• For other protein-related codes, see List of MeSH codes (D12.776). (wikipedia.org)
  • Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). (biomedcentral.com)
  • Efforts to understand the genes and signaling pathways that promote tumor invasion and metastasis have revealed that several G-protein coupled receptors (GPCRs) and their respective ligands function as metastatic drivers in breast as well other cancer types [ 2 - 6 ]. (biomedcentral.com)
  • Additionally, a taste-enriched G protein γ-subunit, Gγ 13 , colocalizes with Gα gust and mediates the denatonium-stimulated production of inositol 1,4,5-triphosphate (IP 3 ). (nyu.edu)
  • Additionally, a taste-enriched G protein γ-subunit, Gγ13, colocalizes with Gαgust and mediates the denatonium-stimulated production of inositol 1,4,5-triphosphate (IP3). (nyu.edu)
  • When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. (jefferson.edu)
  • GTP-Binding Protein alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • A common feature of all three GPCRs is that they can couple to the G12 family of heterotrimeric G proteins [ 13 ]. (biomedcentral.com)
  • Among these, the G12 family, consisting of Gα12 and Gα13, (the products of the GNA12 and GNA13 genes, respectively) is one of the most important in the context of cancer. (biomedcentral.com)
  • The AceA/ICL protein family shares the catalytic domain I, triosephosphate isomerase barrel (TIM-barrel). (bvsalud.org)
  • This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications. (jefferson.edu)
  • Heterotrimeric G-proteins, consisting of Gα, Gβ and Gγ subunits are the major effector molecules of GPCR signaling. (biomedcentral.com)
  • IP 3 production is inhibited by antibodies specific to phospholipase C-β 2 (PLC-β 2 ), a PLC isoform known to be activated by Gβγ-subunits. (nyu.edu)
  • Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. (jefferson.edu)
  • Ectopic expression of miR-31 in MDA-MB-231 cells significantly reduced GNA13 mRNA and protein levels, as well as GNA13-3′-UTR-reporter activity. (biomedcentral.com)
  • Conversely, blocking miR-31 activity in MCF-10a cells induced GNA13 mRNA, protein and 3′-UTR reporter activity. (biomedcentral.com)
  • However, it remains to be clarified how GPR56 functions in brain development and which signaling pathways are activated by GPR56. (nih.gov)
  • Our findings show that the actions of thrombin on the proliferation of RA SFs, cell-cycle progression to the S phase, and IL-6 secretion were mainly mediated by the G13 and RhoGEF pathways. (biomedcentral.com)
  • G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J Biol Chem. (uchicago.edu)
  • Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells. (biomedcentral.com)
  • GPR56 encodes an orphan G protein-coupled receptor, and its mutations reduce the cell surface expression. (nih.gov)
  • Gustducin heterotrimers (α-gustducin/Gβ1/Gγ13) were activated by taste cell membranes plus bitter denatonium. (nyu.edu)
  • Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (ER), ranging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content or intracisternal granules. (bvsalud.org)
  • Gustducin is a transducin-like G protein selectively expressed in taste receptor cells. (nyu.edu)
  • We identified a G- protein γ subunit (Gγ13) that colocalized with α-gustducin in taste receptor cells. (nyu.edu)
  • note = "Funding Information: We thank N. Gautam and D. Logothetis for providing the cDNA clones for Gβ and Gγ subunits, W. He for help in isolation of taste cells, A. Kozak for help with in-situ hybridization and T. McClintock, J. Kay, L. Ruiz-Avila, E. Basyuk, L. Briggemann, R. Ramkumar and B. Knox for discussions. (nyu.edu)
  • Synovial cells are markedly activated by cytokines, adhesion molecules, and coagulation factors, resulting in hyperplasia of the synovial tissue, and the activated synovial cells produce inflammatory cytokines and degradative enzymes. (biomedcentral.com)