Successfully produced human stem cells clone cells. Medical search. Frequent questions

In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. (wikipedia.org)
Development will ensue normally and after many mitotic divisions, the single cell forms a blastocyst (an early stage embryo with about 100 cells) with an identical genome to the original organism (i.e. a clone). (wikipedia.org)
Stem cells can then be obtained by the destruction of this clone embryo for use in therapeutic cloning or in the case of reproductive cloning the clone embryo is implanted into a host mother for further development and brought to term. (wikipedia.org)
The aim of carrying out this procedure is to obtain pluripotent cells from a cloned embryo. (wikipedia.org)
Embryonic stem cells are undifferentiated cells of an embryo. (wikipedia.org)
Other than a tiny number of weird scientists, it's hard to find anyone who likes the idea of implanting a cloned embryo into a woman's womb, risking not only the health of the "mother" but almost certainly producing babies with birth defects. (wtnnews.com)
Other policy options, such as supposed compromises that would prohibit "reproductive cloning" but permit "therapeutic cloning" by prohibiting not the act of creating a cloned embryo but the act of transferring a cloned embryo to a woman's uterus, would inherently mandate the wide-scale destruction of human embryos. (thenewatlantis.com)
Among the largest Asian countries, Japan was an early pioneer in regulating human embryo research, pledging international cooperation on the issue following pronouncements on the subject at a June 1997 meeting of the Group of Eight in Denver, Colorado. (publicintegrity.org)
Several western scientists have been conducting their research in Asian countries in the past few years, including Cibelli, formerly of Advanced Cell Technology, an early U.S. pioneer of embryo research, as well as Alan Colman, now located in Singapore, one of the scientists who helped create the first mammalian clone, the sheep Dolly. (publicintegrity.org)
The predominant bioethical concern arising from this technology is that the blastocyt-stage embryo must be destroyed in the process of isolating and separating the embryonic stem cells from the inner mass region of the pre-embryo. (jcpa.org)
The destruction of the pre-embryo has been the critical issue in the U.S. behind imposing limits on federal government-sponsored research in embryonic stem cells. (jcpa.org)
That's why Father Pacholczyk, director of education at the National Catholic Bioethics Center in Philadelphia, said that the efforts to help people understand the immorality of embryo reserch, including human cloning, must focus on humanizing the issue and appreciating our own embryonic origins, not just on the desired results of embryonic or other types of stem-cell research. (archstl.org)
The National Institutes of Health defines a human embryo as "the developing organism from the time of fertilization until the end of the eighth week of gestation. (archstl.org)
During the process of harvesting embryotic stem cells, the embryo is destroyed. (healthline.com)
Opponents believe that an embryo is a living human being. (healthline.com)
They isolate skin cells, then using the same procedure that created Dolly, they create an embryo from them. (biologywriter.com)
The egg with its skin cell nucleus is allowed to form a 120-cell embryo. (biologywriter.com)
The embryo is then destroyed, its cells used as embryonic stem cells for transfer to injured tissue. (biologywriter.com)
The mouse experiment carried out by the Rockefeller researchers would have been far more controversial if it had been carried out in humans, because the 120-cell embryo could in principle be brought to term by inserting it into a human uterus. (biologywriter.com)
Last year, Hwang's team said it successfully cloned a human embryo from embryonic stem cells. (blogspot.com)
According to MBC, the scientist "maintains that Hwang's team fabricated data because in reality it failed to clone a somatic cell and instead used a frozen embryo from the hospital to make stem cells. (blogspot.com)
In animals , parthenogenesis means development of an embryo from an unfertilized egg cell. (alchetron.com)
Gynogenesis and pseudogamy are closely related phenomena in which a sperm or pollen triggers the development of the egg cell into an embryo but makes no genetic contribution to the embryo. (alchetron.com)
But it is perhaps not auspicious to quote him for purposes of the scientific debates on human cloning, because Ramsey agreed with and supported the scientific myth of the "pre-embryo" 47 made famous by Jesuit Richard McCormick and frog embryologist Clifford Grobstein. (lifeissues.net)
Thus, while Ramsey agreed that there is a human being present immediately at fertilization, he did not agree that it was also a human embryo or a human person - the classic "pre-embryo" argument. (lifeissues.net)
The human embryo did not begin until after 14-days, thus the above quote from Saunders would not apply. (lifeissues.net)
Perhaps Ramsey would give other extraordinarily powerful arguments as to why human cloning is unethical, but he obviously would not be able to base it on his unscientific "pre-embryo" position. (lifeissues.net)
6. " ... any living human embryo has the inherent 'potential' to develop into a healthy baby . (lifeissues.net)
Originally the relevant philosophical term was "potency" (or inherent power or capacity conveyed by a specific nature) was used to apply to an already existing substance - such as a new living human embryo. (lifeissues.net)
In that sense, the human embryo would not be even a human being yet, much less a human person. (lifeissues.net)
Thus if by "potential" one means "potency" - i.e., that the early human embryo already exists with a human nature that is already there, and has its own inherent power or capacity (provided by that human nature) to simply grow bigger and bigger through all the usual developmental stages through birth, then such a statement stands as accurate - both scientifically and philosophically. (lifeissues.net)
That is, it would be acknowledging that the human embryo and the human " baby " are the same human being and human person throughout all of his/her development. (lifeissues.net)
On the other hand, if by "potential" one means that the human embryo is not a human being or human person yet , but might be later once it has been born (i.e., a "baby"), then that statement is both scientifically and philosophically incorrect. (lifeissues.net)
Otherwise, such a treaty would not recognize the inherent human nature of the early human embryo or fetus until after birth , and thus cloning them and using them for research - both "therapeutic" and "reproductive" -- would not be banned, and women undergoing "infertility treatments" could surely be put in danger. (lifeissues.net)
Again, Saunders is referring to SCNT as "THE" cloning procedure, when there are many other ways to clone a human being as well, and he is scientifically mis-defining the product of SCNT (i.e., the cloned human embryo). (lifeissues.net)
It is also our view that there are no sound reasons for treating the early-stage human embryo or cloned human embryo as anything special, or as having moral status greater than human somatic cells in tissue culture. (wikiquote.org)
Researchers create embryonic stem cells without embryo. (curtisrobertmacdonald.com)
The cardioids are roughly the size of a sesame seed and are commensurate with the heart of a 25 day old human embryo. (ebaumsworld.com)
These morally problematic cells, obtained by destroying human embryos, are, however, limited in their degree of flexibility, lacking the ability to "rewind" and make an entire embryo. (archokc.org)
When a researcher from Cambridge University and another in Israel recently announced that they had been able to produce such an "embryo model," a longstanding "line in the biological sand" appears to have been crossed, along with some important ethical lines as well. (archokc.org)
Second, if scientists are able to successfully produce a living human embryo by this technology, this would clearly raise additional serious ethical objections. (archokc.org)
Any time we create living human embryos by other approaches, whether by cloning, by IVF, by synthetic embryo construction, or by other novel methods, we cross a key moral line. (archokc.org)
Scientists are likely to continue to improve their techniques so as to generate better embryo stand-ins, enabling them to study in ever greater detail the way that early human development unfolds. (archokc.org)
Alfonso Martinez Arias, a developmental biologist at Pompeu Fabra University in Barcelona, Spain agreed, describing them as "masses of cells separated into compartments, but no embryo-like organization. (archokc.org)
He suggested that the cell manipulation "confuses what [the] cells do" so that a real embryo is not produced. (archokc.org)
The research team based at the Weizmann Institute in Israel, however, produced extremely realistic synthetic embryo models that grew for up to two weeks. (archokc.org)
They exhibited characteristics quite similar to regular embryos, as developmental biologist Jesse Veenvliet of the Max Planck Institute of Molecular Cell Biology and Genetics pointed out: "The similarity to the natural embryo is remarkable, almost uncanny. (archokc.org)
By employing terms like "embryo structures," "synthetic embryos," "stem cell embryo models," or even "stembryos," researchers may be seeking to go around ethics by relying on euphemism. (archokc.org)
Obtaining stem cells from a human embryo is highly unethical. (all.org)
There is only one way to obtain stem cells from a developing human embryo, and it involves killing the embryo. (all.org)
A human embryo is an innocent human being in his first stage of life. (all.org)
The limit to these studies had been the amount of time an embryo could be successfully cultivated ex vivo. (asu.edu)
The biomedical accomplishment of human in vitro fertilization and embryo transfer (IVF-ET) took years to become the successful technique that presently enables infertile couples to have their own children. (asu.edu)
The researchers used cryopreserved gaur skin cells combined with an embryo of a domestic cow (Bos taurus). (asu.edu)
A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo," by Rita Levi-Montalcini and Viktor Hamburger, appeared in 1953 in the Journal of Experimental Zoology. (asu.edu)
For example, in one previous experiment, researchers injected rat stem cells into the embryo of a mouse that lacked the ability to grow a pancreas. (jstor.org)
In 1972, he became the first scientist to successfully freeze, thaw and transfer a calf embryo, which he called "Frostie," to a surrogate mother. (yahoo.com)

It is used in both therapeutic and reproductive cloning. (wikipedia.org)
While use of therapeutic cloning to produce "replacement" body parts is possible, the grand opening of "Body Parts 'R Us" is years and probably decades away. (wtnnews.com)
But cloning for therapeutic reasons - meaning, carefully regulated research into disease using human embryonic embryos - is an entirely different matter. (wtnnews.com)
What's new is therapeutic cloning of human stem cells. (wtnnews.com)
Therapeutic cloning isn't being done in Wisconsin today, but Doyle wisely refused to cut off the possibility it might someday happen. (wtnnews.com)
Certainly, it's being done in South Korea and the United Kingdom, where therapeutic cloning was protected four years ago. (wtnnews.com)
A growing number of U.S. legislators seem prepared to support research on therapeutic cloning. (publicintegrity.org)
Using this procedure, called therapeutic cloning, the researchers succeeded in making cells from the tail of a mouse convert into the dopamine-producing cells of the brain that are lost in Parkinsons disease (figure 48.7). (biologywriter.com)
Therapeutic cloning successfully addresses the key problem that must be solved before stem cells can be used to repair human tissues damaged by heart attack, nerve injury, diabetes, or Parkinsons, which is immune acceptance. (biologywriter.com)
One important distinction is that while the method might be considered a technique for cloning stem cells, commonly called therapeutic cloning, the same method would not likely be successful in producing human clones otherwise known as reproductive cloning. (ohsu.edu)
There is also peer-reviewed evidence of the therapeutic benefit to patients who have received an adult stem cell treatment for 72 disease and conditions. (freerepublic.com)
This led to the development of therapeutic cloning as a source for genetically matching replacement cells for patients with degenerative diseases. (ed.ac.uk)
However, therapeutic cloning depends on the availability of human eggs, which are in very limited supply. (ed.ac.uk)
Second Australian state to permit therapeutic cloning? (progress.org.uk)
The Lower House in New South Wales, Australia, voted last week to overturn a ban on therapeutic cloning by 65 votes to 26. (progress.org.uk)
Therapeutic cloning uses has some deficiency regarding the use of stem cells? (curtisrobertmacdonald.com)
Yet, human embryonic stem cell research has thus far been unsuccessful in the quest to develop any therapeutic treatments. (all.org)
Dr Xavier Donadeu from the Roslin Institute, an author of the study, said: "Stem cells hold huge therapeutic potential both for people and animals. (sciencedaily.com)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)

In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. (wikipedia.org)
Controversy surrounds human ESC work due to the destruction of viable human embryos, leading scientists to seek alternative methods of obtaining pluripotent stem cells, SCNT is one such method. (wikipedia.org)
In the United States, scientists at the Harvard Stem Cell Institute, the University of California San Francisco, the Oregon Health & Science University, Stemagen (La Jolla, CA) and possibly Advanced Cell Technology are currently researching a technique to use somatic cell nuclear transfer to produce embryonic stem cells. (wikipedia.org)
Dolly, a Finn Dorset sheep, was introduced to the public in 1997 after scientists at the Roslin Institute at the University of Edinburgh in Scotland implanted the cell nucleus from a sheep into an egg that was subsequently fertilized to create a clone. (pewresearch.org)
1 No one has ever cloned a human being , though scientists have cloned animals other than Dolly , including dogs, pigs, cows, horses and cats. (pewresearch.org)
just a few stories about scientists around the world who claim - falsely, of course - to have cloned babies. (wtnnews.com)
First or all, scientists have been cloning human cells or their components for years. (wtnnews.com)
South Korean scientists were the first to report successfully doing so in early 2004, but they produced just one cell line from 200 tries. (wtnnews.com)
Since then, the South Korean scientists have reported creating nearly a dozen new lines of human embryonic stem cells that for the first time carry the genetic signature of diseased or injured patients. (wtnnews.com)
Not even the South Korean scientists claim they're close to transplanting cells into a human, however. (wtnnews.com)
Scientists announced this week that they have successfully produced embryonic stem cells by transferring the DNA of human skin cells into unfertilized human eggs to produce embryos, a technique the Church considers to be an abuse of human life. (womenofgrace.com)
Scientists at Stanford University in California have been able to coax embryonic stem cells into becoming eggs and sperm, which could one day lead to the creation of children through entirely artificial means. (womenofgrace.com)
British scientists are hailing the recent creation of human sperm cells that they believe could revolutionize fertility treatment. (womenofgrace.com)
However, following the successful derivation of human embryonic stem cells in 1998, the debate over human cloning largely shifted to the question of whether it is acceptable for scientists to create human embryos only to destroy them. (thenewatlantis.com)
But cloning research continued, and American scientists announced in 2013 that they had for the first time successfully obtained stem cells from cloned human embryos. (thenewatlantis.com)
Chinese scientists at various research institutions have reported successful experiments in human cloning, including the production of human-rabbit hybrid embryonic stem cells, according to the claims of Professor Lu Guangxiu at Xiangya Medical College, who told the Wall Street Journal in March of 2002 that researchers at the College had been successfully cloning embryos for two years. (publicintegrity.org)
In Japan, scientists at Kyoto University announced in January that they had successfully produced embryonic stem cells domestically for the first time. (publicintegrity.org)
This policy is similar to that of other countries, including Israel, where scientists are funded by Government to study embryonic stem cells despite the aforementioned bioethical issue. (jcpa.org)
Dr. Claire Higgins and her colleague Dr. Colin Jahoda have published an overview of hair cloning and the challenges scientists face in attempting to develop hair regeneration therapies for androgenetic alopecia or common balding. (bernsteinmedical.com)
The first is the difficulty in getting dermal papilla cells in humans to self-aggregate and form hair follicles and the second is the inability, thus far, of scientists to generate normal hairs and follicles. (bernsteinmedical.com)
Having made significant progress in improving this vital communication link between dermal papillae cells, scientists still have to contend with a series of obstacles that stand in the way of a hair cloning therapy for human hair loss. (bernsteinmedical.com)
For the first time, a team of scientists reports successfully growing human hairs from dermal papilla cells taken from the inside of donor hair follicles. (medicalnewstoday.com)
Scientists already know that dermal papilla cells, that are found inside the hair follicles, can give rise to new follicles. (medicalnewstoday.com)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
Scientists are hoping that the cells can be made from someone's own skin to treat a disease. (healthline.com)
By surgically transplanting embryonic stem cells, scientists have performed the remarkable feat of repairing disabled body tissues in mice. (biologywriter.com)
Scientists named Dolly after singer Dolly Parton, because she was cloned using a cell from the mammary gland of a six-year-old Dorset Finn ewe, and she was kept a secret for the first months of her life. (stv.tv)
Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. (ohsu.edu)
Professor Alan Mackay Sim's Queensland team of scientists working on nasal stem cell research for spinal cord injuries and Professor Pritinder Kaur's team at Peter MacCallum Cancer Centre working on using adult stem cells for burns victims are both supported by grants from the Sydney archdiocese. (freerepublic.com)
The goal of CIRM Grant ID1-06557 is to generate high quality induced pluripotent stem cells (iPSC) from blood and skin samples from 3000 donors, many of whom suffer from untreatable medical conditions, and place them in a Repository accessible to scientists around the world. (ca.gov)
Our lab has been tasked with converting control and patient blood or skin cells, collected by scientists throughout the state of California, into high quality iPSCs. (ca.gov)
These lines are being used to produce large Distribution Banks that will be made available to scientists globally. (ca.gov)
Some of the most serious A significant hurdle to this use and most uses of stem cells is that scientists do not yet it may become possible to generate healthy What specific types of conditions can stem cell therapy help treat? (curtisrobertmacdonald.com)
Scientists at Seoul National University, led by stem cell researcher Byeong-Chun Lee, successfully created a set of transgenic puppies: beagles which carry a red fluorescent gene from glowing sea anemones. (ebaumsworld.com)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
Horses suffering from neurological conditions similar to those that affect humans could be helped by a breakthrough from stem cell scientists. (sciencedaily.com)
Horse stem cells have been produced in the laboratory before but this is the first time that scientists have created working cells of a specific type from them. (sciencedaily.com)
A protein that is necessary for the formation of the vertebrate brain has been identified by researchers at the Harvard Stem Cell Institute (HSCI) and Boston Children's Hospital, in collaboration with scientists from Oxford and Rio de Janeiro. (scitechdaily.com)
The researchers say the finding, which has been successfully demonstrated in frog embryos, will help scientists control the differentiation of various cell types. (scitechdaily.com)

A linkurl:report;http://stemcells.alphamedpress.org/cgi/reprint/2007-0252v1.pdf published online today that researchers have cloned human embryos is not that much of an advance, according to one stem cell expert, Douglas Melton, at Harvard University. (the-scientist.com)
Using eggs from adult women who had previously donated for successful fertility treatments, the researchers used SCNT to transfer DNA into the egg cells. (the-scientist.com)
In a 2013 Pew Research Center poll , half of all adults surveyed (50%) said that by 2050 researchers will be able to use cloning to bring back extinct species, with 48% predicting such a development won't occur. (pewresearch.org)
While an international framework to regulate cloning remains stalled in the United Nations, some Asian countries are offering more stable climates for researchers to pursue their work. (publicintegrity.org)
Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)
Researchers are making great strides with hair cloning, but I have no idea how many years it's going to be before anything reliably safe and effective is commercially available. (baldingblog.com)
From observing this process over the years, the researchers developed a hunch that one reason rodent hair transplants easily is because once they are in culture, rodent skin papillae tend to spontaneously aggregate, unlike human papillae. (medicalnewstoday.com)
The pig had been genetically edited to avoid the human intolerable sugar and immune system attack.For this procedure, the researchers had kept a diseased woman's body on a ventilator after her family had agreed to the experiment. (er-journal.com)
Advancing to the 20th century researchers were already attempting transplants of organs from baboons to humans. (er-journal.com)
hero" is the right word for how Hwang Woo-suk is revered by the media -- and by a large section of the Korean public who have bought into the false promises of embryonic stem cell and cloning researchers. (blogspot.com)
A Korean television station whose investigative report was the nail in the coffin that prompted human cloning scientist Hwang Woo-suk to admit he lied about egg donations his researchers made says he may have lied about the results of his research as well. (blogspot.com)
Through moving findings between monkey cells and human cells, the researchers were able to develop a successful method. (ohsu.edu)
Little has been produced except massive grants for the researchers. (freerepublic.com)
After more than 25 years of experiments with embryonic stem cells in animal models, researchers have yet to develop one successful treatment in mice for any disease that could be used as a model to undertake the first steps for a clinical trial with human patients. (freerepublic.com)
However, his results and improved methods inspired researchers at The Roslin Institute to use nuclear transfer to clone sheep and produce Dolly the Sheep, the first animal to be cloned from an adult cell. (ed.ac.uk)
Researchers create embryonic stem cells mature cells turn off some of the epigenetic controls that Stem Cell Science Frequently Asked Questions. (curtisrobertmacdonald.com)
The researchers created 342 mini-brains using stem cells and pre-existing neural tissue, 72% of which sprouted optic cups. (ebaumsworld.com)
Researchers at Duke University, fed up with the distinct lack of experiment-ready human lungs available, have developed mini-lungs (similar to the mini-brain and mini-heart) that almost exactly replicate alveoli, the small air-sacs inside lungs that permit molecular transmission into the bloodstream. (ebaumsworld.com)
Researchers at Sichuan University have developed a way to manufacture ears INSIDE mice by injecting them with a "bio-ink" made of hydrogel particles and cartilage cells and then shining ear-shaped light patters onto the injection site. (ebaumsworld.com)
Researchers can make various cell types out of them, whether nerve cells or pancreatic islet cells, and these could, in theory, be used to treat diseases like Parkinson's or diabetes. (archokc.org)
Researchers claim that synthetic embryos could be used to help them unlock the mysteries of very early human development and address early pregnancy loss. (archokc.org)
Researchers who are the first to create working nerve cells from horse stem cells say the advance may pave the way for cell therapies that target conditions similar to motor neuron disease. (sciencedaily.com)
The researchers took skin cells from a young horse and turned them into stem cells using a technique that was originally developed for human cells. (sciencedaily.com)
15, 2021 Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. (sciencedaily.com)
Researchers from the Harvard Stem Cell Institute have identified a vital protein that can help determine embryonic development. (scitechdaily.com)
In collaboration with researchers from University of Oxford and Federal University of Rio de Janeiro, He and colleagues compared how frog embryos - which are considered models for human embryos - developed with and without Notum. (scitechdaily.com)
These findings could benefit stem cell researchers trying to create specific tissue types or organs in the lab. (scitechdaily.com)
In order to guide or direct stem cells to differentiate into a given cell type, such as neural cells or muscle cells, researchers continue to alter their experimental recipes, fine-tuning which molecules should be added to their dishes in what sequence and amount. (scitechdaily.com)
For those trying to create neural cells, "Notum is a necessary ingredient and new tool in the kit box for researchers to instruct human progenitor cells to become neural tissues," said He, who is also an American Cancer Society research professor. (scitechdaily.com)
Additionally, the researchers were able to demonstrate how Notum deactivates Wnt, which is a family of proteins that direct stem cells to "self-renew," or make more stem cells, among other things. (scitechdaily.com)
In 2000 ACT researchers in the United States cloned a gaur (Bos gaurus), an Asian ox with a then declining wild population. (asu.edu)
Japanese researchers are creating a human-animal hybrid. (jstor.org)
To create a chimaera, researchers inject stem cells from one organism into a mutant strain of a different organism. (jstor.org)
Researchers have successfully tricked Google's Cloud Video Intelligence application programming interface into identifying a video about gorillas as one dealing with an unrelated topic. (acm.org)
Researchers have developed flexible, inkjet-printable memory cells they say could lead to mass-produced printable electronics. (acm.org)

In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. (wikipedia.org)
Still, a majority of adults (60%) say cloning animals like Dolly is morally wrong, compared with 34% who say it's morally acceptable. (pewresearch.org)
Those were side effects during the process that led to the cloning of Dolly the sheep. (wtnnews.com)
When the world learned in 1997 of Dolly the sheep, the first clone produced from an adult mammal, a broad public discussion about the ethics of human cloning ensued, largely focused on the nature, meaning, and future of human procreation. (thenewatlantis.com)
It became a hot topic in 1996 when Dolly the sheep was cloned via a process called somatic cell nuclear transfer. (archstl.org)
From a cell in adult ewe's mammary gland, Wilmot and his colleagues managed to create a frisky lamb named Dolly, scoring an advance in reproductive technology as unsettling as it was startling (Anibeze 2007).Unlike offspring produced in the usual fashion, Dolly does not merely take after her biological mother, she is indeed a carbon copy, a laboratory counterfeit so exact that she is indeed her mother/s identical twin. (er-journal.com)
Professor Sir Ian Wilmut was part of a team at the Roslin Institute at the University of Edinburgh which successfully cloned Dolly in 1996. (stv.tv)
Tributes have been paid to the scientist who led the team which cloned Dolly the sheep 27 years ago after he died at the age of 79. (stv.tv)
Dolly was the first mammal to be cloned from an adult cell, but not the first ever sheep to be cloned. (stv.tv)
Prof Wilmut hoped cloning would mean no species became extinct - but Dolly also helped to pioneer stem cell research. (stv.tv)
Ian led the research team that produce the first cloned mammal in Dolly. (stv.tv)
He was a titan of the scientific world, leading the Roslin Institute team who cloned Dolly the sheep - the first mammal to be cloned from an adult cell - which transformed scientific thinking at the time. (stv.tv)
Together, Gurdon's and the Dolly team's successes introduced the concept of reprogramming the DNA of specialized cells to be able to make new organisms or new stem cells. (ed.ac.uk)
Although many species produce clonal offspring in this fashion, Dolly, the lamb born in 1996 at a research institute in Scotland, was the first asexually produced mammalian clone. (who.int)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
is a British developmental biologist who was the first to use nuclear transfer of differentiated adult cells to generate a mammalian clone, a Finn Dorset sheep named Dolly, born in 1996. (mathisfunforum.com)
Sir Ian Wilmut, the scientist who led the team that cloned Dolly the sheep in 1996, has died at 79. (yahoo.com)
Dolly was the first successful cloning of a mammal from an adult somatic cell, demonstrating the viability of somatic cell nuclear transfer (SCNT). (yahoo.com)
A year before Dolly, he successfully cloned two lambs (Megan and Morag) whose cells were taken from sheep embryos. (yahoo.com)
While Dolly proved that cells could be used to create a copy of the animal they came from, Wilmut's next experiment proved that they could also be altered. (yahoo.com)

The Threat of Human Cloning concludes by calling for laws prohibiting both human cloning and the creation of embryos for research. (thenewatlantis.com)
China enacted regulations early this year to allow the cloning of human embryos for research, and South Korea enacted similar legislation to allow research days ahead of the February announcement. (publicintegrity.org)
Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)

Twenty years ago today, the world's first clone made from the cells of an adult mammal made her public debut. (pewresearch.org)
Dolly's successful birth in 1996 marked the first time a mammal was successfully cloned from an adult cell. (yahoo.com)
Polly, born in 1997, was the first genetically modified cloned mammal. (yahoo.com)

The egg is now viable and capable of producing an adult organism containing all necessary genetic information from just one parent. (wikipedia.org)
These cells genetically matched the donor organism from which they came. (wikipedia.org)
These cells are deemed to have a pluripotent potential because they have the ability to give rise to all of the tissues found in an adult organism. (wikipedia.org)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
This observation led to the belief that the DNA in specialised cells was 'fixed' and could not be used to produce a new organism. (ed.ac.uk)
On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)
The science fiction definition of "clone" suggests that the cloned organism would be an exact genetic copy of another creature-human or beast-created in the laboratory by any of a number of means. (all.org)
There are differences-so much so that despite the "exact copy" claim, the cloned organism is actually unique genetically. (all.org)

The genetic material of the donor egg cell is removed and discarded, leaving it 'deprogrammed. (wikipedia.org)
Part of the reason is that cloning can introduce profound genetic errors , which can result in early and painful death. (pewresearch.org)
This form of genetic engineering would deny the children it produces an open future, burdening them with the expectation that they will be like the individuals from whom they were cloned. (thenewatlantis.com)
And cloning could make possible still more dramatic forms of genetic engineering. (thenewatlantis.com)
And when they tested the DNA of the new hair follicles that had been generated in each transplant, the team found it was human and a genetic match to that of the donors. (medicalnewstoday.com)
These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)
It involves transplanting the nucleus of one cell, containing an individual's DNA, into an egg cell that has had its genetic material removed. (ohsu.edu)
Furthermore, because these reprogrammed cells can be generated with nuclear genetic material from a patient, there is no concern of transplant rejection," explained Dr. Mitalipov. (ohsu.edu)
Metaphase is a stage in the cell's natural division process (meiosis) when genetic material aligns in the middle of the cell before the cell divides. (ohsu.edu)
The offspring having all of the mother's genetic material are called full clones and those having only half are called half clones. (alchetron.com)
The UK Draft Human Tissue and Embryos Bill, published recently, explicitly covers a number of uses of preimplantation genetic diagnosis (PGD). (progress.org.uk)
Stem Cells Potential Uses Stem Cells Genetic Engineering. (curtisrobertmacdonald.com)
Most natural cloning occurs in those species that produce their descendants asexually, that is, without combining the male and female genetic material. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
Recent reports suggest it may now be possible to generate "synthetic embryos" from embryonic stem cells through various manipulations, including genetic reprogramming steps and mixing various cell types together, without the need for sperm and egg. (archokc.org)
No two stem cells are identical, even if they are genetic clones. (acm.org)

In fact, human papillae, when grown in a laboratory culture, can act as "mesenchymal stem cells" and differentiate into a variety of cell types. (bernsteinmedical.com)
RepliCel Life Sciences Inc. today announced that it has been granted a patent by Japan's Ministry of International Trade and Industry for hair follicle mesenchymal stem cells and their use thereof. (baldingblog.com)
Some unipotent stem cells, such as mesenchymal stem cells. (curtisrobertmacdonald.com)
Stem cell research and ethical dilemmas: How far have The two possible suggestions to counteract this slope is to either Stem cell uses have advanced, Some unipotent stem cells, such as mesenchymal stem cells. (curtisrobertmacdonald.com)

This gives them the ability to create patient specific pluripotent cells, which could then be used in therapies or disease research. (wikipedia.org)
Embryonic stem cells are known as pluripotent stem cells. (healthline.com)
These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
In 2006, Shinya Yamanaka and Kazutoshi Takahashi successfully reprogrammed specialised cells into induced pluripotent (iPS) cells. (ed.ac.uk)
First year progress on grant ID1-06557, " Generation and Characterization of High-Quality, Footprint-Free Human Induced Pluripotent Stem Cell (iPSC) Lines From 3000 Donors to Investigate Multigenic Disease" has met all agreed-upon milestones. (ca.gov)
Since human induced pluripotent stem cell (iPSC)-platelet products can be supplied independently from the donor, it is expected to complement current platelet products. (biomedcentral.com)
The reprogrammed cells are pluripotent, which means they can be induced to become any type of cell in the body. (sciencedaily.com)
Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells. (sciencedaily.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)

Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
To induce differentiation and maturation of the immortalized cell lines, terminating the HPV-E6/E7 expression through a gene induction system has been believed to be essential. (lu.se)
Here, we report that erythroid cell lines established from human bone marrow using simple expression of HPV-E6/E7 are capable of normal erythroid differentiation, without turning gene expression off. (lu.se)
Upon differentiation, other ELLU clones shift from fetal to adult hemoglobin expression, giving rise to more mature cells. (lu.se)
Our findings propose that it is not necessary to employ gene induction systems to establish immortalized erythroid cell lines sustaining differentiation potential and describe novel cellular characteristics for desired functionally competent clones. (lu.se)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)

However, once the dermal papilla cells are put into conventional, two-dimensional tissue culture, they revert to basic skin cells and lose their ability to produce hair follicles. (medicalnewstoday.com)
So they tested their idea by harvesting dermal papillae from seven human donors and cloned them in tissue culture - without adding any additional growth factors. (medicalnewstoday.com)
After a few days, they transplanted the papillae clones, which had formed into three-dimensional "spheroids" in the tissue culture, between the dermis and epidermis of human skin that had been grafted onto the backs of mice. (medicalnewstoday.com)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
Three days ago the science journal Nature reported that mouse tissue cells in the US and Japan were turned into embryonic-type stem cells without the use of eggs or embryos. (freerepublic.com)
Procedures for the shipping, infectious disease testing, and processing of donor samples were successfully implemented with the seven Tissue Collectors. (ca.gov)
If there are intact cells in this tissue they have been 'stored' frozen. (wikiquote.org)
A blastocyst (cloned or not), because it lacks any trace of a nervous system, has no capacity for suffering or conscious experience in any form - the special properties that, in our view, spell the difference between biological tissue and a human life worthy of respect and rights. (wikiquote.org)
Using 3D scans of the real thing, doctors 3D-printed a "scaffolding" on which stem cells and a tissue sample were added before placing them in a bioreactor. (ebaumsworld.com)
Obtaining stem cells from fatty tissue, bone marrow, or the umbilical cord after the birth of a baby, on the other hand, may be done ethically. (all.org)
Direct transfer of tissue between animals and humans raises concerns about animal diseases crossing over to humans, potentially threatening a large population. (jstor.org)
They note that even if human tissue somehow migrated to an animal's developing brain, it would still probably develop as animal brain tissue. (jstor.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

Although the latest scientific work related to cloning has been focused on potential medical applications, much of that research is relevant to the creation of cloned children. (thenewatlantis.com)

The blastocyst stage is developed by the egg to help create embryonic stem cells from the inner cell mass of the blastocyst. (wikipedia.org)
The stem cells derived from the inner mass of a blastocyst lack the ability to form a fetus when implanted into a woman, but are self-renewing and can be maintained for long periods of time in the laboratory as undifferentiated stem cells. (jcpa.org)
In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. (frontiersin.org)

We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)

Another application of SCNT stem cell research is using the patient specific stem cell lines to generate tissues or even organs for transplant into the specific patient. (wikipedia.org)
not for stem cells but for organs and body parts," Right to Life's Sue Armacost was quoted as saying. (wtnnews.com)
Not that everyone would think producing human organs in a lab is evil, by the way, given that thousands of people die for lack of transplantable organs every year. (wtnnews.com)
Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
The Church also supports research and therapies using adult stem cells, which are cells that come from any person who has been born - including umbilical cord blood, bone marrow, skin and other organs. (archstl.org)
These stem cells come from developed organs and tissues in the body. (healthline.com)
The increasing life expectancy of humans has led to growing number of people with diseased organs. (er-journal.com)
Xenotransplantation is any procedure that involves the use of live cells, tissues or organs from a nonhuman source for transplantation, implantation or infusion into a human recipient. (er-journal.com)
The dream of transferring bodily organs from animals to humans goes back to antiquity, as articulated in the myth of Daedalus and Icarus in Greek mythology. (er-journal.com)
By the 17th century the possibility of transferring animal organs to humans came into practice with stumbling attempts to use animal blood for transfusions. (er-journal.com)
Similarly, clinical use of animal organs such as the transplantation of a rabbit kidney to humans was documented in 1905 (Nagarian 2003). (er-journal.com)
Pigs have large litters, short gestation periods and organs comparable to humans. (er-journal.com)
This exotic biological engineering seems to have opened a vista of possibilities both for propagating endangered species and producing replacement organs for transplant patients. (er-journal.com)
doctors strip a donor penis of all its cells using some sort of f**ked up detergent, leaving behind a collagen "scaffold" and then plant smooth muscle cells (the stuff organs are made of) and endothelial cells (which regulate blood-flow and transmission between blood vessels and surrounding tissues). (ebaumsworld.com)
The ultimate goal of this type of work would be to grow human organs that are immune-compatible with recipients, thereby easing a major shortage of donor organs. (jstor.org)
The research, however, is a long way from producing human organs, if indeed it ever does. (jstor.org)
If this research is pursued, and especially if a working model of animal-human organs is developed, many animals will die. (jstor.org)
Creating human organs in chimaera pigs: an ethical source of immunocompatible organs? (jstor.org)

At the same time, labs in a variety of countries have successfully cloned human embryos for the purpose of producing stem cells that can be used in medical therapies. (pewresearch.org)
The Catholic Church has always held that stem-cell research and therapies are morally acceptable, as long as they don't involve the creation and destruction of human embryos. (archstl.org)
It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. (ohsu.edu)
This is a remarkable accomplishment by the Mitalipov lab that will fuel the development of stem cell therapies to combat several diseases and conditions for which there are currently no treatments or cures," said Dr. Dan Dorsa, Ph.D. , OHSU Vice President for Research. (ohsu.edu)
Vets around the world are already using stem cell therapies to treat horses for other types of conditions. (sciencedaily.com)
Our research is an important step towards realising that potential for horses and provides an opportunity to validate stem-cell based therapies before clinical studies in humans. (sciencedaily.com)
Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a significant alternative in future transfusion therapies. (lu.se)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

The basic strategy for repairing damaged tissues is to surgically transfer embryonic stem cells to the damaged area, where the stem cells can form healthy replacement cells. (biologywriter.com)
In theraputic cloning, the body readily accepts stem cells because they are cloned from its own tissues, and so pass the immune system s self identity check. (biologywriter.com)
iii potential uses of stem cells for generating human tissues and, Although it is not possible to What are the potential applications of cloning animals? (curtisrobertmacdonald.com)
In a 2012 letter to Children of God for Life, PepsiCo stated that "Senomyx does not use HEK cells or any other tissues or cell lines derived from human embryos or babies for research performed on behalf of PepsiCo. (hli.org)

In human SCNT experiments, these eggs are obtained through consenting donors, utilizing ovarian stimulation. (wikipedia.org)
For example, if a person with Parkinson's disease donated their somatic cells, the stem cells resulting from SCNT would have genes that contribute to Parkinson's disease. (wikipedia.org)
Only a handful of the labs in the world are currently using SCNT techniques in human stem cell research. (wikipedia.org)
The technique used by Drs. Mitalipov, Paula Amato, M.D. , and their colleagues in OHSU's Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT. (ohsu.edu)

The technique consists of taking an denucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. (wikipedia.org)
The resulting cells would be genetically identical to the somatic cell donor, thus avoiding any complications from immune system rejection. (wikipedia.org)
If reliable hair cloning ever does come about to allow for unlimited donor hair, I could see possibly more people having their existing hair thickened. (baldingblog.com)
This method offers the possibility of inducing large numbers of hair follicles or rejuvenating existing hair follicles, starting with cells grown from just a few hundred donor hairs. (medicalnewstoday.com)
However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
By the end of year three, we have generated iPSC clones from 1737 donor samples (out of 2670 received). (ca.gov)
Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)
The idea of, say, a pig with a human mind being used as an organ donor is horrifying. (jstor.org)
If living cells from mouse strain CBA were injected into an adult mouse of strain A, some immunologic process destroyed the CBA cells, and the A-line mouse that received the CBA cells quickly destroyed any subsequent graft from the same donor strain. (medscape.com)

Higgins and Jahoda describe how it has been known for decades, through the work of Lille and Wang and others, that rat dermal papillae self-organize into new hair-producing follicles when they are injected or grafted into the skin. (bernsteinmedical.com)

Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
They can differentiate into all types of specialized cells in the body. (healthline.com)
The breakthrough has created a way to "de-differentiate" the stem cells. (healthline.com)
Through simply changing cell culture conditions, a newly established cell line, Erythroid Line from Lund University (ELLU), is able to differentiate toward mature cells, including enucleated reticulocytes. (lu.se)
ELLU is heterogeneous and, unexpectedly, clones expressing adult hemoglobin rapidly differentiate and produce fragile cells. (lu.se)

Human dermal papilla cells, on the other hand, have never exhibited what they call the "aggregation phenomena," and instead they disperse in the skin in what appears to be a wound healing mechanism. (bernsteinmedical.com)
Hair growth in adults occurs naturally in a process known as hair neogenesis â€" where cells called dermal papilla cells that span the top two layers of skin coax surrounding cells to form hair follicles. (baldingblog.com)
We also need to establish the role of the host epidermal cells that the dermal papilla cells interact with, to make the new structures. (medicalnewstoday.com)

Cloning-for-biomedical-research also endangers the health and safety of the women called on to undergo dangerous hormone treatments to serve as egg donors. (thenewatlantis.com)
The developments utilizing adult stem cells, however, have been truly amazing with medical treatments (not mere potential or grand promises) already helping thousands of people. (blogspot.com)
While there is much work to be done in developing safe and effective stem cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine. (ohsu.edu)
Claims that you could clone individual treatments of human beings to treat common diseases like diabetes, suggests you need a huge supply of human eggs. (wikiquote.org)
The efficacy of these treatments has not been completely proven and they use adult stem cells, which are harder to maintain and are more restricted in the types of cells that they can become. (sciencedaily.com)

For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
Platelets are released from megakaryocytes (MKs) in the bone marrow and circulate as anucleate blood cells with a diameter of about 2-4 μm. (biomedcentral.com)

Although these experiments were successful when Briggs and King used unspecialised cells, they found that they could not make cloned frogs when they used more specialised cells. (ed.ac.uk)
While his tadpoles matured to fully functioning adult frogs at the time, subsequent experiments trying to clone frogs using fully adult cells only produced tadpoles that did not mature. (ed.ac.uk)
During the the 30's, Ferdinando Cazzamalli conducted experiments to highlight existence of electromagnetic radiation produced by brain electrical activity . (remote-neural-monitoring.com)
Human cloning is a reality, with human cloning experiments now being conducted-not by fictional wild-eyed rebels, but by credentialed experts working in some of the world's most respected institutions, some of which are publicly funded with tax dollars. (all.org)

Wilmut moved to the University of Edinburgh the following decade, focusing on using cloning to make stem cells for regenerative medicine. (yahoo.com)

A new controversy is brewing over government backing of Ebola vaccines that are using aborted fetal cell lines even though vaccines developed from moral alternatives are just as effective. (womenofgrace.com)
Which Cosmetics Use Fetal Cells? (hli.org)
However, regardless of how strongly you support life, you may unknowingly be cooperating in aborted fetal cell research by purchasing products that use aborted fetuses either in the product itself or in its development. (hli.org)
Your children might enjoy using coffee creamers and eat soup with artificial flavor enhancers (Senomyx and Firmenich) tested on artificial taste buds engineered from aborted fetal cells. (hli.org)
To do this, they had to produce an army of never-tiring taste testers - that is, flavor receptors engineered from human embryonic kidney cells (HEK-293, a fetal kidney cell line popular in pharmaceutical research). (hli.org)
The merge does not seem to have stopped the use of aborted fetal cells in development. (hli.org)
The fetal skin cell line that PSPs are based on was taken from an electively aborted baby whose body was donated to the University. (hli.org)
The Vaccine Chart of the Sound Choice Pharmaceutical Institute (SCPI) lists dozens of vaccines and medical products that contain aborted fetal cell lines. (hli.org)

Doctors at the Wake Forest Institute for Regenerative Medicine successfully created fully-functioning vaginal implants for four women in the US born with vaginal aplasia, a condition in which the vagina fails to form properly in the womb. (ebaumsworld.com)
The same team from the Wake Forest Institute for Regenerative Medicine, after finding success with their lab-grown vaginas, are approaching readiness to begin human testing for lab-grown penises. (ebaumsworld.com)

For example, iPSC lines from patients with heart disease can be converted into heart cells, iPSC lines from patients with Alzheimer's disease can be converted to brain cell, and iPSC lines from patients with pulmonary fibrosis can be converted into cells of the lung. (ca.gov)
Based on these developments, we initiated the first-in-human clinical trial of iPSC-derived platelets to a patient with alloimmune platelet transfusion refractoriness (allo-PTR) using an autologous product. (biomedcentral.com)
That's what led me by the nose to genetics-because if you're going to focus on something, the best lens to use initially is human genetics, and from human genetics to IPSC and the genome editing tools that we use today in the lab. (medscape.com)

4 The public is divided about the prospect of using cloning to bring back to life species of animals that are currently extinct , such as the carrier pigeon or even the woolly mammoth. (pewresearch.org)
Previous unsuccessful attempts by several labs showed that human egg cells appear to be more fragile than eggs from other species. (ohsu.edu)
In 1958, Gurdon showed otherwise by making clones using specialised cells from the intestines of tadpoles of a different species ( Xenopus laevis ). (ed.ac.uk)
Given that we have an efficiency of 1% cloning for livestock species and if only one in a thousand cells are viable then around 100,000 cells would need to be transferred. (wikiquote.org)

It would be hard to call this a major advance," Douglas Melton, a stem cell researcher at Harvard University, told The Scientist in an Email. (the-scientist.com)
Alzheimer's researcher Ned Potter said, however, that human embryonic stem cell research would not help the Alzheimer's patient at all. (all.org)

Research is underway to find ways to produce iPSCs safely. (healthline.com)
iPSCs have the great advantage that they can be generated from adults suffering from a known disease and then converted ("differentiated") into any cell type in the body. (ca.gov)
To overcome this issue, we established immortalized megakaryocyte cell lines (imMKCLs) by introducing three transgenes, c-MYC, BMI1, and BCL-XL, sequentially into hematopoietic and megakaryocytic progenitor stage cells derived from iPSCs. (biomedcentral.com)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)
We were right there in the race for the first human IPSCs. (medscape.com)

While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
Father Tad Pacholczyk is convinced that embryonic stem cells will someday cure diseases. (archstl.org)
Diseases or conditions that might be treated through stem cell therapy include Parkinson's disease, multiple sclerosis, cardiac disease and spinal cord injuries. (ohsu.edu)
information on stem cells, cloning and What diseases and conditions can be treated with stem cells? (curtisrobertmacdonald.com)
Potential benefits of stem of stem cells and the realization of these uses, Some of the potential uses of stem cells are to study the way cells function and hopefully that will lead to cures for various diseases like cancer. (curtisrobertmacdonald.com)
There are more than 70 diseases or conditions-including leukemia, immune system and other blood disorders, cancers, and autoimmune diseases-that respond well when adult stem cell therapy is used. (all.org)
believe the risk of either zoonotic diseases or developing human characteristics is low. (jstor.org)
He strived to create modified sheep that would produce milk with proteins that could treat human diseases. (yahoo.com)

The report offers an ethical and policy analysis, articulating what makes cloning morally repugnant and calling for the practice to be definitively prohibited in the United States. (thenewatlantis.com)
Adult stem cells don't present any ethical problems. (healthline.com)
The animal is produced mainly for food, so using them for organ supply raises fewer ethical concerns. (er-journal.com)
We now have the right mechanism for sourcing cells without ethical quibbles,' said Peter Mountford, head of the Melbourne- and London-based Stem Cell Sciences. (freerepublic.com)
a technique that could potentially help to resolve the ongoing ethical debate over stem cell research. (progress.org.uk)
Stem cell research and ethical dilemmas How far have we. (curtisrobertmacdonald.com)
At least two notable ethical concerns arise in the wake of this new technology: First, the use of unethically derived cell types in biomedical research, especially human embryonic stem cells, still remains a major concern. (archokc.org)
If they are, we have walked right into the ethical landmine of creating human beings solely to be exploited for research or experimental purposes. (archokc.org)
New progress in stem-cell research raises some thorny ethical questions. (jstor.org)

Cloning-for-biomedical-research is also profoundly unethical, as it turns human reproduction into a manufacturing process in the most literal sense: human embryos are created to serve as raw materials for the production of biomedical research supplies. (thenewatlantis.com)
MPs may have voted for stem cell research, but it is unethical and a scientific dead end, writes Cardinal George Pell. (freerepublic.com)

The United States currently has no comprehensive law, and legislation that would have banned both research and reproductive cloning has failed to reach a vote in the Senate after approval in the House of Representatives in July 2001. (publicintegrity.org)

General Assembly the following year,3 and the World Medical Association's Resolution on Cloning, endorsed in 1997, have confronted the issue but lack binding legal force. (who.int)

In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)
Specifically, many wondered: If they're doing sheep now, how long until they clone humans? (yahoo.com)
His team spliced the host's genes with a human gene to create a sheep that would produce a protein missing from people with hemophilia. (yahoo.com)

A potential use of stem cells genetically matched to a patient would be to create cell lines that have genes linked to a patient's particular disease. (wikipedia.org)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
4 , 5 , 6 The idea, however, that miRNAs may play an important role in some human disease/disorders is gaining momentum, and as these molecules have the ability to silence many genes simultaneously, dysregulation of even a single miRNA can have a significant polygenic effect. (nature.com)
It involves introduction of modified DNA into embryonic stem-cells, which will take up the DNA and hopefully express the desired genes. (freeonlineresearchpapers.com)
The approach was applied to five different hybridomas producing human monoclonal antibodies and variable regions for both bold gamma and mu heavy chain and kappa and lambda light chain genes were successfully cloned. (lu.se)

The dramatic increase in efficiency - more than one cell line for every 20 attempts - could pave the way for treating conditions such as diabetes and spinal cord injury with stem cell transplants. (wtnnews.com)

Briggs and King were the first to perform cloning by nuclear transfer using eggs and cells from the Northern Leopard Frog, Rana pipiens . (ed.ac.uk)
Recent figures released by the UK fertility regulator, the Human Fertilisation and Embryology Authority (HFEA), show a tenfold plus increase in women over 40 seeking fertility treatment using their own eggs. (progress.org.uk)
Even if you don't have a religious view of the sanctity of life, you have to ask is there going to be a massive trade in human eggs from poor women to rich countries. (wikiquote.org)
We describe instances of malformed nematode eggs (primarily from members of the superfamily Ascaridoidea) from human clinical practice and experimental trials on animals. (cdc.gov)

As the fertilized egg divides from one cell into two, physicians can separate these two cells and implant each one of them into a woman's uterus to generate two genetically identical children. (jcpa.org)
In biology , cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria , insects or plants reproduce asexually . (wikiquote.org)
Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)

Japan subsequently enacted legislation in late 2000 criminalizing the cloning of human embryos for reproductive purposes. (publicintegrity.org)

The process of somatic cell nuclear transfer involves two different cells. (wikipedia.org)

Not only would cloning-to-produce-children be a dangerous experimental procedure, one that cannot be consented to by its subjects (the children created by it), it is also a profound distortion of the moral meaning of human procreation. (thenewatlantis.com)
7. "[footnote 16]: The cloning procedure supplies the oocyte with a complete set of chromosomes, all of which are contained in the nucleus which is transferred into the denucleated oocyte. (lifeissues.net)

Cloning-to-produce-children could also be used to attempt to control the physical and even psychological traits of children, extending the eugenic logic of those who would use reproductive biotechnology to have the perfect child. (thenewatlantis.com)
China has reportedly been increasing its funding for cloning and other biotechnology research efforts. (publicintegrity.org)
Cloning in biotechnology refers to processes used to create copies of DNA fragments ( molecular cloning ), cells (cell cloning), or organisms . (wikiquote.org)
Developments in biotechnology have raised new concerns about animal welfare, as farm animals now have their genomes modified (genetically engineered) or copied (cloned) to propagate certain traits useful to agribusiness, such as meat yield or feed conversion. (wikiquote.org)
Advanced Cell Technology (ACT), a stem cell biotechnology company in Worcester, Massachusetts, showed the potential for cloning to contribute to conservation efforts. (asu.edu)

Neither should anyone be tricked into believing that opponents of this bill are insensitive to human suffering or inactive in the search for cures. (freerepublic.com)

The U.S. Food and Drug Administration (FDA) has approved the world's first human clinical trial of a therapy involving embryonic stem cells, a move that has been condemned by the Vatican as "unacceptable. (womenofgrace.com)
This patent approval is an important milestone as RepliCel's licensing partner, Shiseido Company, prepares to conduct human clinical trials using RCH-01. (baldingblog.com)
Meanwhile, in the US alone there are currently 1422 government-approved clinical trials related to adult stem cells either on patients or recruiting patients. (freerepublic.com)
Blood Stem Cells Clinical Trials Cord Blood Eye Disease. (curtisrobertmacdonald.com)
Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)

The term applies not only to entire organisms but also to copies of molecules (such as DNA) and cells. (who.int)

The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)

2 Eight-in-ten American adults (81%) say cloning a human being is not morally acceptable, according to a May 2016 Gallup poll . (pewresearch.org)
Just 13% of adults in 2016 say cloning is morally acceptable. (pewresearch.org)

It will be recalled that in 1998, a British embryologist became the first living proof to show that an adult cell can revert to embryonic stage and produce a full new being. (er-journal.com)
It is always and in every case morally wrong to intentionally kill an innocent human being at any point in life, including the embryonic stage of development. (all.org)

The New Atlantis is building a culture in which science and technology work for, not on, human beings. (thenewatlantis.com)
human beings have developed innovative technologies to treat and cure disease, to enhance human living conditions, and to protect or improve the environment. (jcpa.org)
Elaboration of an international convention against reproductive cloning of human beings has been under consideration in the United Nations since December 2001 when the subject was included in the agenda of the fifty- sixth session as a supplementary agenda item at the request of France and Germany. (who.int)
New human beings are entitled to the respect of entering the world only through the marital embrace. (archokc.org)
A stem cell is a type of cell found throughout the body of all human beings. (all.org)
If you're armed with the facts, you can defend millions of embryonic human beings, and maybe even help celebrities and media figures learn the truth. (all.org)

During a recent appearance on the Oprah Winfrey show, the popular cardiovascular surgeon and television personality, Dr. Mehmet Oz, announced to a stunned audience that due to advances in adult stem cell technology, the debate over embryonic stem cells "is dead. (womenofgrace.com)
Despite the many advances in adult stem cell research, the federal and Victorian parliaments have already passed bad legislation legitimising the destruction of human embryos. (freerepublic.com)

In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
They don't have eight legs, but they have spider DNA in every single one of their cells and, more importantly, produce spider-silk proteins in their milk that visible and can be collected as the real mccoy. (ebaumsworld.com)
[ 5 ] The Fc region of IgG facilitates interaction with and signaling through Fc receptors on phagocytes, B cells, and other cells and with Fc-binding plasma proteins (eg, components of the complement system). (medscape.com)

However, by the time the fertilized egg divides into 8 or 16 cells something changes and each respective cell, if separated, no longer has the potential to create a fetus. (jcpa.org)
If hair cloning is a viable option in the future (perhaps in 15-20 years since I know the time line keeps moving every year) would you expect to see a large number of people elect to have a hair transplant for the sole reason of increasing overall hair density? (baldingblog.com)
For the first time, new human hairs have been coaxed into growing from specialised skin cells that can be multiplied in number to potentially create a full head of hair. (baldingblog.com)
However, if we think back to what actually happened to the animal - it died, even if from the cold, the cells in the body would have taken some time to freeze. (wikiquote.org)
This time lag would allow for breakdown of the cells, which normally happens when any animal dies. (wikiquote.org)
The marketplace for this human trafficking is the Metaverse , a Digital World powered by an advanced 3D engine and populated by Digital Avatars fed with real time brain imaging data. (remote-neural-monitoring.com)
Stem cells can reproduce themselves over a long period of time without changing. (all.org)
Therefore, it is speculated that those who support human embryonic stem cell research are clamoring loudly for taxpayer dollars because private companies know human embryonic stem cell research is neither worth their time nor their money. (all.org)
On the other hand, research involving adult stem cells has not only been around for a long time, it has also been used successfully for decades! (all.org)
In 1969, more than ten years after the first attempts to treat infertilities with IVF technologies, the British developmental biologist Robert Geoffrey Edwards fertilized human oocytes in a Petri dish for the first time. (asu.edu)
Recently, two baby monkeys were cloned-the first time primates have been successfully duplicated. (jstor.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

The process known as "DNA cloning," "molecular cloning" or "gene cloning" has been used widely since the 1970s. (wtnnews.com)
In times of stress, offspring produced by sexual reproduction may be fitter as they have new, possibly beneficial gene combinations. (alchetron.com)
Most common and most controversial is embryonic stem-cell mediated gene transfer. (freeonlineresearchpapers.com)
The ectopic expression of human papilloma virus (HPV) E6/E7 gene has successfully been employed to establish these cell lines. (lu.se)

A thorough examination of the stem cells derived through this technique demonstrated their ability to convert just like normal embryonic stem cells, into several different cell types, including nerve cells, liver cells and heart cells. (ohsu.edu)
In Alzheimer's, it is the degeneration of the nerve cells that cause the problem because they lose their ability to connect with each other. (all.org)
The team used them to create nerve cells in the laboratory and tested whether they were functional by showing that they could transmit nerve signals in a test tube. (sciencedaily.com)
Ganglia are clusters of nerve cells, from which nerve fibers emerge. (asu.edu)

This kind of cloning is today being performed at several scientific labs in the United States, despite the availability of alternative techniques that produce cells of nearly the same scientific and medical value but that require neither the creation nor destruction of human embryos. (thenewatlantis.com)

The debate over stem cell research is complicated enough without "sci-fi" claims that mislead policymakers and the public. (wtnnews.com)

Dolly's debut set off a firestorm about both the practical value and ethics of cloning, including the possibility of human cloning. (pewresearch.org)
Doyle and a significant number of legislators from both parties simply want to hold open the possibility of continuing all forms of stem cell research in Wisconsin, the state that pioneered the process less than 10 years ago. (wtnnews.com)
Gurdon's results surprised the scientific community and stirred talk of the possibility of cloning other animals, including humans. (ed.ac.uk)

When Notum was not present, the embryos would become a sack of skin cells with no head and a tiny brain, a result of embryonic progenitor cells making only epidermal but not neural cells. (scitechdaily.com)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

Xenotransfusion of blood from lambs to humans were recorded as far back as 1667 (Aristizabal et al 2017). (er-journal.com)

Anatomy59

Organisms15

Diseases8

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes58

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Embryo57

Therapeutic19

Scientists41

Researchers35

Dolly20

Embryos for research3

Mammal3

Organism8

Genetic17

Mesenchymal stem4

Pluripotent11

Differentiation7

Tissue14

Creation of cloned1

Blastocyst3

Harvard Stem Cell Institute1

Organs18

Therapies8

Tissues4

SCNT4

Donor9

Hair-producing1

Differentiate6

Dermal papilla cells3

Treatments5

Bone marrow7

Experiments4

Wilmut1

Fetal8

Regenerative medicine2

IPSC3

Species4

Researcher2

IPSCs5

Diseases8

Ethical9

Unethical2

Research and reproductive1

19971

Sheep3

Genes5

Transplants1

Eggs4

Genetically identical3

Reproductive purposes1

Involves1

Procedure2

Biotechnology5

Cures1

Clinical9

Organisms1

Adult somatic cell1

Morally acceptable2

Embryonic stage2

Beings6

Advances in adult stem2

Proteins3

Time12

Gene4

Nerve cells4

Destruction of human embryos1

Debate over stem cell res1

Possibility3

Progenitor cells2

Lambs1