Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
CD20-transduced T cells with and without co-transferred T-cell receptor were efficiently eliminated by complement dependent cytotoxicity induced by therapeutic anti-CD20 antibody rituximab. (haematologica.org)
T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
In 1989, Zelig Eshhar and colleagues realized that the inability of T cells to recognize surface tumour antigens could be overcome by replacing domains of the T cell receptor (TCR) with antibody parts with specificity towards proteins on these cells. (nature.com)
There remains an urgent need for the noninvasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor functionality. (snmjournals.org)
Findings from their preclinical study lay the groundwork for a new approach to targeting folate receptor alpha (FR⍺), an antigen commonly present in epithelial ovarian cancer and associated with advanced disease, chemotherapy resistance and disease relapse. (ecancer.org)
Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
The development of chimeric antigen receptor T cells has provided hope for patients with hematologic malignancies, but their commercial use has been limited to an option of last resort. (richardvigilantebooks.com)
Currently many stem or progenitor cell therapies including T cell receptor (TCR) or chimeric antigen receptor (CAR) focusing on epitopes indicated on malignant cells are under development for medical translation (17C20). (bioskinrevive.com)
BERLIN, Aug. 06, 2020 (GLOBE NEWSWIRE) -- T-knife GmbH, a next-generation adoptive T-cell company using its proprietary humanized T-cell receptor (HuTCR) mouse platform to treat solid tumors, announced today the closing of a €66 million Series A round of financing. (globenewswire.com)
T-knife is a next-generation adoptive T-cell company utilizing its proprietary humanized T-cell receptor (HuTCR) mouse platform technology to treat solid tumors. (globenewswire.com)
2007). Adoptive Transfer of Chimeric Antigen Receptor Re-directed Cytolytic T Lymphocyte Clones in Patients with Neuroblastoma. (igem.org)
We determined if adoptive transfer of natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donors may prolong event-free survival in children with intermediate-risk AML who were in first complete remission after chemotherapy. (biomedcentral.com)
The first evidence for the therapeutic effectiveness of natural killer (NK) cells in AML was established in a study of 57 adult patients, in which none of the 20 individuals who received haploidentical cell transplantation from a killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donor experienced disease relapse [ 2 ]. (biomedcentral.com)
Transferred T cells that persist in the blood and form memory have a phenotype consistent with a less differentiated state (CD27/CD28/IL-7 receptor-α) [ 3 ]. (biomedcentral.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Immunotherapy18
Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
ACT immunotherapy can result in complete and lasting therapeutic responses - no evidence of disease after treatment - for patients with other types of cancer, but so far it has been less successful against ovarian cancer. (ecancer.org)
We successfully applied this strategy to the human TAAs p53, gp100 and MDM2-specific TCRs as promising antigens-driven immunotherapy for both melanoma and hematologic malignancies. (unimedizin-mainz.de)
Adoptive immunotherapy using genetically engineered T cells seeks to induce expression of novel genes in cytotoxic T cells that facilitate tumor recognition, enhance T-cell activation, induce tumor-specific cytotoxicity, and/or augment immune memory. (richardvigilantebooks.com)
NK cells play a pivotal role in rapid and highly efficient cancer surveillance and represent a promising avenue for adoptive cell transfer either as a mono- or combination immunotherapy. (maxcyte.com)
This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Receptors9
They combined the variable region of an antibody with the constant regions of the TCR chains, thus producing chimeric antigen receptors (CARs) that provided T cells with antibody-type specificity. (nature.com)
Adoptive transfer of autologous T cells with chimeric antigen receptors (CARs) targeting CD19 has been very successful in treating relapsed and refractory CD19-positive diseases, such as non-Hodgkin lymphoma. (bethematchclinical.org)
Chimeric antigen receptors (CARs) endow T cells with antigen-specific recognition, activation, and proliferation independent of major histocompatibility complex ( 1 - 3 ). (snmjournals.org)
Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
CTLs can recognize malignant cells by interacting tumor antigens with the T cell receptors (TCR), and release cytotoxins as well as cytokines to kill malignant cells. (psu.edu)
Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)
Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors. (igem.org)
The inhibitory KIRs 2DL1 (CD158a), 2DL2/3 (CD158b), and 3DL1 (CD158e1) are such surface receptors and allow adoptively transferred donor NK cells to exert potent antileukemic effects if the cognate HLA class I ligands are absent in the recipients [ 3 ]. (biomedcentral.com)
The binding of specific T cell receptors (TCR) to major histocompatibility complex (MHC)/antigen complexes on cancer cells induces the TCR/CD3-mediated signal transduction pathway and stimulates the release of specific toxins (perforin and granzyme) for cancer elimination [ 6 , 7 ]. (biomedcentral.com)
Autologous6
3 Autologous lymphocytes genetically modified with the TCR for MART-1/Melan-A have been adoptively transferred to patients with advanced melanoma. (haematologica.org)
In 2010, James Kochenderfer and colleagues achieved a breakthrough with a CAR T cell therapy, reporting tumour regression in a patient with advanced follicular lymphoma, who received two infusions of autologous T cells genetically engineered to express a CAR specifically recognizing the antigen CD19 expressed on B cells. (nature.com)
Early studies on the transfer of unmodified autologous or allogeneic NK cells have established their clinical safety and demonstrated modest anti-tumor efficacy. (maxcyte.com)
This phase II trial studies the side effects and how well white blood cells taken from person's own (autologous) cluster of differentiation (CD)8+ antigen-specific T cells, cyclophosphamide, aldesleukin, and ipilimumab work in treating patients with melanoma that has spread to another place in the body. (survivornet.com)
Autologous CD8+ antigen-specific T cells are white blood cells that are designed in the laboratory to find melanoma cells and may kill them. (survivornet.com)
Giving autologous CD8+ antigen-specific T cells with cyclophosphamide, aldesleukin, and ipilimumab may be an effective treatment for patients with metastatic melanoma. (survivornet.com)
Melanoma7
In 2006, Rosenberg and colleagues transferred TCR T cells specifically recognizing the melanoma antigen MART-1 in 15 patients, two of whom achieved regression and still showed high levels of engineered cells in circulation one year after the infusion. (nature.com)
Other successful studies quickly followed, such as those demonstrating sustained complete and partial responses in patients with melanoma and treatment of synovial cell sarcoma with TCR T cells against the NY-ESO-1 antigen. (nature.com)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
These were whether to choose local intratumoral treatment or systemic treatment, whether patients with stage IIIA melanoma require adjuvant therapy or not, whether treatment is better changed at disease progression or during stable disease, whether adoptive cell transfer (ACT) therapy is more appropriate used before or in combination with checkpoint inhibition therapy, and whether treatment can be stopped while the patient is still on response. (biomedcentral.com)
I. Evaluate the safety and efficacy of adoptively transferred cytotoxic T-lymphocytes (CTL) targeting melanoma tumors combined with anti-CTLA4. (survivornet.com)
Recognition5
Donor T cells may also induce GvHD due to recognition of allo-antigens on non-malignant tissues of the patient. (haematologica.org)
Physiologic recognition of tumour antigens by T cells is mediated by the TCR-CD3 complex. (nature.com)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
Licensed recognition of these antigens by effector T cells may in turn trigger the collapse of the tumor stroma and aid in the regression of large vascularized lesions. (gsea-msigdb.org)
The authors postulated that the age of the animal at the time of its first encounter with a foreign body was the critical factor in determining its responsiveness and, hence, its recognition of nonself antigens. (medscape.com)
Malignant cells1
1 , 2 The anti-tumor effect of DLI is mediated by donor T cells recognizing allo-antigens on the malignant cells of the recipient. (haematologica.org)
The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. (haematologica.org)
Transfer of HSV-tk to DLI preserves the beneficial anti-tumor effect and allows in vivo elimination of donor T cells if severe GvHD occurs. (haematologica.org)
4 In addition, TCRs for minor histocompatibility antigens, including HA-1 and HA-2, have been transferred to donor-derived virus-specific T cells to treat patients with hematologic malignancies after allogeneic stem cell transplantation. (haematologica.org)
Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
In this study, we investigated the use of CD20 as safety switch after retroviral transfer to T cells with different cytomegalovirus (CMV) specificities, and conclude that CD20 may be broadly applicable as safeguard in adoptive T-cell therapy. (haematologica.org)
BACKGROUND: Adoptive transfer of virus-specific T cells may accelerate reconstitution of antigen-specific immunity and limit the morbidity and mortality of viral infections following allogeneic hematopoietic stem cell transplantation. (ox.ac.uk)
RESULTS: Cell selection was successful in all cases, yielding a product biased towards CD4(+) over CD8(+) T cells. (ox.ac.uk)
Expansions of both CD4(+) and CD8(+) cytomegalovirus-specific T cells were observed in vivo within days of adoptive transfer. (ox.ac.uk)
Adoptive cell therapies (ACT) leverage this cytotoxic capacity of T cells to eradicate tumours. (nature.com)
In the first published gene therapy clinical trial, TILs engineered to express a foreign gene with a retrovirus to mark the infused cells were safely transferred to patients. (nature.com)
This study also showed that modified T cells could persist for months after transfer - a key requisite for future ACT. (nature.com)
The T cells expressing CARs recognized and eliminated target cells, and produced interleukin 2 in the presence of the antigen, providing a proof of concept that this approach triggers a cellular immune response. (nature.com)
Another ACT developed in parallel to CAR T cells is engineering T cells to express TCRs that recognize tumour-associated antigens. (nature.com)
Dr. Sarah Cooley and colleagues describe techniques to activate NK cells using cytokines, checkpoint modulators, and immune engagers, and then administering these in combination with novel therapeutic agents to potentially increase NK targeting of specific antigens on leukemic cells. (bethematchclinical.org)
Successful treatment of B-cell malignancies with CD19-CAR T cells was a milestone for this approach ( 4 , 5 ). (snmjournals.org)
Their approach involves a twist on conventional adoptive T-cell therapy (ACT), in which the patient's own T cells are removed from the body and in some cases modified or engineered to recognise cancer cells. (ecancer.org)
The Roswell Park investigators built their strategy around FR⍺, a tumour antigen (or target) commonly found on ovarian cancer cells. (ecancer.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
However, due to difficulties in obtaining a high number of such CTLs from patients, there is an urgent need to find a new approach to generate highly reactive Ag-specific CTLs for successful ACT-based therapies.TCR transduction of the self-renewable stem cells for immune reconstitution has a therapeutic potential for the treatment of diseases 8-10 . (psu.edu)
Here, we present methods for the generation of T lymphocytes from iPS cells in vitro, and in vivo programming of antigen-specific CTLs from iPS cells for promoting cancer immune surveillance. (psu.edu)
Stimulation in vitro with a Notch ligand drives T cell differentiation from iPS cells, and TCR gene transduction results in iPS cells differentiating into antigen-specific T cells in vivo, which prevents tumor growth. (psu.edu)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)
vivo activation and expansion of T cells or NK cells and passive transfer of these cells into the cancer patient. (richardvigilantebooks.com)
Cells for adoptive therapy can be obtained either from the patient or from a separate individual. (richardvigilantebooks.com)
In contrast with CD10, CD19 and CD20 antigen, CD22 antigen is still present on lymphoplasmacytoid cells but is dininished on the fully mature plasma cells. (bioskinrevive.com)
Background Adoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of T cells with poor function or persistence. (bmj.com)
Results Herein we reveal a new way to reverse the tolerant state of adoptively transferred CD8 + T cells against tumors using TLR-activated B cells. (bmj.com)
Isolated B cells also imparted T cells with the CpG-associated phenotype and improved tumor immunity without the aid of additional antigen-presenting cells or other immune cells in the culture. (bmj.com)
Interferon (IFN)-Cproducing Compact disc8+ T cells are essential for the successful quality from the obligate intracellular parasite by avoiding the reactivation or controlling a do it again infection. (researchassistantresume.com)
To our understanding, this is actually the 1st demonstration from the essential role of sponsor IL-15 within the advancement of antigen-specific storage Compact disc8+ T cells against an intracellular infections. (researchassistantresume.com)
SERK1 Moreover, sIL-15R exacerbated the condition by obstructing the proliferation of antigen-specific memory space Compact disc8+ cells essential to the protecting immunity against toxoplasmosis. (researchassistantresume.com)
B16F10-bearing mice were preconditioned with 5Gy TBI and given a tripartite ACT therapy (consisting of transferred pmel-1 CD8 + T cells, vaccination with fowlpox encoding gp100, and IL-2) along with TLR4 agonist LPS. (biomedcentral.com)
Here we report that while exogenous administration of LPS was able to enhance adoptively transferred CD8 + T cells' tumor destruction, LPS treatment alone did not replace individual components of the tripartite ACT regimen, or obviate TBI. (biomedcentral.com)
In contrast, administering LPS after ACT potentiated the antitumor effectiveness of the regimen, thereby supporting the expansion of transferred tumor-specific CD8 + T cells over host CD4 + T cells. (biomedcentral.com)
Patients may alternatively receive lympho-depleting chemotherapy followed by adoptive transfer of purified NK cells from an alloreactive donor, resulting in homeostatic lymphocyte proliferation with transient donor NK cell expansion in recipients [ 7 ]. (biomedcentral.com)
To our knowledge, three investigators[76, 106-108] reported the treatment of post-HSCT CMV infection using adoptive transfer of fresh CMV-specific CD8+ T cells generated by an immunomagnetic strategy based on HLA-peptide multimers from HSCT donors or third-party haploidentical donors. (bestpfe.com)
Moreover CD4+ T-cells are necessary to support in vivo expansion and survival of CD8+ T cells [75, 112] to maintain virus-specific immune response following adoptive transfer for a long time. (bestpfe.com)
In contrast, IFNγ-capture approach can select both CD4+ and CD8+ antigen-specific T cells in an HLA unrestricted manner. (bestpfe.com)
Recovered peripheral blood mononuclear cells (PBMCs) are stimulated for 6 to 16 hours with a viral antigen [77, 113-116]. (bestpfe.com)
They reported that antigen specific proliferation of T cells and cytotoxicity of HLA-A1 antigen specific CTL line were only inhibited by CP and MTX among all the tested drugs. (bestpfe.com)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
Instead, IL-12 sensitized host bone marrow-derived tumor-stromal cells, partly through interferon-gamma, to indirectly enhance the effects of adoptively-transferred T cells. (gsea-msigdb.org)
Direct presentation of antigen by tumor was not necessary, but MHC class I expression on endogenous cells was essential for IL-12 mediated anti-tumor enhancements. (gsea-msigdb.org)
Upon successful treatment with IL-12TD cells, we observed the selective elimination of tumor-infiltrating CD11b+ F4/80+ macrophages, CD11b+/ClassII+/CD11c+ dendritic cells and CD11b+/Ly6C+/Ly6G- but not CD11b+/Ly6C+/Ly6G+ myeloid-derived suppressor cells within regressing lesions. (gsea-msigdb.org)
These results are consistent with a model whereby IL-12 triggers the maturation of myeloid-derived cells into competent antigen cross-presenting cells. (gsea-msigdb.org)
Only 10% of the human population is homozygous for this polymorphism, suggesting that genetic manipulation of NK cells to express CD16-158V prior to adoptive transfer may improve clinical success not only of NK cell therapies but also anti-tumor IgG1 antibodies. (maxcyte.com)
Non-viral engineering of NK cells using MaxCyte ® mRNA electroporation provides significant benefits including high efficiency and low toxicity as well as clinical scalability enabling rapid development of novel adoptive cell therapy approaches. (maxcyte.com)
Post electroporation, cells were resuspended in NK cell media and transferred to culture flasks for in vitro analysis. (maxcyte.com)
While increased CD16 expression was transient in nature, this may not negatively impact the therapeutic potential of engineered NK cells due to the short persistence of adoptively transferred NK cells. (maxcyte.com)
One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
In addition, ACT provides an opportunity to manipulate the host before cell transfer to provide a more favorable environment for the transferred cells. (biomedcentral.com)
Successful TIL therapy starts with the identification, enrichment, stimulation, and expansion of potent tumor-reactive T cells. (biomedcentral.com)
2015年11月11日, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Bacterial pathogens provoke B cells responding to blood group A-antigens to be resistant to calcineurin inhibitors through TLR-MyD88 pathway. (hiroshima-u.ac.jp)
In immediate hypersensitivity, the antigen reacts with the IgE antibody that is bound to mast cells. (ivoryresearch.com)
In delayed-type hypersensitivity, the antigen stimulates T-cells to release lymphokines which regulate a series of cellular reactions necessary to eliminate the antigen. (ivoryresearch.com)
Specifically, his team are developing approaches that can enable CAR T cells to overcome factors such as immunosuppression, trafficking and tumour antigen heterogeneity which prevent the successful application of CAR T cells in the solid tumour setting. (asi2022.org)
However, the gene transfer technology used in current CAR T cells primarily depends on retrovirus or lentivirus systems, which will randomly insert the CAR gene into the T cell genome and may pose a potential carcinogenic risk [ 19 , 20 ]. (biomedcentral.com)
In mice, TLR2 agonists can induce an antigen-specific CD8+ T cell response, especially when linked to the antigen.16-18 Here, we show that SMIP2.1 is also a good inducer of a CTL response when mixed with the antigen as Santacruzamate A aqueous suspension using either mice or human cells. (cckn-ia.org)
Mice that received OVA-specific OT-I TCR transgenic cells by adoptive transfer showed increased CD8+ T cell proliferation, cytokine production, and cytotoxic activity upon inclusion of SMIP2.1 Santacruzamate A in the Santacruzamate A OVA vaccine formulation. (cckn-ia.org)
While it is already known that DCs can cross-present exogenous antigens, the role of B cells in this process is less clear.19-21 Using transnuclear B cells that express a BCR specific for OVA, we demonstrated for the first time that B cells can cross-present OVA upon TLR2 stimulation. (cckn-ia.org)
This Pik3r1 study shows that SMIP2.1 could assist in the generation of antigen specific CTL along with the robust activation of CD4+ T cells, and thus could be exploited in the design of effective adjuvants for antitumor and antiviral vaccines. (cckn-ia.org)
Evaluate the influence of anti-CTLA4 on the induction of T cells to non-targeted tumor-associated antigens (antigen-spreading) following adoptive transfer antigen-specific CTL, and the correlation of these responses with clinical outcome. (survivornet.com)
However, the number of antigen-specific CD8(+) but not CD4(+) T cells declined more rapidly and to a greater extent in c-IAP2(H570A) mice than in WT controls. (bioxcell.com)
Studies with T-cell adoptive transfer demonstrated that the enhanced decay of memory cells was T-cell intrinsic. (bioxcell.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
CD191
Most successful results were obtained in hematological malignancies with the use of CD19-directed CAR T cell therapy and already led to the commercial approval by the FDA. (richardvigilantebooks.com)
Therapies4
Our studies provide a potentially more efficient approach for generating antigen-specific CTLs for ACT-based therapies and facilitate the development of therapeutic strategies for diseases. (psu.edu)
Alex Mayweg of Versant Ventures commented, "While CAR-T-based therapies have already demonstrated their power in the treatment of hematological cancers, their foray into solid tumors has proven to be less successful. (globenewswire.com)
Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
TIL therapy is a type of adoptive cellular therapy leveraging the patient's own immune system to treat tumors. (biomedcentral.com)
Allogeneic1
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
Vivo2
Subsequently, a murine model of HSC transplantation shown successful in vivo detection of T cell repopulation at 2, 4, and 8 weeks post-HSC transplant using the 89Zr-radiolabeled anti-CD4 and -CD8 cDbs. (bioskinrevive.com)
I. Evaluate the influence of anti-CTLA4 on the duration of in vivo persistence and anti-tumor efficacy achieved following adoptive transfer of antigen-specific CTL. (survivornet.com)
Checkpoint3
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
In particular, immune stimulation effected by intralesional agents may promote the release and presentation of tumor-derived antigens which may synergise with the systemic effects of checkpoint inhibitor agents. (biomedcentral.com)
There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)
Transgenic1
Here, we evaluated the safety issues raised by the risk of TAA-TCR gene transfer-associated on/off-target toxicities and the therapeutic potential in relevant transgenic mouse models of adoptive transfer. (unimedizin-mainz.de)
Immunotherapies1
T cell transfer, Kaempferol hematopoietic stem cell or progenitor cell transfer, little molecule and antibody-based immunotherapies, and combos thereof, entire body immuno-positron emission tomography (immunoPET) concentrating on of immune system cell subtypes could offer spatial and temporal details that is difficult utilizing current strategies. (bioskinrevive.com)
Pathways1
She has made fundamental discoveries that have advanced our understanding of antigen presentation pathways and dendritic cell biology. (asi2022.org)
Tumors2
T-knife has developed an exciting technology as its TCR-T cell therapy targets tumor antigens in an MHC-restricted manner, allowing it to be one of the few platforms that is able to target solid tumors. (globenewswire.com)
Nevertheless, the successful application of TIL therapy currently is still limited to several types of tumors. (biomedcentral.com)
Lymphocytes1
Adoptive cell transfer (ACT) of antigen-specific CD8 + cytotoxic T lymphocytes (CTLs) is a promising treatment for a variety of malignancies 1 . (psu.edu)
Using and experiments we showed that SMIP2.1 can activate the innate immune system via a TLR2-dependent mechanism, induce the maturation of APCs, and elicit a strong antibody response against influenza and tetanus toxoid antigens. (cckn-ia.org)
Responses3
Fig. 3: Examples of complete responses mediated by TIL-recognizing tumor antigens. (nature.com)
T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
Calderon and Hay (l984 a,b) induced acute and chronic infection in BALB/c mice with Tricophyton quinckeanum and investigated immune responses by lymphocyte transformation and cell transfer experiments. (ivoryresearch.com)
Genetically1
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
CD201
The data support the broad value of CD20 as safety switch in adoptive T-cell therapy. (haematologica.org)
Exogenous1
Therefore, vaccination with an exogenous antigen formulated with Santacruzamate A SMIP2.1 is a successful strategy for the induction of a cytotoxic T cell response along with antibody production. (cckn-ia.org)
Patients1
Fig. 4: Summary of tumor-specific antigens tested for all patients. (nature.com)
Specific4
T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. (biomedcentral.com)
It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)
Enhances1
Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (biomedcentral.com)
Clinical2
Co-transfer of a suicide gene would provide a desirable safety switch in clinical TCR gene therapy. (haematologica.org)
The first successful clinical applications of ACT for cancer treatment occurred in the 1980s. (nature.com)
and T-cell epitopes, and the heavily glycosylated portion of Reports of P. jirovecii colonization detected by molecular the antigen plays a central role in the interaction of the probes in persons ranging from healthy young children to organism with the host ( 6 - 10 , 20 ). (cdc.gov)