ICH-1 is activated during neuronal PCD. (rupress.org)
Our data suggest that similar to ICE, CPP32 is made of two subunits, p20 and p11, which form the active CPP32 complex. (deathbase.org)
Mch3, a novel human apoptotic cysteine protease highly related to CPP32. (deathbase.org)
These data suggest that proMch3 alpha and proCPP32 can interact to form an active Mch3 alpha/CPP32 heteromeric complex. (deathbase.org)

Taken together, our findings suggest that H 2 S alleviates kiwifruit ripening and senescence by antagonizing the effect of ethylene through reduction of oxidative stress and inhibition of ethylene synthesis pathway. (ashs.org)
The pathogenesis of COPD includes inflammation, oxidative stress, and protease/antiprotease imbalance. (researchsquare.com)

Our findings provide novel insights into the mechanism underlying αSyn-induced neuronal pathology, and they suggest that ClpP might be a useful therapeutic target for PD and other synucleinopathies. (springer.com)
Despite these findings suggesting that mitochondria might be a key link between αSyn toxicity and neuronal degeneration in PD, the field still lacks an understanding of how αSyn abnormality and mitochondrial functional deficiency influence each other. (springer.com)
[ 7 ] More recent data from striatal neuronal cultures transfected with mutant huntingtin and transgenic mice carrying the spinocerebellar ataxia-1 (SCA-1) gene (another CAG repeat disorder) suggest that NIIs may not be necessary or sufficient to cause neuronal cell death, but translocation into the nucleus is sufficient to cause neuronal cell death. (medscape.com)

Entamoeba histolytica expresses at least 5 types of cysteine proteases (ACP1, ACP2, ACP3, EhCP5, and EhCP112) and can invade host tissue (leading to amoebiasis), while Entamoeba dispar expresses at least three types of cysteine proteases (EdCP1, EdCP2, and EdCP3) without the ability to invade host tissue. (blastocystis.net)

A specific inhibitor of vacuolar ATPase, concanamycin A, interrupted both the acidification and degradation in phagosomes in both species, suggesting the ubiquitous role of vacuolar ATPase in the acidification and degradation in Entamoeba. (elsevierpure.com)

An alternative ubiquitous promoter of was recently identified and the expression of several 65-19-0 p94 variants in various organs, including the brain, has been reported [22C24], suggesting that p94 is important for tissues other than skeletal muscles. (ecolowood.com)

Supplemental materials from the first linked paper suggest nsp3 has a different amino acid sequence between SARS-CoV and SARS-CoV-2. (stackexchange.com)

The involvement of PCD suggests that xylogenesis could be manipulated by controlling the PCD. (europa.eu)
These data suggest the presence of biochemical or functional differences in the involvement of microtubules and proteases in phagosome maturation and degradation between the two species. (elsevierpure.com)

These results suggest that cysteine P may be activated in the rat stomach after E or A exposure, and cysteine P may have a role in the pathogenesis of E- or A-induced gastric HML. (jci.org)
In light of prior human polymorphism data and recent mouse data highlighting cystatin C's ability to interfere with amyloid aggregation, the new findings suggest a more complex character for cystatin C and make it challenging to say whether it plays a "good" or "bad" role in AD pathogenesis. (alzforum.org)
Numerous studies suggest a key role for αSyn in the pathogenesis of PD. (springer.com)

Taken together, our findings suggest a crucial role of endoplasmic reticulum stress in cone degeneration associated with CNG channel deficiency. (cipsm.de)

In addition, differences in cellular distribution and intracellular localization may contribute to defining specific functional roles for some of these proteases. (canada.ca)

The first evidence of amoebic pathology is local depletion of intestinal mucus and disruption of the epithelial barrier as a result of degradation of the extracellular matrix, which occurs in part from the action of cysteine proteases. (blastocystis.net)

Stability studies suggested that the observed activity was due mainly to intact derivatives and not to released GEM. (cysteineprotease-receptor.com)
The study links protease activity to amoebic forms of Blastocystis, which the authors found in symptomatic carriers but not in asymptomatic carriers. (blastocystis.net)
role that the p94 molecule plays is not fully understood, it is possible that the dys-trophic muscle phenotype observed in LGMD2A is the result of accumulated losses in cellular responses to various physiological perturbations because p94 lacks its protease activity. (ecolowood.com)
As a consequence of its autolysis, analysis of p94 protease activity using standard methodologies is difficult. (ecolowood.com)

Gum infection may play a central role in the development of Alzheimer's disease (AD), new research suggests. (medscape.com)
The link between AD and bacterial infection has been suggested before and, additionally, emerging evidence has suggested that Aβ 1-42 is an antimicrobial peptide," Dominy said. (medscape.com)
This outcome suggests that about 1 of 8 patients with COVID-19 will experience PASC after their COVID-19 infection has resolved. (asm.org)
This is the first finding of natural infection of P. kandelakii by L. infantum in this region suggesting P. kandelakii may be the vector of L. infantum in the area although it is the second most prevalent phlebotomine species. (who.int)

Being enzymes, proteases digest substrates, can be inhibited, and their functions are dependent on pH and temperature. (blastocystis.net)

A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, and Rat based on 100% sequence homology. (novusbio.com)
Background: Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. (unifesp.br)
reagent labeling Cell culture and transfection (electroporation) methods for COS7 cells, cDNA constructs for expressing human p94s, wild-type (WT) and a protease-inactive p94:C129S mutant (CS) were described previously [27]. (ecolowood.com)

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. (rupress.org)

Importantly, cysteine proteases are critical to host invasion in a number of parasites. (blastocystis.net)

When cells are lysed for these studies, proteases, many of which are contained within lysosomes, are released. (wikipedia.org)
We investigated this particular pathogen because multiple prior studies, including epidemiology and mechanistic studies, had been published suggesting a link between Porphyromonas gingivalis and AD," he continued. (medscape.com)
Studies suggest that expression of cystatin A is inversely associated with malignant progression of cancer 9 . (bvsalud.org)
Studies suggest that, through unknown mechanisms, the subunit produced from the PSMB8 gene in particular may be involved in the maturation of fat cells (adipocytes). (medlineplus.gov)

This suggest that exposure reduction may be one of the methods for reduction of risk, in relation to control of the allergic airway diseases. (cdc.gov)

Furthermore, periodontitis has been shown to be associated with systemic cardiovascular disease ( 5 - 7 ), which suggests its close association with vascular endothelial cells. (spandidos-publications.com)

While the study is small, investigation of Blastocystis proteases has been going on for a while, and I thought it would be useful to go over some of the literature. (blastocystis.net)
The scientific literature suggests that many environmental factors contribute to the increase in sensitization and development of airway allergies. (cdc.gov)

Family C1 cysteine proteases : biological diversity or redundancy? (canada.ca)
Grade 0 cases have no detectable histologic neuropathology in the presence of a typical clinical picture and positive family history suggesting HD. (medscape.com)

the data strongly suggest that heparin is altering the ionization of catalytic (Cys(25))-S-/(His(163))-Im(+) H ion pair of the rCPB2.8. (unifesp.br)

The results suggest that the biovalence transformation of high levels of selenite may involve a dithiol system. (iospress.com)
These results suggest that a Complex cross talk among several cold and warm sensitive pathways shapes thermal perception. (cysteineprotease-receptor.com)
Our results suggest the diametrically opposed fitness costs in the presence and absence of insecticides is a reason for the variations in frequencies between the 410L+1016I+1534C and 1534C alleles in field populations. (bvsalud.org)
These results suggest that the effects of YS involved lung microbes and anti-inflammatory mechanisms. (researchsquare.com)

There is evidence to suggest that dysbiosis of pulmonary microbiota participates in COPD development. (researchsquare.com)

Anatomy12

Organisms37

Diseases3

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Inhibitors3

Inhibitor of cysteine proteases2

Cathepsin11

Interleukin-1 beta-conver4

Apoptosis11

Proteins4

Serine4

Proteinase5

Genes4

Enzyme2

Degrade1

Calpain2

Papain1

Cleave2

Encodes1

Parasite2

Protein8

CPP324

Oxidative2

Neuronal3

Invade1

Entamoeba1

Tissues1

Amino1

Involvement2

Pathogenesis3

Findings suggest1

Differences1

Degradation1

Activity4

Infection4

Digest1

Human3

Neurons1

Host1

Studies4

Exposure1

Cells1

Literature2

Family2

Catalytic1

Results suggest4

Evidence1