To evaluate the Swarm screening system, we optimized a series of heterologous optogenetic spiking HEK293 cell assays for several voltage-gated sodium channel subtypes including Nav1.2, Nav1.5, and Nav1.7. (frontiersin.org)
Genetic etiology of PE is mutations on SCN9A , the encoding gene of a voltage-gated sodium channel subtype Nav1.7. (biomedcentral.com)
This review mainly focuses on PE and the causative gene SCN9A -- its mutations and their effects on Nav1.7 channels' electrophysiological properties. (biomedcentral.com)
The causative gene for PE, SCN9A , encodes a voltage-gated sodium channel (VGSC) subtype Nav1.7. (biomedcentral.com)
PE is exclusively caused by mutations in SCN9A , the encoding gene of sodium channel subtype Nav1.7 and can be sub-classified into familial (inherited erythromelalgia) and sporadic forms. (biomedcentral.com)
Blockers2
The Swarm was able to record pseudo-action potentials stably across all 24 objectives and provided pharmacological characterization of diverse sodium channel blockers. (frontiersin.org)
It targets the site 3 of voltage-gated sodium channels, thus mainly prolonging the inactivation time course of the channel. (wikipedia.org)
Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. (frontiersin.org)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. (antibodiesinc.com)
Nav1.22
Bulk Order Inquiry for Anti-Nav1.2 Na+ Channel Antibody ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. (antibodiesinc.com)
Neurons3
The sea anemone Bunodosoma caissarum toxin BcIII modulates the sodium current kinetics of rat dorsal root ganglia neurons and is displaced in a voltage-dependent manner. (wikipedia.org)
When a neuron receives signals from other neurons via synapses, ion channels open and the neuronal charge becomes either more positive or negative, depending on the type of ion. (epiphanyasd.com)
Scn2a1
It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. (antibodiesinc.com)
20171
Yin L, Rasch MJ, He Q, Wu S, Dou F, Shu Y. (2017), ' Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. . (antibodiesinc.com)
Dysfunction3
Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study. (cdc.gov)
It is known that a dysfunction of the gene, SCN1A, that encodes encoding voltage-gated sodium channel Na V 1.1 causes Dravet's syndrome. (epiphanyasd.com)
Hyperexcitability1
2015), ' Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability. . (antibodiesinc.com)
Gene1
BACKGROUND: Duplications of the long arm of chromosome 3 are rare, and associated to a well-defined contiguous gene syndrome known as partial trisomy 3q syndrome. (bvsalud.org)
Neuronal2
Ion channels are critical for shaping neuronal excitability. (epiphanyasd.com)
Variations in ion channel genes are likely to affect a myriad of brain functions. (epiphanyasd.com)
Open2
The channel remains longer in the open state before inactivating, leading to an increase in the peak amplitude of the sodium current Moreover, BcIII acts in a voltage-dependent manner. (wikipedia.org)
Reducing Nav1 .6 expression attenuates the pathogenesis of Alzheimer ' s disease by suppressing BACE1 transcription. (nih.gov)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Specific1
In today's post we will look at some very extensive research by Dr Catterall , who seems to be the world's expert on a specific sodium ion channel called Na V 1.1. (epiphanyasd.com)
Increase1
Ion channels may even provide a link between genetics and the environment because environmental factors like mercury increase calcium signaling. (epiphanyasd.com)