• We observed in different tumor cell models that TRAP1 diminished in vivo tumor cell respiration by inhibiting the succinate:coenzyme Q reductase (SQR) activity of Complex II. (unipd.it)
  • We found that TRAP1 is associated to succinate dehydrogenase (SDH), the Complex II of the respiratory chain. (unipd.it)
  • This Complex II inhibition was further enhanced in TRAP1-expressing cells that progressed through a focus forming assay (in vitro tumorigenesis assay), causing an accumulation of succinate that led to the stabilization of the pro-neoplastic transcription factor HIF1alpha thus favouring the metabolic switch necessary for tumor growth and progression. (unipd.it)
  • Covalently bound flavin was not detectable in B. subtilis succinate dehydrogenase expressed in Escherichia coli despite normal N-terminal processing of the apoprotein. (lu.se)
  • This provides an explanation to why the succinate dehydrogenase synthesized in E. coli is not functional and demonstrates that host-specific factors regulate the coenzyme attachment. (lu.se)
  • A relative lack of endogenous coenzyme Q, as well as a circadian rhythm of this coenzyme, highly influenced the activity of succinate dehydrogenase. (springer.com)
  • It is concluded that succinate dehydrogenase activity in the pineal gland of the rat is regulated by changing the concentration of the active enzyme itself as well as the level of the endogenous coenzyme Q. Whether this is caused by a circadian rhythm in the synthesis or in the catabolism of the enzyme and the coenzyme was not revealed by the present study. (springer.com)
  • A novel succinate dehydrogenase type B mutation in an Iranian family. (springer.com)
  • Burnichon N, Rohmer V, Amar L, et al, 2009 The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. (springer.com)
  • Membrane-bound succinate oxidoreductases are flavoenzymes containing one each of a 2Fe, a 3Fe and a 4Fe iron-sulfur center. (lu.se)
  • The aim of this study was to investigate succinate dehydrogenase (SDH) expression in breast cancer according to breast cancer molecular subtype using immunohistochemistry and to assess the clinical implications of SDH expression. (springeropen.com)
  • Avenot HF, Michailides TJ (2010) Progress in understanding molecular mechanisms and evolution of resistance to succinate dehydrogenase inhibiting (SDHI) fungicides in phytopathogenic fungi. (springer.com)
  • The sensitivity of 94 isolates (66 collected during 2013 and 28 in 2017) of D. applanata to the succinate dehydrogenase inhibitor, fluxapyroxad, was evaluated in this study. (springer.com)