• Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. (nih.gov)
  • Amantadine hydrochloride is designated chemically as 1-adamantanamine hydrochloride. (nih.gov)
  • Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug. (nih.gov)
  • Each amantadine hydrochloride capsule, USP intended for oral administration contains 100 mg of amantadine hydrochloride, USP. (nih.gov)
  • Amantadine hydrochloride capsules have long duration of action [6] . (ispub.com)
  • Amantadine HCl, also known as amantadine hydrochloride, is a medication that falls under the Antiparkinson Dopaminergics class. (qwarkhealth.com)
  • But if you have many infections or are at greater risk for complications, your consultant may suggest an antiviral drug to cure the flu. (vigourfact.com)
  • Amantadine is an antiviral drug which seems to have some benefit in patients where rigidity is a problem. (drgeraldlewis.com)
  • Common side effects of amantadine HCl may include nausea, dizziness, lightheadedness, and dry mouth. (qwarkhealth.com)
  • The effects of amantadine were observed within 15 min following drug administration and confirmed in Huh-7.5 cells transfected with an infectious HCV genome. (unifg.it)
  • Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. (cdc.gov)
  • In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation. (cdc.gov)
  • Genetic analysis showed that all oseltamivir-resistant strains of subtype H1N1 virus remained susceptible to amantadine. (cdc.gov)
  • In Hong Kong Special Administrative Region, People's Republic of China, amantadine and oseltamivir are not commonly used to treat patients with influenza. (cdc.gov)
  • Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in 2006 after a high rate of amantadine resistance was reported among subtype H3N2 viruses ( 2 ) and a stockpile of oseltamivir was purchased for pandemic preparedness. (cdc.gov)
  • We report detection of subtype H1N1 virus isolates that became resistant to amantadine and oseltamivir because of genetic reassortment and spontaneous mutation. (cdc.gov)
  • A subtype H1N1 virus resistant to oseltamivir, but sensitive to amantadine, was first detected in Hong Kong in January 2008, which coincided with the emergence of clade 2B A/Brisbane/59/2007-like viruses. (cdc.gov)
  • They all carried the H274Y mutation in the NA gene and showed an ≈1,000-fold reduction in susceptibility to oseltamivir (50% inhibitory concentration values increased from 0.5 nmol/L to 500 nmol/L). Analysis of the M2 genes showed that 3 (3.4%) of 87 oseltamivir-resistant isolates also carried the S31N mutation associated with amantadine resistance. (cdc.gov)
  • The results demonstrated that N30 inhibited the replication of H1N1, H3N2, influenza B viruses, including oseltamivir and amantadine resistant strains in vitro. (biomedcentral.com)
  • In the present study, we developed the broad-spectrum antiviral activity of N30 in vitro, including oseltamivir-resistant strains and amantadine-resistant strains of influenza virus, coxsackie B virus, coronavirus, and respiratory syncytial virus. (biomedcentral.com)
  • The rest of the proof suggests oseltamivir didn't decrease influenza related lower respiratory system 4673-26-1 complications (risk percentage 0.55, 95% confidence period 0.22 to at least one 1.35). (healthdisparitiesks.org)
  • The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. (nih.gov)
  • The mechanism of action of Amantadine Hcl in the treatment of fibroid is not known. (ispub.com)
  • Amantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e. (nih.gov)
  • A quantitative relationship between the in vitro susceptibility of influenza A virus to amantadine and the clinical response to therapy has not been established in man. (nih.gov)
  • Sensitivity test results, expressed as the concentration of amantadine required to inhibit by 50% the growth of virus (ED 50 ) in tissue culture vary greatly (from 0.1 mcg/mL to 25 mcg/mL) depending upon the assay protocol used, size of virus inoculum, isolates of influenza A virus strains tested, and the cell type used. (nih.gov)
  • While findings from clinical trials thus far suggest some efficacy for specific pharmacological treatments, conflicting reports also exist. (springer.com)
  • Investigators concluded that the findings of the NM201 study, together with the results of the marmoset pre-clinical study, suggest that through its anti-inflammatory and insulin-sensitizing properties, NE3107 may possess intrinsic pro-motoric and potentially levodopa-enhancing activities, while having a favorable safety profile, and support further investigation of the safety and clinical benefit of nondopaminergic therapies in late-phase clinical trials. (itbusinessnet.com)
  • Some of these patients (n = 12) had been administered amantadine on clinical grounds and, for this paper, served as the experimental group, while the drug naive (n = 31) served as a control. (elsevierpure.com)
  • A clear assessment of whether the psychological symptoms in this group of patients are the primary or secondary clinical manifestation of the infection or a complication of amantadine treatment is difficult. (bvsalud.org)
  • Her treatment started with 100 mg amantadine and 0.375 mg pramipexole per day, and her clinical symptoms slightly improved. (e-jmd.org)
  • To assess the longitudinal difference in trajectories between amantadine users and nonusers, a generalized linear mixed model was used to regress each clinical outcome on the time-dependent "amantadine use" variable while adjusting for age, disease duration, Hoehn and Yahr (HY) stage, and initial score of outcome of interest. (mdsabstracts.org)
  • Seed 156, geller tj, hunter, and clinical evidence suggests an nmda partial agonism symptoms of delta-tetrahydrocannabinol and lexapro. (myjuicecup.com)
  • Influenza A variants with reduced in vitro sensitivity to amantadine have been isolated from epidemic strains in areas where adamantane derivatives are being used. (nih.gov)
  • However, recent boxun reports describe several H5N1 strains in China that can infect humans and most strains in China are amantadine sensitive , based on wild type polymorphisms at positions 26 and 31 of their M2 protein. (recombinomics.com)
  • The isolates were also tested for resistance to amantadine by an in-house-designed PCR (protocol available on request) and nucleotide sequencing of the matrix (M2) gene segment. (cdc.gov)
  • All public H5N1 sequences from Vietnam and Thailand since 2004 have two resistance markers in the MP gene, precluding the use of amantadine. (recombinomics.com)
  • These isolates have been described in recent Nature and Science reports and there was no mention of amantadine resistance markers. (recombinomics.com)
  • Resistance is known to develop quickly to amantadine, making it unsuitable for stockpiling. (parliament.uk)
  • Amantadine HCl is a medication classified as an antiparkinsonian drug that is used to treat symptoms of Parkinson's disease and certain movement disorders. (qwarkhealth.com)
  • The exact way in which amantadine HCl works to improve symptoms of Parkinson's is not fully understood, but it is believed to have both direct and indirect effects on the dopamine system in the brain. (qwarkhealth.com)
  • Amantadine HCl, as an antiparkinson dopaminergic medication, is commonly used to treat symptoms of Parkinson's disease and some movement disorders. (qwarkhealth.com)
  • Utilization and longitudinal impact of amantadine use in Parkinson's disease. (mdsabstracts.org)
  • To evaluate baseline predictors and longitudinal impact of amantadine use in Parkinson's disease (PD). (mdsabstracts.org)
  • Data obtained in vitro suggested a role of amantadine in inhibiting HCV p7-mediated cation conductance. (unifg.it)
  • Patients were randomly assigned to receive amantadine or placebo for 4 weeks and were followed for 2 weeks after the treatment was discontinued. (nih.gov)
  • Amantadine accelerated the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness. (nih.gov)
  • Considering co-occurring disorders may be particularly important when devising a treatment plan for GD: extant data suggest that the opioid antagonist naltrexone may by the most effective form of current pharmacotherapy for GD, particularly for individuals with a co-occurring substance-use disorder (SUD) or with a family history of alcoholism. (springer.com)
  • Amantadine treatment more efficiently blocked infection in specific immune cells. (nih.gov)
  • Amantadine is approved for prophylactic treatment of adult influenza infections. (recombinomics.com)
  • Results showed that mean immobility scores with NE3107 monotherapy (during weeks 8 and 9 on therapy) were significantly lower, indicating improved mobility, than comparison treatment with amantadine HCl or vehicle only. (itbusinessnet.com)
  • These improvements within 24 hours of initiating NE3107 monotherapy, suggesting a direct influence on neuro-motor signaling, as opposed to an effect that increased with time of treatment, which might imply a link to neuroprotection. (itbusinessnet.com)
  • A move to prioritisation of treatment would only be made if information became available to suggest that demand for antiviral treatment would outstrip supply. (parliament.uk)
  • In summary, the proper use of Amantadine HCl involves following the prescribed dosage and frequency, monitoring for any side effects, and maintaining open communication with your healthcare provider throughout the treatment process. (qwarkhealth.com)
  • Moreover, amantadine treatment increased the calcium threshold required to trigger mitochondrial permeability transition opening. (unifg.it)
  • Single reports suggest the effectiveness of amantadine in the treatment. (bvsalud.org)
  • This damage to her kidneys made them unable to adequately filter out the amantadine, causing her to overdose and thus causing injury to her organs and all of her unexplained symptoms. (wikipedia.org)
  • Amantadine Hcl improved the therapeutic outcome through relieving symptoms and shrinkage of leiomyoma without any effect on the hormonal panel. (ispub.com)
  • Mr. C's symptoms suggest possible catatonia, a neuropsychiatric syndrome of motor dysregulation found in up to 10% of acutely ill psychiatric inpatients. (mhaus.org)
  • In this context, we attempted to describe a case of a patient with psychotic symptoms who was confirmed with SARS-CoV-2 infection and treated with amantadine. (bvsalud.org)
  • Studies into the subject showed a link between fatigue and other symptoms such as sleep disturbances, depression, anxiety, or sensory symptoms, on the basis of which the authors suggest that the distinction between primary fatigue associated with PD and the secondary fatigue is almost impossible [ 16 ]. (hindawi.com)
  • One of the first strategies a vet typically suggests to mitigate symptoms is honing your dog's nutrition. (pakamana.com)
  • While there is some evidence to suggest that Namenda may be effective in treating certain symptoms of ASD, more research is needed to fully understand its potential benefits and risks. (lovingthespectrum.com)
  • To further mitigate the dystonic symptoms, amantadine 200 mg was also added. (psychiatryinvestigation.org)
  • Amantadine is a modestly effective agent for a variety of motor symptoms and can also reduce levodopa-induced dyskinesias. (parkinsonsinfoclub.com)
  • Many of these drugs are effective, but with time their benefits can become less, and some doctors suggest holding back until symptoms warrant their use as there does seem to be a fixed duration of their benefits. (drgeraldlewis.com)
  • Amantadine is an antiviral and antiparkinsonian drug that has been evaluated in combination therapies against hepatitis C virus (HCV) infection. (unifg.it)
  • Isolates from the swine are similar to Yunnan isolates , and all Yunnan H5N1 sequences at GenBank are amantadine sensitive. (recombinomics.com)
  • The acquisition of polymorphisms as seen in recent isolates of 2005-07 from distinct geographical regions suggests the possibility of transportation of H5N1 viruses through migratory birds. (biomedcentral.com)
  • Fibromas had a tendency to regress spontaneously and supported their hypothesis that amantadine probably acted due to its dopaminergic effect [9] . (ispub.com)
  • Amantadine is well absorbed orally. (nih.gov)
  • This study was carried out on 29 women receiving 100 mg of Amantadine Hcl orally twice daily for 6 months. (ispub.com)
  • In conclusion, these results support a role of amantadine in preserving cellular bioenergetics and redox homeostasis in HCV-infected cells and unveil an effect of the drug which might be exploited for a broader therapeutic utilization. (unifg.it)
  • Background: A previous study suggested that the routine use of drugs intended to improve attention and arousal, such as methylphenidate, tend to have a variable but not significant effect on sleep-wake cycles. (elsevierpure.com)
  • Many vets will first suggest non-steroidal anti-inflammatory drugs (NSAIDs). (pakamana.com)
  • Conclusion: This study fails to demonstrate that the use of amantadine on an inpatient brain injury population will affect sleep/wake quantity. (elsevierpure.com)
  • The latest in vivo data on use of Tamiflu to treat H5N1 bird flu suggests pandemic use may be limited , especially at the recommended dose and duration. (recombinomics.com)
  • Recent reports from Indonesia suggest that the fatalities of three family members may be due to H5N1, which may be transmissible human-to-human and lethal in all three family members . (recombinomics.com)
  • Amantadine users had significantly worse communication, stigma, and ADL PDQ-39subscores. (mdsabstracts.org)
  • L104M, L115Q, V210A) between the HA of the virus from the Chilean case and A/Astrakhan/3212/2020-like candidate vaccine, and they are not in major antigenic epitopes strongly suggesting that antibodies elicited by the A/Astrakhan/3212/2020-like vaccine would be expected to have good cross-reactivity - and therefore protection - against this virus. (cdc.gov)
  • As amantadine is a frequently employed drug in brain injury rehabilitation, with known effects on fatigue and motor processing speed, this study examined the effect of amantadine on the sleep-wake behaviour of patients with brain injury undergoing rehabilitation. (elsevierpure.com)
  • As my most recent neuro has suggested I try amantadine for fatigue, I would be very interested in hearing how you are getting on with it. (parkinsons.org.uk)
  • Due to its heterogeneous nature, it is suggested that the term "fatigue syndrome" should be used [ 12 ]. (hindawi.com)
  • Compte tenu du nombre croissant d'infections et de décès par le virus de la grippe pandémique (H1N1) 2009 confirmés en laboratoire dans la Région OMS de la Méditerranée orientale, le Bureau régional a convoqué une réunion consultative d'experts impliqués dans la prise en charge clinique de patients infectés par ce virus. (who.int)
  • La consultation a permis d'élaborer des lignes directrices temporaires et un algorithme pour la prise en charge clinique de l'infection par le virus de la grippe pandémique (H1N1) 2009 en milieu de soins. (who.int)
  • Data from earlier animal studies suggest that amantadine may have direct and indirect effects on dopamine neurons. (nih.gov)
  • Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation. (nih.gov)
  • The accomplishment will lead to a better understanding of how flu infections spread and may suggest new strategies for combating them. (nih.gov)
  • This suggests that, although the generation of broadly neutralizing antibodies is possible, SARS-CoV-2 infection and current vaccines are unlikely to provide protection against the emergence of novel SARS-related viruses," explains Professor Tomohiro Kurosaki from the WPI Immunology Frontier Research Center at Osaka University in Japan. (dominicjonesjewelry.com)
  • All Neuraminidase inhibitors are generally well tolerated by patients but the side effects from amantadine make it less suitable for stockpiling. (parliament.uk)
  • Identified patients were observed for a full 24 hours a day 2 weeks before and 2 weeks after starting amantadine. (elsevierpure.com)
  • The Dr. suggests the patients should see improvements in their condition in about two weeks. (nadh.com)
  • However, functional neuroimaging and electrophysiological studies suggest that some degree of consciousness or awareness that has not been or could not be determined by behavioral evaluations alone may be present in some of these patients who, hence, have covert consciousness. (medlink.com)
  • Considerable evidence suggests that patients should be encouraged to adopt a regular program of exercise from the time of diagnosis. (parkinsonsinfoclub.com)
  • More recent studies have demonstrated that amantadine is a weak, non-competitive NMDA receptor antagonist (K 1 = 10μM). (nih.gov)
  • The ceramide-induced down-regulation of PKC results in abnormal cellular phenotypes, suggesting these metabolic cascades are responsible for the beige phenotype [ 13 ]. (biomedcentral.com)
  • The objective of this case report is to discuss the successful use of amantadine that resulted in the remission of benzodiazepine-resistant catatonia associated with COVID-19 infection. (psychiatrist.com)
  • Dystrophic effect induced by Amantadine on uterine myoma was tried successfully in 1982 by Manlio Luisi and Stefano Luisi to avoid surgical and gynecological complications. (ispub.com)
  • The therapy of Amantadine Hcl in 160 women for 6 months was with good subjective and objective results. (ispub.com)
  • Our data suggest long term beneficial effect of amantadine on objective measures of gait (as measured by TUG), no negative impact on cognition but worsening of certain QoL metrics without a significant decrease in overall QoL score. (mdsabstracts.org)
  • In addition to epithelial cells, a large proportion of immune cells were GFP positive, suggesting active infection of these cells. (nih.gov)
  • In keeping with the fact that mitochondria are responsible to ionic fluxes and that HCV infection impairs mitochondrial function, we investigated a potential role of amantadine in modulating mitochondrial function. (unifg.it)
  • Mechanistically, neuraminidase inhibition assay and hemagglutination inhibition assay suggested that N30 did not directly target the two envelope glycoproteins required for viral adsorption or release. (biomedcentral.com)
  • If your dog shows signs of arthritis, we strongly suggest taking them to your nearest vet clinic for assessment and following their specialized guidance. (pakamana.com)
  • Host cells in tissue culture readily tolerated amantadine up to a concentration of 100 mcg/mL. (nih.gov)
  • Concentration-equilibrated conditions without a concentration gradient suggested that a proportion of the uptake of propranolol and imipramine is via a carrier-mediated process. (uos.ac.uk)
  • Preliminary studies have suggested that amantadine may promote functional recovery. (nih.gov)
  • Using a well-characterized inducible cell line expressing the full-length HCV polyprotein, we found that amantadine not only prevented but also rescued HCV protein-mediated mitochondrial dysfunction. (unifg.it)
  • As reported previously by Medscape Medical News , evidence suggests that the inflammatory cytokines involved in ME/CFS are different from those that induce C-reactive protein. (medscape.com)
  • She took a heavy dose of two or three amantadine pills, right as the garbage truck plowed into the bus. (wikipedia.org)
  • Together this suggests the involvement of specific members of SLC and ABC drug transporter families in pharmaceutical transport. (uos.ac.uk)
  • The Qingahi MP gene is most closely related to a chicken isolate from Shantou, which is amantadine sensitive. (recombinomics.com)
  • it is expected that amantadine, by reducing the expression of the cathepsin L gene, may interfere with SARS-CoV-2 replication. (bvsalud.org)
  • Amantadine users were more likely to be younger, have earlier age of PD diagnosis, higher HY stage, motor fluctuations, be treated with levodopa, have better cognition, and have fewer comorbid conditions. (mdsabstracts.org)
  • The data suggest that amantadine has no direct bearing on sleep/wake cycles using these parameters. (elsevierpure.com)
  • cimetidine, MK571, cyclosporine A and quinidine inhibited propranolol uptake, whilst amantadine and verapamil were without effect. (uos.ac.uk)
  • There is preclinical data that amantadine has neuroprotective properties, however to date, few studies have assessed impact of long-term use on PD progression, particularly on cognition, gait and quality of life (QoL). (mdsabstracts.org)
  • Despite early evidence suggesting that IFN-beta might also be associated with depression, subsequent evidence based on large, randomized, controlled trials did not support an association of IFN-beta (1a and 1b) and depression. (medscape.com)