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Platelet Glycoprotein GPIb-IX ComplexBlood PlateletsPlatelet Membrane GlycoproteinsPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Adhesivenessvon Willebrand FactorAntigens, Human PlateletPlatelet CountRistocetinCrotalid VenomsGlycoproteinsImmunoglobulin Fab FragmentsProtein SubunitsBernard-Soulier SyndromePlatelet Aggregation InhibitorsAntibodies, MonoclonalMolecular Sequence DataAmino Acid SequenceFibrinogenBleeding TimeThrombastheniaThrombinPlatelet Factor 4Platelet ActivationPlatelet Function TestsPlatelet TransfusionPlatelet Membrane Glycoprotein IIbMegakaryocytesThrombosisThrombocytopeniaIntegrin alpha2Adenosine DiphosphateMolecular WeightProtein BindingPlatelet Activating FactorMacromolecular SubstancesElectrophoresis, Polyacrylamide Gelvon Willebrand DiseasesBinding SitesP-Selectinbeta 2-Glycoprotein IRecombinant ProteinsHemorrhageIntegrin beta3Purpura, ThrombocytopenicReceptors, CollagenViral Envelope ProteinsCollagenBase SequenceHeparinKineticsCricetinaeMembrane GlycoproteinsPeptide FragmentsPeptidesCHO CellsEpitopesAspirinCell LineHemostasisThrombospondinsBenzamidinesCell MembraneGlycosylationMembrane ProteinsProtein ConformationBlood Platelet DisordersGlycopeptidesCell AdhesionChromatography, AffinityOligopeptidesBlood CoagulationAurintricarboxylic AcidImmunoelectrophoresis, Two-DimensionalProtein Structure, TertiaryAngina, UnstableIntegrinsTyrosineOrosomucoidCloning, MolecularViper VenomsMutationMyelin-Associated GlycoproteinIntegrin alpha2beta1Flow CytometryPurpura, Thrombocytopenic, IdiopathicHemorheologyTransfectionDisulfidesMyocardial InfarctionSequence Homology, Amino AcidRabbitsAntibody SpecificityReceptors, Cell SurfaceFibrinolytic AgentsStructure-Activity RelationshipAngioplasty, Balloon, CoronaryReceptors, VitronectinRecombinant Fusion Proteins
AggregationIIIaWillebrandMembrane glycoproteinsAntigenProteinReceptorsELISA KitTransmembrane glycoproteinAnti-plateletBeta subunitsEndothelial cellsReceptor complexThrombospondinVascularHuman plateletGP1BbGPIIbMultimericExtracellular matrixSuggests that plateletsIntegrin alphaMegakaryocytesCD41ITGA2bActivated by thrombinHigh molecular weight multimersPathwaysPolymorphismActivationTransfusionLeucine-richFlow CytometryTrimerActivatesHemostasisSource:HGNC SymbolGeneInteractionGPIbImpairsProteinsINTEGRINSThrombinPhysiologicalCollagenSynthesisDeficiencyAlphaITGB3
Aggregation22
IIIa13
  • In consequence, this complex activates GPIIb / IIIa membrane glycoproteins, allowing them to bind fibrinogen. (wikipedia.org)
  • In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex. (wikipedia.org)
  • The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
  • Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
  • Each multimeric subunit has binding sites for the receptor glycoprotein Ib on nonactivated platelets and the receptor glycoprotein IIb/IIIa on activated platelets. (medscape.com)
  • Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes. (rupress.org)
  • Platelet membrane glycoprotein IIb-IIIa forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. (rupress.org)
  • CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. (exbio.cz)
  • Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. (exbio.cz)
  • In this study we aimed to investigate the effect of ITGA2B (integrin alpha 2b, platelet glycoprotein IIb of IIb/IIIa complex) gene polymorphism on the magnitude of inflammatory response after CPB. (peertechzpublications.com)
  • [1] It belongs to the glycoprotein IIb/IIIa inhibitors class of medications and works by temporarily preventing platelets for clumping together. (mdwiki.org)
  • The platelet surface hosts a panel of receptors mediating platelet activation and ultimately they all converge towards glycoprotein (GP) IIb/IIIa fibrinogen receptor complex. (crispr-reagents.com)
  • In the search for genetic mechanisms to explain inadequate platelet inhibition by aspirin especially the IIIa subunit of the complex continues to be scrutinized [10]. (crispr-reagents.com)
Willebrand13
Membrane glycoproteins4
Antigen1
  • It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)
Protein13
  • In the resting state the contact between the two protein subunits (necessary for the complex activation) is prevented by aggregin, which disables their contact necessary for the complex activation. (wikipedia.org)
  • GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. (rupress.org)
  • G protein subunit alpha q [Source:HGNC S. (gsea-msigdb.org)
  • Glycoprotein Ib (platelet), beta polypeptide ( GP1BB ) also known as CD42c ( C luster of D ifferentiation 42c ), is a protein that in humans is encoded by the GP1BB gene. (wikidoc.org)
  • Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. (wikidoc.org)
  • The proteins produced from these genes are pieces (subunits) of a protein complex called glycoprotein (GP)Ib-IX-V. This complex is found on the surface of platelets and plays an important role in blood clotting . (medlineplus.gov)
  • Ectopic expression of miR-103b decreased the luciferase reporter activity in HeLa cells and decreased ITGB3 mRNA and protein levels in platelets, concomitant with an increase in apoptosis. (eurekaselect.com)
  • The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)
  • The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
  • The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
  • Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. (medlineplus.gov)
  • This abnormally active protein is unable to reach the surface of the platelet where it is needed to bind to other platelets during clot formation. (medlineplus.gov)
  • In the presence of divalent cations, the secreted protein binds to the surface of the activated platelets and is responsible for the endogenous lectin-like activity associated with activated platelets. (dadamo.com)
Receptors5
  • CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
  • However given the considerable interdependency of platelet activation pathways and the fact that aspirin has effects impartial of COX-1 [8]-[9] the effect of aspirin may also be susceptible to genetically decided changes of various other receptors. (crispr-reagents.com)
  • It is well known, that platelets have an armament of soluble molecules, factors, mediators, chemokines, cytokines and neurotransmitters in their granules, and have multiple adhesion molecules and receptors on their surface. (biomedcentral.com)
  • Nevertheless, their distinctive armament of soluble mediators as well as the presence of surface receptors suggests that platelets must have further roles in several physiological and pathophysiological regulatory processes[ 14 ]. (biomedcentral.com)
  • Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
ELISA Kit3
  • Description: A sandwich ELISA kit for detection of Calcium Channel, Voltage Dependent, T-Type, Alpha 1H Subunit from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • Description: A sandwich ELISA kit for detection of Serine Palmitoyltransferase, Long Chain Base Subunit 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
  • Description: Quantitativecompetitive ELISA kit for measuring Human leucine-rich alpha-2 glycoprotein 1 (LRG1) in samples from serum, urine, cell culture supernates, tissue homogenates. (resourcerecovery.be)
Transmembrane glycoprotein3
  • This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
  • Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
  • CD42b, also known as GP1Ba (GP1B alpha, Glycoprotein 1Ba) is a single pass transmembrane glycoprotein that functions as the key ligand binding subunit of the GP1B platelet surface receptor. (peprotech.com)
Anti-platelet4
  • Support for the manuscript revealed to innovate, but about of these steps associated to a JavaScript anti-platelet. (viotechsolutions.com)
  • Thus, Notch pathway can be a potential anti-platelet/anti-thrombotic therapeutic target. (elifesciences.org)
  • Advances in the discovery of novel anti-platelet therapeutics remains an unmet need. (elifesciences.org)
  • 1. Chen S, Cooper N, Müller M, Bein G, Sachs UJ (2020) Piperacillin-dependent anti-platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid-onset thrombocytopenia. (uni-giessen.de)
Beta subunits1
  • Immunoprecipitation of [35S]methionine pulse-chase-labeled cell extracts by antibodies specific for the alpha or beta subunits of GPIIb indicated that GPIIb was derived from a precursor of Mr 130,000 that contains the alpha and beta subunits. (rupress.org)
Endothelial cells3
  • This complex is located mainly on endothelial cells but also on smooth muscle cells, macrophages and platelets. (wikipedia.org)
  • Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells and osteoclasts and at very low levels by platelets. (thermofisher.com)
  • In response to numerous stimuli, vWF is released from storage granules in platelets and endothelial cells. (medscape.com)
Receptor complex1
  • 613160) receptor complex, glycoprotein Ib (GP Ib). (nih.gov)
Thrombospondin6
  • ITGA2B is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin and functions in platelet activation (5). (peertechzpublications.com)
  • Thrombospondin 1 (TSP1) is a multidomain, multifunctional glycoprotein from platelets and certain vascular cells which has been shown to play an important role in cell-cell and cell-matrix interactions. (bioporto.com)
  • Many functions have been suggested for the large amounts of thrombospondin-1 that are stored in α-granules of platelets. (ashpublications.org)
  • Isenberg et al describe a new role whereby thrombospondin-1 counteracts NO and allows platelet activation to take place in situations in which NO is being generated. (ashpublications.org)
  • Thrombospondin, one of the major glycoproteins released from alpha-granules of thrombin-stimulated platelets, is a disulfide-linked trimer of 160,000-dalton subunits. (cornell.edu)
  • Thrombospondin (TSP) is a glycoproteins secreted from the alpha-granules of platelets upon activation. (dadamo.com)
Vascular4
  • The binding between GPIbα and vWF mediates the capture of platelets to the injured vascular wall. (wikipedia.org)
  • Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
  • Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
  • First, it mediates the adhesion of platelets to sites of vascular injury. (medscape.com)
Human platelet1
  • 3. Holzwarth ST, Strobel J, Cooper N, Leyh J, Bayat B, Bein G, Zingsem J, Sachs UJ (2020) A point mutation c.473A G of ITGB3 is responsible for the formation of the Woa human platelet alloantigen. (uni-giessen.de)
GP1Bb2
  • Most mutations in GP1BA , GP1BB , or GP9 prevent the formation of the GPIb-IX-V complex on the surface of platelets. (medlineplus.gov)
  • GP Ib is composed of 4 subunits encoded by 4 separate genes: GP1BA, GP1BB, GP9, and GP5 (173511). (nih.gov)
GPIIb3
  • The αIIb (GPIIb) is composed of two subunits linked by disulfide bridges. (wikipedia.org)
  • Its α5 subunit is 36% identical to the GPIIb subunit. (wikipedia.org)
  • The GPIIb precursor is then processed with conversion of high-mannose to complex type carbohydrates yielding the mature subunits GPIIb alpha (Mr 116,000) and GPIIb beta (Mr 25,000). (rupress.org)
Multimeric1
  • vWF, a large, multimeric glycoprotein, circulates in blood plasma at concentrations of approximately 10 mg/mL. (medscape.com)
Extracellular matrix1
  • Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
Suggests that platelets1
  • Recently, a growing body of evidence suggests that platelets have the pivotal role in the pathogenesis of several poor prognostic mediacal conditions like inflammation and cancer (10). (peertechzpublications.com)
Integrin alpha1
Megakaryocytes1
CD411
  • Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin a2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin a2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG 1 Allophycocyanin Isotype Control (Catalog # IC002A ). (rndsystems.com)
ITGA2b2
  • Koray Ak, Ergun S, Altınoz H, Uyguner ZO, Tetik S (2016) GG Polymorphism of Platelet ITGA2B Gene Increases the Magnitude of Interleukin-6 Release after Cardiopulmonary Bypass. (peertechzpublications.com)
  • The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. (medlineplus.gov)
Activated by thrombin1
  • Also known as fibrin-stabilizing factor, the 320,000-Dalton glycoprotein is activated by thrombin in the presence of calcium and has a plasma half-life of approximately 10 days. (medscape.com)
High molecular weight multimers2
  • High-molecular weight multimers have higher numbers of platelet-binding sites and greater adhesive properties. (medscape.com)
  • vWD type IIM (for multimer) involves qualitative variants with decreased platelet-dependent function not resulting from absence of high-molecular weight multimers. (medscape.com)
Pathways1
  • Through these pathways activated platelets are accumulated in the follicular vessels surrounding the follicle and due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters) locally increase oocyte maturation and hormone secretion. (biomedcentral.com)
Polymorphism2
  • The surface expression of this complex shows high variability, particularly in relation to the polymorphism of GPIa subunit gene. (wikipedia.org)
  • The exact biological mechanism remains elusive but the effect of this polymorphism may be related to changes in platelet activation. (crispr-reagents.com)
Activation6
Transfusion1
  • Background: Blood bank-stored human platelets are one of the life-saving transfusion products to prevent bleeding in multiple clinical settings. (eurekaselect.com)
Leucine-rich3
  • Description: Quantitative sandwich ELISA for measuring Rat Leucine-rich alpha-2 glycoprotein 1 (LRG1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (resourcerecovery.be)
  • Description: A competitive ELISA for quantitative measurement of Rat Leucine rich Alpha 2 glycoprotein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
  • Description: Quantitative sandwich ELISA for measuring Human Leucine-rich alpha-2 glycoprotein 1 (LRG1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (resourcerecovery.be)
Flow Cytometry1
  • Transcripts/peptides of Notch1 and Delta-like ligand (DLL)-4 were detected in platelets isolated from human blood by RT-qPCR, Western analysis and flow cytometry. (elifesciences.org)
Trimer2
  • TSP1 is a calcium-sensitive, disulfide-bonded trimer with a subunit molecular mass of 150 kDa. (bioporto.com)
  • Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. (lookformedical.com)
Activates2
  • The signal (PAF, or other tissue/cell specific factors) comes from the stimulated (by the e.g., hypophyseal hormones, bacteria, external factors, etc.) organs or cells, and activates platelets. (biomedcentral.com)
  • In platelets, a nonproteolytic process activates cellular factor XIII. (medscape.com)
Hemostasis4
Source:HGNC Symbol1
Gene4
  • Although most people with only one copy of the mutated gene do not show signs and symptoms of the condition, some have platelets that are slightly larger than normal or very mild bleeding abnormalities. (medlineplus.gov)
  • The mutations that cause this disorder occur in both copies of the gene in each cell and impair the production or activity of the beta3 subunit, which disrupts the formation of functional integrin αIIbβ3. (medlineplus.gov)
  • Mutations in the ITGB3 gene can also cause another rare bleeding disorder called platelet-type bleeding disorder 16. (medlineplus.gov)
  • Because the mutation that causes this disorder affects only one copy of the ITGB3 gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (medlineplus.gov)
Interaction4
  • The interaction with collagen leads to stabilization of the platelets. (wikipedia.org)
  • Previous studies suggest that the coagulation function in pigs differs from that in humans, especially with respect to the interaction between vWF and platelets. (edu.au)
  • Objective: Our objective of this study is to validate the abundance of miR-103b in stored platelets and identify whether ITGB3 is a target of miR-103b for the downregulation and this interaction promotes apoptosis. (eurekaselect.com)
  • Normally, plasma vWF is inert in its interaction towards platelets until it encounters an exposed subendothelial surface. (medscape.com)
GPIb3
  • Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome , velocardiofacial syndrome and giant platelet disorder . (wikidoc.org)
  • Observations to date have identified a critical region of vWF involved in the binding of vWF to the platelet receptor glycoprotein Ib (GpIb). (medscape.com)
  • The large multimers have the highest affinity for GpIb and are rapidly cleared from the plasma along with the bound platelets, resulting in thrombocytopenia and the characteristic loss of large multimers. (medscape.com)
Impairs1
  • The abnormally shaped platelets have a shortened lifespan, so platelet numbers are often reduced, which impairs clot formation. (medlineplus.gov)
Proteins1
  • The overactive integrin αIIbβ3 binds inappropriately to clotting proteins within the cell during the formation of platelets, causing the platelets to become misshapen and large. (medlineplus.gov)
INTEGRINS2
  • The β1 subunit has four cysteine-rich regions and a structure similar to other β-integrins. (wikipedia.org)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Thrombin1
  • Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba. (edu.au)
Physiological2
  • Integrin beta 3 (ITGB3) glycoprotein plays multiple roles in platelet physiological processes, and it was reported in other cell types that downregulation of ITGB3 induces apoptosis. (eurekaselect.com)
  • Our study presents compelling evidence in support of non-canonical juxtacrine Notch signaling within platelet aggregates that synergizes with physiological agonists to generate occlusive intramural thrombi. (elifesciences.org)
Collagen3
  • The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. (lookformedical.com)
  • Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (lookformedical.com)
  • Platelet thrombus on immobilized collagen was quantified using microfluidics platform. (elifesciences.org)
Synthesis3
  • The deficiency in glycoprotein Ib-IX-V complex synthesis leads to Bernard-Soulier syndrome. (wikipedia.org)
  • [ 4 , 5 ] The primary site for the synthesis of subunit A in plasma factor XIII seems to exist in cells that originate in the marrow. (medscape.com)
  • Synthesis of the B subunit occurs in the liver. (medscape.com)
Deficiency1
  • Patients with vWD type III, a severe, quantitative deficiency associated with very little or no detectable plasma or platelet vWF, have a profound bleeding disorder. (medscape.com)
Alpha5
  • integrin subunit alpha 2 [Source:HGNC Sy. (gsea-msigdb.org)
  • Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
  • This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
ITGB33
  • However, whether miR-103b can target and downregulate ITGB3 in stored platelets and such miRNA regulation promotes apoptosis is not known. (eurekaselect.com)
  • Final validation of the functional role of miR-103b in ITGB3 downregulation and resulting induction of apoptosis was assessed in stored platelets by FACS analysis following ectopic expression of miR-103b. (eurekaselect.com)
  • Conclusion: The results demonstrate that in stored platelets, miR-103b is highly expressed and can interact with and downregulate ITGB3 and promote apoptosis in stored platelets. (eurekaselect.com)