Subunit protein domain carrier proteins. Medical search. Frequent questions

protein_coding" "AGT24181","N559_2495","Klebsiella pneumoniae","cytochrome C biogenesis protein transmembrane region [Ensembl]. (ntu.edu.sg)

The alpha subunit of PCC contains the biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains. (wikipedia.org)
A domain known as the BT domain is also located on the alpha subunit and is essential for interactions with the beta subunit. (wikipedia.org)

This provides clear evidence of crucial dimeric interaction between alpha and beta subunits. (wikipedia.org)
The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. (embl.de)

Mutations in PCC, either in the α subunit (PCCα) or β subunit (PCCβ) can cause propionic acidemia in humans. (wikipedia.org)
A number of human diseases arise from mutations in VWA domains. (embl.de)
Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
To date, most identified mutations leading to severe FXIII deficiency and a bleeding disorder involve subunit A, with very few mutations reported involving subunit B. The gene for subunit A is located on chromosome 6 bands p24-25. (medscape.com)

A biotinyl domain shuttles its covalently attached biotin prosthetic group between the active sites of a biotin carboxylase and a carboxyl transferase. (rcsb.org)
In Escherichia coli, the three components reside in separate subunits: a biotinyl domain is the functional portion of one of these, biotin carboxy carrier protein (BCCP). (rcsb.org)
The α-subunits of the oxaloacetate and methylmalonyl-CoA decarboxylases are homologous to many biotin-containing enzymes including (1) pyruvate carboxylases, (2) homocitrate synthases, (3) biotin carboxyl carrier proteins, (4) isopropylmalate synthases and (5) acyl-CoA carboxylase. (tcdb.org)
The enzyme transfers CO 2 from glutaconyl-CoA to a biotin carrier protein (the γ-subunit) that is subsequently decarboxylated by the carboxybiotin decarboxylation site within the Na + pumping beta subunit (Gcdβ). (tcdb.org)

The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
These unusual ORFs are maternally inherited, and effectively translated into novel mitochondrial proteins, with the resulting failure to produce functional pollen as the sole observed phenotype ( Chen and Liu, 2014 ). (frontiersin.org)
In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)

Water 2H and 17O spin relaxation is used to study water dynamics in the hydration layers of two small peptides, two globular proteins and in living cells of two microorganisms. (lu.se)
This distribution comprises a small fraction of protein-specific hydration sites, where water rotation is strongly retarded, and a dominant fraction of generic hydration sites, where water rotation is as fast as in the hydration shells of small peptides. (lu.se)

DMSO reductase anchor subunit (DmsC) [Interproscan]. (ntu.edu.sg)
Nitrate reductase delta subunit [Interproscan]. (ntu.edu.sg)
Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
protein_coding" "AGT25156","N559_3508","Klebsiella pneumoniae","putative short-chain dehydrogenase/reductase SDR [Ensembl]. (ntu.edu.sg)

Human propionyl-CoA carboxylase contains two subunits, each encoded by a separate gene: A deficiency is associated with propionic acidemia. (wikipedia.org)
The α-subunit of the glutaconate decarboxylase is homologous to propionyl-CoA carboxylase. (tcdb.org)

Tries to crystallize the YchM STAS area resulted in spontaneous co-crystallization with acyl carrier proteins (ACP) liganded with malonyl coA (Babu et al. (exposed-skin-care.net)

AMPA receptor variants were identified with a polyclonal antibody recognizing the conserved extracellular loop region of all four AMPA receptor subunits (GluR1-4, both flip and flop ), whereas NMDA receptors were immunolabeled with a polyclonal antibody that binds to an extracellular N-terminal epitope of the NR1 subunit, common to all splice variants. (jneurosci.org)
AMPA receptors are composed of four subunits, GluR1-4. (jneurosci.org)
NMDA receptors comprise the essential NR1 subunit and one or more of the modulatory NR2 subunits, NR2A-D ( Hollmann and Heinemann 1994 ). (jneurosci.org)
Using subunit-specific antibodies, however, it is not possible to distinguish between the absence of AMPA receptors and the lack of a particular subunit on the cell surface. (jneurosci.org)
Several G-protein coupled receptors, such as the beta1-adrenergic receptor (beta1-AR), contain polyproline motifs within their intracellular domains. (duke.edu)
The coronavirus spike (S) glycoprotein is a class I viral fusion protein on the outer envelope of the virion that plays a critical role in viral infection by recognizing host cell receptors and mediating fusion of the viral and cellular membranes. (biolegend.com)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
These receptors typically contain five subunits with the cysteine-loop occurring near an N-terminal extracellular domain. (bvsalud.org)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
2 μg/lane of Biotinylated Recombinant Human IFN‑ gamma R1/CD119 Avi-tag His-tag Protein (Catalog # AVI11030) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 42‑55 kDa. (rndsystems.com)
The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)
Previously, we have designed genetic constructs that encode various recombinant derivatives of DT and proHB-EGF structural parts and domains. (org.ua)
Most of our recombinant proteins are fluorescent derivatives of various DT and proHB-EGF. (org.ua)
When recombinant SARS-CoV-2 B.1.1.7 Spike Protein S1 is immobilized at 2 μg/mL, recombinant human ACE2-Fc Chimera (Cat. (biolegend.com)
Recombinant SARS-CoV-2 B.1.1.7 Spike Protein S1 was aliquoted in PBS at 0.2 mg/mL. (biolegend.com)
The 678 amino acid recombinant protein has a predicted molecular mass of approximately 76 kD. (biolegend.com)
When Recombinant Human NETO1 His-tag Protein is immobilized at 4.00 µg/mL (100 µL/well), Recombinant Human APP695 +1 Fc Chimera binds with an ED 50 of 0.200-1.20 μg/mL. (bio-techne.com)
Recombinant Human NETO1 His-tag Protein SDS-PAGE 2 μg/lane of Recombinant Human NETO1 His-tag Protein (Catalog # 11103-NO) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 34-48 kDa. (bio-techne.com)

2010). NMR answer structures have already been resolved for the STAS BIIE 0246 supplier domain name of putative sulfate transporter Rv1739c from (Sharma et al. (exposed-skin-care.net)
Open up in another window Physique 2 Structural topology style of SLC26 polypeptides displaying the brief cytoplasmic N-terminal area accompanied by a transmembrane domain name with 12 putative membrane-spanning -helices, as well as the C-terminal cytoplasmic area, largely composed of the STAS domain name. (exposed-skin-care.net)
abstract = 'Proteins containing PSD-95/Discs-large/ZO-1 homology (PDZ) domains play key roles in the assembly and regulation of cellular signaling pathways and represent putative targets for new pharmacotherapeutics. (ku.dk)
protein_coding" "AGT23894","N559_2182","Klebsiella pneumoniae","putative ABC-type taurine transport system periplasmic binding component [Ensembl]. (ntu.edu.sg)
protein_coding" "AGT24100","N559_2404","Klebsiella pneumoniae","putative ABC transporter substrate binding protein [Ensembl]. (ntu.edu.sg)

When multiple copies of a polypeptide encoded by a gene form an aggregate, this protein structure is referred to as a multimer. (wikipedia.org)
Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)

VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). (embl.de)
These proteins form heterodimeric receptor complexes that mediate class II cytokine signals. (rndsystems.com)
Such motifs in other proteins are known to mediate protein-protein interactions such as with Src homology (SH)3 domains. (duke.edu)

Pretreatment of cultured hippocampal neurons with FSC231 inhibited coimmunopreciptation of the AMPA receptor GluR2 subunit with PICK1. (ku.dk)

The specificity of FSC231 for the PICK1 PDZ domain was supported by the lack of binding to PDZ domains of postsynaptic density protein 95 (PSD-95) and glutamate receptor interacting protein 1 (GRIP1). (ku.dk)
Human Neuronal apoptosis inhibitory protein (NAIP) ELISA Kit has high sensitivity and excellent specificity for detection of Human NAIP. (abbkine.com)

Mature mouse IFN‑ alpha / beta R1 consists of a 403 aa extracellular domain (ECD), a 20 aa transmembrane segment, and a 141 aa cytoplasmic domain (4). (rndsystems.com)
Mature human IFNGR1 consists of an extracellular domain (ECD) with 2 Ig-like domains, a transmembrane domain and an intracellular domain with both Jak1 and Stat1 binding motifs. (rndsystems.com)
The 511 amino acid (aa) residue mature human NETO1 contains a 322 aa extracellular domain (ECD) with two CUB domains and one class A LDL-receptor segment, a 21 aa transmembrane domain, and a 168 aa cytosol domain (1). (bio-techne.com)

Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. (embl.de)
The β-subunits possess 9 transmembrane α-helical spanners (TMSs), and the protein may dip into the membrane twice between TMSs III and IV. (tcdb.org)
Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6. (ox.ac.uk)
This "solubilization by depletion" mechanism of PrBP/δ differs from the extraction of prenylated proteins by the similar folded solubilization factor RhoGDI, which interacts with membrane bound cargo via an N-terminal structural element lacking in PrBP/δ. (ox.ac.uk)
B-subunit is composed of two domains: receptor domain or R-domain, which is responsible for binding to cell DT receptor, and transmembrane or T-domain, which is involved in the process of C-domain transfer in the cytosol across endosomal membrane. (org.ua)
For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
Dennis et al suggest that vesicle-associated membrane protein (VAMP7) mediates fusion of BLOC-1-dependent transport carriers with melanosomes and that soluble attachment protein receptor (SNARE) recycling from melanosomes is a critical BLOC-3-dependent step. (medscape.com)

non-etheless, deletion in mycobacteria of ABC sulfate transporter complicated subunits will not prevent contamination. (exposed-skin-care.net)

The active full-length CRYAA protein corresponding to amino acids 1-173 of CRYAA was recombined. (molvis.org)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
This single-chain 535 amino acid long protein causes the symptoms of acute diphtheria infection. (org.ua)
The S glycoprotein is synthesized as a precursor protein consisting of ~1,300 amino acids that is then cleaved into an amino (N)-terminal S1 subunit (~700 amino acids) and a carboxyl (C)-terminal S2 subunit (~600 amino acids). (biolegend.com)
SARS-CoV-2 B.1.1.7 Spike Protein S1, amino acid Val16-Arg685 (Accession # QHD43416.1), with (HV69-70del, Y144del, N501Y, A570D, P681H) and a C-terminal 8-His tag was expressed in CHO cells. (biolegend.com)
PPR proteins have in common a canonical P-type 35 amino acid domain repeated in tandem up to 30 times. (frontiersin.org)
The study showed that the reduction in transport of large amino acids by the encoded SLC7A5 protein leads to neurons switching from metabolizing lipids instead of amino acids and higher levels of neuronal cell death. (genewhisperer.com)

In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. (embl.de)
TIM barrel domain, Glyoxalase/fosfomycin resistance/dioxygenase domain, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily [InterProScan]. (ntu.edu.sg)

Intracellular VWA domains and homologues in prokaryotes have recently been identified. (embl.de)
Accordingly, we used the proline-rich third intracellular loop of the beta1-AR either as a glutathione S-transferase fusion protein in biochemical 'pull-down' assays or as bait in the yeast two-hybrid system to search for interacting proteins. (duke.edu)

Comparisons of the domain distributions in eukaryotes and prokaryotes enabled distinctions to be made between the domains originating prior to the last common ancestor of all known life forms and those apparently originating as consequences of horizontal gene transfer events. (embl.de)
The gene is 160 kilobases in length and has 15 exons and 14 introns with specific structural and functional domains. (medscape.com)
We have recently reordered our solute carrier gene group into individual families - you can read more about this in our recent blog post: Solute Carriers. (genewhisperer.com)
One of the solute carriers has recently been in the news - a recent study provided mechanistic data to explain how a mutation in the SLC7A5 gene that causes a rare form of autism affects the brain. (genewhisperer.com)

A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)

The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)

Intact COMP is pentameric, with 5 equal subunits and the carboxy-terminal globular domain of native COMP binds to collagens I, II, and IX. (prospecbio.com)

Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)

Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
Certainly, STAS domain-encoding SulP genes have already been found as the different parts of antibiotic operons, like the BLM bleomycin biosynthesis operon of (Du et al. (exposed-skin-care.net)
We have updated the nomenclature of a number of genes based on the identification of their encoded proteins as being associated with microtubules. (genewhisperer.com)
The following genes that previously had placeholder symbols have recently been shown to encode proteins that are found in the lumen of microtubules. (genewhisperer.com)

On the other hand, DT represents a very interesting molecular machine which allows using this protein in different bioengineering applications, such as ablation of certain cell types in transgenic mice, development of immunotoxins targeted for specific cell markers and also for delivery of certain proteins into the cytosol. (org.ua)
The exact molecular mechanism of C-domain transport across the lipid bilayer is unknown but it is known that T-domain is strongly involved in this process. (org.ua)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)

The N-terminal domain binds the glutaconyl-CoA, and the C-terminal domain binds the biotinyl lysine moiety. (tcdb.org)

1 Similarly, succinate may derive from the γ-aminobutyric acid shunt pathway that correlates with levels of expression of the γ-aminobutyric acid transporters solute carrier family 6 members 12 and 13 (SLC6A12, SLC6A13). (haematologica.org)
A small amount of bacterial SulP transporters absence a C-terminal STAS domain name, but have in its place an enzymatically energetic (Nishimori et al. (exposed-skin-care.net)

A major difference was found between the distributions of enzyme families that are typically found in all three divisions of cellular life and non-enzymatic domain families that are usually eukaryote-specific. (embl.de)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
HP1383 restriction modification system S subunit HP1388 hypothetical protein HP1390 hypothetical protein HP1396 hypothetical protein HP1397 hypothetical protein HP1400+ iron(III) dicitrate transport protein (fecA) HP1402 type I restriction enzyme R protein (hsdR) HP1410 hypothetical protein HP1411 hypothetical protein HP1412 hypothetical protein HP1415 tRNA delta(2)-isopentenylpyrophosphate transferase (miaA). (lbl.gov)
The S1 subunit contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. (biolegend.com)

When different mutant skin fibroblast cell lines defective in PCCβ were fused in pairwise combinations, the β heteromultimeric protein formed as a result often exhibited a higher level of activity than would be expected based on the activities of the parental enzymes. (wikipedia.org)
protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)

Tubulin gamma complex associated protein family and the Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase complex. (genewhisperer.com)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)

This protein family is largely expanded in land plant genomes. (frontiersin.org)

Nowadays, growing scientific interest to DT is associated with possibility of its use in medicine as a carrier protein in conjugate vaccines, a component of immunotoxin drugs, and in anticancer therapy. (org.ua)

Open up in another window Physique 1 Phylogenetic romantic relationship of BIIE 0246 supplier human being SLC26 polypeptides generated with Jalview (http://www.jalview.org) using NCBI proteins sequences listed in Desk 1. (exposed-skin-care.net)
Has 0 Blast hits to 0 proteins in 0 species (source: NCBI BLink). (yokohama-cu.ac.jp)

5 4 Succinate functions as a competitive inhibitor for prolyl hydroxylase domain (PHD) proteins that are central to degradation of hypoxia-inducible factor (HIF)-1α subunit. (haematologica.org)
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD . Proceedings of the National Academy of Science of the United States of America , 107 (1), 413-8. (ku.dk)
Here we describe the first small-molecule inhibitor (FSC231) of the PDZ domain in protein interacting with C kinase 1 (PICK1) identified by a screening of approximately 44,000 compounds in a fluorescent polarization assay. (ku.dk)
The inhibitor bound the PICK1 PDZ domain with an affinity similar to that observed for endogenous peptide ligands (K(i) approximately 10.1 microM). (ku.dk)
Neuronal apoptosis inhibitory protein encoded by NAIP contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. (abbkine.com)

Eukaryotic signalling domain homologues in archaea and bacteria. (embl.de)
Phyletic distributions of eukaryotic signalling domains were studied using recently developed sensitive methods for protein sequence analysis, with an emphasis on the detection and accurate enumeration of homologues in bacteria and archaea. (embl.de)

This leads to an almost complete arrest of protein synthesis in the cell and its death. (org.ua)
[ 4 , 5 ] The primary site for the synthesis of subunit A in plasma factor XIII seems to exist in cells that originate in the marrow. (medscape.com)
Synthesis of the B subunit occurs in the liver. (medscape.com)

IFN‑ alpha / beta R1 activation depends on tyrosine phoshorylation as well as palmitoylation of its cytoplasmic domain (8, 9). (rndsystems.com)
The molecule of this receptor is composed of four functional portions: heparin-binding, EGF-like, transmembrane and cytoplasmic domains. (org.ua)

Previously undetected bacterial homologues were identified for# plant pathogenesis-related proteins, Pad1, von Willebrand factor type A, src homology 3 and YWTD repeat-containing domains. (embl.de)

COMP is a non-collagenous glycoprotein and is belongs to the thrombospondin family of extracellular proteins. (prospecbio.com)

protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)

The alpha subunits are arranged as monomers, decorating the central beta-6 hexameric core. (wikipedia.org)

Anatomy13

Organisms15

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes75

Disciplines and Occupations2

Information Science10

Health Care2

Cytochrome1

Alpha subunit2

Beta subunits2

Mutations4

Biotin4

Mitochondrial5

Peptides2

Reductase4

Propionyl-CoA carboxy2

Acyl1

Receptors9

Recombinant12

Putative5

Polypeptide2

Mediate3

GluR21

Specificity2

Extracellular domain3

Membrane9

Transporter1

Amino7

Superfamily2

Intracellular2

Gene4

Glutathione S-transfera1

Outer1

Globular1

Endoplasmic1

Genes4

Molecular2

Interactions3

Biotinyl1

Transporters2

Enzyme4

Enzymes2

Tubulin1

Chromosome1

Genomes1

Conjugate1

NCBI2

Inhibitor5

Bacteria2

Synthesis3

Cytoplasmic2

Homology1

Thrombospondin1

Escherichia2

Monomers1