Alpha-subunitsSubfamilyRectifier potassiumKCNAB2ShakerMembranesProteinSIMILARITYBetaFunctionalFormsTypeGeneCellExpressionUbiquitin-proteiAltersProteinsVoltage-gated ion channelsGenesAccessorySubcellularNeuronal excitabilityTransientOutwardNative neuronalReceptor typeNeuronsComplexAlphaClassDomainBrain
Alpha-subunits4
- This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (wikipedia.org)
- Forms heteromultimeric complex with alpha subunits. (ucsc.edu)
- channel properties depend on the type of alpha subunits that are part of the channel (By similarity). (nih.gov)
- Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). (nih.gov)
Subfamily3
- This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
- Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
- This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
Rectifier potassium2
- The delayed rectifier potassium conductance in the sarcolemma and the transverse tubular system membranes of mammalian skeletal muscle fibers. (uni-bielefeld.de)
- This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
KCNAB22
- Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene. (wikipedia.org)
- In melanocytic cells KCNAB2 gene expression may be regulated by MITF. (wikipedia.org)
Shaker2
- Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
- Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
Membranes2
- Due to the prominent role of potassium channels in regulating the electrical properties of membranes, modulation of these channels by ERK could play an important role in mediating learning-related synaptic plasticity in the CNS. (utmb.edu)
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (nih.gov)
Protein1
SIMILARITY1
- may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 (By similarity). (ucsc.edu)
Beta1
- Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
Functional1
- Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
Forms1
Type2
- Vullhorst D, Klocke R, Bartsch JW, Jockusch H. Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. (uni-bielefeld.de)
- Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus. (utmb.edu)
Gene1
- The ion channel-related gene set was significantly enriched upon analysis of these significant genes. (bvsalud.org)
Cell1
Expression2
- We conclude that KV3.4 expression in mouse skeletal muscle is regulated by the pattern of excitation. (uni-bielefeld.de)
- The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Ubiquitin-protei1
- Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Alters1
- Gating is thought to involve conformational changes of the ion channel which alters selective permeability. (lookformedical.com)
Proteins3
- This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (wikipedia.org)
- AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
- Accumulating evidence suggests that this functional diversity is generated by multiple mechanisms, including the expression and subcellular distributions of IA channels encoded by different voltage-gated K(+) (Kv) channel pore-forming (α) subunits, interactions of Kv α subunits with cytosolic and/or transmembrane accessory subunits and regulatory proteins and post-translational modifications of channel subunits. (nih.gov)
Voltage-gated ion channels1
- Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
Genes2
- Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
- HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Accessory1
Subcellular1
- Multiple mechanisms regulate the properties, subcellular targeting, and cell-surface expression of Kv4.2-encoded channels. (nih.gov)
Neuronal excitability1
- Together, the results presented here identify Navβ1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability. (nih.gov)
Transient1
- A heterogenous group of transient or low voltage activated type CALCIUM CHANNELS. (lookformedical.com)
Outward1
- Potassium channels where the flow of K+ ions into the cell is greater than the outward flow. (lookformedical.com)
Native neuronal1
- Here, we review the diverse molecular mechanisms that have been shown or proposed to underlie the functional diversity of native neuronal IA channels. (nih.gov)
Receptor type1
- Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) is an intracellular Ca2+ release channel important for a number of fundamental cellular functions. (bvsalud.org)
Neurons1
- CALCIUM CHANNELS located in the neurons of the brain. (lookformedical.com)
Complex1
- The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)
Alpha1
- The alpha-1 subunit is the binding site for calcium-based antagonists. (lookformedical.com)
Class1
- A class of drugs that act by inhibition of potassium efflux through cell membranes. (lookformedical.com)
Domain1
- To determine whether GOF in ITPR1 itself has pathological ramifications, we employed a newly developed mouse model expressing an ITPR1 mutation in the gating domain of the channel, D2594K, that markedly increased the channel's sensitivity to activation by IP3. (bvsalud.org)