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  • mutant
  • The mutant construct of CDK6 3′UTR was generated using the QuikChange Site-Directed Mutagenesis kit (Agilent Technologies, Inc., Santa Clara, CA, USA). (spandidos-publications.com)
  • In patients with KRAS -mutant lung adenocarcinoma, co-occurring alterations in STK11 conferred primary resistance to PD-1 blockade, suggesting that genomic profiling may guide selection of patients likely to respond. (aacrjournals.org)
  • Genetic
  • This combined with the fact that only 10-20% of smokers are affected by NSCLC suggest that genetic susceptibility and environmental factors also contribute to the risk of NSCLC. (hindawi.com)
  • proteins
  • C ) Immunoblot demonstrates elevated levels of CDK6, cyclin D1, and phospho-RB proteins in Hh-associated medulloblastoma. (jci.org)
  • diseases
  • Emerging data suggest that hypercholesterolemia has stimulatory effects on adaptive immunity and that these effects can promote atherosclerosis and perhaps other inflammatory diseases. (jci.org)
  • acts
  • Recent reports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilization is the oncogenic effector of SPOP mutation. (jci.org)
  • together
  • Taken together, our findings suggest that the anti-inflammatory and anticancer activities of the Antarctic freshwater microalga, Micractinium sp. (medsci.org)
  • whole
  • Western blot analysis of whole cell lysates probed with cdk6 antibody ( VMA00022 ) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P ) and visualized on the ChemiDoc MP with 106 second exposure. (bio-rad-antibodies.com)
  • effective
  • These specificities increased in blood after TIL transfer and persisted long term suggesting they contributed to the effective antitumor immune response. (jci.org)